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David G. Nathan, MD

David G. Nathan, MD

Pediatric Hematology/Oncology
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Contact Information

Fax

617-632-2161

Appointments

888-733-4662 (New Pediatric Patients)
617-632-3270 (Established Pediatric Patients)

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Biography

David G. Nathan, MD

Dr. Nathan received his MD from Harvard Medical School in 1955, and was senior resident in medicine at Peter Bent Brigham Hospital and clinical associate at the National Cancer Institute. Between 1967 and 1984, he was chief of hematology at Children's Hospital Boston (CHB), and then chief of hematology and oncology at CHB and DFCI. He chaired the Department of Pediatrics from 1985 to 1995, and served as president of DFCI until 2000.

Researcher

Physician

President Emeritus, Dana-Farber Cancer Institute
Robert A. Stranahan Distinguished Professor of Pediatrics and Professor of Medicine, Harvard Medical School

Centers/Programs

Clinical Interests

Aplastic anemia, Sickle cell disease, Thalassemia

Diseases Treated

Board Certification

  • Internal Medicine
  • Pediatrics

Fellowship

  • National Cancer Institute

Residency

  • Brigham and Women's Hospital

Medical School

  • Harvard Medical School

Recent Awards

  • National Medal of Science 1990
  • Annual Award for Excellence in Clinical Research, NIH 1996
  • Henry Stratton Medal, American Society of Hematology 1995
  • Howland Medal of the American Pediatric Society 2003
  • George M. Kober Medal of the Association of American Physicians 2006
  • John Stearns Medal for Lifetime Achievement in Medicine of the New York Academy of Medicine 2009

Research

    View Dr. Nathan’s Research

    Treatment of Sickle Cell Crisis with Inhibitors of NKT cell activation RC2HL101367 2010-2012

    This is a consortium grant of which I am clinical co-PI and my colleague Joel Linden of the LaJolla Institute of Allergy and Immunology is the basic science co-PI. Linden has studied sickle cell disease mice and found that inhibition of iNKT cells with either antibodies or adenosine analogues markedly improves pulmonary disease in these animals. Therefore Linden and I together with colleagues at Children's Hospital, Brigham and Women's Hospital, Beth Israel Deaconess Hospital and Washington University in St Louis have established a program in which we intend to determine whether Lexiscan, an FDA approved adenosine analogue, can be administered safely in doses capable of inhibiting iNKT cells in sickle cell anemia patients. After a satisfactory dose is determined, we will treat such patients with Lexiscan with the hope that the drug will reduce the impact of both painful vaso-occlusive crises and acute chest syndrome. We now have FDA and local IRB approval. Patient accrual should begin in March of 2010. The first experiments will be dose finding efforts. Meanwhile Linden and co-workers are searching in the laboratory for better drugs and antibodies that may be more effective than Lexiscan in blunting of the adenosine A2a receptors that richly decorate INKT cells without activating other classes of adenosine receptors on the vascular endothelial cells.

    Research Departments

    Publications

      View Dr. Nathan's Publications

      • Correcting the record on anemia of aging: a statistical reanalysis. Blood Adv. 2023 07 25; 7(14):3642-3643. View in: Pubmed

      • COVID-19, nuclear war, and global warming: lessons for our vulnerable world. Lancet. 2020 06 27; 395(10242):1967-1968. View in: Pubmed

      • The Genetic Landscape of Diamond-Blackfan Anemia. Am J Hum Genet. 2018 12 06; 103(6):930-947. View in: Pubmed

      • The Pathophysiology of Acquired Aplastic Anemia: Current Concepts Revisited. Hematol Oncol Clin North Am. 2018 Aug; 32(4):581-594. View in: Pubmed

      • Training. Pediatr Blood Cancer. 2018 02; 65(2). View in: Pubmed

      • Cholesterol: the debate should be terminated. FASEB J. 2017 07; 31(7):2722-2728. View in: Pubmed

      • Eulogy for the clinical research center. J Clin Invest. 2016 07 01; 126(7):2388-91. View in: Pubmed

      • Thalassemia: a look to the future. Ann N Y Acad Sci. 2016 03; 1368(1):11-5. View in: Pubmed

      • Amino acid uptake in erythropoiesis. Sci Signal. 2015 Apr 14; 8(372):fs9. View in: Pubmed

      • A conversation with David Nathan. J Clin Invest. 2014 Dec; 124(12):5090-1. View in: Pubmed

      • Hereditary xerocytosis revisited. Am J Hematol. 2014 Dec; 89(12):1142-6. View in: Pubmed

      • A tribute to Emil Frei III. J Clin Invest. 2013 Aug 1; 123(8):3188-9. View in: Pubmed

      • Pathophysiology and Clinical Manifestations of the ß-Thalassemias. Cold Spring Harb Perspect Med. 2012 Dec 01; 2(12):a011726. View in: Pubmed

      • Exome sequencing identifies GATA1 mutations resulting in Diamond-Blackfan anemia. J Clin Invest. 2012 Jul; 122(7):2439-43. View in: Pubmed

      • Sickle cell disease (SCD), iNKT cells, and regadenoson infusion. Trans Am Clin Climatol Assoc. 2012; 123:312-7; discussion 317-8. View in: Pubmed

      • Fetal hemoglobin levels and morbidity in untransfused patients with ß-thalassemia intermedia. Blood. 2012 Jan 12; 119(2):364-7. View in: Pubmed

      • Guilt by association. Blood. 2011 Oct 06; 118(14):3758-9. View in: Pubmed

      • Reversing the hemoglobin switch. N Engl J Med. 2010 Dec 02; 363(23):2258-60. View in: Pubmed

      • Thalassemia: an overview of 50 years of clinical research. Hematol Oncol Clin North Am. 2010 Dec; 24(6):1005-20. View in: Pubmed

      • A life-long quest to understand and treat genetic blood disorders. Cell. 2010 Oct 01; 143(1):17-20. View in: Pubmed

      • Pulmonary hypertension and nitric oxide depletion in sickle cell disease. Blood. 2010 Aug 05; 116(5):687-92. View in: Pubmed

      • Musings on genome medicine: Hepatitis C. Genome Med. 2010 Jan 27; 2(1):4. View in: Pubmed

      • Sickle cell disease and stroke. Blood. 2009 Dec 10; 114(25):5117-25. View in: Pubmed

      • Musings on genome medicine: enzyme-replacement therapy of the lysosomal storage diseases. Genome Med. 2009 Dec 09; 1(12):114. View in: Pubmed

      • Musings on genome medicine: Crohn's disease. Genome Med. 2009 Nov 05; 1(11):103. View in: Pubmed

      • Musings on genome medicine: the slow but inexorable process of medical care reform in the United States. Genome Med. 2009 Oct 12; 1(10):94. View in: Pubmed

      • Call for a slower approach to health care reform. J Clin Invest. 2009 Oct; 119(10):2847-8. View in: Pubmed

      • Musings on genome medicine: the Obama effect redux. Genome Med. 2009 Sep 11; 1(9):86. View in: Pubmed

      • Musings on genome medicine: cholesterol and coronary artery disease. Genome Med. 2009 Jun 08; 1(6):60. View in: Pubmed

      • Musings on genome medicine: cancer genetics and the promise of effective treatment. Genome Med. 2009 May 06; 1(5):49. View in: Pubmed

      • Musings on genome medicine: gene therapy. Genome Med. 2009 Apr 03; 1(4):38. View in: Pubmed

      • Musings on genome medicine: the Obama effect. Genome Med. 2009 Mar 09; 1(3):30. View in: Pubmed

      • Musings on genome medicine: abuse of genetic tests. Genome Med. 2009 Feb 16; 1(2):18. View in: Pubmed

      • Musings on genome medicine: genome wide association studies. Genome Med. 2009 Jan 20; 1(1):3. View in: Pubmed

      • Judah Folkman, MD, 1933-2008. Pharos Alpha Omega Alpha Honor Med Soc. 2009; 4-8. View in: Pubmed

      • Targeting the cell death-survival equation. Clin Cancer Res. 2007 Dec 15; 13(24):7250-3. View in: Pubmed

      • Stanley J. Korsmeyer. Proc Am Philos Soc. 2007 Jun; 151(2):243-6. View in: Pubmed

      • Acceptance of the 2006 Kober medal. J Clin Invest. 2007 Apr; 117(4):1107-13. View in: Pubmed

      • The cancer treatment revolution. Trans Am Clin Climatol Assoc. 2007; 118:317-23. View in: Pubmed

      • Ribosomal protein S24 gene is mutated in Diamond-Blackfan anemia. Am J Hum Genet. 2006 Dec; 79(6):1110-8. View in: Pubmed

      • NIH support for basic and clinical research: biomedical researcher angst in 2006. JAMA. 2006 Jun 14; 295(22):2656-8. View in: Pubmed

      • The several Cs of translational clinical research. J Clin Invest. 2005 Apr; 115(4):795-7. View in: Pubmed

      • New developments in iron chelators. Curr Opin Hematol. 2005 Mar; 12(2):129-34. View in: Pubmed

      • Thalassemia: the continued challenge. Ann N Y Acad Sci. 2005; 1054:1-10. View in: Pubmed

      • RNA and protein evidence for haplo-insufficiency in Diamond-Blackfan anaemia patients with RPS19 mutations. Br J Haematol. 2004 Oct; 127(1):105-13. View in: Pubmed

      • Determination can win the battle. Lancet. 2004 Jul 17-23; 364(9430):301. View in: Pubmed

      • Acceptance of the 2003 John Howland Award: a journey in clinical research. Pediatr Res. 2004 Aug; 56(2):169-76. View in: Pubmed

      • Clinical research and the NIH--a report card. N Engl J Med. 2003 Nov 06; 349(19):1860-5. View in: Pubmed

      • First-trimester sex hormone binding globulin and subsequent gestational diabetes mellitus. Am J Obstet Gynecol. 2003 Jul; 189(1):171-6. View in: Pubmed

      • Deferiprone and hepatic fibrosis. Blood. 2003 Jun 15; 101(12):5089-90; author reply 5090-1. View in: Pubmed

      • Effectiveness and safety of ICL670 in iron-loaded patients with thalassaemia: a randomised, double-blind, placebo-controlled, dose-escalation trial. Lancet. 2003 May 10; 361(9369):1597-602. View in: Pubmed

      • Deferiprone versus desferrioxamine in thalassaemia, and T2* validation and utility. Lancet. 2003 Jan 11; 361(9352):183; author reply 183-4. View in: Pubmed

      • Clinical research: a tale of two studies. Trans Am Clin Climatol Assoc. 2003; 114:219-30; discussion 230-2. View in: Pubmed

      • Academic freedom in clinical research. N Engl J Med. 2002 Oct 24; 347(17):1368-71. View in: Pubmed

      • A novel diagnostic screen for defects in the Fanconi anemia pathway. Blood. 2002 Dec 15; 100(13):4649-54. View in: Pubmed

      • Careers in translational clinical research-historical perspectives, future challenges. JAMA. 2002 May 08; 287(18):2424-7. View in: Pubmed

      • Educational-debt relief for clinical investigators--a vote of confidence. N Engl J Med. 2002 Jan 31; 346(5):372-4. View in: Pubmed

      • Comprehensive cancer centres and the war on cancer. Nat Rev Cancer. 2001 Dec; 1(3):240-5. View in: Pubmed

      • Neurovisual abnormalities preceding the retinopathy in patients with long-term type 1 diabetes mellitus. Graefes Arch Clin Exp Ophthalmol. 2001 Sep; 239(9):643-8. View in: Pubmed

      • Evidence for linkage of familial Diamond-Blackfan anemia to chromosome 8p23.3-p22 and for non-19q non-8p disease. Blood. 2001 Apr 01; 97(7):2145-50. View in: Pubmed

      • The National Institutes of Health and clinical research: a progress report. Nat Med. 2000 Nov; 6(11):1201-4. View in: Pubmed

      • Congenital bone marrow failure syndromes. Br J Haematol. 2000 Oct; 111(1):30-42. View in: Pubmed

      • One-day ex vivo culture allows effective gene transfer into human nonobese diabetic/severe combined immune-deficient repopulating cells using high-titer vesicular stomatitis virus G protein pseudotyped retrovirus. Blood. 1999 Apr 01; 93(7):2217-24. View in: Pubmed

      • Academia and industry: lessons from the unfortunate events in Toronto. Lancet. 1999 Mar 06; 353(9155):771-2. View in: Pubmed

      • Iron chelation with oral deferiprone in patients with thalassemia. N Engl J Med. 1998 Dec 03; 339(23):1711-2; author reply 1713-4. View in: Pubmed

      • Clinical research: perceptions, reality, and proposed solutions. National Institutes of Health Director's Panel on Clinical Research. JAMA. 1998 Oct 28; 280(16):1427-31. View in: Pubmed

      • Pioneers and modern ideas. Prospective on thalassemia. Pediatrics. 1998 Jul; 102(1 Pt 3):281-3; discussion 288-9. View in: Pubmed

      • The beta chain of the interleukin-3 receptor functionally associates with the erythropoietin receptor. Blood. 1997 Sep 01; 90(5):1867-73. View in: Pubmed

      • The beta c component of the granulocyte-macrophage colony-stimulating factor (GM-CSF)/interleukin 3 (IL-3)/IL-5 receptor interacts with a hybrid GM-CSF/erythropoietin receptor to influence proliferation and beta-globin mRNA expression. Mol Med. 1996 Nov; 2(6):766-73. View in: Pubmed

      • Cooperation between core binding factor and adjacent promoter elements contributes to the tissue-specific expression of interleukin-3. J Biol Chem. 1996 Jun 14; 271(24):14020-7. View in: Pubmed

      • Diamond-Blackfan anemia. Natural history and sequelae of treatment. Medicine (Baltimore). 1996 Mar; 75(2):77-8. View in: Pubmed

      • Iron Deficiency Anemia Associated with an Error of Iron Metabolism in Two Siblings: A Thirty Year Follow Up. Hematology. 1996; 1(1):65-73. View in: Pubmed

      • An orally active iron chelator. N Engl J Med. 1995 Apr 06; 332(14):953-4. View in: Pubmed

      • Survival in medically treated patients with homozygous beta-thalassemia. N Engl J Med. 1994 Sep 01; 331(9):574-8. View in: Pubmed

      • Interleukin-3 expression by activated T cells involves an inducible, T-cell-specific factor and an octamer binding protein. Blood. 1993 Feb 15; 81(4):928-34. View in: Pubmed

      • Academic careers: choice and activity of graduates of a pediatric residency program 1974-1986. Trans Am Clin Climatol Assoc. 1993; 104:180-95; discussion 195-7. View in: Pubmed

      • Hydroxyurea-induced HbF production in anemic primates: augmentation by erythropoietin, hematopoietic growth factors, and sodium butyrate. Exp Hematol. 1992 Nov; 20(10):1156-64. View in: Pubmed

      • Careers chosen by graduates of a major pediatrics residency program, 1974-1986. Acad Med. 1992 Apr; 67(4):272-4. View in: Pubmed

      • A service chief model for general pediatric inpatient care and residency training. Pediatrics. 1992 Apr; 89(4 Pt 1):601-7. View in: Pubmed

      • Restoration of phagocyte function by interferon-gamma in X-linked chronic granulomatous disease occurs at the level of a progenitor cell. Blood. 1990 Dec 15; 76(12):2443-8. View in: Pubmed

      • Intrinsic potential for high fetal hemoglobin production in a Druz family with beta-thalassemia is due to an unlinked genetic determinant. Hum Genet. 1990 Dec; 86(2):175-80. View in: Pubmed

      • The effect of desferrithiocin, an oral iron chelator, on T-cell function. Blood. 1990 Nov 15; 76(10):2052-9. View in: Pubmed

      • The treatment of Cooley's anemia. Haematologica. 1990 Sep-Oct; 75 Suppl 5:57-65. View in: Pubmed

      • Treatment of Cooley's anemia. Blood. 1990 Aug 01; 76(3):435-44. View in: Pubmed

      • Positive and negative elements regulate human interleukin 3 expression. Proc Natl Acad Sci U S A. 1990 Jul; 87(13):5046-50. View in: Pubmed

      • Regulation of hematopoiesis. Pediatr Res. 1990 May; 27(5):423-31. View in: Pubmed

      • Oral iron chelators. Semin Hematol. 1990 Apr; 27(2):83-5. View in: Pubmed

      • The Jeremiah Metzger lecture. Regulation of hematopoiesis. Trans Am Clin Climatol Assoc. 1990; 101:135-53. View in: Pubmed

      • Pharmacologic manipulation of fetal hemoglobin in the hemoglobinopathies. Ann N Y Acad Sci. 1990; 612:179-83. View in: Pubmed

      • The beneficence of neonatal hematopoiesis. N Engl J Med. 1989 Oct 26; 321(17):1190-1. View in: Pubmed

      • Granulocyte-macrophage colony-stimulating factor and interleukin-3 mRNAs are produced by a small fraction of blood mononuclear cells. Blood. 1989 Oct; 74(5):1525-30. View in: Pubmed

      • Expression of human interleukin-3 (multi-CSF) is restricted to human lymphocytes and T-cell tumor lines. Blood. 1989 Mar; 73(4):945-51. View in: Pubmed

      • Beta-thalassemia due to two novel nucleotide substitutions in consensus acceptor splice sequences of the beta-globin gene. Blood. 1989 Mar; 73(4):914-8. View in: Pubmed

      • Combinations of recombinant colony-stimulating factors are required for optimal hematopoietic differentiation in serum-deprived culture. Blood. 1989 Feb 15; 73(3):688-93. View in: Pubmed

      • Regulation of the human interleukin-3 gene. Trans Assoc Am Physicians. 1989; 102:240-51. View in: Pubmed

      • Saudi Arabian sickle cell anemia. A molecular approach. Ann N Y Acad Sci. 1989; 565:143-51. View in: Pubmed

      • Combinations of purified recombinant colony-stimulating factors are required for optimal hematopoietic differentiation. Trans Assoc Am Physicians. 1988; 101:282-7. View in: Pubmed

      • Decreased hematopoietic accessory cell function following bone marrow transplantation. Exp Hematol. 1987 Nov; 15(10):1013-21. View in: Pubmed

      • Leukemia and the regulation of hematopoiesis. Leukemia. 1987 Oct; 1(10):683-96. View in: Pubmed

      • Analysis of hemoglobin F production in Saudi Arabian families with sickle cell anemia. Blood. 1987 Sep; 70(3):716-20. View in: Pubmed

      • Stimulation of human hematopoietic colony formation by recombinant gibbon multi-colony-stimulating factor or interleukin 3. J Clin Invest. 1987 Sep; 80(3):818-23. View in: Pubmed

      • Recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF) shortens the period of neutropenia after autologous bone marrow transplantation in a primate model. J Clin Invest. 1987 Aug; 80(2):573-7. View in: Pubmed

      • Molecular analysis of the high-hemoglobin-F phenotype in Saudi Arabian sickle cell anemia. N Engl J Med. 1987 Jan 29; 316(5):244-50. View in: Pubmed

      • Analysis of high fetal hemoglobin production in sickle cell anemia patients from the Eastern Province of Saudi Arabia. Prog Clin Biol Res. 1987; 251:415-26. View in: Pubmed

      • Regulation of fetal hemoglobin synthesis in sickle cell anemia. Trans Am Clin Climatol Assoc. 1987; 98:21-8. View in: Pubmed

      • Investigations of the simian ontogenic switch from fetal to adult hemoglobin at the progenitor cell level. J Clin Invest. 1986 Dec; 78(6):1497-503. View in: Pubmed

      • High fetal hemoglobin production in sickle cell anemia in the eastern province of Saudi Arabia is genetically determined. Blood. 1986 May; 67(5):1404-10. View in: Pubmed

      • Dependence of highly enriched human bone marrow progenitors on hemopoietic growth factors and their response to recombinant erythropoietin. J Clin Invest. 1986 Jan; 77(1):74-81. View in: Pubmed

      • Bone marrow transplantation for paroxysmal nocturnal hemoglobinuria: eradication of the PNH clone and documentation of complete lymphohematopoietic engraftment. Blood. 1985 Dec; 66(6):1247-50. View in: Pubmed

      • Purification of fetal hematopoietic progenitors and demonstration of recombinant multipotential colony-stimulating activity. J Clin Invest. 1985 Sep; 76(3):1286-90. View in: Pubmed

      • Influence of cell cycle phase-specific agents on simian fetal hemoglobin synthesis. J Clin Invest. 1985 Jun; 75(6):1999-2005. View in: Pubmed

      • Determination of the hemoglobin F program in human progenitor-derived erythroid cells. J Clin Invest. 1985 Apr; 75(4):1359-68. View in: Pubmed

      • Identification of three accessory cell populations in human bone marrow with erythroid burst-promoting properties. J Clin Invest. 1985 Apr; 75(4):1278-84. View in: Pubmed

      • Current therapy and new approaches to the treatment of thalassemia major. Ann N Y Acad Sci. 1985; 445:248-55. View in: Pubmed

      • Regulation of fetal hemoglobin synthesis by cell cycle specific drugs. Prog Clin Biol Res. 1985; 191:475-500. View in: Pubmed

      • Regulation of fetal hemoglobin synthesis in the hemoglobinopathies. Ann N Y Acad Sci. 1985; 445:177-87. View in: Pubmed

      • Hydroxyurea enhances fetal hemoglobin production in sickle cell anemia. J Clin Invest. 1984 Aug; 74(2):652-6. View in: Pubmed

      • Augmentation of fetal-hemoglobin production in anemic monkeys by hydroxyurea. N Engl J Med. 1984 Apr 05; 310(14):869-73. View in: Pubmed

      • Hydroxyurea increases fetal hemoglobin production in sickle cell anemia. Trans Assoc Am Physicians. 1984; 97:268-74. View in: Pubmed

      • Nutrition classics: the Journal of Clinical Investigation, volume 43, 1964. Iron deficiency anemia associated with an error of iron metabolism in two siblings. Nutr Rev. 1983 Oct; 41(10):315-7. View in: Pubmed

      • Evidence for genetic restriction in the suppression of erythropoiesis by a unique subset of T lymphocytes in man. J Clin Invest. 1983 Aug; 72(2):694-706. View in: Pubmed

      • Synthesis of hemoglobin F in adult simian erythroid progenitor-derived colonies. J Clin Invest. 1982 Oct; 70(4):752-61. View in: Pubmed

      • Clinical removal of iron. Annu Rev Med. 1982; 33:509-19. View in: Pubmed

      • Exercise-induced hemolysis in xerocytosis. Erythrocyte dehydration and shear sensitivity. J Clin Invest. 1981 Sep; 68(3):631-8. View in: Pubmed

      • Heterogeneity of DNA deletion in gamma delta beta-thalassemia. J Clin Invest. 1981 Mar; 67(3):878-84. View in: Pubmed

      • Control of the simian fetal hemoglobin switch at the progenitor cell level. J Clin Invest. 1981 Feb; 67(2):458-66. View in: Pubmed

      • The molecular genetics of thalassemia. Adv Hum Genet. 1981; 11:233-80. View in: Pubmed

      • Treatment of acute myelogenous leukemia in children and adults. N Engl J Med. 1980 Aug 28; 303(9):473-8. View in: Pubmed

      • Aplastic and hypoplastic anemia. Pediatr Clin North Am. 1980 May; 27(2):217-35. View in: Pubmed

      • New approaches to the transfusion management of thalassemia. Blood. 1980 Jan; 55(1):55-60. View in: Pubmed

      • Prenatal diagnosis of hemoglobinopathies: the New England approach. Ann N Y Acad Sci. 1980; 344:151-64. View in: Pubmed

      • Monocytes do not inhibit peripheral blood erythroid burst forming unit colony formation. J Clin Invest. 1980 Jan; 65(1):219-23. View in: Pubmed

      • F-cell regulation. Ann N Y Acad Sci. 1980; 344:219-32. View in: Pubmed

      • Prenatal diagnosis of hemoglobinopathies. Clin Perinatol. 1979 Sep; 6(2):275-91. View in: Pubmed

      • Progress in thalassemia research. Nature. 1979 Jul 26; 280(5720):275-6. View in: Pubmed

      • Partial deletion of beta-globin gene DNA in certain patients with beta 0-thalassemia. Proc Natl Acad Sci U S A. 1979 May; 76(5):2400-4. View in: Pubmed

      • The molecular basis of alpha-thalassemias: frequent occurrence of dysfunctional alpha loci among non-Asians with Hb H disease. Cell. 1979 May; 17(1):33-42. View in: Pubmed

      • Application of endonuclease mapping to the analysis and prenatal diagnosis of thalassemias caused by globin-gene deletion. N Engl J Med. 1978 Jul 27; 299(4):166-72. View in: Pubmed

      • Antenatal diagnosis of thalassaemia major. Br Med J. 1978 Feb 11; 1(6109):350-3. View in: Pubmed

      • Erythroid precursors in congenital hypoplastic (Diamond-Blackfan) anemia. J Clin Invest. 1978 Feb; 61(2):489-98. View in: Pubmed

      • Treatment of iron overload in adults with continuous parenteral desferrioxamine. Am J Med. 1977 Dec; 63(6):958-66. View in: Pubmed

      • Continuous subcutaneous administration of deferoxamine in patients with iron overload. N Engl J Med. 1977 08 25; 297(8):418-23. View in: Pubmed

      • Fetal research: an investigator's view. Villanova Law Rev. 1977 Jan; 22(2):384-94. View in: Pubmed

      • Prenatal diagnosis of hemoglobinopathies: detection of alpha-thalassemia trait and of sickle cell disease in utero. Hemoglobin. 1977; 1(4):395-400. View in: Pubmed

      • Evaluation of continuous desferrioxamine administration in adults with transfusional hemosiderosis. Trans Assoc Am Physicians. 1977; 90:335-41. View in: Pubmed

      • Prenatal diagnosis of hemoglobinopathies. A review of 15 cases. N Engl J Med. 1976 Dec 23; 295(26):1437-43. View in: Pubmed

      • The thalassemias. N Engl J Med. 1976 Sep 23; 295(13):710-4. View in: Pubmed

      • Reassessment of the use of desferrioxamine B in iron overload. N Engl J Med. 1976 Jun 24; 294(26):1421-3. View in: Pubmed

      • Prenatal diagnosis of sickle-cell anemia and alpha G Philadelphia. Study of a Fetus also at risk for H b S/beta+-thalassemia. N Engl J Med. 1976 May 06; 294(19):1040-1. View in: Pubmed

      • The acute and transient nature of idiopathic immune hemolytic anemia in childhood. J Pediatr. 1976 May; 88(5):780-3. View in: Pubmed

      • The molecular genetics of thalassemia. Birth Defects Orig Artic Ser. 1976; 12(8):145-59. View in: Pubmed

      • Molecular pathology of the thalassemias. Adv Intern Med. 1976; 21:97-128. View in: Pubmed

      • Expression of the beta-thalassemia gene in the first trimester fetus. Proc Natl Acad Sci U S A. 1975 Sep; 72(9):3633-7. View in: Pubmed

      • Antenatal diagnosis of hemoglobinopathies: social and technical considerations. Semin Hematol. 1975 Jul; 12(3):305-21. View in: Pubmed

      • Hemoglobin Syracuse (alpha2beta2-143(H21)His leads to Pro), a new high-affinity variant detected by special electrophoretic methods. Observations on the auto-oxidation of normal and variant hemoglobins. J Clin Invest. 1975 Mar; 55(3):469-77. View in: Pubmed

      • Thalassemia. Annu Rev Med. 1975; 26:345-51. View in: Pubmed

      • Ethical problems in fetal research. J Gen Educ. 1975; 27(3):165-75. View in: Pubmed

      • Progress in the methodology for antenatal diagnosis of the beta chain hemoglobinopathies. Trans Assoc Am Physicians. 1975; 88:168-76. View in: Pubmed

      • Globin translation in thalassemic bone marrow. Ann N Y Acad Sci. 1974 Nov 29; 241(0):253-61. View in: Pubmed

      • In utero diagnosis of: hemoglobinopathies. Hemoglobin synthesis in fetal red cells. N Engl J Med. 1974 May 09; 290(19):1067-8. View in: Pubmed

      • Relation of beta to gamma synthesis during the first trimester: an approach to prenatal diagnosis of thalassemia. Pediatr Res. 1974 May; 8(5):553-60. View in: Pubmed

      • Intrauterine diagnosis of thalassemia. Ann N Y Acad Sci. 1974; 232(0):145-51. View in: Pubmed

      • Translational control of hemoglobin synthesis in thalassemic bone marrow. Ann N Y Acad Sci. 1974; 232(0):40-3. View in: Pubmed

      • Effects of cyanate and 2,3-diphosphoglycerate on sickling. Relationship to oxygenation. J Clin Invest. 1973 Oct; 52(10):2542-7. View in: Pubmed

      • The mortality of acquired aplastic anemia in children. Blood. 1972 Aug; 40(2):153-62. View in: Pubmed

      • Equal synthesis of - and -globin chains in erythroid precursors in heterozygous -thalassemia. J Clin Invest. 1972 Jul; 51(7):1906-9. View in: Pubmed

      • Energy metabolism in human erythrocytes. II. Effects of glucose depletion. J Clin Invest. 1972 Jun; 51(6):1547-54. View in: Pubmed

      • Thalassemia. N Engl J Med. 1972 Mar 16; 286(11):586-94. View in: Pubmed

      • Changes in fatty acid metabolism after erythrocyte peroxidation: stimulation of a membrane repair process. J Clin Invest. 1972 Feb; 51(2):338-44. View in: Pubmed

      • Gamma-beta thalassemia: a cause of hemolytic disease of the newborn. N Engl J Med. 1972 Jan 20; 286(3):129-34. View in: Pubmed

      • Oxidant injury of caucasian glucose-6-phosphate dehydrogenase-deficient red blood cells by phagocytosing leukocytes during infection. J Clin Invest. 1971 Dec; 50(12):2466-73. View in: Pubmed

      • Amino acid oxidase of leukocytes in relation to H 2 O 2 -mediated bacterial killing. J Clin Invest. 1971 Sep; 50(9):1985-91. View in: Pubmed

      • Energy metabolism in human erythrocytes. I. Effects of sodium fluoride. J Clin Invest. 1971 Aug; 50(8):1731-7. View in: Pubmed

      • Selective reticulocyte destruction in erythrocyte pyruvate kinase deficiency. J Clin Invest. 1971 Mar; 50(3):688-99. View in: Pubmed

      • Endogenous production of carbon monoxide in normal and erythroblastotic newborn infants. J Clin Invest. 1971 Jan; 50(1):1-8. View in: Pubmed

      • Normal and variant isoenzymes of human blood cell hexokinase and the isoenzyme patterns in hemolytic anemia. Blood. 1970 Aug; 36(2):219-27. View in: Pubmed

      • Correction of metabolic deficiencies in the leukocytes of patients with chronic granulomatous disease. J Clin Invest. 1970 May; 49(5):865-70. View in: Pubmed

      • Mild thalassemia: the result of interactions of alpha and beta thalassemia genes. J Clin Invest. 1970 Apr; 49(4):635-42. View in: Pubmed

      • Mild thalassemia--a guide to therapy. N Engl J Med. 1969 Dec 11; 281(24):1363-4. View in: Pubmed

      • Unbalanced globin chain synthesis in alpha-thalassemia heterozygotes. Ann N Y Acad Sci. 1969 Nov 20; 165(1):288-94. View in: Pubmed

      • Globin chain synthesis in the alpha thalassemia syndromes. J Clin Invest. 1969 Nov; 47(11):2512-22. View in: Pubmed

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      Dana-Farber Cancer Institute

      450 Brookline Avenue Dana 1644 Boston, MA 02215
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      42.3374, -71.1082

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