Leonard I. Zon, MD

Colorimetric Barcoding to Track, Isolate, and Analyze Hematopoietic Stem Cell Clones. Methods Mol Biol. 2024; 2707:265-277. View in: Pubmed

Structural basis for inactivation of PRC2 by G-quadruplex RNA. Science. 2023 09 22; 381(6664):1331-1337. View in: Pubmed

Transcription factors interact with RNA to regulate genes. Mol Cell. 2023 07 20; 83(14):2449-2463.e13. View in: Pubmed

Microenvironmental control of hematopoietic stem cell fate via CXCL8 and protein kinase C. Cell Rep. 2023 05 30; 42(5):112528. View in: Pubmed

PGE2 alters chromatin through H2A.Z-variant enhancer nucleosome modification to promote hematopoietic stem cell fate. Proc Natl Acad Sci U S A. 2023 05 09; 120(19):e2220613120. View in: Pubmed

Transcription factor induction of vascular blood stem cell niches in vivo. Dev Cell. 2023 06 19; 58(12):1037-1051.e4. View in: Pubmed

Oncogenic CDK13 mutations impede nuclear RNA surveillance. Science. 2023 04 21; 380(6642):eabn7625. View in: Pubmed

Identification of unique a4 chain structure and conserved antiangiogenic activity of a3NC1 type IV collagen in zebrafish. Dev Dyn. 2023 07; 252(7):1046-1060. View in: Pubmed

Transplantation-based screen identifies inducers of muscle progenitor cell engraftment across vertebrate species. Cell Rep. 2023 Apr 25; 42(4):112365. View in: Pubmed

Clonal hematopoiesis and inflammation - the perpetual cycle. Trends Cell Biol. 2023 Aug; 33(8):695-707. View in: Pubmed

The effects of intensive feeding on reproductive performance in laboratory zebrafish (Danio rerio). PLoS One. 2022; 17(11):e0278302. View in: Pubmed

Cellular barcoding to decipher clonal dynamics in disease. Science. 2022 10 14; 378(6616):eabm5874. View in: Pubmed

Loss of NECTIN1 triggers melanoma dissemination upon local IGF1 depletion. Nat Genet. 2022 12; 54(12):1839-1852. View in: Pubmed

Quality assurance of hematopoietic stem cells by macrophages determines stem cell clonality. Science. 2022 09 23; 377(6613):1413-1419. View in: Pubmed

Single-cell analyses reveal early thymic progenitors and pre-B cells in zebrafish. J Exp Med. 2022 09 05; 219(9). View in: Pubmed

Modeling Spitz melanoma in zebrafish using sequential mutagenesis. Dis Model Mech. 2022 08 01; 15(8). View in: Pubmed

External signals regulate continuous transcriptional states in hematopoietic stem cells. Elife. 2021 12 23; 10. View in: Pubmed

Resistance to inflammation underlies enhanced fitness in clonal hematopoiesis. Science. 2021 Nov 05; 374(6568):768-772. View in: Pubmed

Dissecting melanocytes to predict melanoma. Nat Cell Biol. 2021 09; 23(9):930-931. View in: Pubmed

In memory of Paul Sylvain Frenette, a pioneering explorer of the hematopoietic stem cell niche who left far too early. Exp Hematol. 2021 Aug 14. View in: Pubmed

Telomerase RNA recruits RNA polymerase II to target gene promoters to enhance myelopoiesis. Proc Natl Acad Sci U S A. 2021 08 10; 118(32). View in: Pubmed

Synergistic melanoma cell death mediated by inhibition of both MCL1 and BCL2 in high-risk tumors driven by NF1/PTEN loss. Oncogene. 2021 09; 40(38):5718-5729. View in: Pubmed

Nucleotide stress responses in neural crest cell fate and melanoma. Cell Cycle. 2021 08; 20(15):1455-1467. View in: Pubmed

Single-cell ATAC-seq reveals GATA2-dependent priming defect in myeloid and a maturation bottleneck in lymphoid lineages. Blood Adv. 2021 07 13; 5(13):2673-2686. View in: Pubmed

NNT mediates redox-dependent pigmentation via a UVB- and MITF-independent mechanism. Cell. 2021 08 05; 184(16):4268-4283.e20. View in: Pubmed

Zebrafish disease models in drug discovery: from preclinical modelling to clinical trials. Nat Rev Drug Discov. 2021 08; 20(8):611-628. View in: Pubmed

From development toward therapeutics, a collaborative effort on blood progenitors. Stem Cell Reports. 2021 07 13; 16(7):1674-1685. View in: Pubmed

A phase II trial of all-trans retinoic acid (ATRA) in advanced adenoid cystic carcinoma. Oral Oncol. 2021 08; 119:105366. View in: Pubmed

Mitochondrial function in development and disease. Dis Model Mech. 2021 06 01; 14(6). View in: Pubmed

Cell-specific transcriptional control of mitochondrial metabolism by TIF1? drives erythropoiesis. Science. 2021 05 14; 372(6543):716-721. View in: Pubmed

Identification of Basp1 as a novel angiogenesis-regulating gene by multi-model system studies. FASEB J. 2021 05; 35(5):e21404. View in: Pubmed

'Enhancing' red cell fate through epigenetic mechanisms. Curr Opin Hematol. 2021 05 01; 28(3):129-137. View in: Pubmed

A uniform format for manuscript submission. Cell. 2021 04 01; 184(7):1654-1656. View in: Pubmed

SPRED1 deletion confers resistance to MAPK inhibition in melanoma. J Exp Med. 2021 03 01; 218(3). View in: Pubmed

Melanoma models for the next generation of therapies. Cancer Cell. 2021 05 10; 39(5):610-631. View in: Pubmed

SATB2 induction of a neural crest mesenchyme-like program drives melanoma invasion and drug resistance. Elife. 2021 02 02; 10. View in: Pubmed

Blood in the water: recent uses of zebrafish to study myeloid biology. Curr Opin Hematol. 2021 01; 28(1):43-49. View in: Pubmed

Common variants in signaling transcription-factor-binding sites drive phenotypic variability in red blood cell traits. Nat Genet. 2020 12; 52(12):1333-1345. View in: Pubmed

Recurrent co-alteration of HDGF and SETDB1 on chromosome 1q drives cutaneous melanoma progression and poor prognosis. Pigment Cell Melanoma Res. 2021 05; 34(3):641-647. View in: Pubmed

Calmodulin inhibitors improve erythropoiesis in Diamond-Blackfan anemia. Sci Transl Med. 2020 10 21; 12(566). View in: Pubmed

Impact of COVID-19 Pandemic on Cancer Research. Cancer Cell. 2020 11 09; 38(5):591-593. View in: Pubmed

CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation. Proc Natl Acad Sci U S A. 2020 09 22; 117(38):23626-23635. View in: Pubmed

Cross-species analysis of enhancer logic using deep learning. Genome Res. 2020 12; 30(12):1815-1834. View in: Pubmed

A Transgenic System for Rapid Magnetic Enrichment of Rare Embryonic Cells. Zebrafish. 2020 10; 17(5):354-357. View in: Pubmed

An evolutionarily ancient mechanism for regulation of hemoglobin expression in vertebrate red cells. Blood. 2020 07 16; 136(3):269-278. View in: Pubmed

PRL3-DDX21 Transcriptional Control of Endolysosomal Genes Restricts Melanocyte Stem Cell Differentiation. Dev Cell. 2020 08 10; 54(3):317-332.e9. View in: Pubmed

Long-Range Optogenetic Control of Axon Guidance Overcomes Developmental Boundaries and Defects. Dev Cell. 2020 06 08; 53(5):577-588.e7. View in: Pubmed

Massively parallel reporter assays of melanoma risk variants identify MX2 as a gene promoting melanoma. Nat Commun. 2020 06 01; 11(1):2718. View in: Pubmed

Transcriptome Dynamics of Hematopoietic Stem Cell Formation Revealed Using a Combinatorial Runx1 and Ly6a Reporter System. Stem Cell Reports. 2020 05 12; 14(5):956-971. View in: Pubmed

Difference in biophysical properties of cancer-initiating cells in melanoma mutated zebrafish. J Mech Behav Biomed Mater. 2020 07; 107:103746. View in: Pubmed

Gain-of-Function Genetic Alterations of G9a Drive Oncogenesis. Cancer Discov. 2020 07; 10(7):980-997. View in: Pubmed

Zebrafish patient avatars in cancer biology and precision cancer therapy. Nat Rev Cancer. 2020 05; 20(5):263-273. View in: Pubmed

RNA helicase DDX21 mediates nucleotide stress responses in neural crest and melanoma cells. Nat Cell Biol. 2020 04; 22(4):372-379. View in: Pubmed

Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells. Nature. 2020 01; 577(7792):676-681. View in: Pubmed

From blood development to disease: a paradigm for clinical translation. Dis Model Mech. 2020 01 09; 13(1). View in: Pubmed

The Paf1 complex and P-TEFb have reciprocal and antagonist roles in maintaining multipotent neural crest progenitors. Development. 2019 12 16; 146(24). View in: Pubmed

Use of Zebrafish in Drug Discovery Toxicology. Chem Res Toxicol. 2020 01 21; 33(1):95-118. View in: Pubmed

Slow phosphorylation of a tyrosine residue in LAT optimizes T cell ligand discrimination. Nat Immunol. 2019 11; 20(11):1481-1493. View in: Pubmed

Zebrafish modeling reveals that SPINT1 regulates the aggressiveness of skin cutaneous melanoma and its crosstalk with tumor immune microenvironment. J Exp Clin Cancer Res. 2019 Sep 13; 38(1):405. View in: Pubmed

Tumor-Derived Extracellular Vesicles Breach the Intact Blood-Brain Barrier via Transcytosis. ACS Nano. 2019 12 24; 13(12):13853-13865. View in: Pubmed

Author Correction: Epoxyeicosatrienoic acids enhance embryonic haematopoiesis and adult marrow engraftment. Nature. 2019 Sep; 573(7772):E1. View in: Pubmed

Inflammasome Regulates Hematopoiesis through Cleavage of the Master Erythroid Transcription Factor GATA1. Immunity. 2019 07 16; 51(1):50-63.e5. View in: Pubmed

Modeling Cancer with Flies and Fish. Dev Cell. 2019 05 06; 49(3):317-324. View in: Pubmed

AIBP-mediated cholesterol efflux instructs hematopoietic stem and progenitor cell fate. Science. 2019 03 08; 363(6431):1085-1088. View in: Pubmed

Improving the visibility of developmental biology: time for induction and specification. Development. 2019 01 16; 146(2). View in: Pubmed

Estrogen Activation of G-Protein-Coupled Estrogen Receptor 1 Regulates Phosphoinositide 3-Kinase and mTOR Signaling to Promote Liver Growth in Zebrafish and Proliferation of Human Hepatocytes. Gastroenterology. 2019 05; 156(6):1788-1804.e13. View in: Pubmed

Nfe2 is dispensable for early but required for adult thrombocyte formation and function in zebrafish. Blood Adv. 2018 12 11; 2(23):3418-3427. View in: Pubmed

Stem cell safe harbor: the hematopoietic stem cell niche in zebrafish. Blood Adv. 2018 11 13; 2(21):3063-3069. View in: Pubmed

Generation of mouse-zebrafish hematopoietic tissue chimeric embryos for hematopoiesis and host-pathogen interaction studies. Dis Model Mech. 2018 11 05; 11(11). View in: Pubmed

Human tumor genomics and zebrafish modeling identify SPRED1 loss as a driver of mucosal melanoma. Science. 2018 11 30; 362(6418):1055-1060. View in: Pubmed

FAM210B is an erythropoietin target and regulates erythroid heme synthesis by controlling mitochondrial iron import and ferrochelatase activity. J Biol Chem. 2018 12 21; 293(51):19797-19811. View in: Pubmed

Stu Orkin is a superhero. J Clin Invest. 2018 10 01; 128(10):4213-4217. View in: Pubmed

Zebrafish blastomere screen identifies retinoic acid suppression of MYB in adenoid cystic carcinoma. J Exp Med. 2018 10 01; 215(10):2673-2685. View in: Pubmed

Specific oxylipins enhance vertebrate hematopoiesis via the receptor GPR132. Proc Natl Acad Sci U S A. 2018 09 11; 115(37):9252-9257. View in: Pubmed

Making HSCs in vitro: don't forget the hemogenic endothelium. Blood. 2018 09 27; 132(13):1372-1378. View in: Pubmed

JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia. J Exp Med. 2018 07 02; 215(7):1929-1945. View in: Pubmed

Protection from UV light is an evolutionarily conserved feature of the haematopoietic niche. Nature. 2018 06; 558(7710):445-448. View in: Pubmed

Neural crest state activation in NRAS driven melanoma, but not in NRAS-driven melanocyte expansion. Dev Biol. 2019 05 15; 449(2):107-114. View in: Pubmed

NOTCH signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cells. Nat Commun. 2018 05 08; 9(1):1828. View in: Pubmed

Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma. Cancer Cell. 2018 04 09; 33(4):785. View in: Pubmed

RNA helicase, DDX27 regulates skeletal muscle growth and regeneration by modulation of translational processes. PLoS Genet. 2018 03; 14(3):e1007226. View in: Pubmed

Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma. Cancer Cell. 2018 02 12; 33(2):322-336.e8. View in: Pubmed

The histone demethylase Jmjd3 regulates zebrafish myeloid development by promoting spi1 expression. Biochim Biophys Acta Gene Regul Mech. 2018 Feb; 1861(2):106-116. View in: Pubmed

Purification of zebrafish erythrocytes as a means of identifying a novel regulator of haematopoiesis. Br J Haematol. 2018 02; 180(3):420-431. View in: Pubmed

PD-L1 genetic overexpression or pharmacological restoration in hematopoietic stem and progenitor cells reverses autoimmune diabetes. Sci Transl Med. 2017 Nov 15; 9(416). View in: Pubmed

Cancer immunotherapy: The dark side of PD-1 receptor inhibition. Nature. 2017 12 07; 552(7683):41-42. View in: Pubmed

Toddler signaling regulates mesodermal cell migration downstream of Nodal signaling. Elife. 2017 11 09; 6. View in: Pubmed

Loci associated with skin pigmentation identified in African populations. Science. 2017 11 17; 358(6365). View in: Pubmed

KIT Suppresses BRAFV600E-Mutant Melanoma by Attenuating Oncogenic RAS/MAPK Signaling. Cancer Res. 2017 11 01; 77(21):5820-5830. View in: Pubmed

Fishing for answers in precision cancer medicine. Proc Natl Acad Sci U S A. 2017 09 26; 114(39):10306-10308. View in: Pubmed

A chemical screen in zebrafish embryonic cells establishes that Akt activation is required for neural crest development. Elife. 2017 08 23; 6. View in: Pubmed

Efforts to enhance blood stem cell engraftment: Recent insights from zebrafish hematopoiesis. J Exp Med. 2017 Oct 02; 214(10):2817-2827. View in: Pubmed

PGE2 pulsing of murine bone marrow cells reduces migration of daughter monocytes/macrophages in vitro and in vivo. Exp Hematol. 2017 12; 56:64-68. View in: Pubmed

Blood on the tracks: hematopoietic stem cell-endothelial cell interactions in homing and engraftment. J Mol Med (Berl). 2017 08; 95(8):809-819. View in: Pubmed

Identification of Padi2 as a novel angiogenesis-regulating gene by genome association studies in mice. PLoS Genet. 2017 Jun; 13(6):e1006848. View in: Pubmed

From fish bowl to bedside: The power of zebrafish to unravel melanoma pathogenesis and discover new therapeutics. Pigment Cell Melanoma Res. 2017 07; 30(4):402-412. View in: Pubmed

Using Zebrafish to Study Pathways that Regulate Hematopoietic Stem Cell Self-Renewal and Migration. Stem Cell Reports. 2017 06 06; 8(6):1465-1471. View in: Pubmed

Efficient Transduction of Zebrafish Melanoma Cell Lines and Embryos Using Lentiviral Vectors. Zebrafish. 2017 08; 14(4):379-382. View in: Pubmed

Distinct Roles for Matrix Metalloproteinases 2 and 9 in Embryonic Hematopoietic Stem Cell Emergence, Migration, and Niche Colonization. Stem Cell Reports. 2017 05 09; 8(5):1226-1241. View in: Pubmed

Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes. Elife. 2017 04 07; 6. View in: Pubmed

CXCR1 remodels the vascular niche to promote hematopoietic stem and progenitor cell engraftment. J Exp Med. 2017 04 03; 214(4):1011-1027. View in: Pubmed

Drug discovery for Diamond-Blackfan anemia using reprogrammed hematopoietic progenitors. Sci Transl Med. 2017 02 08; 9(376). View in: Pubmed

EXTL3 mutations cause skeletal dysplasia, immune deficiency, and developmental delay. J Exp Med. 2017 03 06; 214(3):623-637. View in: Pubmed

Corrigendum: Clonal fate mapping quantifies the number of haematopoietic stem cells that arise during development. Nat Cell Biol. 2017 01 31; 19(2):142. View in: Pubmed

Sorting zebrafish thrombocyte lineage cells with a Cd41 monoclonal antibody enriches hematopoietic stem cell activity. Blood. 2017 03 09; 129(10):1394-1397. View in: Pubmed

Chemical screening in zebrafish for novel biological and therapeutic discovery. Methods Cell Biol. 2017; 138:651-679. View in: Pubmed

Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in Erythropoiesis. Am J Hum Genet. 2017 Jan 05; 100(1):51-63. View in: Pubmed

Aging Hematopoietic Stem Cells Make Their History. Dev Cell. 2016 11 21; 39(4):390-391. View in: Pubmed

Clonal fate mapping quantifies the number of haematopoietic stem cells that arise during development. Nat Cell Biol. 2017 Jan; 19(1):17-27. View in: Pubmed

Development: For cloche the Bell Tolls. Curr Biol. 2016 10 10; 26(19):R890-R892. View in: Pubmed

Understanding the regulation of vertebrate hematopoiesis and blood disorders - big lessons from a small fish. FEBS Lett. 2016 Nov; 590(22):4016-4033. View in: Pubmed

Transplantation in zebrafish. Methods Cell Biol. 2017; 138:629-647. View in: Pubmed

MED12 Regulates HSC-Specific Enhancers Independently of Mediator Kinase Activity to Control Hematopoiesis. Cell Stem Cell. 2016 12 01; 19(6):784-799. View in: Pubmed

Identification of novel regulators of developmental hematopoiesis using Endoglin regulatory elements as molecular probes. Blood. 2016 10 13; 128(15):1928-1939. View in: Pubmed

Loss-of-function mutations in the C9ORF72 mouse ortholog cause fatal autoimmune disease. Sci Transl Med. 2016 07 13; 8(347):347ra93. View in: Pubmed

CAT7 and cat7l Long Non-coding RNAs Tune Polycomb Repressive Complex 1 Function during Human and Zebrafish Development. J Biol Chem. 2016 09 09; 291(37):19558-72. View in: Pubmed

Chromatin immunoprecipitation and an open chromatin assay in zebrafish erythrocytes. Methods Cell Biol. 2016; 135:387-412. View in: Pubmed

c-myb hyperactivity leads to myeloid and lymphoid malignancies in zebrafish. Leukemia. 2017 01; 31(1):222-233. View in: Pubmed

Generation of Parabiotic Zebrafish Embryos by Surgical Fusion of Developing Blastulae. J Vis Exp. 2016 06 11; (112). View in: Pubmed

Engineering Hematopoietic Stem Cells: Lessons from Development. Cell Stem Cell. 2016 06 02; 18(6):707-720. View in: Pubmed

Modeling human diseases: an education in interactions and interdisciplinary approaches. Dis Model Mech. 2016 06 01; 9(6):597-600. View in: Pubmed

Long-term drug administration in the adult zebrafish using oral gavage for cancer preclinical studies. Dis Model Mech. 2016 07 01; 9(7):811-20. View in: Pubmed

Ex vivo tools for the clonal analysis of zebrafish hematopoiesis. Nat Protoc. 2016 May; 11(5):1007-20. View in: Pubmed

Tissue-specific gene targeting using CRISPR/Cas9. Methods Cell Biol. 2016; 135:189-202. View in: Pubmed

Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma. Mol Cell. 2016 Apr 07; 62(1):34-46. View in: Pubmed

Insight into GATA1 transcriptional activity through interrogation of cis elements disrupted in human erythroid disorders. Proc Natl Acad Sci U S A. 2016 Apr 19; 113(16):4434-9. View in: Pubmed

A Tribute to George Stamatoyannopoulos. Hum Gene Ther. 2016 Apr; 27(4):280-6. View in: Pubmed

Fish to Learn: Insights into Blood Development and Blood Disorders from Zebrafish Hematopoiesis. Hum Gene Ther. 2016 Apr; 27(4):287-94. View in: Pubmed

Embryonic cell culture in zebrafish. Methods Cell Biol. 2016; 133:1-10. View in: Pubmed

The Red Light District and Its Effects on Zebrafish Reproduction. Zebrafish. 2016 06; 13(3):226-9. View in: Pubmed

GATA Factor-G-Protein-Coupled Receptor Circuit Suppresses Hematopoiesis. Stem Cell Reports. 2016 Mar 08; 6(3):368-82. View in: Pubmed

A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation. Science. 2016 Jan 29; 351(6272):aad2197. View in: Pubmed

Dynamic Control of Enhancer Repertoires Drives Lineage and Stage-Specific Transcription during Hematopoiesis. Dev Cell. 2016 Jan 11; 36(1):9-23. View in: Pubmed

Identifying Novel Cancer Therapies Using Chemical Genetics and Zebrafish. Adv Exp Med Biol. 2016; 916:103-24. View in: Pubmed

Targeted Application of Human Genetic Variation Can Improve Red Blood Cell Production from Stem Cells. Cell Stem Cell. 2016 Jan 07; 18(1):73-78. View in: Pubmed

Hematopoietic stem cells develop in the absence of endothelial cadherin 5 expression. Blood. 2015 Dec 24; 126(26):2811-20. View in: Pubmed

Generating and evaluating a ranked candidate gene list for potential vertebrate heart field regulators. Genom Data. 2015 Dec; 6:199-201. View in: Pubmed

Chamber identity programs drive early functional partitioning of the heart. Nat Commun. 2015 Aug 26; 6:8146. View in: Pubmed

A Quantitative System for Studying Metastasis Using Transparent Zebrafish. Cancer Res. 2015 10 15; 75(20):4272-4282. View in: Pubmed

Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells. Nat Cell Biol. 2015 Aug; 17(8):994-1003. View in: Pubmed

Epoxyeicosatrienoic acids enhance embryonic haematopoiesis and adult marrow engraftment. Nature. 2015 Jul 23; 523(7561):468-71. View in: Pubmed

Mutation of kri1l causes definitive hematopoiesis failure via PERK-dependent excessive autophagy induction. Cell Res. 2015 Aug; 25(8):946-62. View in: Pubmed

TopBP1 Governs Hematopoietic Stem/Progenitor Cells Survival in Zebrafish Definitive Hematopoiesis. PLoS Genet. 2015 Jul; 11(7):e1005346. View in: Pubmed

A point mutation of zebrafish c-cbl gene in the ring finger domain produces a phenotype mimicking human myeloproliferative disease. Leukemia. 2015 Dec; 29(12):2355-65. View in: Pubmed

Screening for melanoma resistance genes in vivo. Pigment Cell Melanoma Res. 2015 Jul; 28(4):375-6. View in: Pubmed

Adenosine signaling promotes hematopoietic stem and progenitor cell emergence. J Exp Med. 2015 May 04; 212(5):649-63. View in: Pubmed

Flow-induced protein kinase A-CREB pathway acts via BMP signaling to promote HSC emergence. J Exp Med. 2015 May 04; 212(5):633-48. View in: Pubmed

A CRISPR/Cas9 vector system for tissue-specific gene disruption in zebrafish. Dev Cell. 2015 Mar 23; 32(6):756-64. View in: Pubmed

Angiopoietin-like proteins stimulate HSPC development through interaction with notch receptor signaling. Elife. 2015 Feb 25; 4. View in: Pubmed

DNA methyltransferase 1 functions through C/ebpa to maintain hematopoietic stem and progenitor cells in zebrafish. J Hematol Oncol. 2015 Feb 22; 8:15. View in: Pubmed

Hematopoietic stem cell arrival triggers dynamic remodeling of the perivascular niche. Cell. 2015 Jan 15; 160(1-2):241-52. View in: Pubmed

Notch1 acts via Foxc2 to promote definitive hematopoiesis via effects on hemogenic endothelium. Blood. 2015 Feb 26; 125(9):1418-26. View in: Pubmed

A zebrafish model of myelodysplastic syndrome produced through tet2 genomic editing. Mol Cell Biol. 2015 Mar; 35(5):789-804. View in: Pubmed

A comparison of non-integrating reprogramming methods. Nat Biotechnol. 2015 Jan; 33(1):58-63. View in: Pubmed

Selective microRNA uridylation by Zcchc6 (TUT7) and Zcchc11 (TUT4). Nucleic Acids Res. 2014 Oct; 42(18):11777-91. View in: Pubmed

Getting more for your marrow: boosting hematopoietic stem cell numbers with PGE2. Exp Cell Res. 2014 Dec 10; 329(2):220-6. View in: Pubmed

Intrinsic expression of a multiexon type 3 deiodinase gene controls zebrafish embryo size. Endocrinology. 2014 Oct; 155(10):4069-80. View in: Pubmed

From fish tank to bedside in cancer therapy: an interview with Leonard Zon. Dis Model Mech. 2014 Jul; 7(7):735-8. View in: Pubmed

Dissection of vertebrate hematopoiesis using zebrafish thrombopoietin. Blood. 2014 Jul 10; 124(2):220-8. View in: Pubmed

Whole-exome sequencing and functional studies identify RPS29 as a novel gene mutated in multicase Diamond-Blackfan anemia families. Blood. 2014 Jul 03; 124(1):24-32. View in: Pubmed

Neural crest development and craniofacial morphogenesis is coordinated by nitric oxide and histone acetylation. Chem Biol. 2014 Apr 24; 21(4):488-501. View in: Pubmed

Mutations in QARS, encoding glutaminyl-tRNA synthetase, cause progressive microcephaly, cerebral-cerebellar atrophy, and intractable seizures. Am J Hum Genet. 2014 Apr 03; 94(4):547-58. View in: Pubmed

Unexpectedly uneven: posttransplant skeletal distribution of hematopoietic stem cell clones. J Exp Med. 2014 Mar 10; 211(3):384-5. View in: Pubmed

Translational research: the path for bringing discovery to patients. Cell Stem Cell. 2014 Feb 06; 14(2):146-8. View in: Pubmed

Tissue specific roles for the ribosome biogenesis factor Wdr43 in zebrafish development. PLoS Genet. 2014 Jan; 10(1):e1004074. View in: Pubmed

A non-canonical function of telomerase RNA in the regulation of developmental myelopoiesis in zebrafish. Nat Commun. 2014; 5:3228. View in: Pubmed

Novel cardiovascular gene functions revealed via systematic phenotype prediction in zebrafish. Development. 2014 Jan; 141(1):224-35. View in: Pubmed

Of fish and men: using zebrafish to fight human diseases. Trends Cell Biol. 2013 Dec; 23(12):584-6. View in: Pubmed

A network of epigenetic regulators guides developmental haematopoiesis in vivo. Nat Cell Biol. 2013 Dec; 15(12):1516-25. View in: Pubmed

A Cdx4-Sall4 regulatory module controls the transition from mesoderm formation to embryonic hematopoiesis. Stem Cell Reports. 2013; 1(5):425-36. View in: Pubmed

A zebrafish embryo culture system defines factors that promote vertebrate myogenesis across species. Cell. 2013 Nov 07; 155(4):909-921. View in: Pubmed

zebraflash transgenic lines for in vivo bioluminescence imaging of stem cells and regeneration in adult zebrafish. Development. 2013 Dec; 140(24):4988-97. View in: Pubmed

The zebrafish granulocyte colony-stimulating factors (Gcsfs): 2 paralogous cytokines and their roles in hematopoietic development and maintenance. Blood. 2013 Dec 05; 122(24):3918-28. View in: Pubmed

Induction of multipotential hematopoietic progenitors from human pluripotent stem cells via respecification of lineage-restricted precursors. Cell Stem Cell. 2013 Oct 03; 13(4):459-70. View in: Pubmed

Zebrafish cancer: the state of the art and the path forward. Nat Rev Cancer. 2013 Sep; 13(9):624-36. View in: Pubmed

Prostaglandin-modulated umbilical cord blood hematopoietic stem cell transplantation. Blood. 2013 Oct 24; 122(17):3074-81. View in: Pubmed

Assaying hematopoiesis using zebrafish. Blood Cells Mol Dis. 2013 Dec; 51(4):271-6. View in: Pubmed

Site-directed zebrafish transgenesis into single landing sites with the phiC31 integrase system. Dev Dyn. 2013 Aug; 242(8):949-963. View in: Pubmed

Zebrafish rhabdomyosarcoma reflects the developmental stage of oncogene expression during myogenesis. Development. 2013 Jul; 140(14):3040-50. View in: Pubmed

Hematopoiesis. Development. 2013 Jun; 140(12):2463-7. View in: Pubmed

The histone methyltransferase SUV39H1 suppresses embryonal rhabdomyosarcoma formation in zebrafish. PLoS One. 2013; 8(5):e64969. View in: Pubmed

A novel chemical screening strategy in zebrafish identifies common pathways in embryogenesis and rhabdomyosarcoma development. Development. 2013 Jun; 140(11):2354-64. View in: Pubmed

The zebrafish reference genome sequence and its relationship to the human genome. Nature. 2013 Apr 25; 496(7446):498-503. View in: Pubmed

A model for primary melanoma of the CNS implicates NRAS. Cancer Discov. 2013 Apr; 3(4):382-3. View in: Pubmed

Ageing: Stem cells on a stress-busting diet. Nature. 2013 Feb 21; 494(7437):317-8. View in: Pubmed

The genetic heterogeneity and mutational burden of engineered melanomas in zebrafish models. Genome Biol. 2013; 14(10):R113. View in: Pubmed

Signaling axis involving Hedgehog, Notch, and Scl promotes the embryonic endothelial-to-hematopoietic transition. Proc Natl Acad Sci U S A. 2013 Jan 08; 110(2):E141-50. View in: Pubmed

Phospholipase C gamma-1 is required for granulocyte maturation in zebrafish. Dev Biol. 2013 Feb 01; 374(1):24-31. View in: Pubmed

TiF1-gamma plays an essential role in murine hematopoiesis and regulates transcriptional elongation of erythroid genes. Dev Biol. 2013 Jan 15; 373(2):422-30. View in: Pubmed

The transcriptional landscape of hematopoietic stem cell ontogeny. Cell Stem Cell. 2012 Nov 02; 11(5):701-14. View in: Pubmed

CHMP1A encodes an essential regulator of BMI1-INK4A in cerebellar development. Nat Genet. 2012 Nov; 44(11):1260-4. View in: Pubmed

Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma. Cell. 2012 Sep 14; 150(6):1135-46. View in: Pubmed

Formation of a PKC?/ß-catenin complex in endothelial cells promotes angiopoietin-1-induced collective directional migration and angiogenic sprouting. Blood. 2012 Oct 18; 120(16):3371-81. View in: Pubmed

Ccdc94 protects cells from ionizing radiation by inhibiting the expression of p53. PLoS Genet. 2012; 8(8):e1002922. View in: Pubmed

Teleost growth factor independence (gfi) genes differentially regulate successive waves of hematopoiesis. Dev Biol. 2013 Jan 15; 373(2):431-41. View in: Pubmed

A splice site mutation in laminin-a2 results in a severe muscular dystrophy and growth abnormalities in zebrafish. PLoS One. 2012; 7(8):e43794. View in: Pubmed

Cancer and inflammation: an aspirin a day keeps the cancer at bay. Curr Biol. 2012 Jul 10; 22(13):R522-5. View in: Pubmed

Hooked! Modeling human disease in zebrafish. J Clin Invest. 2012 Jul; 122(7):2337-43. View in: Pubmed

Histocompatibility and hematopoietic transplantation in the zebrafish. Adv Hematol. 2012; 2012:282318. View in: Pubmed

A great match. Cell Stem Cell. 2012 Jun 14; 10(6):638-639. View in: Pubmed

In situ hybridization assay-based small molecule screening in zebrafish. Curr Protoc Chem Biol. 2012 Jun 01; 4(2). View in: Pubmed

Zebrafish globin switching occurs in two developmental stages and is controlled by the LCR. Dev Biol. 2012 Jun 15; 366(2):185-94. View in: Pubmed

Nanog-like regulates endoderm formation through the Mxtx2-Nodal pathway. Dev Cell. 2012 Mar 13; 22(3):625-38. View in: Pubmed

Small molecule screening in zebrafish: swimming in potential drug therapies. Wiley Interdiscip Rev Dev Biol. 2012 May-Jun; 1(3):459-68. View in: Pubmed

Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors. Mol Cell. 2012 Feb 10; 45(3):330-43. View in: Pubmed

Linking hematopoietic regeneration to developmental signaling pathways: a story of BMP and Wnt. Cell Cycle. 2012 Feb 01; 11(3):424-5. View in: Pubmed

Stem cells: The right neighbour. Nature. 2012 Jan 25; 481(7382):453-5. View in: Pubmed

Hematopoietic stem cells, hematopoiesis and disease: lessons from the zebrafish model. Genome Med. 2011 Dec 29; 3(12):83. View in: Pubmed

Extensive genetic diversity and substructuring among zebrafish strains revealed through copy number variant analysis. Proc Natl Acad Sci U S A. 2012 Jan 10; 109(2):529-34. View in: Pubmed

An optical platform for cell tracking in adult zebrafish. Cytometry A. 2012 Feb; 81(2):176-82. View in: Pubmed

Hematopoietic defects in rps29 mutant zebrafish depend upon p53 activation. Exp Hematol. 2012 Mar; 40(3):228-237.e5. View in: Pubmed

Lineage regulators direct BMP and Wnt pathways to cell-specific programs during differentiation and regeneration. Cell. 2011 Oct 28; 147(3):577-89. View in: Pubmed

The NOTCH pathway contributes to cell fate decision in myelopoiesis. Haematologica. 2011 Dec; 96(12):1753-60. View in: Pubmed

Zebrafish as a model for normal and malignant hematopoiesis. Dis Model Mech. 2011 Jul; 4(4):433-8. View in: Pubmed

A new system for the rapid collection of large numbers of developmentally staged zebrafish embryos. PLoS One. 2011; 6(6):e21715. View in: Pubmed

Stromal cell-derived factor-1 and hematopoietic cell homing in an adult zebrafish model of hematopoietic cell transplantation. Blood. 2011 Jul 21; 118(3):766-74. View in: Pubmed

Prostaglandin E2 enhances human cord blood stem cell xenotransplants and shows long-term safety in preclinical nonhuman primate transplant models. Cell Stem Cell. 2011 Apr 08; 8(4):445-58. View in: Pubmed

Modeling Diamond Blackfan anemia in the zebrafish. Semin Hematol. 2011 Apr; 48(2):81-8. View in: Pubmed

DHODH modulates transcriptional elongation in the neural crest and melanoma. Nature. 2011 Mar 24; 471(7339):518-22. View in: Pubmed

The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset. Nature. 2011 Mar 24; 471(7339):513-7. View in: Pubmed

Clonal analysis of hematopoietic progenitor cells in the zebrafish. Blood. 2011 Aug 04; 118(5):1274-82. View in: Pubmed

Characterization of immune-matched hematopoietic transplantation in zebrafish. Blood. 2011 Apr 21; 117(16):4234-42. View in: Pubmed

Isolation and transcriptome analysis of adult zebrafish cells enriched for skeletal muscle progenitors. Muscle Nerve. 2011 May; 43(5):741-50. View in: Pubmed

cpsf1 is required for definitive HSC survival in zebrafish. Blood. 2011 Apr 14; 117(15):3996-4007. View in: Pubmed

The ERGonomics of hematopoietic stem cell self-renewal. Genes Dev. 2011 Feb 15; 25(4):289-93. View in: Pubmed

The zebrafish dag1 mutant: a novel genetic model for dystroglycanopathies. Hum Mol Genet. 2011 May 01; 20(9):1712-25. View in: Pubmed

Stem cell migration: a zebrafish model. Methods Mol Biol. 2011; 750:157-68. View in: Pubmed

Ubiquitous transgene expression and Cre-based recombination driven by the ubiquitin promoter in zebrafish. Development. 2011 Jan; 138(1):169-77. View in: Pubmed

Chromatin immunoprecipitation in adult zebrafish red cells. Methods Cell Biol. 2011; 104:341-52. View in: Pubmed

The zon laboratory guide to positional cloning in zebrafish. Methods Cell Biol. 2011; 104:287-309. View in: Pubmed

Advanced zebrafish transgenesis with Tol2 and application for Cre/lox recombination experiments. Methods Cell Biol. 2011; 104:173-94. View in: Pubmed

Transplantation in zebrafish. Methods Cell Biol. 2011; 105:403-17. View in: Pubmed

Genetic suppressor screens in haploids. Methods Cell Biol. 2011; 104:129-36. View in: Pubmed

Chemical screening in zebrafish for novel biological and therapeutic discovery. Methods Cell Biol. 2011; 105:493-516. View in: Pubmed

The zebrafish. Preface. Methods Cell Biol. 2011; 105:xxi-xxii. View in: Pubmed

Stem cells: The blood balance. Nature. 2010 Dec 02; 468(7324):644-5. View in: Pubmed

T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation. Cancer Cell. 2010 Oct 19; 18(4):353-66. View in: Pubmed

PGE2-regulated wnt signaling and N-acetylcysteine are synergistically hepatoprotective in zebrafish acetaminophen injury. Proc Natl Acad Sci U S A. 2010 Oct 05; 107(40):17315-20. View in: Pubmed

Fishing at the cellular level. Nat Methods. 2010 Aug; 7(8):600-1. View in: Pubmed

Blood flow: metalloproteases cut loose in primitive erythrocytes. Curr Biol. 2010 Jul 13; 20(13):R561-2. View in: Pubmed

TIF1gamma controls erythroid cell fate by regulating transcription elongation. Cell. 2010 Jul 09; 142(1):133-43. View in: Pubmed

Newly emerging roles for prostaglandin E2 regulation of hematopoiesis and hematopoietic stem cell engraftment. Curr Opin Hematol. 2010 Jul; 17(4):308-12. View in: Pubmed

Cdx4 is dispensable for murine adult hematopoietic stem cells but promotes MLL-AF9-mediated leukemogenesis. Haematologica. 2010 Oct; 95(10):1642-50. View in: Pubmed

Zebrafish models of p53 functions. Cold Spring Harb Perspect Biol. 2010 Aug; 2(8):a001123. View in: Pubmed

Interaction of retinoic acid and scl controls primitive blood development. Blood. 2010 Jul 15; 116(2):201-9. View in: Pubmed

The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML. Science. 2010 Mar 26; 327(5973):1650-3. View in: Pubmed

Resolving the controversy about N-cadherin and hematopoietic stem cells. Cell Stem Cell. 2010 Mar 05; 6(3):199-202. View in: Pubmed

The new age of chemical screening in zebrafish. Zebrafish. 2010 Mar; 7(1):1. View in: Pubmed

A chemical genetic screen in zebrafish for pathways interacting with cdx4 in primitive hematopoiesis. Zebrafish. 2010 Mar; 7(1):61-8. View in: Pubmed

Swimming into the future of drug discovery: in vivo chemical screens in zebrafish. ACS Chem Biol. 2010 Feb 19; 5(2):159-61. View in: Pubmed

High-throughput cell transplantation establishes that tumor-initiating cells are abundant in zebrafish T-cell acute lymphoblastic leukemia. Blood. 2010 Apr 22; 115(16):3296-303. View in: Pubmed

Melanocytes in development and cancer. J Cell Physiol. 2010 Jan; 222(1):38-41. View in: Pubmed

The zebrafish: cellular and developmental biology, part A. Preface. Methods Cell Biol. 2010; 100:xiii. View in: Pubmed

Small molecule screen in zebrafish and HSC expansion. Methods Mol Biol. 2010; 636:301-16. View in: Pubmed

Hematopoietic development in the zebrafish. Int J Dev Biol. 2010; 54(6-7):1127-37. View in: Pubmed

Mlck1a is expressed in zebrafish thrombocytes and is an essential component of thrombus formation. J Thromb Haemost. 2010 Mar; 8(3):588-95. View in: Pubmed

Retro-orbital injection in adult zebrafish. J Vis Exp. 2009 Dec 07; (34). View in: Pubmed

Zebrafish tumor assays: the state of transplantation. Zebrafish. 2009 Dec; 6(4):339-46. View in: Pubmed

Oncogenic NRAS cooperates with p53 loss to generate melanoma in zebrafish. Zebrafish. 2009 Dec; 6(4):397-404. View in: Pubmed

Chemical genetic screening in the zebrafish embryo. Nat Protoc. 2009; 4(10):1422-32. View in: Pubmed

Zebrafish blood stem cells. J Cell Biochem. 2009 Sep 01; 108(1):35-42. View in: Pubmed

Hematopoietic stem cell development is dependent on blood flow. Cell. 2009 May 15; 137(4):736-48. View in: Pubmed

Zebrafish kidney stromal cell lines support multilineage hematopoiesis. Blood. 2009 Jul 09; 114(2):279-89. View in: Pubmed

Topoisomerase II alpha is required for embryonic development and liver regeneration in zebrafish. Mol Cell Biol. 2009 Jul; 29(13):3746-53. View in: Pubmed

A genetic screen in zebrafish defines a hierarchical network of pathways required for hematopoietic stem cell emergence. Blood. 2009 Jun 04; 113(23):5776-82. View in: Pubmed

Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration. Cell. 2009 Mar 20; 136(6):1136-47. View in: Pubmed

Construction and application of a zebrafish array comparative genomic hybridization platform. Genes Chromosomes Cancer. 2009 Feb; 48(2):155-70. View in: Pubmed

Lessons from the Niche for Generation and Expansion of Hematopoietic Stem Cells. Drug Discov Today Ther Strateg. 2009; 6(4):135-140. View in: Pubmed

Defining cancer stem cells by xenotransplantation in zebrafish. Methods Mol Biol. 2009; 568:1-5. View in: Pubmed

LPS response and tolerance in the zebrafish (Danio rerio). Fish Shellfish Immunol. 2009 Feb; 26(2):326-31. View in: Pubmed

Transferrin-a modulates hepcidin expression in zebrafish embryos. Blood. 2009 Mar 19; 113(12):2843-50. View in: Pubmed

Potential of zebrafish for anticancer drug screening. Expert Opin Drug Discov. 2008 Dec; 3(12):1451-60. View in: Pubmed

The effect of a depth gradient on the mating behavior, oviposition site preference, and embryo production in the zebrafish, Danio rerio. Zebrafish. 2008 Dec; 5(4):335-9. View in: Pubmed

Melanoma biology and the promise of zebrafish. Zebrafish. 2008 Dec; 5(4):247-55. View in: Pubmed

Regulation of stem cells in the zebra fish hematopoietic system. Cold Spring Harb Symp Quant Biol. 2008; 73:111-8. View in: Pubmed

Abnormal nuclear pore formation triggers apoptosis in the intestinal epithelium of elys-deficient zebrafish. Gastroenterology. 2009 Mar; 136(3):902-11. View in: Pubmed

A non-canonical function of zebrafish telomerase reverse transcriptase is required for developmental hematopoiesis. PLoS One. 2008; 3(10):e3364. View in: Pubmed

Eya4 regulation of Na+/K+-ATPase is required for sensory system development in zebrafish. Development. 2008 Oct; 135(20):3425-34. View in: Pubmed

Melanocytes in development, regeneration, and cancer. Cell Stem Cell. 2008 Sep 11; 3(3):242-52. View in: Pubmed

Zebrafish mutants with disrupted early T-cell and thymus development identified in early pressure screen. Dev Dyn. 2008 Sep; 237(9):2575-84. View in: Pubmed

Intestinal differentiation in zebrafish requires Cdx1b, a functional equivalent of mammalian Cdx2. Gastroenterology. 2008 Nov; 135(5):1665-75. View in: Pubmed

Molecular association between beta-catenin degradation complex and Rac guanine exchange factor DOCK4 is essential for Wnt/beta-catenin signaling. Oncogene. 2008 Oct 02; 27(44):5845-55. View in: Pubmed

montalcino, A zebrafish model for variegate porphyria. Exp Hematol. 2008 Sep; 36(9):1132-42. View in: Pubmed

Self-renewal and differentiation at Cell Stem Cell. Cell Stem Cell. 2008 Jun 05; 2(6):510. View in: Pubmed

Zebrafish VEGF receptors: a guideline to nomenclature. PLoS Genet. 2008 May 30; 4(5):e1000064. View in: Pubmed

APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development. Dev Biol. 2008 Aug 01; 320(1):161-74. View in: Pubmed

Intrinsic and extrinsic control of haematopoietic stem-cell self-renewal. Nature. 2008 May 15; 453(7193):306-13. View in: Pubmed

Co-injection strategies to modify radiation sensitivity and tumor initiation in transgenic Zebrafish. Oncogene. 2008 Jul 10; 27(30):4242-8. View in: Pubmed

Minimum information specification for in situ hybridization and immunohistochemistry experiments (MISFISHIE). Nat Biotechnol. 2008 Mar; 26(3):305-12. View in: Pubmed

SnapShot: hematopoiesis. Cell. 2008 Feb 22; 132(4):712. View in: Pubmed

Hematopoiesis: an evolving paradigm for stem cell biology. Cell. 2008 Feb 22; 132(4):631-44. View in: Pubmed

Transparent adult zebrafish as a tool for in vivo transplantation analysis. Cell Stem Cell. 2008 Feb 07; 2(2):183-9. View in: Pubmed

Combinatorial regulation of novel erythroid gene expression in zebrafish. Exp Hematol. 2008 Apr; 36(4):424-32. View in: Pubmed

BMP and Wnt specify hematopoietic fate by activation of the Cdx-Hox pathway. Cell Stem Cell. 2008 Jan 10; 2(1):72-82. View in: Pubmed

APC and colon cancer: two hits for one. Nat Med. 2007 Nov; 13(11):1286-7. View in: Pubmed

Generation and characterization of transgenic zebrafish lines using different ubiquitous promoters. Transgenic Res. 2008 Apr; 17(2):265-79. View in: Pubmed

Prostaglandin E2: making more of your marrow. Cell Cycle. 2007 Dec 15; 6(24):3054-7. View in: Pubmed

Teratoma formation assays with human embryonic stem cells: a rationale for one type of human-animal chimera. Cell Stem Cell. 2007 Sep 13; 1(3):253-8. View in: Pubmed

Duplicate VegfA genes and orthologues of the KDR receptor tyrosine kinase family mediate vascular development in the zebrafish. Blood. 2007 Nov 15; 110(10):3627-36. View in: Pubmed

Definition of the zebrafish genome using flow cytometry and cytogenetic mapping. BMC Genomics. 2007 Jun 27; 8:195. View in: Pubmed

The zebrafish runzel muscular dystrophy is linked to the titin gene. Dev Biol. 2007 Sep 15; 309(2):180-92. View in: Pubmed

Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. Nature. 2007 Jun 21; 447(7147):1007-11. View in: Pubmed

Functional conservation of erythropoietin signaling in zebrafish. Blood. 2007 Oct 01; 110(7):2718-26. View in: Pubmed

The zebra fish cassiopeia mutant reveals that SIL is required for mitotic spindle organization. Mol Cell Biol. 2007 Aug; 27(16):5887-97. View in: Pubmed

Ultrasound biomicroscopy permits in vivo characterization of zebrafish liver tumors. Nat Methods. 2007 Jul; 4(7):551-3. View in: Pubmed

New waves of discovery: modeling cancer in zebrafish. J Clin Oncol. 2007 Jun 10; 25(17):2473-9. View in: Pubmed

Cell stem cell. Cell Stem Cell. 2007 Jun 07; 1(1):7. View in: Pubmed

Heat shock-inducible Cre/Lox approaches to induce diverse types of tumors and hyperplasia in transgenic zebrafish. Proc Natl Acad Sci U S A. 2007 May 29; 104(22):9410-5. View in: Pubmed

Effects of RAS on the genesis of embryonal rhabdomyosarcoma. Genes Dev. 2007 Jun 01; 21(11):1382-95. View in: Pubmed

Network of coregulated spliceosome components revealed by zebrafish mutant in recycling factor p110. Proc Natl Acad Sci U S A. 2007 Apr 17; 104(16):6608-13. View in: Pubmed

Zebrafish orthologs of human muscular dystrophy genes. BMC Genomics. 2007 Mar 20; 8:79. View in: Pubmed

Notch and MAML signaling drives Scl-dependent interneuron diversity in the spinal cord. Neuron. 2007 Mar 15; 53(6):813-27. View in: Pubmed

Transplantation of whole kidney marrow in adult zebrafish. J Vis Exp. 2007 Feb 25; (2):159. View in: Pubmed

Gene Duplication of the zebrafish kit ligand and partitioning of melanocyte development functions to kit ligand a. PLoS Genet. 2007 Jan 26; 3(1):e17. View in: Pubmed

A mutation in separase causes genome instability and increased susceptibility to epithelial cancer. Genes Dev. 2007 Jan 01; 21(1):55-9. View in: Pubmed

Homing sweet homing: odyssey of hematopoietic stem cells. Immunity. 2006 Dec; 25(6):859-62. View in: Pubmed

Cdx4 dysregulates Hox gene expression and generates acute myeloid leukemia alone and in cooperation with Meis1a in a murine model. Proc Natl Acad Sci U S A. 2006 Nov 07; 103(45):16924-9. View in: Pubmed

A chemical genetic screen for cell cycle inhibitors in zebrafish embryos. Chem Biol Drug Des. 2006 Oct; 68(4):213-9. View in: Pubmed

A novel endothelial-specific heat shock protein HspA12B is required in both zebrafish development and endothelial functions in vitro. J Cell Sci. 2006 Oct 01; 119(Pt 19):4117-26. View in: Pubmed

Small molecule screening in the zebrafish. Methods. 2006 Jul; 39(3):255-61. View in: Pubmed

AlphaA-crystallin expression prevents gamma-crystallin insolubility and cataract formation in the zebrafish cloche mutant lens. Development. 2006 Jul; 133(13):2585-93. View in: Pubmed

BMP signaling restricts hemato-vascular development from lateral mesoderm during somitogenesis. Development. 2006 Jun; 133(11):2177-87. View in: Pubmed

Mitoferrin is essential for erythroid iron assimilation. Nature. 2006 Mar 02; 440(7080):96-100. View in: Pubmed

Piloting the zebrafish genome browser. Dev Dyn. 2006 Mar; 235(3):747-53. View in: Pubmed

The caudal-related homeobox genes cdx1a and cdx4 act redundantly to regulate hox gene expression and the formation of putative hematopoietic stem cells during zebrafish embryogenesis. Dev Biol. 2006 Apr 15; 292(2):506-18. View in: Pubmed

Derivation of adult stem cells during embryogenesis. Harvey Lect. 2006-2007; 102:117-32. View in: Pubmed

Genetic analysis of cavefish reveals molecular convergence in the evolution of albinism. Nat Genet. 2006 Jan; 38(1):107-11. View in: Pubmed

Zebrafish KLF4 is essential for anterior mesendoderm/pre-polster differentiation and hatching. Dev Dyn. 2005 Dec; 234(4):992-6. View in: Pubmed

Small molecules that delay S phase suppress a zebrafish bmyb mutant. Nat Chem Biol. 2005 Dec; 1(7):366-70. View in: Pubmed

A critical role for calponin 2 in vascular development. J Biol Chem. 2006 Mar 10; 281(10):6664-72. View in: Pubmed

Zebrafish to humans: evolution of the alpha3-chain of type IV collagen and emergence of the autoimmune epitopes associated with Goodpasture syndrome. Blood. 2006 Mar 01; 107(5):1908-15. View in: Pubmed

Hematopoietic stem cell fate is established by the Notch-Runx pathway. Genes Dev. 2005 Oct 01; 19(19):2331-42. View in: Pubmed

A zebrafish bmyb mutation causes genome instability and increased cancer susceptibility. Proc Natl Acad Sci U S A. 2005 Sep 13; 102(37):13194-9. View in: Pubmed

Transcriptional regulation of hematopoietic stem cell development in zebrafish. Exp Hematol. 2005 Sep; 33(9):1007-14. View in: Pubmed

Deficiency of glutaredoxin 5 reveals Fe-S clusters are required for vertebrate haem synthesis. Nature. 2005 Aug 18; 436(7053):1035-39. View in: Pubmed

Analysis of thrombocyte development in CD41-GFP transgenic zebrafish. Blood. 2005 Dec 01; 106(12):3803-10. View in: Pubmed

Zebrafish slc4a2/ae2 anion exchanger: cDNA cloning, mapping, functional characterization, and localization. Am J Physiol Renal Physiol. 2005 Oct; 289(4):F835-49. View in: Pubmed

Regulation of the lmo2 promoter during hematopoietic and vascular development in zebrafish. Dev Biol. 2005 May 15; 281(2):256-69. View in: Pubmed

Ferroportin1 is required for normal iron cycling in zebrafish. J Clin Invest. 2005 Jun; 115(6):1532-41. View in: Pubmed

The complex cartography of stem cell commitment. Cell. 2005 Apr 22; 121(2):160-2. View in: Pubmed

Mutant-specific gene programs in the zebrafish. Blood. 2005 Jul 15; 106(2):521-30. View in: Pubmed

The zebrafish: a new model of T-cell and thymic development. Nat Rev Immunol. 2005 Apr; 5(4):307-17. View in: Pubmed

The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. Cell Metab. 2005 Mar; 1(3):191-200. View in: Pubmed

Mutation in the transcriptional coactivator EYA4 causes dilated cardiomyopathy and sensorineural hearing loss. Nat Genet. 2005 Apr; 37(4):418-22. View in: Pubmed

BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma. Curr Biol. 2005 Feb 08; 15(3):249-54. View in: Pubmed

Zebrafish scl functions independently in hematopoietic and endothelial development. Dev Biol. 2005 Jan 15; 277(2):522-36. View in: Pubmed

tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors. Proc Natl Acad Sci U S A. 2005 Jan 11; 102(2):407-12. View in: Pubmed

Use of the zebrafish system to study primitive and definitive hematopoiesis. Annu Rev Genet. 2005; 39:481-501. View in: Pubmed

Taking human cancer genes to the fish: a transgenic model of melanoma in zebrafish. Zebrafish. 2005; 1(4):363-8. View in: Pubmed

In vivo drug discovery in the zebrafish. Nat Rev Drug Discov. 2005 Jan; 4(1):35-44. View in: Pubmed

Loss of gata1 but not gata2 converts erythropoiesis to myelopoiesis in zebrafish embryos. Dev Cell. 2005 Jan; 8(1):109-16. View in: Pubmed

Analysis of hematopoietic development in the zebrafish. Methods Mol Med. 2005; 105:171-98. View in: Pubmed

The chianti zebrafish mutant provides a model for erythroid-specific disruption of transferrin receptor 1. Development. 2004 Dec; 131(24):6225-35. View in: Pubmed

The clinical potential of stem cells. Curr Opin Cell Biol. 2004 Dec; 16(6):713-20. View in: Pubmed

An Mll-dependent Hox program drives hematopoietic progenitor expansion. Curr Biol. 2004 Nov 23; 14(22):2063-9. View in: Pubmed

Hematopoietic gene expression profile in zebrafish kidney marrow. Proc Natl Acad Sci U S A. 2004 Nov 16; 101(46):16240-5. View in: Pubmed

The 'definitive' (and 'primitive') guide to zebrafish hematopoiesis. Oncogene. 2004 Sep 20; 23(43):7233-46. View in: Pubmed

Two distinct teleost hepatocyte nuclear factor 1 genes, hnf1alpha/tcf1 and hnf1beta/tcf2, abundantly expressed in liver, pancreas, gut and kidney of zebrafish. Gene. 2004 Aug 18; 338(1):35-46. View in: Pubmed

The zebrafish moonshine gene encodes transcriptional intermediary factor 1gamma, an essential regulator of hematopoiesis. PLoS Biol. 2004 Aug; 2(8):E237. View in: Pubmed

Expression and mapping of duplicate neuropilin-1 and neuropilin-2 genes in developing zebrafish. Gene Expr Patterns. 2004 Jul; 4(4):361-70. View in: Pubmed

Taking the stem cell debate to the public. PLoS Biol. 2004 Jun; 2(6):e188. View in: Pubmed

Effects of lethal irradiation in zebrafish and rescue by hematopoietic cell transplantation. Blood. 2004 Sep 01; 104(5):1298-305. View in: Pubmed

In vivo tracking of T cell development, ablation, and engraftment in transgenic zebrafish. Proc Natl Acad Sci U S A. 2004 May 11; 101(19):7369-74. View in: Pubmed

The use of zebrafish to understand immunity. Immunity. 2004 Apr; 20(4):367-79. View in: Pubmed

The pu.1 promoter drives myeloid gene expression in zebrafish. Blood. 2004 Sep 01; 104(5):1291-7. View in: Pubmed

The Zon laboratory guide to positional cloning in zebrafish. Methods Cell Biol. 2004; 77:305-29. View in: Pubmed

Use of the DsRed fluorescent reporter in zebrafish. Methods Cell Biol. 2004; 76:3-12. View in: Pubmed

Allan j. Erslev, m.d.: truly a great dane (1919-2003). Stem Cells. 2004; 22(1):121-2. View in: Pubmed

Transplantation and in vivo imaging of multilineage engraftment in zebrafish bloodless mutants. Nat Immunol. 2003 Dec; 4(12):1238-46. View in: Pubmed

Modeling human hematopoietic and cardiovascular diseases in zebrafish. Dev Dyn. 2003 Nov; 228(3):568-83. View in: Pubmed

The zebrafish van gogh mutation disrupts tbx1, which is involved in the DiGeorge deletion syndrome in humans. Development. 2003 Oct; 130(20):5043-52. View in: Pubmed

cdx4 mutants fail to specify blood progenitors and can be rescued by multiple hox genes. Nature. 2003 Sep 18; 425(6955):300-6. View in: Pubmed

The zebrafish spi1 promoter drives myeloid-specific expression in stable transgenic fish. Blood. 2003 Nov 01; 102(9):3238-40. View in: Pubmed

Inhibition of zebrafish epidermal growth factor receptor activity results in cardiovascular defects. Mech Dev. 2003 Jul; 120(7):811-22. View in: Pubmed

Cancer genetics and drug discovery in the zebrafish. Nat Rev Cancer. 2003 Jul; 3(7):533-9. View in: Pubmed

Cell-specific mitotic defect and dyserythropoiesis associated with erythroid band 3 deficiency. Nat Genet. 2003 May; 34(1):59-64. View in: Pubmed

The dystrophin associated protein complex in zebrafish. Hum Mol Genet. 2003 Mar 15; 12(6):601-15. View in: Pubmed

Characterization of embryonic globin genes of the zebrafish. Dev Biol. 2003 Mar 01; 255(1):48-61. View in: Pubmed

Biomedicine. Love, honor, and protect (your liver). Science. 2003 Feb 07; 299(5608):835-7. View in: Pubmed

Myc-induced T cell leukemia in transgenic zebrafish. Science. 2003 Feb 07; 299(5608):887-90. View in: Pubmed

The zebrafish as a model organism to study development of the immune system. Adv Immunol. 2003; 81:253-330. View in: Pubmed

Ontogeny of hematopoiesis: examining the emergence of hematopoietic cells in the vertebrate embryo. Curr Top Dev Biol. 2003; 53:139-58. View in: Pubmed

Isolation and characterization of runxa and runxb, zebrafish members of the runt family of transcriptional regulators. Exp Hematol. 2002 Dec; 30(12):1381-9. View in: Pubmed

Use of zebrafish models for the analysis of human disease. Curr Protoc Hum Genet. 2002 Nov; Chapter 15:Unit 15.3. View in: Pubmed

Portrait of a stem cell. Dev Cell. 2002 Nov; 3(5):612-3. View in: Pubmed

Isolation and characterization of zebrafish NFE2. Physiol Genomics. 2002 Oct 29; 11(2):91-8. View in: Pubmed

SUMO-1 protease-1 regulates gene transcription through PML. Mol Cell. 2002 Oct; 10(4):843-55. View in: Pubmed

SUMO-1 modification represses Sp3 transcriptional activation and modulates its subnuclear localization. Mol Cell. 2002 Oct; 10(4):831-42. View in: Pubmed

Characterization of zebrafish merlot/chablis as non-mammalian vertebrate models for severe congenital anemia due to protein 4.1 deficiency. Development. 2002 Sep; 129(18):4359-70. View in: Pubmed

Molecular cloning and developmental expression of Tlx (Hox11) genes in zebrafish (Danio rerio). Mech Dev. 2002 Sep; 117(1-2):243-8. View in: Pubmed

The zebrafish mutant gene chardonnay (cdy) encodes divalent metal transporter 1 (DMT1). Blood. 2002 Dec 15; 100(13):4655-9. View in: Pubmed

Attack of the fish clones. Nat Biotechnol. 2002 Aug; 20(8):785-6. View in: Pubmed

Neuropilin-1 is required for vascular development and is a mediator of VEGF-dependent angiogenesis in zebrafish. Proc Natl Acad Sci U S A. 2002 Aug 06; 99(16):10470-5. View in: Pubmed

Zebrafish SPI-1 (PU.1) marks a site of myeloid development independent of primitive erythropoiesis: implications for axial patterning. Dev Biol. 2002 Jun 15; 246(2):274-95. View in: Pubmed

Evolutionary conservation of zebrafish linkage group 14 with frequently deleted regions of human chromosome 5 in myeloid malignancies. Proc Natl Acad Sci U S A. 2002 Apr 30; 99(9):6136-41. View in: Pubmed

Hematopoiesis and stem cells: plasticity versus developmental heterogeneity. Nat Immunol. 2002 Apr; 3(4):323-8. View in: Pubmed

Zebrafish as a cancer model system. Cancer Cell. 2002 Apr; 1(3):229-31. View in: Pubmed

Walking the walk: migration and other common themes in blood and vascular development. Cell. 2002 Mar 22; 108(6):731-4. View in: Pubmed

Non-cell autonomous requirement for the bloodless gene in primitive hematopoiesis of zebrafish. Development. 2002 Feb; 129(3):649-59. View in: Pubmed

Organogenesis--heart and blood formation from the zebrafish point of view. Science. 2002 Jan 18; 295(5554):457-62. View in: Pubmed

Molecular cloning, genetic mapping, and expression analysis of four zebrafish c/ebp genes. Gene. 2001 Dec 27; 281(1-2):43-51. View in: Pubmed

The art and design of genetic screens: zebrafish. Nat Rev Genet. 2001 Dec; 2(12):956-66. View in: Pubmed

The LN54 radiation hybrid map of zebrafish expressed sequences. Genome Res. 2001 Dec; 11(12):2127-32. View in: Pubmed

Development. Endothelium--chicken soup for the endoderm. Science. 2001 Oct 19; 294(5542):530-1. View in: Pubmed

neptune, a Krüppel-like transcription factor that participates in primitive erythropoiesis in Xenopus. Curr Biol. 2001 Sep 18; 11(18):1456-61. View in: Pubmed

The zebrafish klf gene family. Blood. 2001 Sep 15; 98(6):1792-801. View in: Pubmed

Molecular cloning of a human Vent-like homeobox gene. Genomics. 2001 Aug; 76(1-3):21-9. View in: Pubmed

Myelopoiesis in the zebrafish, Danio rerio. Blood. 2001 Aug 01; 98(3):643-51. View in: Pubmed

Primitive erythropoiesis in the Xenopus embryo: the synergistic role of LMO-2, SCL and GATA-binding proteins. Development. 2001 Jun; 128(12):2301-8. View in: Pubmed

Fishing for lymphoid genes. Trends Immunol. 2001 Jun; 22(6):302-7. View in: Pubmed

Hepatic maturation in differentiating embryonic stem cells in vitro. FEBS Lett. 2001 May 18; 497(1):15-9. View in: Pubmed

A novel myeloid-restricted zebrafish CCAAT/enhancer-binding protein with a potent transcriptional activation domain. Blood. 2001 May 01; 97(9):2611-7. View in: Pubmed

Role of MEKK2-MEK5 in the regulation of TNF-alpha gene expression and MEKK2-MKK7 in the activation of c-Jun N-terminal kinase in mast cells. Proc Natl Acad Sci U S A. 2001 Apr 10; 98(8):4599-604. View in: Pubmed

Self-renewal versus differentiation, a job for the mighty morphogens. Nat Immunol. 2001 Feb; 2(2):142-3. View in: Pubmed

Structure of the mouse Stat 3/5 locus: evolution from Drosophila to zebrafish to mouse. Genomics. 2001 Jan 15; 71(2):150-5. View in: Pubmed

Zebrafish homolog of the leukemia gene CBFB: its expression during embryogenesis and its relationship to scl and gata-1 in hematopoiesis. Blood. 2000 Dec 15; 96(13):4178-84. View in: Pubmed

Hereditary spherocytosis in zebrafish riesling illustrates evolution of erythroid beta-spectrin structure, and function in red cell morphogenesis and membrane stability. Development. 2000 Dec; 127(23):5123-32. View in: Pubmed

Effects of infectious hematopoietic necrosis virus and infectious pancreatic necrosis virus infection on hematopoietic precursors of the zebrafish. Blood Cells Mol Dis. 2000 Oct; 26(5):445-52. View in: Pubmed

Characterization of zebrafish full-length prothrombin cDNA and linkage group mapping. Blood Cells Mol Dis. 2000 Oct; 26(5):479-89. View in: Pubmed

In vivo immunological function of mast cells derived from embryonic stem cells: an approach for the rapid analysis of even embryonic lethal mutations in adult mice in vivo. Proc Natl Acad Sci U S A. 2000 Aug 01; 97(16):9186-90. View in: Pubmed

An orthologue of the kit-related gene fms is required for development of neural crest-derived xanthophores and a subpopulation of adult melanocytes in the zebrafish, Danio rerio. Development. 2000 Jul; 127(14):3031-44. View in: Pubmed

Zebrafish: a model system for the study of human disease. Curr Opin Genet Dev. 2000 Jun; 10(3):252-6. View in: Pubmed

FOG acts as a repressor of red blood cell development in Xenopus. Development. 2000 May; 127(10):2031-40. View in: Pubmed

Realizing the potential of zebrafish as a model for human disease. Physiol Genomics. 2000 Mar 13; 2(2):49-51. View in: Pubmed

Zebrafish: a genetic approach in studying hematopoiesis. Curr Opin Hematol. 2000 Mar; 7(2):79-84. View in: Pubmed

Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. Nature. 2000 Feb 17; 403(6771):776-81. View in: Pubmed

Developmental derivation of embryonic and adult macrophages. Curr Opin Hematol. 2000 Jan; 7(1):3-8. View in: Pubmed

Turning mesoderm into blood: the formation of hematopoietic stem cells during embryogenesis. Curr Top Dev Biol. 2000; 50:45-60. View in: Pubmed

A healthy community through health system partnerships: the approach of Markham Stouffville Hospital. Healthc Pap. 2000; 1(2):96-103; discussion 104-7. View in: Pubmed

The gene encoding TBC1D1 with homology to the tre-2/USP6 oncogene, BUB2, and cdc16 maps to mouse chromosome 5 and human chromosome 4. Cytogenet Cell Genet. 2000; 89(3-4):272-5. View in: Pubmed

Dissecting hematopoiesis and disease using the zebrafish. Dev Biol. 1999 Dec 01; 216(1):1-15. View in: Pubmed

Concentration-dependent positive and negative regulation of a MAP kinase by a MAP kinase kinase. Oncogene. 1999 Nov 18; 18(48):6647-57. View in: Pubmed

Gene duplication of zebrafish JAK2 homologs is accompanied by divergent embryonic expression patterns: only jak2a is expressed during erythropoiesis. Blood. 1999 Oct 15; 94(8):2622-36. View in: Pubmed

Specification of hematopoietic and vascular development by the bHLH transcription factor SCL without direct DNA binding. Development. 1999 Oct; 126(20):4603-15. View in: Pubmed

Radiation hybrid mapping of the zebrafish genome. Proc Natl Acad Sci U S A. 1999 Aug 17; 96(17):9745-50. View in: Pubmed

A G protein-coupled receptor from zebrafish is activated by human parathyroid hormone and not by human or teleost parathyroid hormone-related peptide. Implications for the evolutionary conservation of calcium-regulating peptide hormones. J Biol Chem. 1999 Aug 13; 274(33):23035-42. View in: Pubmed

Zebrafish stat3 is expressed in restricted tissues during embryogenesis and stat1 rescues cytokine signaling in a STAT1-deficient human cell line. Dev Dyn. 1999 Aug; 215(4):352-70. View in: Pubmed

Generation of a zebrafish P1 artificial chromosome library. Genomics. 1999 Jun 01; 58(2):211-3. View in: Pubmed

Protein-damaging stresses activate c-Jun N-terminal kinase via inhibition of its dephosphorylation: a novel pathway controlled by HSP72. Mol Cell Biol. 1999 Apr; 19(4):2547-55. View in: Pubmed

Zebrafish: a new model for human disease. Genome Res. 1999 Feb; 9(2):99-100. View in: Pubmed

Simple sequence-length polymorphism analysis. Methods Cell Biol. 1999; 60:181-3. View in: Pubmed

Genetic backgrounds and some standard stocks and strains used in zebrafish developmental biology and genetics. Methods Cell Biol. 1999; 60:357-9. View in: Pubmed

Zebrafish YAC, BAC, and PAC genomic libraries. Methods Cell Biol. 1999; 60:235-58. View in: Pubmed

Overview of the Zebrafish system. Methods Cell Biol. 1999; 59:3-10. View in: Pubmed

Collection, storage, and use of zebrafish sperm. Methods Cell Biol. 1999; 60:365-72. View in: Pubmed

Centromeric markers in the zebrafish. Methods Cell Biol. 1999; 60:361-3. View in: Pubmed

Primary fibroblast cell culture. Methods Cell Biol. 1999; 59:39-43. View in: Pubmed

Mapping zebrafish mutations by AFLP. Methods Cell Biol. 1999; 60:195-211. View in: Pubmed

Vascular and blood gene expression. Methods Cell Biol. 1999; 59:313-36. View in: Pubmed

Cooperative effects of growth factors involved in the induction of hematopoietic mesoderm. Blood. 1998 Dec 01; 92(11):4128-37. View in: Pubmed

Positional cloning of the zebrafish sauternes gene: a model for congenital sideroblastic anaemia. Nat Genet. 1998 Nov; 20(3):244-50. View in: Pubmed

Cloning of Mix-related homeodomain proteins using fast retrieval of gel shift activities, (FROGS), a technique for the isolation of DNA-binding proteins. Proc Natl Acad Sci U S A. 1998 Sep 15; 95(19):11251-6. View in: Pubmed

Characterization of whole genome radiation hybrid mapping resources for non-mammalian vertebrates. Nucleic Acids Res. 1998 Aug 01; 26(15):3562-6. View in: Pubmed

Analysis of the role of MKK-4/Sek-1 in T cell development and apoptosis. Int Immunol. 1998 Aug; 10(8):1077-82. View in: Pubmed

Gene mapping in zebrafish using single-strand conformation polymorphism analysis. Genomics. 1998 Jul 15; 51(2):216-22. View in: Pubmed

SCL specifies hematopoietic mesoderm in Xenopus embryos. Development. 1998 Jul; 125(14):2611-20. View in: Pubmed

SEK1 deficiency reveals mitogen-activated protein kinase cascade crossregulation and leads to abnormal hepatogenesis. Proc Natl Acad Sci U S A. 1998 Jun 09; 95(12):6881-6. View in: Pubmed

The cloche and spadetail genes differentially affect hematopoiesis and vasculogenesis. Dev Biol. 1998 May 15; 197(2):248-69. View in: Pubmed

Development of T-cells during fish embryogenesis. Dev Comp Immunol. 1998 May-Jun; 22(3):253-63. View in: Pubmed

SEK1/MKK4 is required for maintenance of a normal peripheral lymphoid compartment but not for lymphocyte development. Immunity. 1998 May; 8(5):625-34. View in: Pubmed

Modification of bacterial artificial chromosomes through chi-stimulated homologous recombination and its application in zebrafish transgenesis. Proc Natl Acad Sci U S A. 1998 Apr 28; 95(9):5121-6. View in: Pubmed

Transcriptional regulation of blood formation during Xenopus development. Semin Immunol. 1998 Apr; 10(2):103-9. View in: Pubmed

Vertebrate genome evolution and the zebrafish gene map. Nat Genet. 1998 Apr; 18(4):345-9. View in: Pubmed

SCL/Tal-1 transcription factor acts downstream of cloche to specify hematopoietic and vascular progenitors in zebrafish. Genes Dev. 1998 Mar 01; 12(5):621-6. View in: Pubmed

Molecular insights into early hematopoiesis. Curr Opin Hematol. 1998 Mar; 5(2):156-60. View in: Pubmed

Forced GATA-1 expression in the murine myeloid cell line M1: induction of c-Mpl expression and megakaryocytic/erythroid differentiation. Blood. 1998 Jan 15; 91(2):450-7. View in: Pubmed

Cloning and genetic mapping of zebrafish BMP-2. Dev Genet. 1998; 23(2):97-103. View in: Pubmed

Use of the zebrafish (Danio rerio) to define hematopoiesis. Stem Cells. 1998; 16 Suppl 2:67-78. View in: Pubmed

Use of the zebrafish (Danio rerio) to define hematopoiesis. Stem Cells. 1998; 16(2):89-98. View in: Pubmed

The molecular nature of zebrafish swirl: BMP2 function is essential during early dorsoventral patterning. Development. 1997 Nov; 124(22):4457-66. View in: Pubmed

Bipotential primitive-definitive hematopoietic progenitors in the vertebrate embryo. Immunity. 1997 Sep; 7(3):325-34. View in: Pubmed

MST/MLK2, a member of the mixed lineage kinase family, directly phosphorylates and activates SEK1, an activator of c-Jun N-terminal kinase/stress-activated protein kinase. J Biol Chem. 1997 Jun 13; 272(24):15167-73. View in: Pubmed

Cdc42Hs, but not Rac1, inhibits serum-stimulated cell cycle progression at G1/S through a mechanism requiring p38/RK. J Biol Chem. 1997 May 16; 272(20):13229-35. View in: Pubmed

Characterization of adult alpha- and beta-globin genes in the zebrafish. Blood. 1997 Jan 15; 89(2):688-700. View in: Pubmed

Small pool expression screening: identification of genes involved in cell cycle control, apoptosis, and early development. Methods Enzymol. 1997; 283:83-99. View in: Pubmed

Genetics of erythropoiesis: induced mutations in mice and zebrafish. Annu Rev Genet. 1997; 31:33-60. View in: Pubmed

Induction of cyclin D1 by simian virus 40 small tumor antigen. Proc Natl Acad Sci U S A. 1996 Nov 12; 93(23):12861-6. View in: Pubmed

The role of BMP-4 and GATA-2 in the induction and differentiation of hematopoietic mesoderm in Xenopus laevis. Blood. 1996 Sep 15; 88(6):1965-72. View in: Pubmed

Stimulation of the P-450 side chain cleavage enzyme (CYP11A1) promoter through ras- and Ets-2-signaling pathways. Mol Endocrinol. 1996 Sep; 10(9):1084-94. View in: Pubmed

Thrombopoietin rescues in vitro erythroid colony formation from mouse embryos lacking the erythropoietin receptor. Proc Natl Acad Sci U S A. 1996 Aug 20; 93(17):9126-31. View in: Pubmed

A third Ig light chain gene isotype in Xenopus laevis consists of six distinct VL families and is related to mammalian lambda genes. J Immunol. 1996 Aug 15; 157(4):1544-50. View in: Pubmed

The mixed lineage kinase SPRK phosphorylates and activates the stress-activated protein kinase activator, SEK-1. J Biol Chem. 1996 Aug 09; 271(32):19025-8. View in: Pubmed

BMP-4-responsive regulation of dorsal-ventral patterning by the homeobox protein Mix.1. Nature. 1996 Jul 25; 382(6589):357-60. View in: Pubmed

Genetic regulation of delta-aminolevulinate dehydratase during erythropoiesis. Nucleic Acids Res. 1996 Jul 01; 24(13):2511-8. View in: Pubmed

Intrathymic signals in thymocytes are mediated by p38 mitogen-activated protein kinase. J Immunol. 1996 Jun 15; 156(12):4535-8. View in: Pubmed

The gene encoding protein kinase SEK1 maps to mouse chromosome 11 and human chromosome 17. Genomics. 1996 Jun 15; 34(3):430-2. View in: Pubmed

The stress-activated protein kinase pathway mediates cell death following injury induced by cis-platinum, UV irradiation or heat. Curr Biol. 1996 May 01; 6(5):606-13. View in: Pubmed

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature. 1996 Mar 07; 380(6569):75-9. View in: Pubmed

Reconstitution of novel signalling cascades responding to cellular stresses. Philos Trans R Soc Lond B Biol Sci. 1996 Feb 29; 351(1336):135-41; discussion 142. View in: Pubmed

Signal transduction pathways regulated by mitogen-activated/extracellular response kinase kinase kinase induce cell death. J Biol Chem. 1996 Feb 09; 271(6):3229-37. View in: Pubmed

Stress- and mitogen-activated signal transduction in hematopoietic cells. Curr Opin Hematol. 1996 Jan; 3(1):27-34. View in: Pubmed

c-Abl activation regulates induction of the SEK1/stress-activated protein kinase pathway in the cellular response to 1-beta-D-arabinofuranosylcytosine. J Biol Chem. 1995 Dec 22; 270(51):30278-81. View in: Pubmed

Evolutionarily conserved alternative pre-mRNA splicing regulates structure and function of the spectrin-actin binding domain of erythroid protein 4.1. Blood. 1995 Dec 01; 86(11):4315-22. View in: Pubmed

Intraembryonic hematopoietic cell migration during vertebrate development. Proc Natl Acad Sci U S A. 1995 Nov 07; 92(23):10713-7. View in: Pubmed

Activation of the SAPK pathway by the human STE20 homologue germinal centre kinase. Nature. 1995 Oct 26; 377(6551):750-4. View in: Pubmed

Developmental biology of hematopoiesis. Blood. 1995 Oct 15; 86(8):2876-91. View in: Pubmed

Cloche, an early acting zebrafish gene, is required by both the endothelial and hematopoietic lineages. Development. 1995 Oct; 121(10):3141-50. View in: Pubmed

Molecular cloning of a cDNA with a novel domain present in the tre-2 oncogene and the yeast cell cycle regulators BUB2 and cdc16. Oncogene. 1995 Sep 21; 11(6):1139-48. View in: Pubmed

Cloning and chromosomal localization of a mouse cDNA with homology to the Saccharomyces cerevisiae gene zuotin. Genomics. 1995 Sep 20; 29(2):546-50. View in: Pubmed

Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1. Nature. 1994 Dec 22-29; 372(6508):798-800. View in: Pubmed

Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun. Nature. 1994 Dec 22-29; 372(6508):794-8. View in: Pubmed

Ventral expression of GATA-1 and GATA-2 in the Xenopus embryo defines induction of hematopoietic mesoderm. Dev Biol. 1994 Sep; 165(1):193-205. View in: Pubmed

Novel members of the mitogen-activated protein kinase activator family in Xenopus laevis. Mol Cell Biol. 1993 Sep; 13(9):5738-48. View in: Pubmed

Isolation of a novel receptor tyrosine kinase cDNA expressed by developing erythroid progenitors. Blood. 1993 Aug 15; 82(4):1335-43. View in: Pubmed

GATA-4 is a novel transcription factor expressed in endocardium of the developing heart. Development. 1993 Jul; 118(3):817-27. View in: Pubmed

Expression of mRNA for the GATA-binding proteins in human eosinophils and basophils: potential role in gene transcription. Blood. 1993 Jun 15; 81(12):3234-41. View in: Pubmed

Role of interleukin 6 in the growth of myeloma-derived cell lines. Leuk Res. 1992 Oct; 16(10):951-9. View in: Pubmed

Cell cycle-dependent initiation and lineage-dependent abrogation of GATA-1 expression in pure differentiating hematopoietic progenitors. Proc Natl Acad Sci U S A. 1992 Jul 15; 89(14):6353-7. View in: Pubmed

The erythropoietin receptor transmembrane region is necessary for activation by the Friend spleen focus-forming virus gp55 glycoprotein. Mol Cell Biol. 1992 Jul; 12(7):2949-57. View in: Pubmed

Sequence of the human GATA-1 promoter. Nucleic Acids Res. 1992 Apr 11; 20(7):1812. View in: Pubmed

Hematopoietic transcription regulators and the origins of leukemia. Crit Rev Oncol Hematol. 1992 Mar; 12(2):167-90. View in: Pubmed

GATA-binding transcription factors in mast cells regulate the promoter of the mast cell carboxypeptidase A gene. J Biol Chem. 1991 Dec 05; 266(34):22948-53. View in: Pubmed

Expression of GATA-binding proteins during embryonic development in Xenopus laevis. Proc Natl Acad Sci U S A. 1991 Dec 01; 88(23):10642-6. View in: Pubmed

Activation of the erythropoietin receptor promoter by transcription factor GATA-1. Proc Natl Acad Sci U S A. 1991 Dec 01; 88(23):10638-41. View in: Pubmed

The cytoplasmic region of the erythropoietin receptor contains nonoverlapping positive and negative growth-regulatory domains. Mol Cell Biol. 1991 Apr; 11(4):1980-7. View in: Pubmed

The extinction of erythroid genes after tetradecanoylphorbol acetate treatment of erythroleukemic cells correlates with down-regulation of the tissue-specific factors NF-E1 and NF-E2. J Biol Chem. 1990 Dec 25; 265(36):22090-2. View in: Pubmed

Erythropoietin receptor. Subunit structure and activation. J Clin Invest. 1990 Sep; 86(3):681-7. View in: Pubmed

Structure and transcription of the mouse erythropoietin receptor gene. Mol Cell Biol. 1990 Jul; 10(7):3675-82. View in: Pubmed

Expression of an erythroid transcription factor in megakaryocytic and mast cell lineages. Nature. 1990 Mar 29; 344(6265):444-7. View in: Pubmed

Structure of the erythropoietin receptor in stable fibroblast transfectants. Prog Clin Biol Res. 1990; 352:153-9. View in: Pubmed

The major human erythroid DNA-binding protein (GF-1): primary sequence and localization of the gene to the X chromosome. Proc Natl Acad Sci U S A. 1990 Jan; 87(2):668-72. View in: Pubmed

Pathophysiology and management of HIV-associated hematologic disorders. Blood. 1989 Oct; 74(5):1455-63. View in: Pubmed

The polymerase chain reaction colony miniprep. Biotechniques. 1989 Jul-Aug; 7(7):696-8. View in: Pubmed

Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells. Nature. 1989 Jun 08; 339(6224):446-51. View in: Pubmed

Rapid amplification of lambda gt11 bacteriophage library inserts from plaques using the polymerase chain reaction (PCR). Biotechniques. 1989 Jun; 7(6):568, 570. View in: Pubmed

Breast carcinoma metastatic to a meningioma. Case report and review of the literature. Arch Intern Med. 1989 Apr; 149(4):959-62. View in: Pubmed

Hematologic manifestations of the human immune deficiency virus (HIV). Semin Hematol. 1988 Jul; 25(3):208-18. View in: Pubmed

Haematologic manifestations of the human immune deficiency virus (HIV). Br J Haematol. 1987 Jun; 66(2):251-6. View in: Pubmed

Anticardiolipin antibodies associated with HTLV-III infection. Br J Haematol. 1987 Apr; 65(4):495-8. View in: Pubmed

Suppression of in vitro haematopoiesis following human immunodeficiency virus infection. Nature. 1987 Mar 12-18; 326(6109):200-3. View in: Pubmed

Hemophilus parainfluenzae prostatitis in a homosexual man with chronic lymphadenopathy syndrome and HTLV-III infection. Am J Med. 1987 Jan; 82(1):175-8. View in: Pubmed

Salivary antibodies as a means of detecting human T cell lymphotropic virus type III/lymphadenopathy-associated virus infection. J Clin Microbiol. 1986 Nov; 24(5):873-5. View in: Pubmed

IgA deficiency and salivary transmission of human immunodeficiency virus. Lancet. 1986 Nov 01; 2(8514):1039-40. View in: Pubmed

Antibodies to human T-lymphotropic virus type III (HTLV-III) in saliva of acquired immunodeficiency syndrome (AIDS) patients and in persons at risk for AIDS. Blood. 1986 Mar; 67(3):831-4. View in: Pubmed

Erythropoietin in liver tissue extracts and in liver perfusates from hypoxic rats. Am J Physiol. 1983 May; 244(5):E431-4. View in: Pubmed