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Matthew L. Meyerson, MD, PhD

Matthew L. Meyerson, MD, PhD

Researcher
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617-632-4768

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617-582-7880

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Biography

Matthew L. Meyerson, MD, PhD

Dr. Meyerson received his MD in 1993 and PhD in 1994 from Harvard University. After a residency in clinical pathology at Massachusetts General Hospital and a research fellowship with Dr. Robert Weinberg at the Whitehead Institute, he joined DFCI in 1998. Dr. Meyerson has concentrated on using genomic approaches to understand the biology and genetics of human lung carcinomas. More broadly, his laboratory is focused on cancer genome discovery and pathogen discovery in human disease.Dr. Meyerson serves as Professor of Genetics at Dana-Farber Cancer Institute and Harvard Medical School, as Director of the Center for Cancer Genomics at DFCI, and as an Institute Member of the Broad Institute.

Researcher

Physician

Charles A. Dana Chair in Human Cancer Genetics
Professor of Genetics and Medicine, Harvard Medical School

Recent Awards

  • 23rd Annual Alfred G. Knudson Award in Cancer Genetics, National Cancer Institute 2019
  • Adi F. Gazdar Award for Translational Research, International Association for the Study of Lung Cancer 2018
  • Elected Member, National Academy of Medicine 2018
  • Han-Mo Koo Memorial Award, Van Andel Research Institute 2016
  • American Cancer Society Research Professorship 2015
  • Outstanding Investigator Award, National Cancer Institute 2015
  • Claire W. and Richard P. Morse Award, Dana-Farber Cancer Institute 2013

  • Ilchun Memorial Award, Korean Society of Biochemistry and Molecular Biology

    2012

  • Caine Holter Hope Now Award, Uniting against Lung Cancer Foundation

    2011

  • American Association for Cancer Research Team Science Award 2010
  • Paul Marks Prize in Cancer Research 2009
  • Career Investigator of the American Lung Association 2005
  • Tisch Family Outstanding Achievement Award in Translational Cancer Science 2004
  • Pew Scholar in the Biomedical Sciences 1999

Research

    View Dr. Meyerson’s Research

    Genomic and functional studies of lung and other cancers

    Somatic genetic alterations in cancer: We use genome-scale approaches to discover chromosomal alterations and cancer-causing mutations.  I am a principal investigator for NCI’s “The Cancer Genome Atlas” project for comprehensive cancer genome characterization; this work is based at the Broad Institute. This year, we are publishing numerous manuscripts from TCGA studies; I am co-chair of the lung cancer disease working group for TCGA and corresponding author of the submitted manuscript on squamous cell lung carcinoma, in which we identified loss-of-function HLA-A mutations.

    We developed the use of single-nucleotide polymorphism (SNP) arrays for human cancer genome analysis (Lindblad-Toh et al., 2000).   We have now defined both lineage-specific and cancer-universal regions of amplification and deletion by SNP array analysis of over 2,500 cancer DNAs. Using SNP arrays, we identified the most common DNA amplification in lung adenocarcinoma, which targets the NKX2-1 pneumocyte-specifying transcription factor (Weir et al., 2007), common amplification of the SOX2 transcription factor in squamous cell carcinomas (Bass et al., 2009), and amplification of anti-apoptotic genes including MCL1,across multiple human cancers (Beroukhim et al., 2010).

    Our cancer sequencing projects identified mutations in the epidermal growth factor receptor tyrosine kinase gene, EGFR, in lung adenocarcinomas, associated with clinical response to gefitinib and erlotinib (Paez et al., 2004), and in glioblastoma (Lee et al., 2006). We also identified activating mutations of FGFR2 in multiple cancers (Dutt et al., 2008) and of ALK in glioblastoma (George et al., 2008).  With our colleagues, we recently reported statistically significant mutation of 26 genes in lung adenocarcinoma (Ding et al., 2008).  In addition, we pioneered the use of single-template sequencing in cancer genome analysis (Thomas et al., 2006), which we are now applying widely.  Ongoing projects have identified mutation of MAP3K1 and CBFB and translocation of AKT3 in breast carcinoma (Banerji et al., 2012), translocations of the TCF7L2 gene in colon carcinoma (Bass et al., 2011), and mutations of multiple genes including U2AF1 and RBM10 in lung adenocarcinoma (Imielinski et al., 2012).

    Functional analysis of lung cancer genes: We study oncogenic transformation by the major oncogenes that cause lung cancer, including EGFR and NKX2-1. For EGFR, we demonstrated the concept of mutation-selective therapy: distinct mutations are differentially sensitive or resistant to inhibitors (Greulich et al., 2005) and transformed cells bearing distinct mutations can most effectively be killed by different small molecule inhibitors (Yuza et al., 2007).  For NKX2-1, we have now identified LMO3 as a downstream target (Watanabe et al., 2013).  We have also recently identified multiple drug-sensitive alterations in the squamous cell lung cancer genome: mutations of DDR2 (Hammerman et al., 2011), FGFR2 and FGFR3 (Liao et al., 2013) and amplifications of FGFR1 (Dutt et al., 2011).

    Tumor suppressor proteins and chromatin modification: We showed that several endocrine tumor suppressor proteins, including menin and parafibromin, are associated with histone methyltransferases (Hughes et al., 2004; Rozenblatt-Rosen et al., 2005). We are now working to modulate histone methylation activity for treating endocrine tumors and leukemias, and have showed that deletion of the Rbp2 histone demethylase can reverse tumorigenesis by loss of the menin tumor suppressor (Lin et al., 2011).

    Discovery of pathogenic microbes: We developed a genomic approach to discover microbial sequences in human disease, by sequencing nucleic acids from diseased tissues followed by computational subtraction of human sequences (Weber et al., 2002). We and others have applied our approach to cancers, inflammatory and auto-immune diseases. Recently, we have completed a new software approach for identifying pathogens using next-generation sequencing data (Kostic et al., 2011), have identified an association of Fusobacterium species with colorectal carcinoma (Kostic et al., 2012) and have demonstrated that Fusobacterium infection potentiates lung cancer in mouse models (Kostic et al., 2013). Finally, we have recently identified infection with Bradyrhizobium enterica in transplant-associated cord colitis syndrome (Bhatt et al., 2013).

    Research Departments

    Support my research

    Research Website

    http://meyersonlab.dana-farber.org/

    Publications

      View Dr. Meyerson's Publications

      • Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker. Cancer Discov. 2023 Sep 12. View in: Pubmed

      • Loss of heterozygosity does not occur in BRCA1/2 mutant pediatric solid and central nervous system tumors. Pediatr Blood Cancer. 2023 Nov; 70(11):e30643. View in: Pubmed

      • XRN1 deletion induces PKR-dependent cell lethality in interferon-activated cancer cells. bioRxiv. 2023 Aug 03. View in: Pubmed

      • Oncogenic drivers and therapeutic vulnerabilities in KRAS wild-type pancreatic cancer. Clin Cancer Res. 2023 Jul 18. View in: Pubmed

      • Telomerase inhibition is an effective therapeutic strategy in TERT promoter-mutant glioblastoma models with low tumor volume. Neuro Oncol. 2023 Jul 06; 25(7):1275-1285. View in: Pubmed

      • Cancer aneuploidies are shaped primarily by effects on tumour fitness. Nature. 2023 Jul; 619(7971):793-800. View in: Pubmed

      • Impact of Aneuploidy and Chromosome 9p Loss on Tumor Immune Microenvironment and Immune Checkpoint Inhibitor Efficacy in NSCLC. J Thorac Oncol. 2023 May 27. View in: Pubmed

      • Molecular portraits of lung cancer evolution. Nature. 2023 04; 616(7957):435-436. View in: Pubmed

      • Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker. bioRxiv. 2023 Mar 17. View in: Pubmed

      • Author Correction: Genomic basis for RNA alterations in cancer. Nature. 2023 Feb; 614(7948):E37. View in: Pubmed

      • Correction to "Discovery and Structure-Based Design of Potent Covalent PPAR? Inverse-Agonists BAY-4931 and BAY-0069". J Med Chem. 2022 Dec 21. View in: Pubmed

      • Discovery and characterization of orally bioavailable 4-chloro-6-fluoroisophthalamides as covalent PPARG inverse-agonists. Bioorg Med Chem. 2023 01 15; 78:117130. View in: Pubmed

      • Velcrin-induced selective cleavage of tRNALeu(TAA) by SLFN12 causes cancer cell death. Nat Chem Biol. 2023 03; 19(3):301-310. View in: Pubmed

      • Discovery and Structure-Based Design of Potent Covalent PPAR? Inverse-Agonists BAY-4931 and BAY-0069. J Med Chem. 2022 11 10; 65(21):14843-14863. View in: Pubmed

      • Fusobacterium and Colorectal Cancer: Important Association or Random Coincidence? Cancer Res. 2022 10 17; 82(20):3671-3672. View in: Pubmed

      • Tangent normalization for somatic copy-number inference in cancer genome analysis. Bioinformatics. 2022 10 14; 38(20):4677-4686. View in: Pubmed

      • Patterns of structural variation define prostate cancer across disease states. JCI Insight. 2022 09 08; 7(17). View in: Pubmed

      • Identifying and correcting repeat-calling errors in nanopore sequencing of telomeres. Genome Biol. 2022 08 26; 23(1):180. View in: Pubmed

      • An international report on bacterial communities in esophageal squamous cell carcinoma. Int J Cancer. 2022 Dec 01; 151(11):1947-1959. View in: Pubmed

      • Correction: Functional Genomic Analysis of CDK4 and CDK6 Gene Dependency across Human Cancer Cell Lines. Cancer Res. 2022 Aug 03; 82(15):2808. View in: Pubmed

      • Whole genome sequencing reveals the independent clonal origin of multifocal ileal neuroendocrine tumors. Genome Med. 2022 08 03; 14(1):82. View in: Pubmed

      • Dissecting the clinicopathologic, genomic, and immunophenotypic correlates of KRASG12D-mutated non-small-cell lung cancer. Ann Oncol. 2022 10; 33(10):1029-1040. View in: Pubmed

      • Functional Genomic Analysis of CDK4 and CDK6 Gene Dependency across Human Cancer Cell Lines. Cancer Res. 2022 06 06; 82(11):2171-2184. View in: Pubmed

      • Correction to: Oncogenic RIT1 mutations in lung adenocarcinoma. Oncogene. 2022 May; 41(19):2788. View in: Pubmed

      • Long-read sequencing reveals complex patterns of wraparound transcription in polyomaviruses. PLoS Pathog. 2022 04; 18(4):e1010401. View in: Pubmed

      • Author Correction: Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells. Nat Commun. 2022 Apr 01; 13(1):1894. View in: Pubmed

      • Combined tumor and immune signals from genomes or transcriptomes predict outcomes of checkpoint inhibition in melanoma. Cell Rep Med. 2022 02 15; 3(2):100500. View in: Pubmed

      • Telomerase as a therapeutic target in glioblastoma. Neuro Oncol. 2021 12 01; 23(12):2004-2013. View in: Pubmed

      • Quantification of aneuploidy in targeted sequencing data using ASCETS. Bioinformatics. 2021 08 25; 37(16):2461-2463. View in: Pubmed

      • Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase. Nat Commun. 2021 07 16; 12(1):4375. View in: Pubmed

      • Haplotype-resolved germline and somatic alterations in renal medullary carcinomas. Genome Med. 2021 07 14; 13(1):114. View in: Pubmed

      • Reprogramming of the esophageal squamous carcinoma epigenome by SOX2 promotes ADAR1 dependence. Nat Genet. 2021 06; 53(6):881-894. View in: Pubmed

      • FGFR2 Extracellular Domain In-Frame Deletions Are Therapeutically Targetable Genomic Alterations That Function as Oncogenic Drivers in Cholangiocarcinoma. Cancer Discov. 2021 10; 11(10):2488-2505. View in: Pubmed

      • Pan-ERBB kinase inhibition augments CDK4/6 inhibitor efficacy in oesophageal squamous cell carcinoma. Gut. 2022 04; 71(4):665-675. View in: Pubmed

      • Characterization of Plasmacytoid Dendritic Cells, Microbial Sequences, and Identification of a Candidate Public T-Cell Clone in Kikuchi-Fujimoto Disease. Pediatr Dev Pathol. 2021 May-Jun; 24(3):193-205. View in: Pubmed

      • Whole-genome characterization of lung adenocarcinomas lacking the RTK/RAS/RAF pathway. Cell Rep. 2021 02 02; 34(5):108707. View in: Pubmed

      • Genomic Evolution in a Patient With Lung Adenocarcinoma With a Germline EGFR T790M Mutation. JTO Clin Res Rep. 2021 Apr; 2(4):100146. View in: Pubmed

      • Antigen identification for HLA class I- and HLA class II-restricted T cell receptors using cytokine-capturing antigen-presenting cells. Sci Immunol. 2021 01 22; 6(55). View in: Pubmed

      • Molecular Characterization and Therapeutic Targeting of Colorectal Cancers Harboring Receptor Tyrosine Kinase Fusions. Clin Cancer Res. 2021 03 15; 27(6):1695-1705. View in: Pubmed

      • Genetic Ancestry Contributes to Somatic Mutations in Lung Cancers from Admixed Latin American Populations. Cancer Discov. 2021 03; 11(3):591-598. View in: Pubmed

      • Pervasive generation of non-canonical subgenomic RNAs by SARS-CoV-2. Genome Med. 2020 12 01; 12(1):108. View in: Pubmed

      • Correction: Mechanistic insights into cancer cell killing through interaction of phosphodiesterase 3A and schlafen family member 12. J Biol Chem. 2020 Nov 27; 295(48):16464-16467. View in: Pubmed

      • Bacterial invaders drive CRC progression. Sci Signal. 2020 08 11; 13(644). View in: Pubmed

      • Genomic Profiling of Prostate Cancers from Men with African and European Ancestry. Clin Cancer Res. 2020 09 01; 26(17):4651-4660. View in: Pubmed

      • Fusobacterium nucleatum persistence and risk of recurrence after preoperative treatment in locally advanced rectal cancer. Ann Oncol. 2020 10; 31(10):1366-1375. View in: Pubmed

      • Patterns of chromosome 18 loss of heterozygosity in multifocal ileal neuroendocrine tumors. Genes Chromosomes Cancer. 2020 09; 59(9):535-539. View in: Pubmed

      • Clinicopathological and genomic correlates of programmed cell death ligand 1 (PD-L1) expression in nonsquamous non-small-cell lung cancer. Ann Oncol. 2020 06; 31(6):807-814. View in: Pubmed

      • Comprehensive metagenomic analysis of blastic plasmacytoid dendritic cell neoplasm. Blood Adv. 2020 03 24; 4(6):1006-1011. View in: Pubmed

      • Sensitive Detection of Minimal Residual Disease in Patients Treated for Early-Stage Breast Cancer. Clin Cancer Res. 2020 06 01; 26(11):2556-2564. View in: Pubmed

      • Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli. Nature. 2020 04; 580(7802):269-273. View in: Pubmed

      • Genomic basis for RNA alterations in cancer. Nature. 2020 02; 578(7793):129-136. View in: Pubmed

      • Mechanistic insights into cancer cell killing through interaction of phosphodiesterase 3A and schlafen family member 12. J Biol Chem. 2020 03 13; 295(11):3431-3446. View in: Pubmed

      • Discovering the anti-cancer potential of non-oncology drugs by systematic viability profiling. Nat Cancer. 2020 02; 1(2):235-248. View in: Pubmed

      • Multi-Omics Analysis Identifies MGA as a Negative Regulator of the MYC Pathway in Lung Adenocarcinoma. Mol Cancer Res. 2020 04; 18(4):574-584. View in: Pubmed

      • Genomic and immune profiling of pre-invasive lung adenocarcinoma. Nat Commun. 2019 11 29; 10(1):5472. View in: Pubmed

      • Optimization of PDE3A Modulators for SLFN12-Dependent Cancer Cell Killing. ACS Med Chem Lett. 2019 Nov 14; 10(11):1537-1542. View in: Pubmed

      • Patient-derived lung cancer organoids as in vitro cancer models for therapeutic screening. Nat Commun. 2019 09 05; 10(1):3991. View in: Pubmed

      • Pooled Genomic Screens Identify Anti-apoptotic Genes as Targetable Mediators of Chemotherapy Resistance in Ovarian Cancer. Mol Cancer Res. 2019 11; 17(11):2281-2293. View in: Pubmed

      • Circulating Tumor DNA Provides a Sneak Peek into Treatment Responses in Non-Small Cell Lung Cancer. Cancer Res. 2019 03 15; 79(6):1038-1040. View in: Pubmed

      • A Functional Landscape of Resistance to MEK1/2 and CDK4/6 Inhibition in NRAS-Mutant Melanoma. Cancer Res. 2019 05 01; 79(9):2352-2366. View in: Pubmed

      • Commensal Microbiota Promote Lung Cancer Development via ?d T Cells. Cell. 2019 02 21; 176(5):998-1013.e16. View in: Pubmed

      • Identification and Characterization of Oncogenic SOS1 Mutations in Lung Adenocarcinoma. Mol Cancer Res. 2019 04; 17(4):1002-1012. View in: Pubmed

      • Addendum: The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature. 2019 01; 565(7738):E5-E6. View in: Pubmed

      • Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells. Nat Commun. 2018 12 21; 9(1):5450. View in: Pubmed

      • GATK PathSeq: a customizable computational tool for the discovery and identification of microbial sequences in libraries from eukaryotic hosts. Bioinformatics. 2018 12 15; 34(24):4287-4289. View in: Pubmed

      • Tumor fraction in cell-free DNA as a biomarker in prostate cancer. JCI Insight. 2018 11 02; 3(21). View in: Pubmed

      • Splicing modulation sensitizes chronic lymphocytic leukemia cells to venetoclax by remodeling mitochondrial apoptotic dependencies. JCI Insight. 2018 10 04; 3(19). View in: Pubmed

      • The Amount of Bifidobacterium Genus in Colorectal Carcinoma Tissue in Relation to Tumor Characteristics and Clinical Outcome. Am J Pathol. 2018 12; 188(12):2839-2852. View in: Pubmed

      • Fusobacterium nucleatum in Colorectal Cancer Relates to Immune Response Differentially by Tumor Microsatellite Instability Status. Cancer Immunol Res. 2018 11; 6(11):1327-1336. View in: Pubmed

      • Mutational processes shape the landscape of TP53 mutations in human cancer. Nat Genet. 2018 10; 50(10):1381-1387. View in: Pubmed

      • Comprehensive Molecular Characterization of Muscle-Invasive Bladder Cancer. Cell. 2018 08 09; 174(4):1033. View in: Pubmed

      • Genetic and transcriptional evolution alters cancer cell line drug response. Nature. 2018 08; 560(7718):325-330. View in: Pubmed

      • Genotype-targeted local therapy of glioma. Proc Natl Acad Sci U S A. 2018 09 04; 115(36):E8388-E8394. View in: Pubmed

      • Author Correction: Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes. Nat Med. 2018 Aug; 24(8):1290-1291. View in: Pubmed

      • Publisher Correction: Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes. Nat Med. 2018 Aug; 24(8):1292. View in: Pubmed

      • Detection of Somatic Structural Variants Enables Quantification and Characterization of Circulating Tumor DNA in Children With Solid Tumors. JCO Precis Oncol. 2018; 2018. View in: Pubmed

      • Germline cancer susceptibility gene variants, somatic second hits, and survival outcomes in patients with resected pancreatic cancer. Genet Med. 2019 01; 21(1):213-223. View in: Pubmed

      • Genome-scale analysis identifies paralog lethality as a vulnerability of chromosome 1p loss in cancer. Nat Genet. 2018 07; 50(7):937-943. View in: Pubmed

      • Structural Alterations Driving Castration-Resistant Prostate Cancer Revealed by Linked-Read Genome Sequencing. Cell. 2018 07 12; 174(2):433-447.e19. View in: Pubmed

      • Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes. Nat Med. 2018 05; 24(5):679-690. View in: Pubmed

      • RAS-MAPK Reactivation Facilitates Acquired Resistance in FGFR1-Amplified Lung Cancer and Underlies a Rationale for Upfront FGFR-MEK Blockade. Mol Cancer Ther. 2018 07; 17(7):1526-1539. View in: Pubmed

      • Mechanistic Insights into Transmissible Cancers of Mammals. Cancer Cell. 2018 04 09; 33(4):543-544. View in: Pubmed

      • Oncogenic Signaling Pathways in The Cancer Genome Atlas. Cell. 2018 04 05; 173(2):321-337.e10. View in: Pubmed

      • Genomic and Functional Approaches to Understanding Cancer Aneuploidy. Cancer Cell. 2018 04 09; 33(4):676-689.e3. View in: Pubmed

      • Genomic discovery and clonal tracking in multiple myeloma by cell-free DNA sequencing. Leukemia. 2018 08; 32(8):1838-1841. View in: Pubmed

      • Landscapes of childhood tumours. Nature. 2018 03 15; 555(7696):316-317. View in: Pubmed

      • SvABA: genome-wide detection of structural variants and indels by local assembly. Genome Res. 2018 04; 28(4):581-591. View in: Pubmed

      • Association of Alterations in Main Driver Genes With Outcomes of Patients With Resected Pancreatic Ductal Adenocarcinoma. JAMA Oncol. 2018 Mar 08; 4(3):e173420. View in: Pubmed

      • Autophosphorylation of the carboxyl-terminal domain is not required for oncogenic transformation by lung-cancer derived EGFR mutants. Int J Cancer. 2018 08 01; 143(3):679-685. View in: Pubmed

      • Landscapes of childhood tumours. Nature. 2018 Mar; 555(7696):316-317. View in: Pubmed

      • Unique, dual-indexed sequencing adapters with UMIs effectively eliminate index cross-talk and significantly improve sensitivity of massively parallel sequencing. BMC Genomics. 2018 01 08; 19(1):30. View in: Pubmed

      • High-throughput Phenotyping of Lung Cancer Somatic Mutations. Cancer Cell. 2017 12 11; 32(6):884. View in: Pubmed

      • Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer. Science. 2017 12 15; 358(6369):1443-1448. View in: Pubmed

      • Scalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumors. Nat Commun. 2017 11 06; 8(1):1324. View in: Pubmed

      • Suppression of Adaptive Responses to Targeted Cancer Therapy by Transcriptional Repression. Cancer Discov. 2018 01; 8(1):59-73. View in: Pubmed

      • Comprehensive Molecular Characterization of Muscle-Invasive Bladder Cancer. Cell. 2017 Oct 19; 171(3):540-556.e25. View in: Pubmed

      • Somatic Superenhancer Duplications and Hotspot Mutations Lead to Oncogenic Activation of the KLF5 Transcription Factor. Cancer Discov. 2018 01; 8(1):108-125. View in: Pubmed

      • Genomic Activation of PPARG Reveals a Candidate Therapeutic Axis in Bladder Cancer. Cancer Res. 2017 12 15; 77(24):6987-6998. View in: Pubmed

      • Corrigendum: Recurrent hormone-binding domain truncated ESR1 amplifications in primary endometrial cancers suggest their implication in hormone independent growth. Sci Rep. 2017 06 30; 7:46873. View in: Pubmed

      • Recurrent and functional regulatory mutations in breast cancer. Nature. 2017 07 06; 547(7661):55-60. View in: Pubmed

      • Comparison of Prevalence and Types of Mutations in Lung Cancers Among Black and White Populations. JAMA Oncol. 2017 Jun 01; 3(6):801-809. View in: Pubmed

      • MET Exon 14 Mutation Encodes an Actionable Therapeutic Target in Lung Adenocarcinoma. Cancer Res. 2017 08 15; 77(16):4498-4505. View in: Pubmed

      • Germline and somatic BAP1 mutations in high-grade rhabdoid meningiomas. Neuro Oncol. 2017 04 01; 19(4):535-545. View in: Pubmed

      • Insertions and Deletions Target Lineage-Defining Genes in Human Cancers. Cell. 2017 01 26; 168(3):460-472.e14. View in: Pubmed

      • Copy number alterations unmasked as enhancer hijackers. Nat Genet. 2016 12 28; 49(1):5-6. View in: Pubmed

      • Emerging Concepts and Technologies for the Discovery of Microorganisms Involved in Human Disease. Annu Rev Pathol. 2017 Jan 24; 12:217-244. View in: Pubmed

      • Institutional implementation of clinical tumor profiling on an unselected cancer population. JCI Insight. 2016 11 17; 1(19):e87062. View in: Pubmed

      • Fusobacterium nucleatum in Colorectal Carcinoma Tissue According to Tumor Location. Clin Transl Gastroenterol. 2016 Nov 03; 7(11):e200. View in: Pubmed

      • Genetic interrogation of circulating multiple myeloma cells at single-cell resolution. Sci Transl Med. 2016 11 02; 8(363):363ra147. View in: Pubmed

      • Kmt2a cooperates with menin to suppress tumorigenesis in mouse pancreatic islets. Cancer Biol Ther. 2016 12; 17(12):1274-1281. View in: Pubmed

      • Comprehensive Pan-Genomic Characterization of Adrenocortical Carcinoma. Cancer Cell. 2016 08 08; 30(2):363. View in: Pubmed

      • Whole Exome Sequencing Identifies TSC1/TSC2 Biallelic Loss as the Primary and Sufficient Driver Event for Renal Angiomyolipoma Development. PLoS Genet. 2016 08; 12(8):e1006242. View in: Pubmed

      • High-throughput Phenotyping of Lung Cancer Somatic Mutations. Cancer Cell. 2016 08 08; 30(2):214-228. View in: Pubmed

      • Corrigendum: Recurrent hormone-binding domain truncated ESR1 amplifications in primary endometrial cancers suggest their implication in hormone independent growth. Sci Rep. 2016 06 24; 6:27960. View in: Pubmed

      • Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting. Cancer Discov. 2016 08; 6(8):914-29. View in: Pubmed

      • Metagenomic Characterization of Microbial Communities In Situ Within the Deeper Layers of the Ileum in Crohn's Disease. Cell Mol Gastroenterol Hepatol. 2016 Sep; 2(5):563-566.e5. View in: Pubmed

      • Recurrent hormone-binding domain truncated ESR1 amplifications in primary endometrial cancers suggest their implication in hormone independent growth. Sci Rep. 2016 05 10; 6:25521. View in: Pubmed

      • Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas. Nat Genet. 2016 06; 48(6):607-16. View in: Pubmed

      • Comprehensive Pan-Genomic Characterization of Adrenocortical Carcinoma. Cancer Cell. 2016 05 09; 29(5):723-736. View in: Pubmed

      • VariantBam: filtering and profiling of next-generational sequencing data using region-specific rules. Bioinformatics. 2016 07 01; 32(13):2029-31. View in: Pubmed

      • Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma. Cell. 2016 Jan 28; 164(3):550-63. View in: Pubmed

      • BRAF alteration status and the histone H3F3A gene K27M mutation segregate spinal cord astrocytoma histology. Acta Neuropathol. 2016 Jan; 131(1):147-50. View in: Pubmed

      • Identification of focally amplified lineage-specific super-enhancers in human epithelial cancers. Nat Genet. 2016 Feb; 48(2):176-82. View in: Pubmed

      • Identification of cancer-cytotoxic modulators of PDE3A by predictive chemogenomics. Nat Chem Biol. 2016 Feb; 12(2):102-8. View in: Pubmed

      • Identification of an "Exceptional Responder" Cell Line to MEK1 Inhibition: Clinical Implications for MEK-Targeted Therapy. Mol Cancer Res. 2016 Feb; 14(2):207-15. View in: Pubmed

      • Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma. N Engl J Med. 2016 Jan 14; 374(2):135-45. View in: Pubmed

      • Complete hematologic response of early T-cell progenitor acute lymphoblastic leukemia to the ?-secretase inhibitor BMS-906024: genetic and epigenetic findings in an outlier case. Cold Spring Harb Mol Case Stud. 2015 Oct; 1(1):a000539. View in: Pubmed

      • Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets. Cancer Discov. 2015 Nov; 5(11):1164-1177. View in: Pubmed

      • Characterization of DDR2 Inhibitors for the Treatment of DDR2 Mutated Nonsmall Cell Lung Cancer. ACS Chem Biol. 2015 Dec 18; 10(12):2687-96. View in: Pubmed

      • Fusobacterium nucleatum in colorectal carcinoma tissue and patient prognosis. Gut. 2016 12; 65(12):1973-1980. View in: Pubmed

      • Structure and mechanism of activity-based inhibition of the EGF receptor by Mig6. Nat Struct Mol Biol. 2015 Sep; 22(9):703-711. View in: Pubmed

      • Rapid Intraoperative Molecular Characterization of Glioma. JAMA Oncol. 2015 Aug; 1(5):662-7. View in: Pubmed

      • NSCLC Driven by DDR2 Mutation Is Sensitive to Dasatinib and JQ1 Combination Therapy. Mol Cancer Ther. 2015 Oct; 14(10):2382-2389. View in: Pubmed

      • Near universal detection of alterations in CTNNB1 and Wnt pathway regulators in desmoid-type fibromatosis by whole-exome sequencing and genomic analysis. Genes Chromosomes Cancer. 2015 Oct; 54(10):606-15. View in: Pubmed

      • Prognostic Impact of Novel Molecular Subtypes of Small Intestinal Neuroendocrine Tumor. Clin Cancer Res. 2016 Jan 01; 22(1):250-8. View in: Pubmed

      • Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas. N Engl J Med. 2015 Jun 25; 372(26):2481-98. View in: Pubmed

      • Chromothripsis from DNA damage in micronuclei. Nature. 2015 Jun 11; 522(7555):179-84. View in: Pubmed

      • Prospective derivation of a living organoid biobank of colorectal cancer patients. Cell. 2015 May 07; 161(4):933-45. View in: Pubmed

      • Updated Frequency of EGFR and KRAS Mutations in NonSmall-Cell Lung Cancer in Latin America: The Latin-American Consortium for the Investigation of Lung Cancer (CLICaP). J Thorac Oncol. 2015 May; 10(5):838-843. View in: Pubmed

      • Calibrating genomic and allelic coverage bias in single-cell sequencing. Nat Commun. 2015 Apr 16; 6:6822. View in: Pubmed

      • Pugh et al. reply. Nature. 2015 Apr 16; 520(7547):E12-4. View in: Pubmed

      • DNA copy number analysis of metastatic urothelial carcinoma with comparison to primary tumors. BMC Cancer. 2015 Apr 09; 15:242. View in: Pubmed

      • The tumor virus landscape of AIDS-related lymphomas. Blood. 2015 May 14; 125(20):e14-22. View in: Pubmed

      • Oncotator: cancer variant annotation tool. Hum Mutat. 2015 Apr; 36(4):E2423-9. View in: Pubmed

      • A functional landscape of resistance to ALK inhibition in lung cancer. Cancer Cell. 2015 Mar 09; 27(3):397-408. View in: Pubmed

      • Genomic aberrations in cervical adenocarcinomas in Hong Kong Chinese women. Int J Cancer. 2015 Aug 15; 137(4):776-83. View in: Pubmed

      • Whole-genome and multisector exome sequencing of primary and post-treatment glioblastoma reveals patterns of tumor evolution. Genome Res. 2015 Mar; 25(3):316-27. View in: Pubmed

      • Sporadic hemangioblastomas are characterized by cryptic VHL inactivation. Acta Neuropathol Commun. 2014 Dec 24; 2:167. View in: Pubmed

      • Dynamic epigenetic regulation by menin during pancreatic islet tumor formation. Mol Cancer Res. 2015 Apr; 13(4):689-98. View in: Pubmed

      • Genetic modifiers of EGFR dependence in non-small cell lung cancer. Proc Natl Acad Sci U S A. 2014 Dec 30; 111(52):18661-6. View in: Pubmed

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