Stuart H. Orkin, MD

Stuart H. Orkin, MD

Pediatric Hematology/Oncology

Contact Information

Fax

617-632-4367

Appointments

888-733-4662 (New Pediatric Patients)
617-632-3270 (Established Pediatric Patients)

Biography

Stuart H. Orkin, MD

Dr. Orkin received his MD in 1972 from Harvard Medical School, followed by postdoctoral research at the National Institutes of Health and clinical training in pediatrics and hematology-oncology at Children's Hospital Boston and DFCI, where he joined the faculty in 1978. Dr. Orkin is a Howard Hughes Medical Institute Investigator and was elected to the 2019-2020 Council of the National Academy of Medicine. Over the past decade, his laboratory has defined critical nuclear regulators of hematopoiesis.

Researcher

Physician

Professor of Pediatrics, Harvard Medical School

Clinical Interests

Pediatric hematology/oncology

Fellowship

  • Boston Children's Hospital, Pediatric Hematology/Oncology

Residency

  • Boston Children's Hospital, Pediatrics

Medical School

  • Harvard Medical School

Recent Awards

  • Gruber Genetics Prize, Yale, 2021
  • Tobias Lecture Award, ISSCR, 2021
  • Harrington Prize for Innovation in Medicine, Harrington Discovery Institute and The American Society for Clinical Investigation, 2020
  • King Faisal Prize for Medicine, 2020
  • AAMC Award for Distinguished Research in Medical Sciences, 2005
  • Warren Alpert Foundation Prize, 1993
  • Member, Institute of Medicine, 1992
  • Member, American Academy of Arts and Sciences, 1992
  • Member, National Academy of Sciences, 1991
  • Dameshek Award, American Society of Hematology, 1986

Research

    Molecular Genetics of Blood Cell Development and Stem Cells

    All blood cells arise from committed progenitors, which are descendants of pluripotent hematopoietic stem cells. The goal of our laboratory is to understand how commitment to specific blood lineages is programmed and how cell-specific patterns of gene expression are established. Since gene expression is controlled by nuclear regulatory factors (transcription factors), efforts have centered on identifying those crucial for the development of stem cells or individual lineages. Research encompasses conventional molecular biology and contemporary mouse genetics. Lineage specification and hematopoietic differentiation. Red blood cells and megakaryocytes (which produce platelets) share a common precursor cell. We discovered a transcription factor, GATA1, that participates in the regulation of virtually all red cell (erythroid) and megakaryocyte-specific expressed genes. Expression of GATA1 in progenitors drives cells toward erythroid and megakaryocytic fates. Disruption of the Gata1 gene in mice leads to a failure of maturation of both lineages. In addition to controlling end-stage markers of these lineages, GATA1 influences proliferation and cell death decisions of precursor cells. Using this mouse model to dissect mechanisms of cell differentiation, we have sought to understand how GATA1 functions in transcription. This line of investigation led us to hypothesize and then discover a cofactor required for GATA1's function in these lineages. This novel cofactor, FOG (for friend of GATA1), is also essential for normal red blood cell and megakaryocyte development. Current research focuses on how FOG modulates the function of GATA1 and related factors during hematopoietic and nonhematopoietic cell development. Hematopoiesis-leukemia interface. Remarkably, many genes essential for normal hematopoietic development are involved in chromosomal translocations in human leukemias. This finding reflects perturbation of normal homeostasis by expression of an altered protein or excessive production of an otherwise normal factor. We are studying several transcription factors (e.g., SCL/tal-1, TEL) affected by genetic events in leukemias. Our work is directed toward understanding the normal roles of these transcription factors in hematopoiesis and vascular development. In addition, efforts are ongoing to recreate in mice the common form of childhood leukemia, acute lymphoblastic leukemia, associated with fusion of the TEL and AML1 genes. This animal model will permit improved understanding of the pathogenesis of acute lymphoblastic leukemia and provide a system for testing new therapies.

    Research Departments

    Publications

      • In vivo CRISPR/Cas9 screening identifies Pbrm1 as a regulator of myeloid leukemia development in mice. Blood Adv. 2023 09 26; 7(18):5281-5293. View in: Pubmed

      • Noncoding variants alter GATA2 expression in rhombomere 4 motor neurons and cause dominant hereditary congenital facial paresis. Nat Genet. 2023 07; 55(7):1149-1163. View in: Pubmed

      • Identifying Quantitatively Differential Chromosomal Compartmentalization Changes and Their Biological Significance from Hi-C data using DARIC. Res Sq. 2023 Apr 28. View in: Pubmed

      • Rapid-kinetics degron benchmarking reveals off-target activities and mixed agonism-antagonism of MYB inhibitors. bioRxiv. 2023 Apr 07. View in: Pubmed

      • Fetal Hemoglobin Regulation in Beta-Thalassemia. Hematol Oncol Clin North Am. 2023 04; 37(2):301-312. View in: Pubmed

      • Leukemia core transcriptional circuitry is a sparsely interconnected hierarchy stabilized by incoherent feed-forward loops. bioRxiv. 2023 Mar 15. View in: Pubmed

      • Defining the structure, signals, and cellular elements of the gastric mesenchymal niche. bioRxiv. 2023 Feb 24. View in: Pubmed

      • Polycomb deficiency drives a FOXP2-high aggressive state targetable by epigenetic inhibitors. Nat Commun. 2023 Jan 20; 14(1):336. View in: Pubmed

      • Evolution of nanobodies specific for BCL11A. Proc Natl Acad Sci U S A. 2023 01 17; 120(3):e2218959120. View in: Pubmed

      • A Cell-Permeant Nanobody-Based Degrader That Induces Fetal Hemoglobin. ACS Cent Sci. 2022 Dec 28; 8(12):1695-1703. View in: Pubmed

      • High-efficiency knock-in of degradable tags (dTAG) at endogenous loci in cell lines. Methods Enzymol. 2023; 681:1-22. View in: Pubmed

      • Transcriptional Plasticity Drives Leukemia Immune Escape. Blood Cancer Discov. 2022 09 06; 3(5):394-409. View in: Pubmed

      • Temporal resolution of gene derepression and proteome changes upon PROTAC-mediated degradation of BCL11A protein in erythroid cells. Cell Chem Biol. 2022 08 18; 29(8):1273-1287.e8. View in: Pubmed

      • Unleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML Blasts. Cancer Discov. 2022 07 06; 12(7):1760-1781. View in: Pubmed

      • CD49b identifies functionally and epigenetically distinct subsets of lineage-biased hematopoietic stem cells. Stem Cell Reports. 2022 07 12; 17(7):1546-1560. View in: Pubmed

      • Hypoxic, glycolytic metabolism is a vulnerability of B-acute lymphoblastic leukemia-initiating cells. Cell Rep. 2022 04 26; 39(4):110752. View in: Pubmed

      • Congenital anemia reveals distinct targeting mechanisms for master transcription factor GATA1. Blood. 2022 04 21; 139(16):2534-2546. View in: Pubmed

      • Developmental maturation of the hematopoietic system controlled by a Lin28b-let-7-Cbx2 axis. Cell Rep. 2022 04 05; 39(1):110587. View in: Pubmed

      • A distinct core regulatory module enforces oncogene expression in KMT2A-rearranged leukemia. Genes Dev. 2022 03 01; 36(5-6):368-389. View in: Pubmed

      • Transcription factor-mediated intestinal metaplasia and the role of a shadow enhancer. Genes Dev. 2022 01 01; 36(1-2):38-52. View in: Pubmed

      • Inner nuclear protein Matrin-3 coordinates cell differentiation by stabilizing chromatin architecture. Nat Commun. 2021 10 29; 12(1):6241. View in: Pubmed

      • Mapping the evolving landscape of super-enhancers during cell differentiation. Genome Biol. 2021 09 15; 22(1):269. View in: Pubmed

      • Dietary suppression of MHC class II expression in intestinal epithelial cells enhances intestinal tumorigenesis. Cell Stem Cell. 2021 11 04; 28(11):1922-1935.e5. View in: Pubmed

      • A unified model of human hemoglobin switching through single-cell genome editing. Nat Commun. 2021 08 17; 12(1):4991. View in: Pubmed

      • Reactivation of a developmentally silenced embryonic globin gene. Nat Commun. 2021 07 21; 12(1):4439. View in: Pubmed

      • Indispensable epigenetic control of thymic epithelial cell development and function by polycomb repressive complex 2. Nat Commun. 2021 06 24; 12(1):3933. View in: Pubmed

      • Author Correction: Transcription factor competition at the ?-globin promoters controls hemoglobin switching. Nat Genet. 2021 Apr; 53(4):586. View in: Pubmed

      • Transcription factor competition at the ?-globin promoters controls hemoglobin switching. Nat Genet. 2021 04; 53(4):511-520. View in: Pubmed

      • MOLECULAR MEDICINE: Found in Translation. Med (N Y). 2021 02 12; 2(2):122-136. View in: Pubmed

      • ARID4B is critical for mouse embryonic stem cell differentiation towards mesoderm and endoderm, linking epigenetics to pluripotency exit. J Biol Chem. 2020 12 18; 295(51):17738-17751. View in: Pubmed

      • Arid4b is critical for mouse embryonic stem cell differentiation towards mesoderm and endoderm, linking epigenetics to pluripotency exit. J Biol Chem. 2020 Oct 15. View in: Pubmed

      • A saturating mutagenesis CRISPR-Cas9-mediated functional genomic screen identifies cis- and trans-regulatory elements of Oct4 in murine ESCs. J Biol Chem. 2020 11 20; 295(47):15797-15809. View in: Pubmed

      • Enhancer dependence of cell-type-specific gene expression increases with developmental age. Proc Natl Acad Sci U S A. 2020 09 01; 117(35):21450-21458. View in: Pubmed

      • An Engineered CRISPR-Cas9 Mouse Line for Simultaneous Readout of Lineage Histories and Gene Expression Profiles in Single Cells. Cell. 2020 Jun 25; 181(7):1693-1694. View in: Pubmed

      • An Engineered CRISPR-Cas9 Mouse Line for Simultaneous Readout of Lineage Histories and Gene Expression Profiles in Single Cells. Cell. 2020 06 11; 181(6):1410-1422.e27. View in: Pubmed

      • Multiplexed capture of spatial configuration and temporal dynamics of locus-specific 3D chromatin by biotinylated dCas9. Genome Biol. 2020 03 05; 21(1):59. View in: Pubmed

      • Live-animal imaging of native haematopoietic stem and progenitor cells. Nature. 2020 02; 578(7794):278-283. View in: Pubmed

      • Control of human hemoglobin switching by LIN28B-mediated regulation of BCL11A translation. Nat Genet. 2020 02; 52(2):138-145. View in: Pubmed

      • CUT&RUNTools: a flexible pipeline for CUT&RUN processing and footprint analysis. Genome Biol. 2019 09 09; 20(1):192. View in: Pubmed

      • BORIS promotes chromatin regulatory interactions in treatment-resistant cancer cells. Nature. 2019 08; 572(7771):676-680. View in: Pubmed

      • Rational targeting of a NuRD subcomplex guided by comprehensive in situ mutagenesis. Nat Genet. 2019 07; 51(7):1149-1159. View in: Pubmed

      • TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cells via the MYC Regulatory Network. Mol Cell. 2019 06 20; 74(6):1148-1163.e7. View in: Pubmed

      • Extensive Recovery of Embryonic Enhancer and Gene Memory Stored in Hypomethylated Enhancer DNA. Mol Cell. 2019 05 02; 74(3):542-554.e5. View in: Pubmed

      • Yap1 safeguards mouse embryonic stem cells from excessive apoptosis during differentiation. Elife. 2018 12 18; 7. View in: Pubmed

      • Single-Cell Analysis Identifies LY6D as a Marker Linking Castration-Resistant Prostate Luminal Cells to Prostate Progenitors and Cancer. Cell Rep. 2018 12 18; 25(12):3504-3518.e6. View in: Pubmed

      • CRISPR-SURF: discovering regulatory elements by deconvolution of CRISPR tiling screen data. Nat Methods. 2018 12; 15(12):992-993. View in: Pubmed

      • PRC2 loss induces chemoresistance by repressing apoptosis in T cell acute lymphoblastic leukemia. J Exp Med. 2018 12 03; 215(12):3094-3114. View in: Pubmed

      • FAM210B is an erythropoietin target and regulates erythroid heme synthesis by controlling mitochondrial iron import and ferrochelatase activity. J Biol Chem. 2018 12 21; 293(51):19797-19811. View in: Pubmed

      • Emerging Genetic Therapy for Sickle Cell Disease. Annu Rev Med. 2019 01 27; 70:257-271. View in: Pubmed

      • Polycomb Repressive Complex 2 is essential for development and maintenance of a functional TEC compartment. Sci Rep. 2018 09 25; 8(1):14335. View in: Pubmed

      • Canonical PRC2 function is essential for mammary gland development and affects chromatin compaction in mammary organoids. PLoS Biol. 2018 08; 16(8):e2004986. View in: Pubmed

      • Author Correction: High-fat diet enhances stemness and tumorigenicity of intestinal progenitors. Nature. 2018 08; 560(7717):E26. View in: Pubmed

      • Downregulation of Endothelin Receptor B Contributes to Defective B Cell Lymphopoiesis in Trisomy 21 Pluripotent Stem Cells. Sci Rep. 2018 05 22; 8(1):8001. View in: Pubmed

      • Mapping the Mouse Cell Atlas by Microwell-Seq. Cell. 2018 05 17; 173(5):1307. View in: Pubmed

      • The Polycomb-Dependent Epigenome Controls ß Cell Dysfunction, Dedifferentiation, and Diabetes. Cell Metab. 2018 Jun 05; 27(6):1294-1308.e7. View in: Pubmed

      • 14q32 and let-7 microRNAs regulate transcriptional networks in fetal and adult human erythroblasts. Hum Mol Genet. 2018 04 15; 27(8):1411-1420. View in: Pubmed

      • Integrated design, execution, and analysis of arrayed and pooled CRISPR genome-editing experiments. Nat Protoc. 2018 05; 13(5):946-986. View in: Pubmed

      • Direct Promoter Repression by BCL11A Controls the Fetal to Adult Hemoglobin Switch. Cell. 2018 04 05; 173(2):430-442.e17. View in: Pubmed

      • Dissecting super-enhancer hierarchy based on chromatin interactions. Nat Commun. 2018 03 05; 9(1):943. View in: Pubmed

      • Mapping the Mouse Cell Atlas by Microwell-Seq. Cell. 2018 02 22; 172(5):1091-1107.e17. View in: Pubmed

      • Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS. Cancer Cell. 2018 03 12; 33(3):386-400.e5. View in: Pubmed

      • Regulation of embryonic haematopoietic multipotency by EZH1. Nature. 2018 01 25; 553(7689):506-510. View in: Pubmed

      • Human genetic variation alters CRISPR-Cas9 on- and off-targeting specificity at therapeutically implicated loci. Proc Natl Acad Sci U S A. 2017 12 26; 114(52):E11257-E11266. View in: Pubmed

      • Recent progress in understanding and manipulating haemoglobin switching for the haemoglobinopathies. Br J Haematol. 2018 03; 180(5):630-643. View in: Pubmed

      • First critical repressive H3K27me3 marks in embryonic stem cells identified using designed protein inhibitor. Proc Natl Acad Sci U S A. 2017 09 19; 114(38):10125-10130. View in: Pubmed

      • PRMT1-Mediated Translation Regulation Is a Crucial Vulnerability of Cancer. Cancer Res. 2017 09 01; 77(17):4613-4625. View in: Pubmed

      • Gene correction of HAX1 reversed Kostmann disease phenotype in patient-specific induced pluripotent stem cells. Blood Adv. 2017 Jun 13; 1(14):903-914. View in: Pubmed

      • A molecular roadmap for induced multi-lineage trans-differentiation of fibroblasts by chemical combinations. Cell Res. 2017 06; 27(6):843. View in: Pubmed

      • A molecular roadmap for induced multi-lineage trans-differentiation of fibroblasts by chemical combinations. Cell Res. 2017 06; 27(6):842. View in: Pubmed

      • The 2017 ASPHO distinguished career award goes to Holcombe E. Grier, MD. Pediatr Blood Cancer. 2017 06; 64 Suppl 1. View in: Pubmed

      • Erythropoietin signaling regulates heme biosynthesis. Elife. 2017 05 29; 6. View in: Pubmed

      • Challenges and emerging directions in single-cell analysis. Genome Biol. 2017 05 08; 18(1):84. View in: Pubmed

      • Reduced Erg Dosage Impairs Survival of Hematopoietic Stem and Progenitor Cells. Stem Cells. 2017 07; 35(7):1773-1785. View in: Pubmed

      • EED orchestration of heart maturation through interaction with HDACs is H3K27me3-independent. Elife. 2017 04 10; 6. View in: Pubmed

      • Functional interrogation of non-coding DNA through CRISPR genome editing. Methods. 2017 05 15; 121-122:118-129. View in: Pubmed

      • Transcription control by the ENL YEATS domain in acute leukaemia. Nature. 2017 03 09; 543(7644):270-274. View in: Pubmed

      • Variant-aware saturating mutagenesis using multiple Cas9 nucleases identifies regulatory elements at trait-associated loci. Nat Genet. 2017 Apr; 49(4):625-634. View in: Pubmed

      • Characterization of genomic deletion efficiency mediated by clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 nuclease system in mammalian cells. J Biol Chem. 2017 02 10; 292(6):2556. View in: Pubmed

      • A molecular roadmap for induced multi-lineage trans-differentiation of fibroblasts by chemical combinations. Cell Res. 2017 03; 27(3):386-401. View in: Pubmed

      • The histone demethylase UTX regulates the lineage-specific epigenetic program of invariant natural killer T cells. Nat Immunol. 2017 02; 18(2):184-195. View in: Pubmed

      • Strict in vivo specificity of the Bcl11a erythroid enhancer. Blood. 2016 11 10; 128(19):2338-2342. View in: Pubmed

      • CellMapper: rapid and accurate inference of gene expression in difficult-to-isolate cell types. Genome Biol. 2016 09 29; 17(1):201. View in: Pubmed

      • Bcl11a Deficiency Leads to Hematopoietic Stem Cell Defects with an Aging-like Phenotype. Cell Rep. 2016 09 20; 16(12):3181-3194. View in: Pubmed

      • Chronic Myelogenous Leukemia- Initiating Cells Require Polycomb Group Protein EZH2. Cancer Discov. 2016 11; 6(11):1237-1247. View in: Pubmed

      • Lineage-specific BCL11A knockdown circumvents toxicities and reverses sickle phenotype. J Clin Invest. 2016 10 03; 126(10):3868-3878. View in: Pubmed

      • Single-Cell Transcript Profiles Reveal Multilineage Priming in Early Progenitors Derived from Lgr5(+) Intestinal Stem Cells. Cell Rep. 2016 08 23; 16(8):2053-2060. View in: Pubmed

      • Mathematical modeling of erythrocyte chimerism informs genetic intervention strategies for sickle cell disease. Am J Hematol. 2016 09; 91(9):931-7. View in: Pubmed

      • Analyzing CRISPR genome-editing experiments with CRISPResso. Nat Biotechnol. 2016 07 12; 34(7):695-7. View in: Pubmed

      • The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice. Cancer Cell. 2016 07 11; 30(1):183. View in: Pubmed

      • Loss of Ezh2 synergizes with JAK2-V617F in initiating myeloproliferative neoplasms and promoting myelofibrosis. J Exp Med. 2016 07 25; 213(8):1479-96. View in: Pubmed

      • Adenosine-to-inosine RNA editing by ADAR1 is essential for normal murine erythropoiesis. Exp Hematol. 2016 10; 44(10):947-63. View in: Pubmed

      • An Achilles' Heel for MLL-Rearranged Leukemias: Writers and Readers of H3 Lysine 36 Dimethylation. Cancer Discov. 2016 07; 6(7):700-2. View in: Pubmed

      • Hemoglobin genetics: recent contributions of GWAS and gene editing. Hum Mol Genet. 2016 10 01; 25(R2):R99-R105. View in: Pubmed

      • Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-ß signalling. Nat Commun. 2016 06 22; 7:12047. View in: Pubmed

      • MEDICINE. Paying for future success in gene therapy. Science. 2016 May 27; 352(6289):1059-61. View in: Pubmed

      • Acquired Tissue-Specific Promoter Bivalency Is a Basis for PRC2 Necessity in Adult Cells. Cell. 2016 Jun 02; 165(6):1389-1400. View in: Pubmed

      • Corrigendum: LSD1 is essential for oocyte meiotic progression by regulating CDC25B expression in mice. Nat Commun. 2016 Apr 20; 7:11467. View in: Pubmed

      • Interferon-a signaling promotes embryonic HSC maturation. Blood. 2016 07 14; 128(2):204-16. View in: Pubmed

      • The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice. Cancer Cell. 2016 04 11; 29(4):574-586. View in: Pubmed

      • Customizing the genome as therapy for the ß-hemoglobinopathies. Blood. 2016 05 26; 127(21):2536-45. View in: Pubmed

      • High-fat diet enhances stemness and tumorigenicity of intestinal progenitors. Nature. 2016 Mar 03; 531(7592):53-8. View in: Pubmed

      • Ezh2 Controls an Early Hematopoietic Program and Growth and Survival Signaling in Early T Cell Precursor Acute Lymphoblastic Leukemia. Cell Rep. 2016 Mar 01; 14(8):1953-65. View in: Pubmed

      • Recent advances in globin research using genome-wide association studies and gene editing. Ann N Y Acad Sci. 2016 03; 1368(1):5-10. View in: Pubmed

      • Serum-Based Culture Conditions Provoke Gene Expression Variability in Mouse Embryonic Stem Cells as Revealed by Single-Cell Analysis. Cell Rep. 2016 Feb 02; 14(4):956-965. View in: Pubmed

      • Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin. Science. 2016 Jan 15; 351(6270):285-9. View in: Pubmed

      • Genetic treatment of a molecular disorder: gene therapy approaches to sickle cell disease. Blood. 2016 Feb 18; 127(7):839-48. View in: Pubmed

      • Polycomb Repressive Complex 2 Is a Barrier to KRAS-Driven Inflammation and Epithelial-Mesenchymal Transition in Non-Small-Cell Lung Cancer. Cancer Cell. 2016 Jan 11; 29(1):17-31. View in: Pubmed

      • Dynamic Control of Enhancer Repertoires Drives Lineage and Stage-Specific Transcription during Hematopoiesis. Dev Cell. 2016 Jan 11; 36(1):9-23. View in: Pubmed

      • Corrigendum: Failure to replicate the STAP cell phenomenon. Nature. 2016 Mar 17; 531(7594):400. View in: Pubmed

      • Ezh2 regulates differentiation and function of natural killer cells through histone methyltransferase activity. Proc Natl Acad Sci U S A. 2015 Dec 29; 112(52):15988-93. View in: Pubmed

      • LSD1 is essential for oocyte meiotic progression by regulating CDC25B expression in mice. Nat Commun. 2015 Dec 02; 6:10116. View in: Pubmed

      • SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2. Nat Med. 2015 Dec; 21(12):1491-6. View in: Pubmed

      • The LSD1 Family of Histone Demethylases and the Pumilio Posttranscriptional Repressor Function in a Complex Regulatory Feedback Loop. Mol Cell Biol. 2015 Dec; 35(24):4199-211. View in: Pubmed

      • Failure to replicate the STAP cell phenomenon. Nature. 2015 Sep 24; 525(7570):E6-9. View in: Pubmed

      • Hematopoietic stem cells develop in the absence of endothelial cadherin 5 expression. Blood. 2015 Dec 24; 126(26):2811-20. View in: Pubmed

      • BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis. Nature. 2015 Nov 12; 527(7577):192-7. View in: Pubmed

      • Hemoglobin switching's surprise: the versatile transcription factor BCL11A is a master repressor of fetal hemoglobin. Curr Opin Genet Dev. 2015 Aug; 33:62-70. View in: Pubmed

      • Functional footprinting of regulatory DNA. Nat Methods. 2015 Oct; 12(10):927-30. View in: Pubmed

      • EHMT1 and EHMT2 inhibition induces fetal hemoglobin expression. Blood. 2015 Oct 15; 126(16):1930-9. View in: Pubmed

      • PRC2 Is Required to Maintain Expression of the Maternal Gtl2-Rian-Mirg Locus by Preventing De Novo DNA Methylation in Mouse Embryonic Stem Cells. Cell Rep. 2015 Sep 01; 12(9):1456-70. View in: Pubmed

      • Inactivation of Eed impedes MLL-AF9-mediated leukemogenesis through Cdkn2a-dependent and Cdkn2a-independent mechanisms in a murine model. Exp Hematol. 2015 Nov; 43(11):930-935.e6. View in: Pubmed

      • miRNA-embedded shRNAs for Lineage-specific BCL11A Knockdown and Hemoglobin F Induction. Mol Ther. 2015 Sep; 23(9):1465-74. View in: Pubmed

      • Regulation of Peripheral Nerve Myelin Maintenance by Gene Repression through Polycomb Repressive Complex 2. J Neurosci. 2015 Jun 03; 35(22):8640-52. View in: Pubmed

      • Embryonic stem cells as sources of donor-independent platelets. J Clin Invest. 2015 Jun; 125(6):2261-3. View in: Pubmed

      • BCL11A deletions result in fetal hemoglobin persistence and neurodevelopmental alterations. J Clin Invest. 2015 Jun; 125(6):2363-8. View in: Pubmed

      • Opposing Roles for the lncRNA Haunt and Its Genomic Locus in Regulating HOXA Gene Activation during Embryonic Stem Cell Differentiation. Cell Stem Cell. 2015 May 07; 16(5):504-16. View in: Pubmed

      • The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability. Sci Signal. 2015 Apr 14; 8(372):ra34. View in: Pubmed

      • Flow-induced protein kinase A-CREB pathway acts via BMP signaling to promote HSC emergence. J Exp Med. 2015 May 04; 212(5):633-48. View in: Pubmed

      • 2014 William Allan Award: A hematologist's pursuit of hemoglobin genetics. Am J Hum Genet. 2015 Mar 05; 96(3):354-60. View in: Pubmed

      • Angiopoietin-like proteins stimulate HSPC development through interaction with notch receptor signaling. Elife. 2015 Feb 25; 4. View in: Pubmed

      • Functional Proteomic Analysis of Repressive Histone Methyltransferase Complexes Reveals ZNF518B as a G9A Regulator. Mol Cell Proteomics. 2015 Jun; 14(6):1435-46. View in: Pubmed

      • Developmental control of polycomb subunit composition by GATA factors mediates a switch to non-canonical functions. Mol Cell. 2015 Jan 22; 57(2):304-316. View in: Pubmed

      • Scl binds to primed enhancers in mesoderm to regulate hematopoietic and cardiac fate divergence. EMBO J. 2015 Mar 12; 34(6):759-77. View in: Pubmed

      • Generation of genomic deletions in mammalian cell lines via CRISPR/Cas9. J Vis Exp. 2015 Jan 03; (95):e52118. View in: Pubmed

      • Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma. Proc Natl Acad Sci U S A. 2014 Dec 23; 111(51):E5564-73. View in: Pubmed

      • Characterizing heterogeneity in leukemic cells using single-cell gene expression analysis. Genome Biol. 2014 Dec 03; 15(12):525. View in: Pubmed

      • Mouse regulatory DNA landscapes reveal global principles of cis-regulatory evolution. Science. 2014 Nov 21; 346(6212):1007-12. View in: Pubmed

      • A comparative encyclopedia of DNA elements in the mouse genome. Nature. 2014 Nov 20; 515(7527):355-64. View in: Pubmed

      • Inflammatory signaling regulates embryonic hematopoietic stem and progenitor cell production. Genes Dev. 2014 Dec 01; 28(23):2597-612. View in: Pubmed

      • Myeloproliferative neoplasms can be initiated from a single hematopoietic stem cell expressing JAK2-V617F. J Exp Med. 2014 Oct 20; 211(11):2213-30. View in: Pubmed

      • TMEM14C is required for erythroid mitochondrial heme metabolism. J Clin Invest. 2014 Oct; 124(10):4294-304. View in: Pubmed

      • Characterization of genomic deletion efficiency mediated by clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 nuclease system in mammalian cells. J Biol Chem. 2014 08 01; 289(31):21312-24. View in: Pubmed

      • Reprogramming committed murine blood cells to induced hematopoietic stem cells with defined factors. Cell. 2014 Apr 24; 157(3):549-64. View in: Pubmed

      • Distinct, strict requirements for Gfi-1b in adult bone marrow red cell and platelet generation. J Exp Med. 2014 May 05; 211(5):909-27. View in: Pubmed

      • Corepressor Rcor1 is essential for murine erythropoiesis. Blood. 2014 May 15; 123(20):3175-84. View in: Pubmed

      • Analysis of chromatin-state plasticity identifies cell-type-specific regulators of H3K27me3 patterns. Proc Natl Acad Sci U S A. 2014 Jan 21; 111(3):E344-53. View in: Pubmed

      • Calpain 2 activation of P-TEFb drives megakaryocyte morphogenesis and is disrupted by leukemogenic GATA1 mutation. Dev Cell. 2013 Dec 23; 27(6):607-20. View in: Pubmed

      • Distinct and combinatorial functions of Jmjd2b/Kdm4b and Jmjd2c/Kdm4c in mouse embryonic stem cell identity. Mol Cell. 2014 01 09; 53(1):32-48. View in: Pubmed

      • GATA1s induces hyperproliferation of eosinophil precursors in Down syndrome transient leukemia. Leukemia. 2014 Jun; 28(6):1259-70. View in: Pubmed

      • Polycomb repressive complex 2 regulates normal hematopoietic stem cell function in a developmental-stage-specific manner. Cell Stem Cell. 2014 Jan 02; 14(1):68-80. View in: Pubmed

      • An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level. Science. 2013 Oct 11; 342(6155):253-7. View in: Pubmed

      • Histone deacetylase inhibitors induce apoptosis in myeloid leukemia by suppressing autophagy. Leukemia. 2014 Mar; 28(3):577-88. View in: Pubmed

      • Mapping cellular hierarchy by single-cell analysis of the cell surface repertoire. Cell Stem Cell. 2013 Oct 03; 13(4):492-505. View in: Pubmed

      • Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer. Nat Chem Biol. 2013 Oct; 9(10):643-50. View in: Pubmed

      • Delineating the mixed lineage leukemia gene expression network in hematopoietic stem cells. Proc Natl Acad Sci U S A. 2013 Jul 16; 110(29):11670-1. View in: Pubmed

      • Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation. Elife. 2013 Jun 18; 2:e00633. View in: Pubmed

      • Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A. Proc Natl Acad Sci U S A. 2013 Apr 16; 110(16):6518-23. View in: Pubmed

      • ETV1 directs androgen metabolism and confers aggressive prostate cancer in targeted mice and patients. Genes Dev. 2013 Mar 15; 27(6):683-98. View in: Pubmed

      • Genome-wide association studies of hematologic phenotypes: a window into human hematopoiesis. Curr Opin Genet Dev. 2013 Jun; 23(3):339-44. View in: Pubmed

      • Sustained PU.1 levels balance cell-cycle regulators to prevent exhaustion of adult hematopoietic stem cells. Mol Cell. 2013 Mar 07; 49(5):934-46. View in: Pubmed

      • The switch from fetal to adult hemoglobin. Cold Spring Harb Perspect Med. 2013 Jan 01; 3(1):a011643. View in: Pubmed

      • TiF1-gamma plays an essential role in murine hematopoiesis and regulates transcriptional elongation of erythroid genes. Dev Biol. 2013 Jan 15; 373(2):422-30. View in: Pubmed

      • Altered hematopoiesis in trisomy 21 as revealed through in vitro differentiation of isogenic human pluripotent cells. Proc Natl Acad Sci U S A. 2012 Oct 23; 109(43):17567-72. View in: Pubmed

      • Combinatorial assembly of developmental stage-specific enhancers controls gene expression programs during human erythropoiesis. Dev Cell. 2012 Oct 16; 23(4):796-811. View in: Pubmed

      • Cyclin D3 coordinates the cell cycle during differentiation to regulate erythrocyte size and number. Genes Dev. 2012 Sep 15; 26(18):2075-87. View in: Pubmed

      • Reawakening fetal hemoglobin: prospects for new therapies for the ß-globin disorders. Blood. 2012 Oct 11; 120(15):2945-53. View in: Pubmed

      • Scl represses cardiomyogenesis in prospective hemogenic endothelium and endocardium. Cell. 2012 Aug 03; 150(3):590-605. View in: Pubmed

      • The CACCC-binding protein KLF3/BKLF represses a subset of KLF1/EKLF target genes and is required for proper erythroid maturation in vivo. Mol Cell Biol. 2012 Aug; 32(16):3281-92. View in: Pubmed

      • Exome sequencing identifies GATA1 mutations resulting in Diamond-Blackfan anemia. J Clin Invest. 2012 Jul; 122(7):2439-43. View in: Pubmed

      • MAnorm: a robust model for quantitative comparison of ChIP-Seq data sets. Genome Biol. 2012 Mar 16; 13(3):R16. View in: Pubmed

      • Polycomb repressive complex 2 is required for MLL-AF9 leukemia. Proc Natl Acad Sci U S A. 2012 Mar 27; 109(13):5028-33. View in: Pubmed

      • MicroRNA-21 integrates pathogenic signaling to control pulmonary hypertension: results of a network bioinformatics approach. Circulation. 2012 Mar 27; 125(12):1520-32. View in: Pubmed

      • A human stem cell model of early Alzheimer's disease pathology in Down syndrome. Sci Transl Med. 2012 Mar 07; 4(124):124ra29. View in: Pubmed

      • Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains. Genes Dev. 2012 Feb 15; 26(4):344-9. View in: Pubmed

      • MicroRNA-21 promotes fibrosis of the kidney by silencing metabolic pathways. Sci Transl Med. 2012 Feb 15; 4(121):121ra18. View in: Pubmed

      • Generation of a genomic reporter assay system for analysis of ?- and ß-globin gene regulation. FASEB J. 2012 Apr; 26(4):1736-44. View in: Pubmed

      • PRC2 directly methylates GATA4 and represses its transcriptional activity. Genes Dev. 2012 Jan 01; 26(1):37-42. View in: Pubmed

      • Dnmt3a silences hematopoietic stem cell self-renewal. Nat Genet. 2011 Dec 27; 44(1):13-4. View in: Pubmed

      • Polycomb repressive complex 2 regulates normal development of the mouse heart. Circ Res. 2012 Feb 03; 110(3):406-15. View in: Pubmed

      • Embryonic stem cell-specific signatures in cancer: insights into genomic regulatory networks and implications for medicine. Genome Med. 2011 Nov 29; 3(11):75. View in: Pubmed

      • Zfp281 functions as a transcriptional repressor for pluripotency of mouse embryonic stem cells. Stem Cells. 2011 Nov; 29(11):1705-16. View in: Pubmed

      • Correction of sickle cell disease in adult mice by interference with fetal hemoglobin silencing. Science. 2011 Nov 18; 334(6058):993-6. View in: Pubmed

      • Sox2 maintains self renewal of tumor-initiating cells in osteosarcomas. Oncogene. 2012 May 03; 31(18):2270-82. View in: Pubmed

      • A functional element necessary for fetal hemoglobin silencing. N Engl J Med. 2011 Sep 01; 365(9):807-14. View in: Pubmed

      • MicroRNA-21 limits in vivo immune response-mediated activation of the IL-12/IFN-gamma pathway, Th1 polarization, and the severity of delayed-type hypersensitivity. J Immunol. 2011 Sep 15; 187(6):3362-73. View in: Pubmed

      • Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1. Proc Natl Acad Sci U S A. 2011 Aug 16; 108(33):13379-86. View in: Pubmed

      • Chromatin connections to pluripotency and cellular reprogramming. Cell. 2011 Jun 10; 145(6):835-50. View in: Pubmed

      • Genome Medicine: stem cells, genomics and translational research. Genome Med. 2011 Jun 07; 3(6):34. View in: Pubmed

      • The erythroid/myeloid lineage fate paradigm takes a new player. EMBO J. 2011 Mar 16; 30(6):983-5. View in: Pubmed

      • Context-dependent function of "GATA switch" sites in vivo. Blood. 2011 May 05; 117(18):4769-72. View in: Pubmed

      • Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells. Cell Stem Cell. 2011 Feb 04; 8(2):200-13. View in: Pubmed

      • Update on fetal hemoglobin gene regulation in hemoglobinopathies. Curr Opin Pediatr. 2011 Feb; 23(1):1-8. View in: Pubmed

      • MicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13. Proc Natl Acad Sci U S A. 2011 Jan 25; 108(4):1519-24. View in: Pubmed

      • A transient transgenic RNAi strategy for rapid characterization of gene function during embryonic development. PLoS One. 2010 Dec 16; 5(12):e14375. View in: Pubmed

      • Therapeutic levels of fetal hemoglobin in erythroid progeny of ß-thalassemic CD34+ cells after lentiviral vector-mediated gene transfer. Blood. 2011 Mar 10; 117(10):2817-26. View in: Pubmed

      • Networking erythropoiesis. J Exp Med. 2010 Nov 22; 207(12):2537-41. View in: Pubmed

      • Fine-mapping at three loci known to affect fetal hemoglobin levels explains additional genetic variation. Nat Genet. 2010 Dec; 42(12):1049-51. View in: Pubmed

      • Modifier genes in Mendelian disorders: the example of hemoglobin disorders. Ann N Y Acad Sci. 2010 Dec; 1214:47-56. View in: Pubmed

      • Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformation. Cancer Cell. 2010 Oct 19; 18(4):316-28. View in: Pubmed

      • A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs. Cell. 2010 Oct 15; 143(2):313-24. View in: Pubmed

      • Training program in cancer and blood diseases: Pediatric Hematology/Oncology Fellowship Program, Children's Hospital Boston/Dana-Farber Cancer Institute. Am J Hematol. 2010 Oct; 85(10):793-4. View in: Pubmed

      • Epigenetic memory in induced pluripotent stem cells. Nature. 2010 Sep 16; 467(7313):285-90. View in: Pubmed

      • Differential roles of Sall4 isoforms in embryonic stem cell pluripotency. Mol Cell Biol. 2010 Nov; 30(22):5364-80. View in: Pubmed

      • A single cis element maintains repression of the key developmental regulator Gata2. PLoS Genet. 2010 Sep 09; 6(9):e1001103. View in: Pubmed

      • Transcriptional silencing of fetal hemoglobin by BCL11A. Ann N Y Acad Sci. 2010 Aug; 1202:64-8. View in: Pubmed

      • Developmental stage-specific interplay of GATA1 and IGF signaling in fetal megakaryopoiesis and leukemogenesis. Genes Dev. 2010 Aug 01; 24(15):1659-72. View in: Pubmed

      • Medicine. Sickle cell disease at 100 years. Science. 2010 Jul 16; 329(5989):291-2. View in: Pubmed

      • TIF1gamma controls erythroid cell fate by regulating transcription elongation. Cell. 2010 Jul 09; 142(1):133-43. View in: Pubmed

      • Sumoylation regulates interaction of FOG1 with C-terminal-binding protein (CTBP). J Biol Chem. 2010 Sep 03; 285(36):28064-75. View in: Pubmed

      • Transcriptional silencing of {gamma}-globin by BCL11A involves long-range interactions and cooperation with SOX6. Genes Dev. 2010 Apr 15; 24(8):783-98. View in: Pubmed

      • DNA methylation in adult stem cells: new insights into self-renewal. Epigenetics. 2010 Apr; 5(3):189-93. View in: Pubmed

      • Advances in the understanding of haemoglobin switching. Br J Haematol. 2010 Apr; 149(2):181-94. View in: Pubmed

      • miR-125b-2 is a potential oncomiR on human chromosome 21 in megakaryoblastic leukemia. Genes Dev. 2010 Mar 01; 24(5):478-90. View in: Pubmed

      • Perturbed hematopoiesis in the Tc1 mouse model of Down syndrome. Blood. 2010 Apr 08; 115(14):2928-37. View in: Pubmed

      • Systematic tracking of cell fate changes. Nat Biotechnol. 2010 Feb; 28(2):146-7. View in: Pubmed

      • Musings on genome medicine: Hepatitis C. Genome Med. 2010 Jan 27; 2(1):4. View in: Pubmed

      • Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells. Cell. 2009 Dec 24; 139(7):1303-14. View in: Pubmed

      • Musings on genome medicine: enzyme-replacement therapy of the lysosomal storage diseases. Genome Med. 2009 Dec 09; 1(12):114. View in: Pubmed

      • Insights into GATA-1-mediated gene activation versus repression via genome-wide chromatin occupancy analysis. Mol Cell. 2009 Nov 25; 36(4):682-95. View in: Pubmed

      • Musings on genome medicine: Crohn's disease. Genome Med. 2009 Nov 05; 1(11):103. View in: Pubmed

      • Musings on genome medicine: the slow but inexorable process of medical care reform in the United States. Genome Med. 2009 Oct 12; 1(10):94. View in: Pubmed

      • DNA methyltransferase 1 is essential for and uniquely regulates hematopoietic stem and progenitor cells. Cell Stem Cell. 2009 Oct 02; 5(4):442-9. View in: Pubmed

      • Musings on genome medicine: the Obama effect redux. Genome Med. 2009 Sep 11; 1(9):86. View in: Pubmed

      • Developmental and species-divergent globin switching are driven by BCL11A. Nature. 2009 Aug 27; 460(7259):1093-7. View in: Pubmed

      • Translational isoforms of FOG1 regulate GATA1-interacting complexes. J Biol Chem. 2009 Oct 23; 284(43):29310-9. View in: Pubmed

      • GATA-2 reinforces megakaryocyte development in the absence of GATA-1. Mol Cell Biol. 2009 Sep; 29(18):5168-80. View in: Pubmed

      • TEL-AML1 corrupts hematopoietic stem cells to persist in the bone marrow and initiate leukemia. Cell Stem Cell. 2009 Jul 02; 5(1):43-53. View in: Pubmed

      • Musings on genome medicine: cholesterol and coronary artery disease. Genome Med. 2009 Jun 08; 1(6):60. View in: Pubmed

      • Musings on genome medicine: cancer genetics and the promise of effective treatment. Genome Med. 2009 May 06; 1(5):49. View in: Pubmed

      • Musings on genome medicine: gene therapy. Genome Med. 2009 Apr 03; 1(4):38. View in: Pubmed

      • A genome-wide RNAi screen identifies a new transcriptional module required for self-renewal. Genes Dev. 2009 Apr 01; 23(7):837-48. View in: Pubmed

      • Use of in vivo biotinylation to study protein-protein and protein-DNA interactions in mouse embryonic stem cells. Nat Protoc. 2009; 4(4):506-17. View in: Pubmed

      • Musings on genome medicine: the Obama effect. Genome Med. 2009 Mar 09; 1(3):30. View in: Pubmed

      • Tandem affinity purification of protein complexes in mouse embryonic stem cells using in vivo biotinylation. Curr Protoc Stem Cell Biol. 2009 Mar; Chapter 1:Unit1B.5. View in: Pubmed

      • Musings on genome medicine: abuse of genetic tests. Genome Med. 2009 Feb 16; 1(2):18. View in: Pubmed

      • Mef2C is a lineage-restricted target of Scl/Tal1 and regulates megakaryopoiesis and B-cell homeostasis. Blood. 2009 Apr 09; 113(15):3461-71. View in: Pubmed

      • Musings on genome medicine: genome wide association studies. Genome Med. 2009 Jan 20; 1(1):3. View in: Pubmed

      • Glimpses of the epigenetic landscape. Cell Stem Cell. 2009 Jan 09; 4(1):1-2. View in: Pubmed

      • ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling. Nat Immunol. 2009 Jan; 10(1):109-15. View in: Pubmed

      • Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A. Science. 2008 Dec 19; 322(5909):1839-42. View in: Pubmed

      • EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency. Mol Cell. 2008 Nov 21; 32(4):491-502. View in: Pubmed

      • Polycomb group proteins Ezh2 and Rnf2 direct genomic contraction and imprinted repression in early mouse embryos. Dev Cell. 2008 Nov; 15(5):668-79. View in: Pubmed

      • Rb and hematopoiesis: stem cells to anemia. Cell Div. 2008 Sep 08; 3:13. View in: Pubmed

      • DNA polymorphisms at the BCL11A, HBS1L-MYB, and beta-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease. Proc Natl Acad Sci U S A. 2008 Aug 19; 105(33):11869-74. View in: Pubmed

      • GATA4 mediates gene repression in the mature mouse small intestine through interactions with friend of GATA (FOG) cofactors. Dev Biol. 2008 Oct 01; 322(1):179-89. View in: Pubmed

      • Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease. Genes Dev. 2008 Jun 15; 22(12):1662-76. View in: Pubmed

      • Requirement of Nanog dimerization for stem cell self-renewal and pluripotency. Proc Natl Acad Sci U S A. 2008 Apr 29; 105(17):6326-31. View in: Pubmed

      • Targeted disruption of the basic Krüppel-like factor gene (Klf3) reveals a role in adipogenesis. Mol Cell Biol. 2008 Jun; 28(12):3967-78. View in: Pubmed

      • An extended transcriptional network for pluripotency of embryonic stem cells. Cell. 2008 Mar 21; 132(6):1049-61. View in: Pubmed

      • The emergence of hematopoietic stem cells is initiated in the placental vasculature in the absence of circulation. Cell Stem Cell. 2008 Mar 06; 2(3):252-63. View in: Pubmed

      • PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos. Nat Genet. 2008 Apr; 40(4):411-20. View in: Pubmed

      • Antagonism of FOG-1 and GATA factors in fate choice for the mast cell lineage. J Exp Med. 2008 Mar 17; 205(3):611-24. View in: Pubmed

      • Hematopoiesis: an evolving paradigm for stem cell biology. Cell. 2008 Feb 22; 132(4):631-44. View in: Pubmed

      • SnapShot: hematopoiesis. Cell. 2008 Feb 22; 132(4):712. View in: Pubmed

      • Oct4 dependence of chromatin structure within the extended Nanog locus in ES cells. Genes Dev. 2008 Mar 01; 22(5):575-80. View in: Pubmed

      • Rb intrinsically promotes erythropoiesis by coupling cell cycle exit with mitochondrial biogenesis. Genes Dev. 2008 Feb 15; 22(4):463-75. View in: Pubmed

      • Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia. Proc Natl Acad Sci U S A. 2008 Feb 05; 105(5):1620-5. View in: Pubmed

      • A protein roadmap to pluripotency and faithful reprogramming. Cells Tissues Organs. 2008; 188(1-2):23-30. View in: Pubmed

      • The transcriptional network controlling pluripotency in ES cells. Cold Spring Harb Symp Quant Biol. 2008; 73:195-202. View in: Pubmed

      • Site-directed, virus-free, and inducible RNAi in embryonic stem cells. Proc Natl Acad Sci U S A. 2007 Dec 26; 104(52):20850-5. View in: Pubmed

      • ETV6-NTRK3 fusion oncogene initiates breast cancer from committed mammary progenitors via activation of AP1 complex. Cancer Cell. 2007 Dec; 12(6):542-58. View in: Pubmed

      • Immunology: changed destiny. Nature. 2007 Sep 27; 449(7161):410-1. View in: Pubmed

      • Stem cells down under-ISSCR 2007. Cell Stem Cell. 2007 Sep 13; 1(3):271-6. View in: Pubmed

      • Epigenetic regulation of hematopoietic differentiation by Gfi-1 and Gfi-1b is mediated by the cofactors CoREST and LSD1. Mol Cell. 2007 Aug 17; 27(4):562-72. View in: Pubmed

      • Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. Nature. 2007 Jun 21; 447(7147):1007-11. View in: Pubmed

      • Rb regulates interactions between hematopoietic stem cells and their bone marrow microenvironment. Cell. 2007 Jun 15; 129(6):1081-95. View in: Pubmed

      • Gata4 is necessary for normal pulmonary lobar development. Am J Respir Cell Mol Biol. 2007 Apr; 36(4):391-7. View in: Pubmed

      • Developmental origin of a bipotential myocardial and smooth muscle cell precursor in the mammalian heart. Cell. 2006 Dec 15; 127(6):1137-50. View in: Pubmed

      • A protein interaction network for pluripotency of embryonic stem cells. Nature. 2006 Nov 16; 444(7117):364-8. View in: Pubmed

      • The hypomorphic Gata1low mutation alters the proliferation/differentiation potential of the common megakaryocytic-erythroid progenitor. Blood. 2007 Feb 15; 109(4):1460-71. View in: Pubmed

      • The journey of developing hematopoietic stem cells. Development. 2006 Oct; 133(19):3733-44. View in: Pubmed

      • Rb is dispensable for self-renewal and multilineage differentiation of adult hematopoietic stem cells. Proc Natl Acad Sci U S A. 2006 Jun 13; 103(24):9057-62. View in: Pubmed

      • Notch signaling requires GATA-2 to inhibit myelopoiesis from embryonic stem cells and primary hemopoietic progenitors. J Immunol. 2006 May 01; 176(9):5267-75. View in: Pubmed

      • Characterization of a megakaryocyte-specific enhancer of the key hemopoietic transcription factor GATA1. J Biol Chem. 2006 May 12; 281(19):13733-13742. View in: Pubmed

      • Identification of distinct molecular phenotypes in acute megakaryoblastic leukemia by gene expression profiling. Proc Natl Acad Sci U S A. 2006 Feb 28; 103(9):3339-44. View in: Pubmed

      • Reactions to the Hwang scandal. Science. 2006 Feb 03; 311(5761):606-7. View in: Pubmed

      • Phosphorylation of Gata1 at serine residues 72, 142, and 310 is not essential for hematopoiesis in vivo. Blood. 2006 May 01; 107(9):3527-30. View in: Pubmed

      • Unraveling the transcriptional network controlling ES cell pluripotency. Genome Biol. 2006; 7(8):230. View in: Pubmed

      • Zinc-finger transcription factor Gfi-1: versatile regulator of lymphocytes, neutrophils and hematopoietic stem cells. Curr Opin Hematol. 2006 Jan; 13(1):1-6. View in: Pubmed

      • Specification of astrocytes by bHLH protein SCL in a restricted region of the neural tube. Nature. 2005 Nov 17; 438(7066):360-3. View in: Pubmed

      • Chipping away at the embryonic stem cell network. Cell. 2005 Sep 23; 122(6):828-30. View in: Pubmed

      • The transcription factor GATA2 regulates differentiation of brown adipocytes. EMBO Rep. 2005 Sep; 6(9):879-84. View in: Pubmed

      • Placenta as a site for hematopoietic stem cell development. Exp Hematol. 2005 Sep; 33(9):1048-54. View in: Pubmed

      • Phosphatidylinositol 3-kinase/Akt induced by erythropoietin renders the erythroid differentiation factor GATA-1 competent for TIMP-1 gene transactivation. Mol Cell Biol. 2005 Sep; 25(17):7412-22. View in: Pubmed

      • Stem cells: the road not taken. Nature. 2005 Jun 02; 435(7042):573-5. View in: Pubmed

      • Developmental stage-selective effect of somatically mutated leukemogenic transcription factor GATA1. Nat Genet. 2005 Jun; 37(6):613-9. View in: Pubmed

      • Early asymmetry of gene transcription in embryonic human left and right cerebral cortex. Science. 2005 Jun 17; 308(5729):1794-8. View in: Pubmed

      • Haploinsufficiency of GATA-2 perturbs adult hematopoietic stem-cell homeostasis. Blood. 2005 Jul 15; 106(2):477-84. View in: Pubmed

      • The placenta is a niche for hematopoietic stem cells. Dev Cell. 2005 Mar; 8(3):365-75. View in: Pubmed

      • Tie2Cre-mediated gene ablation defines the stem-cell leukemia gene (SCL/tal1)-dependent window during hematopoietic stem-cell development. Blood. 2005 May 15; 105(10):3871-4. View in: Pubmed

      • Enforced expression of PU.1 rescues osteoclastogenesis from embryonic stem cells lacking Tal-1. Stem Cells. 2005; 23(1):134-43. View in: Pubmed

      • Gene targeting and transgenic strategies for the analysis of hematopoietic development in the mouse. Methods Mol Med. 2005; 105:3-22. View in: Pubmed

      • Coregulation of GATA factors by the Friend of GATA (FOG) family of multitype zinc finger proteins. Semin Cell Dev Biol. 2005 Feb; 16(1):117-28. View in: Pubmed

      • GATA-2 plays two functionally distinct roles during the ontogeny of hematopoietic stem cells. J Exp Med. 2004 Oct 04; 200(7):871-82. View in: Pubmed

      • Toward improving Caenorhabditis elegans phenome mapping with an ORFeome-based RNAi library. Genome Res. 2004 Oct; 14(10B):2162-8. View in: Pubmed

      • Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells. Nature. 2004 Oct 21; 431(7011):1002-7. View in: Pubmed

      • A critical role for eosinophils in allergic airways remodeling. Science. 2004 Sep 17; 305(5691):1776-9. View in: Pubmed

      • Tel/Etv6 is an essential and selective regulator of adult hematopoietic stem cell survival. Genes Dev. 2004 Oct 01; 18(19):2336-41. View in: Pubmed

      • Decoding hematopoietic specificity in the helix-loop-helix domain of the transcription factor SCL/Tal-1. Mol Cell Biol. 2004 Sep; 24(17):7491-502. View in: Pubmed

      • The zebrafish moonshine gene encodes transcriptional intermediary factor 1gamma, an essential regulator of hematopoiesis. PLoS Biol. 2004 Aug; 2(8):E237. View in: Pubmed

      • Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects. Cancer Cell. 2004 Apr; 5(4):375-87. View in: Pubmed

      • Transforming acidic coiled-coil protein 3 (TACC3) controls friend of GATA-1 (FOG-1) subcellular localization and regulates the association between GATA-1 and FOG-1 during hematopoiesis. J Biol Chem. 2004 May 28; 279(22):23597-605. View in: Pubmed

      • Defective neural tube closure and anteroposterior patterning in mice lacking the LIM protein LMO4 or its interacting partner Deaf-1. Mol Cell Biol. 2004 Mar; 24(5):2074-82. View in: Pubmed

      • The SWI/SNF complex--chromatin and cancer. Nat Rev Cancer. 2004 Feb; 4(2):133-42. View in: Pubmed

      • More than blood, a novel gene required for mammalian postimplantation development. Mol Cell Biol. 2004 Feb; 24(3):1168-73. View in: Pubmed

      • Coregulator-dependent facilitation of chromatin occupancy by GATA-1. Proc Natl Acad Sci U S A. 2004 Jan 27; 101(4):980-5. View in: Pubmed

      • Endothelial lineage-mediated loss of the GATA cofactor Friend of GATA 1 impairs cardiac development. Proc Natl Acad Sci U S A. 2003 Nov 25; 100(24):14030-5. View in: Pubmed

      • Priming the hematopoietic pump. Immunity. 2003 Nov; 19(5):633-4. View in: Pubmed

      • Combinatorial interactions of serpent, lozenge, and U-shaped regulate crystal cell lineage commitment during Drosophila hematopoiesis. Proc Natl Acad Sci U S A. 2003 Sep 30; 100(20):11451-6. View in: Pubmed

      • Functional overlap of GATA-1 and GATA-2 in primitive hematopoietic development. Blood. 2004 Jan 15; 103(2):583-5. View in: Pubmed

      • Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression. Nature. 2003 Jul 31; 424(6948):561-5. View in: Pubmed

      • GATA-1 as a regulator of mast cell differentiation revealed by the phenotype of the GATA-1low mouse mutant. J Exp Med. 2003 Feb 03; 197(3):281-96. View in: Pubmed

      • Combinatorial effects of Flk1 and Tal1 on vascular and hematopoietic development in the mouse. Genes Dev. 2003 Feb 01; 17(3):380-93. View in: Pubmed

      • Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene. Nature. 2003 Jan 30; 421(6922):547-51. View in: Pubmed

      • Intrinsic requirement for zinc finger transcription factor Gfi-1 in neutrophil differentiation. Immunity. 2003 Jan; 18(1):109-20. View in: Pubmed

      • The zinc finger transcription factor Gfi1, implicated in lymphomagenesis, is required for inner ear hair cell differentiation and survival. Development. 2003 Jan; 130(1):221-32. View in: Pubmed

      • SCL/tal-1-dependent process determines a competence to select the definitive hematopoietic lineage prior to endothelial differentiation. EMBO J. 2002 Dec 16; 21(24):6700-8. View in: Pubmed

      • Highly penetrant, rapid tumorigenesis through conditional inversion of the tumor suppressor gene Snf5. Cancer Cell. 2002 Nov; 2(5):415-25. View in: Pubmed

      • Gonadal differentiation, sex determination and normal Sry expression in mice require direct interaction between transcription partners GATA4 and FOG2. Development. 2002 Oct; 129(19):4627-34. View in: Pubmed

      • The SCL complex regulates c-kit expression in hematopoietic cells through functional interaction with Sp1. Blood. 2002 Oct 01; 100(7):2430-40. View in: Pubmed

      • Expression of CD41 marks the initiation of definitive hematopoiesis in the mouse embryo. Blood. 2003 Jan 15; 101(2):508-16. View in: Pubmed

      • X-linked thrombocytopenia with thalassemia from a mutation in the amino finger of GATA-1 affecting DNA binding rather than FOG-1 interaction. Blood. 2002 Sep 15; 100(6):2040-5. View in: Pubmed

      • Dysregulation of protein modification by ISG15 results in brain cell injury. Genes Dev. 2002 Sep 01; 16(17):2207-12. View in: Pubmed

      • Stem-cell competition. Nature. 2002 Jul 04; 418(6893):25-7. View in: Pubmed

      • GATA-factor dependence of the multitype zinc-finger protein FOG-1 for its essential role in megakaryopoiesis. Proc Natl Acad Sci U S A. 2002 Jul 09; 99(14):9237-42. View in: Pubmed

      • Targeted deletion of a high-affinity GATA-binding site in the GATA-1 promoter leads to selective loss of the eosinophil lineage in vivo. J Exp Med. 2002 Jun 03; 195(11):1387-95. View in: Pubmed

      • Distinct domains of the GATA-1 cofactor FOG-1 differentially influence erythroid versus megakaryocytic maturation. Mol Cell Biol. 2002 Jun; 22(12):4268-79. View in: Pubmed

      • Transcriptional regulation of erythropoiesis: an affair involving multiple partners. Oncogene. 2002 May 13; 21(21):3368-76. View in: Pubmed

      • Interaction between FOG-1 and the corepressor C-terminal binding protein is dispensable for normal erythropoiesis in vivo. Mol Cell Biol. 2002 May; 22(9):3121-8. View in: Pubmed

      • Hematopoiesis and stem cells: plasticity versus developmental heterogeneity. Nat Immunol. 2002 Apr; 3(4):323-8. View in: Pubmed

      • The zinc-finger proto-oncogene Gfi-1b is essential for development of the erythroid and megakaryocytic lineages. Genes Dev. 2002 Feb 01; 16(3):301-6. View in: Pubmed

      • The search for the hemangioblast. J Hematother Stem Cell Res. 2002 Feb; 11(1):9-17. View in: Pubmed

      • The use of altered specificity mutants to probe specific protein-protein interactions involved in the activation of GATA-1 target genes. Methods. 2002 Jan; 26(1):84-92. View in: Pubmed

      • Heme-regulated eIF2alpha kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency. EMBO J. 2001 Dec 03; 20(23):6909-18. View in: Pubmed

      • E2F1 and E2F2 determine thresholds for antigen-induced T-cell proliferation and suppress tumorigenesis. Mol Cell Biol. 2001 Dec; 21(24):8547-64. View in: Pubmed

      • Mutation of E2F2 in mice causes enhanced T lymphocyte proliferation, leading to the development of autoimmunity. Immunity. 2001 Dec; 15(6):959-70. View in: Pubmed

      • The E2F1-3 transcription factors are essential for cellular proliferation. Nature. 2001 Nov 22; 414(6862):457-62. View in: Pubmed

      • Friend of GATA-1 represses GATA-3-dependent activity in CD4+ T cells. J Exp Med. 2001 Nov 19; 194(10):1461-71. View in: Pubmed

      • Hematopoietic development: a balancing act. Curr Opin Genet Dev. 2001 Oct; 11(5):513-9. View in: Pubmed

      • GATA1-Cre mediates Piga gene inactivation in the erythroid/megakaryocytic lineage and leads to circulating red cells with a partial deficiency in glycosyl phosphatidylinositol-linked proteins (paroxysmal nocturnal hemoglobinuria type II cells). Blood. 2001 Oct 01; 98(7):2248-55. View in: Pubmed

      • Myc requires distinct E2F activities to induce S phase and apoptosis. Mol Cell. 2001 Jul; 8(1):105-13. View in: Pubmed

      • The Friend of GATA proteins U-shaped, FOG-1, and FOG-2 function as negative regulators of blood, heart, and eye development in Drosophila. Proc Natl Acad Sci U S A. 2001 Jun 19; 98(13):7342-7. View in: Pubmed

      • Primitive erythropoiesis in the Xenopus embryo: the synergistic role of LMO-2, SCL and GATA-binding proteins. Development. 2001 Jun; 128(12):2301-8. View in: Pubmed

      • Proper coronary vascular development and heart morphogenesis depend on interaction of GATA-4 with FOG cofactors. Genes Dev. 2001 Apr 01; 15(7):839-44. View in: Pubmed

      • Activation of EGFP expression by Cre-mediated excision in a new ROSA26 reporter mouse strain. Blood. 2001 Jan 01; 97(1):324-6. View in: Pubmed

      • Haploinsufficiency of Snf5 (integrase interactor 1) predisposes to malignant rhabdoid tumors in mice. Proc Natl Acad Sci U S A. 2000 Dec 05; 97(25):13796-800. View in: Pubmed

      • Inositol polyphosphate 4-phosphatase type I regulates cell growth downstream of transcription factor GATA-1. Proc Natl Acad Sci U S A. 2000 Dec 05; 97(25):13696-701. View in: Pubmed

      • Stem cell alchemy. Nat Med. 2000 Nov; 6(11):1212-3. View in: Pubmed

      • Role of SCL/Tal-1, GATA, and ets transcription factor binding sites for the regulation of flk-1 expression during murine vascular development. Blood. 2000 Nov 01; 96(9):3078-85. View in: Pubmed

      • PU.1 inhibits GATA-1 function and erythroid differentiation by blocking GATA-1 DNA binding. Blood. 2000 Oct 15; 96(8):2641-8. View in: Pubmed

      • Antagonism between C/EBPbeta and FOG in eosinophil lineage commitment of multipotent hematopoietic progenitors. Genes Dev. 2000 Oct 01; 14(19):2515-25. View in: Pubmed

      • Diversification of haematopoietic stem cells to specific lineages. Nat Rev Genet. 2000 10; 1(1):57-64. View in: Pubmed

      • Sequential requirements for SCL/tal-1, GATA-2, macrophage colony-stimulating factor, and osteoclast differentiation factor/osteoprotegerin ligand in osteoclast development. Exp Hematol. 2000 Jul; 28(7):833-40. View in: Pubmed

      • Cdc42 is required for PIP(2)-induced actin polymerization and early development but not for cell viability. Curr Biol. 2000 Jun 29; 10(13):758-65. View in: Pubmed

      • FOG-2, a cofactor for GATA transcription factors, is essential for heart morphogenesis and development of coronary vessels from epicardium. Cell. 2000 Jun 23; 101(7):729-39. View in: Pubmed

      • A downstream element in the human beta-globin promoter: evidence of extended sequence-specific transcription factor IID contacts. Proc Natl Acad Sci U S A. 2000 Jun 20; 97(13):7172-7. View in: Pubmed

      • ABC-me: a novel mitochondrial transporter induced by GATA-1 during erythroid differentiation. EMBO J. 2000 Jun 01; 19(11):2492-502. View in: Pubmed

      • FOG acts as a repressor of red blood cell development in Xenopus. Development. 2000 May; 127(10):2031-40. View in: Pubmed

      • Basic fibroblast growth factor positively regulates hematopoietic development. Development. 2000 May; 127(9):1931-41. View in: Pubmed

      • Familial dyserythropoietic anaemia and thrombocytopenia due to an inherited mutation in GATA1. Nat Genet. 2000 Mar; 24(3):266-70. View in: Pubmed

      • Fetal expression of a human Agamma globin transgene rescues globin chain imbalance but not hemolysis in EKLF null mouse embryos. Blood. 2000 Mar 01; 95(5):1827-33. View in: Pubmed

      • An essential role in liver development for transcription factor XBP-1. Genes Dev. 2000 Jan 15; 14(2):152-7. View in: Pubmed

      • Specification of hematopoietic and vascular development by the bHLH transcription factor SCL without direct DNA binding. Development. 1999 Oct; 126(20):4603-15. View in: Pubmed

      • Apoptosis. Cutting red-cell production. Nature. 1999 Sep 30; 401(6752):433, 435-6. View in: Pubmed

      • Proposed changes for NIH's Center for Scientific Review. Panel on Scientific Boundaries for Review. Center for Scientific Review Advisory Committee, National Institutes of Health. Science. 1999 Jul 30; 285(5428):666-7. View in: Pubmed

      • GATA-1 and erythropoietin cooperate to promote erythroid cell survival by regulating bcl-xL expression. Blood. 1999 Jul 01; 94(1):87-96. View in: Pubmed

      • Expression and genetic interaction of transcription factors GATA-2 and GATA-3 during development of the mouse central nervous system. Dev Biol. 1999 Jun 15; 210(2):305-21. View in: Pubmed

      • Different sequence requirements for expression in erythroid and megakaryocytic cells within a regulatory element upstream of the GATA-1 gene. Development. 1999 Jun; 126(12):2799-811. View in: Pubmed

      • Consequences of GATA-1 deficiency in megakaryocytes and platelets. Blood. 1999 May 01; 93(9):2867-75. View in: Pubmed

      • Improved reporter strain for monitoring Cre recombinase-mediated DNA excisions in mice. Proc Natl Acad Sci U S A. 1999 Apr 27; 96(9):5037-42. View in: Pubmed

      • Intersections between blood cell development and leukemia genes. Cancer Res. 1999 Apr 01; 59(7 Suppl):1784s-1787s; discussion 1788s. View in: Pubmed

      • FOG-2: A novel GATA-family cofactor related to multitype zinc-finger proteins Friend of GATA-1 and U-shaped. Proc Natl Acad Sci U S A. 1999 Feb 02; 96(3):950-5. View in: Pubmed

      • Use of altered specificity mutants to probe a specific protein-protein interaction in differentiation: the GATA-1:FOG complex. Mol Cell. 1999 Feb; 3(2):219-28. View in: Pubmed

      • Guanine-adenine ligation-mediated polymerase chain reaction in vivo footprinting. Methods Enzymol. 1999; 304:572-84. View in: Pubmed

      • A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis. Cell. 1998 Dec 23; 95(7):891-902. View in: Pubmed

      • Rescue of the embryonic lethal hematopoietic defect reveals a critical role for GATA-2 in urogenital development. EMBO J. 1998 Nov 16; 17(22):6689-700. View in: Pubmed

      • The TEL/ETV6 gene is required specifically for hematopoiesis in the bone marrow. Genes Dev. 1998 Aug 01; 12(15):2392-402. View in: Pubmed

      • Failure of megakaryopoiesis and arrested erythropoiesis in mice lacking the GATA-1 transcriptional cofactor FOG. Genes Dev. 1998 Apr 15; 12(8):1176-88. View in: Pubmed

      • Knock-in mutation of transcription factor GATA-3 into the GATA-1 locus: partial rescue of GATA-1 loss of function in erythroid cells. Dev Biol. 1998 Apr 15; 196(2):218-27. View in: Pubmed

      • Erythroid Krüppel-like factor is essential for beta-globin gene expression even in absence of gene competition, but is not sufficient to induce the switch from gamma-globin to beta-globin gene expression. Blood. 1998 Apr 01; 91(7):2259-63. View in: Pubmed

      • CREB-binding protein cooperates with transcription factor GATA-1 and is required for erythroid differentiation. Proc Natl Acad Sci U S A. 1998 Mar 03; 95(5):2061-6. View in: Pubmed

      • Unsuspected role for the T-cell leukemia protein SCL/tal-1 in vascular development. Genes Dev. 1998 Feb 15; 12(4):473-9. View in: Pubmed

      • Embryonic stem cells and transgenic mice in the study of hematopoiesis. Int J Dev Biol. 1998; 42(7):927-34. View in: Pubmed

      • Transcription factor GATA-1 in megakaryocyte development. Stem Cells. 1998; 16 Suppl 2:79-83. View in: Pubmed

      • The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation. Proc Natl Acad Sci U S A. 1997 Dec 09; 94(25):13707-12. View in: Pubmed

      • p45 NF-E2 regulates expression of thromboxane synthase in megakaryocytes. EMBO J. 1997 Sep 15; 16(18):5654-61. View in: Pubmed

      • Regulation of the serum concentration of thrombopoietin in thrombocytopenic NF-E2 knockout mice. Blood. 1997 Sep 01; 90(5):1821-7. View in: Pubmed

      • A deletion mutation in the SH2-N domain of Shp-2 severely suppresses hematopoietic cell development. Mol Cell Biol. 1997 Sep; 17(9):5499-507. View in: Pubmed

      • An upstream, DNase I hypersensitive region of the hematopoietic-expressed transcription factor GATA-1 gene confers developmental specificity in transgenic mice. Proc Natl Acad Sci U S A. 1997 Jul 22; 94(15):7976-81. View in: Pubmed

      • Yolk sac angiogenic defect and intra-embryonic apoptosis in mice lacking the Ets-related factor TEL. EMBO J. 1997 Jul 16; 16(14):4374-83. View in: Pubmed

      • FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation. Cell. 1997 Jul 11; 90(1):109-19. View in: Pubmed

      • A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development. EMBO J. 1997 Jul 01; 16(13):3965-73. View in: Pubmed

      • A "knockdown" mutation created by cis-element gene targeting reveals the dependence of erythroid cell maturation on the level of transcription factor GATA-1. Proc Natl Acad Sci U S A. 1997 Jun 24; 94(13):6781-5. View in: Pubmed

      • Transcription factor GATA-2 is required for proliferation/survival of early hematopoietic cells and mast cell formation, but not for erythroid and myeloid terminal differentiation. Blood. 1997 May 15; 89(10):3636-43. View in: Pubmed

      • Regulation of the myeloid-cell-expressed human gp91-phox gene as studied by transfer of yeast artificial chromosome clones into embryonic stem cells: suppression of a variegated cellular pattern of expression requires a full complement of distant cis elements. Mol Cell Biol. 1997 Apr; 17(4):2279-90. View in: Pubmed

      • Erythroid-cell-specific properties of transcription factor GATA-1 revealed by phenotypic rescue of a gene-targeted cell line. Mol Cell Biol. 1997 Mar; 17(3):1642-51. View in: Pubmed

      • Guanine-adenine ligation-mediated PCR in vivo footprinting. Methods. 1997 Feb; 11(2):164-70. View in: Pubmed

      • GATA-2 and GATA-3 regulate trophoblast-specific gene expression in vivo. Development. 1997 Feb; 124(4):907-14. View in: Pubmed

      • Genetics of erythropoiesis: induced mutations in mice and zebrafish. Annu Rev Genet. 1997; 31:33-60. View in: Pubmed

      • Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1. Proc Natl Acad Sci U S A. 1996 Oct 29; 93(22):12355-8. View in: Pubmed

      • Silencing of human fetal globin expression is impaired in the absence of the adult beta-globin gene activator protein EKLF. Proc Natl Acad Sci U S A. 1996 Oct 29; 93(22):12267-71. View in: Pubmed

      • Development of the hematopoietic system. Curr Opin Genet Dev. 1996 Oct; 6(5):597-602. View in: Pubmed

      • Anion exchanger 1 (band 3) is required to prevent erythrocyte membrane surface loss but not to form the membrane skeleton. Cell. 1996 Sep 20; 86(6):917-27. View in: Pubmed

      • Thrombopoietin rescues in vitro erythroid colony formation from mouse embryos lacking the erythropoietin receptor. Proc Natl Acad Sci U S A. 1996 Aug 20; 93(17):9126-31. View in: Pubmed

      • The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages. Cell. 1996 Jul 12; 86(1):47-57. View in: Pubmed

      • E2F-1 functions in mice to promote apoptosis and suppress proliferation. Cell. 1996 May 17; 85(4):549-61. View in: Pubmed

      • The transcriptional control of hematopoiesis. Blood. 1996 May 15; 87(10):4025-39. View in: Pubmed

      • Complexity of the erythroid transcription factor NF-E2 as revealed by gene targeting of the mouse p18 NF-E2 locus. Proc Natl Acad Sci U S A. 1996 Apr 16; 93(8):3514-8. View in: Pubmed

      • Estrogen-induced apoptosis by inhibition of the erythroid transcription factor GATA-1. Mol Cell Biol. 1996 Apr; 16(4):1687-94. View in: Pubmed

      • Isolation and characterization of the cDNA encoding BKLF/TEF-2, a major CACCC-box-binding protein in erythroid cells and selected other cells. Mol Cell Biol. 1996 Apr; 16(4):1695-705. View in: Pubmed

      • In vitro differentiation of murine embryonic stem cells. New approaches to old problems. J Clin Invest. 1996 Feb 01; 97(3):591-5. View in: Pubmed

      • Hematopoiesis: how does it happen? Curr Opin Cell Biol. 1995 Dec; 7(6):870-7. View in: Pubmed

      • A functional initiator element in the human beta-globin promoter. J Biol Chem. 1995 Nov 24; 270(47):28139-44. View in: Pubmed

      • Transcription factor GATA-1 permits survival and maturation of erythroid precursors by preventing apoptosis. Proc Natl Acad Sci U S A. 1995 Oct 10; 92(21):9623-7. View in: Pubmed

      • Erythropoiesis and globin gene expression in mice lacking the transcription factor NF-E2. Proc Natl Acad Sci U S A. 1995 Sep 12; 92(19):8690-4. View in: Pubmed

      • Dependence of globin gene expression in mouse erythroleukemia cells on the NF-E2 heterodimer. Mol Cell Biol. 1995 Aug; 15(8):4640-7. View in: Pubmed

      • Regulation of globin gene expression in erythroid cells. Eur J Biochem. 1995 Jul 15; 231(2):271-81. View in: Pubmed

      • Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development. Cell. 1995 Jun 02; 81(5):695-704. View in: Pubmed

      • Ligand-dependent repression of the erythroid transcription factor GATA-1 by the estrogen receptor. Mol Cell Biol. 1995 Jun; 15(6):3147-53. View in: Pubmed

      • Lethal beta-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF. Nature. 1995 May 25; 375(6529):318-22. View in: Pubmed

      • Self-association of the erythroid transcription factor GATA-1 mediated by its zinc finger domains. Mol Cell Biol. 1995 May; 15(5):2448-56. View in: Pubmed

      • Expression of c-MYC under the control of GATA-1 regulatory sequences causes erythroleukemia in transgenic mice. J Exp Med. 1995 May 01; 181(5):1603-13. View in: Pubmed

      • Functional synergy and physical interactions of the erythroid transcription factor GATA-1 with the Krüppel family proteins Sp1 and EKLF. Mol Cell Biol. 1995 May; 15(5):2437-47. View in: Pubmed

      • cDNA cloning of murine Nrf 2 gene, coding for a p45 NF-E2 related transcription factor. Biochem Biophys Res Commun. 1995 Apr 06; 209(1):40-6. View in: Pubmed

      • Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene. Nature. 1995 Mar 30; 374(6521):470-3. View in: Pubmed

      • Transcription factors and hematopoietic development. J Biol Chem. 1995 Mar 10; 270(10):4955-8. View in: Pubmed

      • Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL. Nature. 1995 Feb 02; 373(6513):432-4. View in: Pubmed

      • The C-terminal zinc finger of GATA-1 or GATA-2 is sufficient to induce megakaryocytic differentiation of an early myeloid cell line. Mol Cell Biol. 1995 Feb; 15(2):634-41. View in: Pubmed

      • GATA transcription factors: key regulators of hematopoiesis. Exp Hematol. 1995 Feb; 23(2):99-107. View in: Pubmed

      • Mouse model of X-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production. Nat Genet. 1995 Feb; 9(2):202-9. View in: Pubmed

      • Rescue of GATA-1-deficient embryonic stem cells by heterologous GATA-binding proteins. Mol Cell Biol. 1995 Feb; 15(2):626-33. View in: Pubmed

      • Microcytic anemia in mk/mk mice is not corrected by retroviral-mediated gene transfer of wild-type p45 NF-E2. Exp Hematol. 1995 Jan; 23(1):74-80. View in: Pubmed

      • Development of hematopoietic cells lacking transcription factor GATA-1. Development. 1995 Jan; 121(1):163-72. View in: Pubmed

      • Hematopoietic development of vav-/- mouse embryonic stem cells. Proc Natl Acad Sci U S A. 1994 Dec 20; 91(26):12755-9. View in: Pubmed

      • An early haematopoietic defect in mice lacking the transcription factor GATA-2. Nature. 1994 Sep 15; 371(6494):221-6. View in: Pubmed

      • Sequence-specific DNA binding of individual cut repeats of the human CCAAT displacement/cut homeodomain protein. Proc Natl Acad Sci U S A. 1994 Aug 02; 91(16):7757-61. View in: Pubmed

      • Phosphorylation of the erythroid transcription factor GATA-1. J Biol Chem. 1994 Jun 17; 269(24):16589-96. View in: Pubmed

      • Regulation of the erythroid Kruppel-like factor (EKLF) gene promoter by the erythroid transcription factor GATA-1. J Biol Chem. 1994 Jun 03; 269(22):15440-4. View in: Pubmed

      • Novel insights into erythroid development revealed through in vitro differentiation of GATA-1 embryonic stem cells. Genes Dev. 1994 May 15; 8(10):1184-97. View in: Pubmed

      • Transcriptional control of erythropoiesis. Curr Opin Hematol. 1994 Mar; 1(2):119-24. View in: Pubmed

      • Infrequent mutation of the WT1 gene in 77 Wilms' Tumors. Hum Mutat. 1994; 3(3):212-22. View in: Pubmed

      • The ubiquitous subunit of erythroid transcription factor NF-E2 is a small basic-leucine zipper protein related to the v-maf oncogene. Proc Natl Acad Sci U S A. 1993 Dec 15; 90(24):11488-92. View in: Pubmed

      • Gene targeting of X chromosome-linked chronic granulomatous disease locus in a human myeloid leukemia cell line and rescue by expression of recombinant gp91phox. Proc Natl Acad Sci U S A. 1993 Nov 01; 90(21):9832-6. View in: Pubmed

      • Long-term in vivo expression of a murine adenosine deaminase gene in rhesus monkey hematopoietic cells of multiple lineages after retroviral mediated gene transfer into CD34+ bone marrow cells. Blood. 1993 Oct 01; 82(7):1975-80. View in: Pubmed

      • Purification of the human NF-E2 complex: cDNA cloning of the hematopoietic cell-specific subunit and evidence for an associated partner. Mol Cell Biol. 1993 Sep; 13(9):5604-12. View in: Pubmed

      • Loss of erythropoietin responsiveness in erythroid progenitors due to expression of the Evi-1 myeloid-transforming gene. Proc Natl Acad Sci U S A. 1993 Jul 15; 90(14):6454-8. View in: Pubmed

      • DNA-binding specificity of GATA family transcription factors. Mol Cell Biol. 1993 Jul; 13(7):3999-4010. View in: Pubmed

      • Expression of mRNA for the GATA-binding proteins in human eosinophils and basophils: potential role in gene transcription. Blood. 1993 Jun 15; 81(12):3234-41. View in: Pubmed

      • Mouse microcytic anaemia caused by a defect in the gene encoding the globin enhancer-binding protein NF-E2. Nature. 1993 Apr 22; 362(6422):768-70. View in: Pubmed

      • Erythroid transcription factor NF-E2 is a haematopoietic-specific basic-leucine zipper protein. Nature. 1993 Apr 22; 362(6422):722-8. View in: Pubmed

      • Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart. Mol Cell Biol. 1993 Apr; 13(4):2235-46. View in: Pubmed

      • Regulation of the beta-globin locus. Curr Opin Genet Dev. 1993 Apr; 3(2):232-7. View in: Pubmed

      • Regional localization of the CCAAT displacement protein gene (CUTL1) to 7q22 by analysis of somatic cell hybrids. Genomics. 1993 Mar; 15(3):695-6. View in: Pubmed

      • The SCL gene product: a positive regulator of erythroid differentiation. EMBO J. 1992 Nov; 11(11):4073-81. View in: Pubmed

      • Splice site mutations are a common cause of X-linked chronic granulomatous disease. Blood. 1992 Sep 15; 80(6):1553-8. View in: Pubmed

      • GATA-binding transcription factors in hematopoietic cells. Blood. 1992 Aug 01; 80(3):575-81. View in: Pubmed

      • Cell cycle-dependent initiation and lineage-dependent abrogation of GATA-1 expression in pure differentiating hematopoietic progenitors. Proc Natl Acad Sci U S A. 1992 Jul 15; 89(14):6353-7. View in: Pubmed

      • In vivo protein-DNA interactions at hypersensitive site 3 of the human beta-globin locus control region. Proc Natl Acad Sci U S A. 1992 Jul 01; 89(13):5809-13. View in: Pubmed

      • In vivo footprinting of the human alpha-globin locus upstream regulatory element by guanine and adenine ligation-mediated polymerase chain reaction. Mol Cell Biol. 1992 May; 12(5):2135-42. View in: Pubmed

      • Rescue of erythroid development in gene targeted GATA-1- mouse embryonic stem cells. Nat Genet. 1992 May; 1(2):92-8. View in: Pubmed

      • Sequence of the human GATA-1 promoter. Nucleic Acids Res. 1992 Apr 11; 20(7):1812. View in: Pubmed

      • Human CCAAT displacement protein is homologous to the Drosophila homeoprotein, cut. Nat Genet. 1992 Apr; 1(1):50-5. View in: Pubmed

      • Human transcription factor GATA-2. Evidence for regulation of preproendothelin-1 gene expression in endothelial cells. J Biol Chem. 1992 Jan 15; 267(2):1279-85. View in: Pubmed

      • Chronic granulomatous disease. Annu Rev Med. 1992; 43:117-24. View in: Pubmed

      • Point mutation in the cytoplasmic domain of the neutrophil p22-phox cytochrome b subunit is associated with a nonfunctional NADPH oxidase and chronic granulomatous disease. Proc Natl Acad Sci U S A. 1991 Dec 15; 88(24):11231-5. View in: Pubmed

      • GATA-binding transcription factors in mast cells regulate the promoter of the mast cell carboxypeptidase A gene. J Biol Chem. 1991 Dec 05; 266(34):22948-53. View in: Pubmed

      • Activation of the erythropoietin receptor promoter by transcription factor GATA-1. Proc Natl Acad Sci U S A. 1991 Dec 01; 88(23):10638-41. View in: Pubmed

      • Expression of GATA-binding proteins during embryonic development in Xenopus laevis. Proc Natl Acad Sci U S A. 1991 Dec 01; 88(23):10642-6. View in: Pubmed

      • Targeting of transgene expression to monocyte/macrophages by the gp91-phox promoter and consequent histiocytic malignancies. Proc Natl Acad Sci U S A. 1991 Oct 01; 88(19):8505-9. View in: Pubmed

      • CCAAT displacement protein as a repressor of the myelomonocytic-specific gp91-phox gene promoter. J Biol Chem. 1991 Sep 05; 266(25):16736-44. View in: Pubmed

      • Restriction of neuroblastoma to the prostate gland in transgenic mice. Mol Cell Biol. 1991 Sep; 11(9):4518-27. View in: Pubmed

      • Regulated expression of endothelin 1 in glomerular capillary endothelial cells. Am J Physiol. 1991 Jul; 261(1 Pt 2):F117-25. View in: Pubmed

      • Functional analysis and in vivo footprinting implicate the erythroid transcription factor GATA-1 as a positive regulator of its own promoter. Genes Dev. 1991 Jun; 5(6):919-31. View in: Pubmed

      • Human GATA-3: a lineage-restricted transcription factor that regulates the expression of the T cell receptor alpha gene. EMBO J. 1991 May; 10(5):1187-92. View in: Pubmed

      • Linkage of the erythroid transcription factor gene (Gf-1) to the proximal region of the X chromosome of mice. Genomics. 1991 Feb; 9(2):309-13. View in: Pubmed

      • Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1. Nature. 1991 Jan 17; 349(6306):257-60. View in: Pubmed

      • Restoration of phagocyte function by interferon-gamma in X-linked chronic granulomatous disease occurs at the level of a progenitor cell. Blood. 1990 Dec 15; 76(12):2443-8. View in: Pubmed

      • Regulated expression of globin chains and the erythroid transcription factor GATA-1 during erythropoiesis in the developing mouse. Mol Cell Biol. 1990 Dec; 10(12):6596-606. View in: Pubmed

      • Cell-specific transcription and cell differentiation in the erythroid lineage. Curr Opin Cell Biol. 1990 Dec; 2(6):1003-12. View in: Pubmed

      • Preparing for the next generation. J Clin Invest. 1990 Dec; 86(6):1773-6. View in: Pubmed

      • Globin gene regulation and switching: circa 1990. Cell. 1990 Nov 16; 63(4):665-72. View in: Pubmed

      • Transcriptional activation and DNA binding by the erythroid factor GF-1/NF-E1/Eryf 1. Genes Dev. 1990 Nov; 4(11):1886-98. View in: Pubmed

      • Human neutrophil cytochrome b light chain (p22-phox). Gene structure, chromosomal location, and mutations in cytochrome-negative autosomal recessive chronic granulomatous disease. J Clin Invest. 1990 Nov; 86(5):1729-37. View in: Pubmed

      • Alternatively spliced platelet-derived growth factor A-chain transcripts are not tumor specific but encode normal cellular proteins. Mol Cell Biol. 1990 Nov; 10(11):6051-4. View in: Pubmed

      • Activity and tissue-specific expression of the transcription factor NF-E1 multigene family. Genes Dev. 1990 Oct; 4(10):1650-62. View in: Pubmed

      • A nonerythroid GATA-binding protein is required for function of the human preproendothelin-1 promoter in endothelial cells. Mol Cell Biol. 1990 Sep; 10(9):4854-62. View in: Pubmed

      • Structure and transcription of the mouse erythropoietin receptor gene. Mol Cell Biol. 1990 Jul; 10(7):3675-82. View in: Pubmed

      • Expression of an erythroid transcription factor in megakaryocytic and mast cell lineages. Nature. 1990 Mar 29; 344(6265):444-7. View in: Pubmed

      • Increased platelet-derived growth factor A-chain expression in human uterine smooth muscle cells during the physiologic hypertrophy of pregnancy. Proc Natl Acad Sci U S A. 1990 Mar; 87(6):2177-81. View in: Pubmed

      • Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping. Nature. 1990 Feb 22; 343(6260):774-8. View in: Pubmed

      • The major human erythroid DNA-binding protein (GF-1): primary sequence and localization of the gene to the X chromosome. Proc Natl Acad Sci U S A. 1990 Jan; 87(2):668-72. View in: Pubmed

      • A rapid method for characterizing transgenic mice. Biotechniques. 1990 Jan; 8(1):34. View in: Pubmed

      • Gene transfer into murine hematopoietic stem cells and bone marrow stromal cells. Ann N Y Acad Sci. 1990; 612:398-406. View in: Pubmed

      • Targeting of transgene expression to monocytes by cytochrome b heavy chain gene 5'-flanking sequences induces histiocytic malignancies. Trans Assoc Am Physicians. 1990; 103:129-36. View in: Pubmed

      • A missense mutation in the neutrophil cytochrome b heavy chain in cytochrome-positive X-linked chronic granulomatous disease. J Clin Invest. 1989 Dec; 84(6):2012-6. View in: Pubmed

      • Association of a Ras-related protein with cytochrome b of human neutrophils. Nature. 1989 Nov 09; 342(6246):198-200. View in: Pubmed

      • Long-term expression of human adenosine deaminase in mice transplanted with retrovirus-infected hematopoietic stem cells. Proc Natl Acad Sci U S A. 1989 Nov; 86(22):8892-6. View in: Pubmed

      • Aberrant expression of platelet-derived growth factor A-chain cDNAs due to cryptic splicing of RNA transcripts in COS-1 cells. Nucleic Acids Res. 1989 Aug 25; 17(16):6591-601. View in: Pubmed

      • The polymerase chain reaction colony miniprep. Biotechniques. 1989 Jul-Aug; 7(7):696-8. View in: Pubmed

      • Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells. Nature. 1989 Jun 08; 339(6224):446-51. View in: Pubmed

      • Rapid amplification of lambda gt11 bacteriophage library inserts from plaques using the polymerase chain reaction (PCR). Biotechniques. 1989 Jun; 7(6):568, 570. View in: Pubmed

      • Absence of both the 91kD and 22kD subunits of human neutrophil cytochrome b in two genetic forms of chronic granulomatous disease. Blood. 1989 May 01; 73(6):1416-20. View in: Pubmed

      • Increased gamma-globin expression in a nondeletion HPFH mediated by an erythroid-specific DNA-binding factor. Nature. 1989 Mar 30; 338(6214):435-8. View in: Pubmed

      • Beta-thalassemia due to two novel nucleotide substitutions in consensus acceptor splice sequences of the beta-globin gene. Blood. 1989 Mar; 73(4):914-8. View in: Pubmed

      • Identification of a point mutation resulting in a heat-labile adenosine deaminase (ADA) in two unrelated children with partial ADA deficiency. J Clin Invest. 1989 Feb; 83(2):497-501. View in: Pubmed

      • X-linked chronic granulomatous disease: more than two years later. Mol Biol Med. 1989 Feb; 6(1):1-5. View in: Pubmed

      • Molecular genetics of chronic granulomatous disease. Annu Rev Immunol. 1989; 7:277-307. View in: Pubmed

      • Saudi Arabian sickle cell anemia. A molecular approach. Ann N Y Acad Sci. 1989; 565:143-51. View in: Pubmed

      • An erythroid-specific DNA binding factor mediates increased gamma-globin expression in hereditary persistence of fetal hemoglobin (HPFH). Prog Clin Biol Res. 1989; 316A:217-28. View in: Pubmed

      • Xp21 DNA microdeletion in a patient with chronic granulomatous disease, retinitis pigmentosa, and McLeod phenotype. Hum Genet. 1988 Sep; 80(1):85-9. View in: Pubmed

      • Partial correction of the phagocyte defect in patients with X-linked chronic granulomatous disease by subcutaneous interferon gamma. N Engl J Med. 1988 Jul 21; 319(3):146-51. View in: Pubmed

      • Induction of phagocyte cytochrome b heavy chain gene expression by interferon gamma. Proc Natl Acad Sci U S A. 1988 Jul; 85(14):5215-9. View in: Pubmed

      • Expression of the X-CGD gene during induced differentiation of myeloid leukemia cell line HL-60. Mol Cell Biol. 1988 Jul; 8(7):2804-10. View in: Pubmed

      • Chronic granulomatous disease. Molecular genetics. Hematol Oncol Clin North Am. 1988 Jun; 2(2):225-40. View in: Pubmed

      • Primary structure and unique expression of the 22-kilodalton light chain of human neutrophil cytochrome b. Proc Natl Acad Sci U S A. 1988 May; 85(10):3319-23. View in: Pubmed

      • Platelet-derived growth factor A chain: gene structure, chromosomal location, and basis for alternative mRNA splicing. Proc Natl Acad Sci U S A. 1988 Mar; 85(5):1492-6. View in: Pubmed

      • The propeptide of von Willebrand factor independently mediates the assembly of von Willebrand multimers. Cell. 1988 Jan 29; 52(2):229-36. View in: Pubmed

      • The human von Willebrand factor gene. Structure of the 5' region. Eur J Biochem. 1988 Jan 15; 171(1-2):51-7. View in: Pubmed

      • Gene therapy of somatic cells: status and prospects. Prog Med Genet. 1988; 7:130-42. View in: Pubmed

      • Gene deletion in a patient with chronic granulomatous disease and McLeod syndrome: fine mapping of the Xk gene locus. Blood. 1988 Jan; 71(1):252-5. View in: Pubmed

      • Molecular genetics of chronic granulomatous disease. Immunodefic Rev. 1988; 1(1):55-69. View in: Pubmed

      • Localization of the human X-linked gene for chronic granulomatous disease to the mouse X chromosome: implications for X-chromosome evolution. Cytogenet Cell Genet. 1988; 48(2):124-5. View in: Pubmed

      • Active human erythropoietin expressed in insect cells using a baculovirus vector: a role for N-linked oligosaccharide. Biochim Biophys Acta. 1987 Dec 08; 910(3):224-32. View in: Pubmed

      • Genetic diagnosis by DNA analysis: progress through amplification. N Engl J Med. 1987 Oct 15; 317(16):1023-5. View in: Pubmed

      • Recombinant interferon gamma augments phagocyte superoxide production and X-chronic granulomatous disease gene expression in X-linked variant chronic granulomatous disease. J Clin Invest. 1987 Oct; 80(4):1009-16. View in: Pubmed

      • Retrovirus-mediated gene transfer of human adenosine deaminase: expression of functional enzyme in murine hematopoietic stem cells in vivo. Mol Cell Biol. 1987 Oct; 7(10):3459-65. View in: Pubmed

      • Clonal analysis using recombinant DNA probes from the X-chromosome. Cancer Res. 1987 Sep 15; 47(18):4806-13. View in: Pubmed

      • An alpha-globin gene initiation codon mutation in a black family with HbH disease. Blood. 1987 Sep; 70(3):729-32. View in: Pubmed

      • Analysis of hemoglobin F production in Saudi Arabian families with sickle cell anemia. Blood. 1987 Sep; 70(3):716-20. View in: Pubmed

      • Alternative RNA splicing affects function of encoded platelet-derived growth factor A chain. Nature. 1987 Aug 13-19; 328(6131):621-4. View in: Pubmed

      • The glycoprotein encoded by the X-linked chronic granulomatous disease locus is a component of the neutrophil cytochrome b complex. Nature. 1987 Jun 25-Jul 1; 327(6124):717-20. View in: Pubmed

      • Molecular analysis of the high-hemoglobin-F phenotype in Saudi Arabian sickle cell anemia. N Engl J Med. 1987 Jan 29; 316(5):244-50. View in: Pubmed

      • "Forward" and "reverse" genetics of inherited human disorders: the thalassemia syndromes and chronic granulomatous disease. Harvey Lect. 1987-1988; 83:57-76. View in: Pubmed

      • Transfer and expression of human ADA in murine hematopoietic stem cells. Prog Clin Biol Res. 1987; 251:567-80. View in: Pubmed

      • Analysis of high fetal hemoglobin production in sickle cell anemia patients from the Eastern Province of Saudi Arabia. Prog Clin Biol Res. 1987; 251:415-26. View in: Pubmed

      • Reverse genetics and human disease. Cell. 1986 Dec 26; 47(6):845-50. View in: Pubmed

      • Structure of pre-pro-von Willebrand factor and its expression in heterologous cells. Nature. 1986 Nov 20-26; 324(6094):270-3. View in: Pubmed

      • Plasma and cytoplasmic gelsolins are encoded by a single gene and contain a duplicated actin-binding domain. Nature. 1986 Oct 2-8; 323(6087):455-8. View in: Pubmed

      • Nucleotide sequence of pre-pro-von Willebrand factor cDNA. Nucleic Acids Res. 1986 Sep 11; 14(17):7125-7. View in: Pubmed

      • On the origin and spread of beta-thalassemia: recurrent observation of four mutations in different ethnic groups. Proc Natl Acad Sci U S A. 1986 Sep; 83(17):6529-32. View in: Pubmed

      • Cloning the gene for an inherited human disorder--chronic granulomatous disease--on the basis of its chromosomal location. Nature. 1986 Jul 3-9; 322(6074):32-8. View in: Pubmed

      • Molecular genetics and potential gene therapy. Clin Immunol Immunopathol. 1986 Jul; 40(1):151-6. View in: Pubmed

      • Characterization of a spontaneous mutation to a beta-thalassemia allele. Am J Hum Genet. 1986 Jun; 38(6):860-7. View in: Pubmed

      • Propolypeptide of von Willebrand factor circulates in blood and is identical to von Willebrand antigen II. Science. 1986 May 23; 232(4753):995-8. View in: Pubmed

      • DNA linkage analysis of X chromosome-linked chronic granulomatous disease. Proc Natl Acad Sci U S A. 1986 May; 83(10):3398-401. View in: Pubmed

      • Exon/intron organization of the genes coding for the delta chains of the human and murine T-cell receptor/T3 complex. Proc Natl Acad Sci U S A. 1986 May; 83(9):2944-8. View in: Pubmed

      • High fetal hemoglobin production in sickle cell anemia in the eastern province of Saudi Arabia is genetically determined. Blood. 1986 May; 67(5):1404-10. View in: Pubmed

      • Somatic gene therapy. Current status and future prospects. J Clin Invest. 1986 Apr; 77(4):1053-6. View in: Pubmed

      • Retrovirus-mediated transfer of human adenosine deaminase gene sequences into cells in culture and into murine hematopoietic cells in vivo. Proc Natl Acad Sci U S A. 1986 Apr; 83(8):2566-70. View in: Pubmed

      • Pathogenesis of B cell lymphoma in a patient with AIDS. Blood. 1986 Mar; 67(3):612-5. View in: Pubmed

      • Expression defects of mutant human adenosine deaminase. Adv Exp Med Biol. 1986; 195 Pt A:217-22. View in: Pubmed

      • Owl monkey gene mapping: the assignment of gene loci for catalase, beta-globin gene cluster, HRAS1, insulin, and parathyroid hormone. Cytogenet Cell Genet. 1986; 43(1-2):57-68. View in: Pubmed

      • Cloning the gene for the inherited disorder chronic granulomatous disease on the basis of its chromosomal location. Cold Spring Harb Symp Quant Biol. 1986; 51 Pt 1:177-83. View in: Pubmed

      • First occurrence of Hb H in Hungary. Haematologia (Budap). 1986; 19(3):193-5. View in: Pubmed

      • Bone marrow transplantation for paroxysmal nocturnal hemoglobinuria: eradication of the PNH clone and documentation of complete lymphohematopoietic engraftment. Blood. 1985 Dec; 66(6):1247-50. View in: Pubmed

      • Post-meiotic transcription of phosphoglycerate-kinase 2 in mouse testes. Biosci Rep. 1985 Dec; 5(12):1087-91. View in: Pubmed

      • Structure of the human phosphoglycerate kinase gene and the intron-mediated evolution and dispersal of the nucleotide-binding domain. Proc Natl Acad Sci U S A. 1985 Oct; 82(20):6965-9. View in: Pubmed

      • Intron structure of the human antithrombin III gene differs from that of other members of the serine protease inhibitor superfamily. J Biol Chem. 1985 Aug 15; 260(17):9608-12. View in: Pubmed

      • Identification of a point mutation in the adenosine deaminase gene responsible for immunodeficiency. J Clin Invest. 1985 Aug; 76(2):894-7. View in: Pubmed

      • Cultured human endothelial cells express platelet-derived growth factor B chain: cDNA cloning and structural analysis. Nature. 1985 Aug 22-28; 316(6030):748-50. View in: Pubmed

      • Human von Willebrand factor (vWF): isolation of complementary DNA (cDNA) clones and chromosomal localization. Science. 1985 Jun 21; 228(4706):1401-6. View in: Pubmed

      • The human phosphoglycerate kinase multigene family. HLA-associated sequences and an X-linked locus containing a processed pseudogene and its functional counterpart. J Biol Chem. 1985 Jun 10; 260(11):6982-92. View in: Pubmed

      • Phenotype of recovering lymphoid cell populations after marrow transplantation. J Exp Med. 1985 Jun 01; 161(6):1483-502. View in: Pubmed

      • Assignment of the gene coding for the T3-delta subunit of the T3-T-cell receptor complex to the long arm of human chromosome 11 and to mouse chromosome 9. Proc Natl Acad Sci U S A. 1985 May; 82(9):2920-4. View in: Pubmed

      • Transient expression of human adenosine deaminase cDNAs: identification of a nonfunctional clone resulting from a single amino acid substitution. Mol Cell Biol. 1985 Apr; 5(4):762-7. View in: Pubmed

      • Thalassemia due to a mutation in the cleavage-polyadenylation signal of the human beta-globin gene. EMBO J. 1985 Feb; 4(2):453-6. View in: Pubmed

      • Origin of cell populations after bone marrow transplantation. Analysis using DNA sequence polymorphisms. J Clin Invest. 1985 Feb; 75(2):596-603. View in: Pubmed

      • cDNA and amino acid sequence of human adenosine deaminase. Ann N Y Acad Sci. 1985; 451:238-44. View in: Pubmed

      • DNA polymorphism and molecular pathology of the human globin gene clusters. Hum Genet. 1985; 69(1):1-14. View in: Pubmed

      • In vivo transcription of a human antithrombin III "minigene". J Biol Chem. 1984 Dec 25; 259(24):15386-92. View in: Pubmed

      • Activity of X-linked genes in stem and differentiated Mus musculus X Mus caroli hybrid cells. Cell Differ. 1984 Dec; 15(2-4):241-8. View in: Pubmed

      • Isolation of cDNA clones encoding the 20K T3 glycoprotein of human T-cell receptor complex. Nature. 1984 Nov 29-Dec 5; 312(5993):413-8. View in: Pubmed

      • Human adenosine deaminase. cDNA and complete primary amino acid sequence. J Biol Chem. 1984 Oct 10; 259(19):12101-6. View in: Pubmed

      • Molecular analysis of human disease: dissection of beta-thalassemia. Clin Res. 1984 Sep; 32(3):329-33. View in: Pubmed

      • Hydroxyurea enhances fetal hemoglobin production in sickle cell anemia. J Clin Invest. 1984 Aug; 74(2):652-6. View in: Pubmed

      • Base substitution at position -88 in a beta-thalassemic globin gene. Further evidence for the role of distal promoter element ACACCC. J Biol Chem. 1984 Jul 25; 259(14):8679-81. View in: Pubmed

      • Abnormal processing of beta Knossos RNA. Blood. 1984 Jul; 64(1):311-3. View in: Pubmed

      • Quantification of the close association between DNA haplotypes and specific beta-thalassaemia mutations in Mediterraneans. Nature. 1984 Jul 12-18; 310(5973):152-4. View in: Pubmed

      • Fetal hemoglobin synthesis in erythroid cultures in hereditary persistence of fetal hemoglobin and beta o-thalassemia. Blood. 1984 Jun; 63(6):1278-84. View in: Pubmed

      • beta-Thalassemia in Chinese: use of in vivo RNA analysis and oligonucleotide hybridization in systematic characterization of molecular defects. Proc Natl Acad Sci U S A. 1984 May; 81(9):2821-5. View in: Pubmed

      • Localization of the beta-globin gene by chromosomal in situ hybridization. Am J Hum Genet. 1984 May; 36(3):576-85. View in: Pubmed

      • Development of homozygosity for chromosome 11p markers in Wilms' tumour. Nature. 1984 May 10-16; 309(5964):172-4. View in: Pubmed

      • Molecular characterization of seven beta-thalassemia mutations in Asian Indians. EMBO J. 1984 Mar; 3(3):593-6. View in: Pubmed

      • Prenatal diagnosis of hemoglobin disorders by DNA analysis. Blood. 1984 Feb; 63(2):249-53. View in: Pubmed

      • Hydroxyurea increases fetal hemoglobin production in sickle cell anemia. Trans Assoc Am Physicians. 1984; 97:268-74. View in: Pubmed

      • Restriction site polymorphism in the phosphoglycerate kinase gene on the X chromosome. Hum Genet. 1984; 66(2-3):217-9. View in: Pubmed

      • The mutation and polymorphism of the human beta-globin gene and its surrounding DNA. Annu Rev Genet. 1984; 18:131-71. View in: Pubmed

      • Boundaries of gene conversion within the duplicated human alpha-globin genes. Concerted evolution by segmental recombination. J Biol Chem. 1983 Dec 25; 258(24):15245-54. View in: Pubmed

      • Molecular cloning of human adenosine deaminase gene sequences. J Biol Chem. 1983 Nov 10; 258(21):12753-6. View in: Pubmed

      • beta-Thalassemia due to a deletion of the nucleotide which is substituted in the beta S-globin gene. Am J Hum Genet. 1983 Sep; 35(5):1028-33. View in: Pubmed

      • ATA box transcription mutation in beta-thalassemia. Nucleic Acids Res. 1983 Jul 25; 11(14):4727-34. View in: Pubmed

      • Isolation of a cDNA clone for human antithrombin III. J Biol Chem. 1983 Jul 10; 258(13):8389-94. View in: Pubmed

      • Early pre-B cells from normal and X-linked agammaglobulinaemia produce C mu without an attached VH region. Nature. 1983 Jul 28-Aug 3; 304(5924):355-8. View in: Pubmed

      • Molecular heterogeneity of inherited antithrombin III deficiency. N Engl J Med. 1983 Jun 30; 308(26):1549-52. View in: Pubmed

      • Inactivation of an acceptor RNA splice site by a short deletion in beta-thalassemia. J Biol Chem. 1983 Jun 25; 258(12):7249-51. View in: Pubmed

      • The molecular basis for the clinical diversity of beta thalassaemia in Cypriots. Lancet. 1983 Jun 04; 1(8336):1235-7. View in: Pubmed

      • The entire beta-globin gene cluster is deleted in a form of gamma delta beta-thalassemia. Blood. 1983 Jun; 61(6):1269-74. View in: Pubmed

      • Specific transcription and RNA splicing defects in five cloned beta-thalassaemia genes. Nature. 1983 Apr 14; 302(5909):591-6. View in: Pubmed

      • Direct detection of the common Mediterranean beta-thalassemia gene with synthetic DNA probes. An alternative approach for prenatal diagnosis. J Clin Invest. 1983 Mar; 71(3):775-9. View in: Pubmed

      • Controlling the fetal globin switch in man. Nature. 1983 Jan 13; 301(5896):108-9. View in: Pubmed

      • Isolation and DNA sequence of a full-length cDNA clone for human X chromosome-encoded phosphoglycerate kinase. Proc Natl Acad Sci U S A. 1983 Jan; 80(2):472-6. View in: Pubmed

      • Structural and functional defects in beta-thalassemia. Prog Clin Biol Res. 1983; 134:99-121. View in: Pubmed

      • Polymorphism and molecular pathology of the human beta-globin gene. Prog Hematol. 1983; 13:49-73. View in: Pubmed

      • Isolation of DNA fragments from chromosome 13. Retina. 1983; 3(2):121-5. View in: Pubmed

      • Characterization of the homopolymer tailing reaction catalyzed by terminal deoxynucleotidyl transferase. Implications for the cloning of cDNA. J Biol Chem. 1982 Dec 25; 257(24):14773-82. View in: Pubmed

      • Abnormal RNA processing due to the exon mutation of beta E-globin gene. Nature. 1982 Dec 23; 300(5894):768-9. View in: Pubmed

      • Duplication followed by deletion accounts for the structure of an Indian deletion beta (0)-thalassemia gene. Nucleic Acids Res. 1982 Dec 20; 10(24):8025-9. View in: Pubmed

      • Evidence for multiple origins of the beta E-globin gene in Southeast Asia. Proc Natl Acad Sci U S A. 1982 Nov; 79(21):6608-11. View in: Pubmed

      • Improved detection of the sickle mutation by DNA analysis: application to prenatal diagnosis. N Engl J Med. 1982 Jul 01; 307(1):32-6. View in: Pubmed

      • Abnormal RNA splicing causes one form of alpha thalassemia. Cell. 1982 Jul; 29(3):895-902. View in: Pubmed

      • Linkage of beta-thalassaemia mutations and beta-globin gene polymorphisms with DNA polymorphisms in human beta-globin gene cluster. Nature. 1982 Apr 15; 296(5858):627-31. View in: Pubmed

      • Genetic diagnosis of the fetus. Nature. 1982 Mar 18; 296(5854):202-3. View in: Pubmed

      • Isolation of mouse x-chromosome specific DNA from an x-enriched lambda phage library derived from flow sorted chromosomes. Cytometry. 1982 Mar; 2(5):282-6. View in: Pubmed

      • Prenatal analysis of human DNA-sequence variation. Methods Cell Biol. 1982; 26:311-30. View in: Pubmed

      • Nonsense and frameshift mutations in beta 0-thalassemia detected in cloned beta-globin genes. J Biol Chem. 1981 Oct 10; 256(19):9782-4. View in: Pubmed

      • Mutation in an intervening sequence splice junction in man. Proc Natl Acad Sci U S A. 1981 Aug; 78(8):5041-5. View in: Pubmed

      • The duplicated human alpha-globin genes: their relative expression as measured by RNA analysis. Cell. 1981 May; 24(2):345-51. View in: Pubmed

      • Heterogeneity of DNA deletion in gamma delta beta-thalassemia. J Clin Invest. 1981 Mar; 67(3):878-84. View in: Pubmed

      • The molecular genetics of thalassemia. Adv Hum Genet. 1981; 11:233-80. View in: Pubmed

      • The 3' untranslated regions of the duplicated human alpha-globin genes are unexpectedly divergent. Cell. 1980 Nov; 22(2 Pt 2):371-7. View in: Pubmed

      • Partial deletion of the alpha-globin structural gene in human alpha-thalassaemia. Nature. 1980 Jul 31; 286(5772):538-40. View in: Pubmed

      • Cloning and direct examination of a structurally abnormal human beta 0-thalassemia globin gene. Proc Natl Acad Sci U S A. 1980 Jun; 77(6):3558-62. View in: Pubmed

      • The alpha thalassemias. Tex Rep Biol Med. 1980-1981; 40:335-42. View in: Pubmed

      • Specific abnormalities of globin gene organization in the thalassemia syndromes. Ann N Y Acad Sci. 1980; 344:48-61. View in: Pubmed

      • Prenatal diagnosis of hemoglobinopathies: the New England approach. Ann N Y Acad Sci. 1980; 344:151-64. View in: Pubmed

      • Precise localization of human beta-globin gene complex on chromosome 11. Proc Natl Acad Sci U S A. 1979 Oct; 76(10):5239-42. View in: Pubmed

      • Deletion of the A gamma-globin gene in G gamma-delta beta-thalassemia. J Clin Invest. 1979 Sep; 64(3):866-9. View in: Pubmed

      • Prenatal diagnosis of hemoglobinopathies. Clin Perinatol. 1979 Sep; 6(2):275-91. View in: Pubmed

      • Partial deletion of beta-globin gene DNA in certain patients with beta 0-thalassemia. Proc Natl Acad Sci U S A. 1979 May; 76(5):2400-4. View in: Pubmed

      • The molecular basis of alpha-thalassemias: frequent occurrence of dysfunctional alpha loci among non-Asians with Hb H disease. Cell. 1979 May; 17(1):33-42. View in: Pubmed

      • The duplicated human alpha globin genes lie close together in cellular DNA. Proc Natl Acad Sci U S A. 1978 Dec; 75(12):5950-4. View in: Pubmed

      • Application of endonuclease mapping to the analysis and prenatal diagnosis of thalassemias caused by globin-gene deletion. N Engl J Med. 1978 Jul 27; 299(4):166-72. View in: Pubmed

      • Fidelity of globin ribonucleic acid synthesis in vitro by isolated nuclei: asymmetric gene expression. Biochemistry. 1978 Feb 07; 17(3):487-92. View in: Pubmed

      • Selective restriction endonuclease cleavage of human globin genes. J Biol Chem. 1978 Jan 10; 253(1):12-5. View in: Pubmed

      • Differentiation of murine erythroleukemic (Friend) cells: an in vitro model of erythropoiesis. In Vitro. 1978 Jan; 14(1):146-54. View in: Pubmed

      • In vitro synthesis of a DNA probe for antisense globin sequences. J Biol Chem. 1977 Aug 25; 252(16):5606-8. View in: Pubmed

      • Globin RNA synthesis in vitro by isolated erythroleukemic cell nuclei: direct evidence for increased transcription during erythroid differentiation. Proc Natl Acad Sci U S A. 1977 Jun; 74(6):2475-9. View in: Pubmed

      • The thalassemias. N Engl J Med. 1976 Sep 23; 295(13):710-4. View in: Pubmed

      • The molecular genetics of thalassemia. Birth Defects Orig Artic Ser. 1976; 12(8):145-59. View in: Pubmed

      • Studies on the overproduction of dihydrofolate reductase by variant hamster cells in culture. Adv Enzyme Regul. 1976; 15:301-17. View in: Pubmed

      • Differentiation of erythroleukemic cells in the presence of inhibitors of DNA synthesis. Science. 1975 Nov 28; 190(4217):893-4. View in: Pubmed

      • Differential expression of alpha- and beta-globin genes during differentiation of cultured erythroleukemic cells. J Biol Chem. 1975 Nov 25; 250(22):8753-60. View in: Pubmed

      • Differentiation in erythroleukemic cells and their somatic hybrids. Proc Natl Acad Sci U S A. 1975 Jan; 72(1):98-102. View in: Pubmed

      • Lambda-chain production in human lymphoblast-mouse fibroblast hybrids. Proc Natl Acad Sci U S A. 1973 Aug; 70(8):2401-5. View in: Pubmed

      • Mutagenesis to aminopterin resistance in cultured hamster cells. Exp Cell Res. 1971 Nov; 69(1):174-80. View in: Pubmed

      • Extrinsic cotton effects in dye-bovine plasma albumin adducts. Proc Natl Acad Sci U S A. 1967 Nov; 58(5):2051-4. View in: Pubmed

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