Research findings could change current practice
Lindsay Frazier, MD
Researchers from Dana-Farber/Children's Hospital Cancer Center
(DF/CHCC) have found that as many as 50 percent of young girls treated
for germ-cell ovarian tumors might safely be spared chemotherapy using a "watch and wait" strategy to determine if the follow-up treatment is needed.
In contrast to the current practice of administering chemotherapy to
all patients following removal of these rare tumors, researchers said
the study demonstrated that treatment could safely be delayed and given
only if the cancer recurred.
Data from the trial involving 25 young women ages 9 to 16 were
presented at the 42nd Congress of the International Society of
Paediatric Oncology (SIOP) in Boston on Friday, Oct. 22.
The study was led by Lindsay Frazier, MD, a pediatric oncologist at DF/CHCC and chair of the Germ Cell Tumor Committee of the Children's Oncology Group.
"I personally think that not giving chemotherapy to half the patients
[women with germ cell ovarian tumors] is a good thing," said Frazier.
"The chemotherapy is just as effective given when the disease recurs. I
would recommend that parents consider a watching and waiting strategy."
Germ cell tumors are malignancies that develop in precursors of sperm
cells in boys and egg cells in girls. Some forms of the tumors are
most often detected immediately following birth; other types are most
common between the ages of 10 and 30.
Previous trials had shown that delaying chemotherapy was safe and
effective in Stage 1 germ cell testicular tumors in boys. Over time, 30
percent of the patients developed a recurrence, but they were all cured
"So instead of giving 100 percent of them chemotherapy, only 30
percent needed it," explained Frazier, who said it's been found that the
usual three cycles of chemotherapy administered for the tumors doubles
the long-term risk of cardiovascular disease or second cancers.
The current study was undertaken to test a similar watch-and-wait
approach in female patients. Frazier said 25 girls with Stage 1 germ
cell ovarian tumors were recruited from about 100 medical centers — an
indication of the cancer's rarity. In all cases, the tumors had been
completely removed by surgery.
Instead of undergoing chemotherapy immediately, the girls were
monitored closely for signs of recurrence. Every three weeks their blood
was tested for biochemical markers signifying a regrowth of the cancer,
and every three months they were scanned with CT or MRI imaging.
"The median time to relapse was two months, and the latest relapse
was at 9 months, so the families were not living with uncertainty for a
long time," Frazier said.
The recurrence rate was 50 percent – higher than in the boys with
germ cell tumors – but the delayed treatment was similarly effective
though one girl died, yielding a survival rate of 96 percent.
Preventing unnecessary chemotherapy treatment for half of girls with
such tumors is still desirable, said Frazier, "because there is evidence
that girls are even more susceptible to long-term harm from chemo than
The study was supported by the National Cancer Institute.