HIV molecular biology and pathogenesis
The major research interest of our lab is to understand molecular mechanisms of HIV replication and pathogenesis, and their implications for understanding pathogen-host interactions, immune responses, and disease outcomes. Using biological, genetic, biochemical, and systems biology approaches, we study:
Ongoing studies seek to understand the mechanism by which Vif protein overcomes innate antiviral activity of APOBEC3G, a cellular cytidine deaminase that induces G to A hypermutation in newly synthesized viral DNA. Current efforts are focused on understanding the mechanisms by which Vif induces degradation of APOBEC3G through association with a Cullin 5 complex, using high-throughput assays to identify small molecules that inhibit Vif-APOBEC3G interactions. These studies will provide a better understanding of virus-host cell interactions in HIV replication, and will also advance the development of Vif as a target for antiviral therapy.
Dana-Farber Cancer Institute450 Brookline Avenue
Center for Life Sciences,Room 1010
Boston, MA 02215
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