Breast cancer survivor offers wisdom at Faulkner satellite center
Call 877-422-3324 today to make an appointment
Make your appointment or second opinion with Dana-Farber today to meet with an onsite specialist.
Can’t get to Boston? Explore our Online Second Opinion service to get expert advice from Dana-Farber oncologists.
Toll-Free Number866-408-DFCI (3324)
Discover the ways to give and how to get involved to support Dana-Farber.
Poet Richard Fox gains insight – and material – through cancer treatment
A family faces cancer in an unfamiliar city – with help
Choosing mastectomy or not: Studying young women's surgical choices
Jeff's targeted therapy has kept his advanced lung cancer at bay.
Development and delivery of RNA therapeutics
The Goldberg Lab seeks to leverage the tools of drug delivery to manipulate the cell-extrinsic aspects of cancer in the tumor microenvironment. In particular, Dr. Goldberg recently joined our faculty to apply RNAi-based therapeutics to cancer immunotherapy. He has particular expertise in the development and delivery of cancer-specific siRNAs that target synthetic lethality and aberrant alternative splicing programs. Dr. Goldberg is credited with delivering the first single-agent synthetic lethal siRNA therapeutic in vivo – siRNA targeting Parp1 – for treatment of BRCA1-deficient ovarian cancer; more recently, he demonstrated that siRNA sequences specific to the cancer-expressed M2 isoform of pyruvate kinase induce apoptosis and tumor regression – independent of the cancer type or underlying genetic lesions – without affecting the viability of normal cells.
The focus of current studies includes targeting siRNA delivery to immune cells in vivo. Dr. Goldberg’s diverse training in chemistry, materials science, biotechnology, and molecular biology is combined with cutting-edge mRNA- and siRNA-based as well as nanoparticle-based therapeutic strategies, promising to yield innovative approaches to cancer immunotherapy.
Dana-Farber Cancer Institute450 Brookline Avenue
Smith Research Laboratories, Room 770C
Boston, MA 02215