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Our department is developing novel approaches for immunotherapy, and we closely collaborate with our clinical colleagues to advance important discoveries to clinical trials.
We are also closely collaborating with our clinical colleagues to advance the development of novel cancer immunotherapies. We are developing novel technology platforms (including mass cytometry, CyTOF) for in-depth characterization of immune cell populations in human cancers and experimental animal models. We believe that this technology will substantially enhance our ability to study immunological mechanisms in patients enrolled in clinical trials of novel immunotherapies. We are also working on a novel technique for isolation of therapeutic antibodies from patients who respond to immunotherapies, based on the observation that such patients can mount immune responses against inhibitory immune molecules (Wucherpfennig and Dranoff Labs).