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The Blais Proteomics Center develops and applies
state-of-the-art proteomics, informatics, and related technologies
for direct interrogation of protein expression, modification, and
function in response to biological perturbation in cell-based
models of human cancer and primary tissues. The Center works with
other Dana-Farber integrative research centers in large-scale
studies designed to leverage disparate capabilities in pursuit of
novel, in-depth, and otherwise unattainable insights into human
biology and disease.
Analytical capabilities in the Blais Proteomics Center include
advanced protein and ultra-hig-pressure peptide separations,
chemical- and affinity-based enrichment techniques, along with
multiple mass spectrometry platforms, including MALDI TOF/TOF,
linear ion trap, Orbitrap, and quadrupole TOF instruments. In
addition, bioinformatics engineers provide customized desktop and
web-based software tools for the analysis of proteomics data within
the context of biological pathways and networks.
Capabilities at the Blais Proteomics Center are deployed at
multiple levels, including fee-for-service, focused
hypothesis-driven research collaborations, and large-scale
discovery or systems-level projects. Scientists in the Center
routinely consult with faculty throughout Dana-Farber in planning
experiments and interpreting results. Blais members also contribute
to the teaching mission at Harvard Medical School and participate
in outreach activities designed to introduce and train young
scientists and others who may not otherwise have access to these
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