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  • Groundbreaking Work in Cancer Chemical Biology Aims to Find New Cancer Treatments

  • SIDTALKSScience, Innovation, and Discovery at Dana-Farber

    Updates from our researchers for our Joint Visiting Committee Symposium

    James (Jay) Bradner, MD
    Groundbreaking Work in Cancer Chemical Biology Aims to Find New Cancer Treatments

    "We've learned more about cancer in the past 10 years than we have in the past 100," says Dr. James Bradner of Dana-Farber Cancer Institute. Watch his SIDTALK, in which he discusses his groundbreaking work in cancer chemical biology aimed at finding new treatments to bring us closer to more cures for cancer.

    About Jay Bradner, MD

    Physician-scientist Jay Bradner, MD, leads a discovery chemistry laboratory at Dana-Farber Cancer Institute. He and his team are working to discover and develop new chemicals targeting pathways of cellular memory, as powerful tools for basic science and as prototype drugs for cancer medicine. As a recognized leader in the development of small-molecule compounds, Dr. Bradner's research focus is the discovery, optimization, and characterization of small-molecule modulators of gene regulatory pathways.

    Jay Bradner, MD  

    Dr. Bradner and his team have innovated and exemplified a new model of drug discovery, which empowers the international research community with free and unrestricted access to first-in-class drugs. Dr. Bradner is a vigorous advocate of open-source drug discovery, which promises to expedite the rapid translation of new medicines.

    Dr. Bradner is staff physician in Dana-Farber's Hematologic Oncology Treatment Center and Stem Cell Transplantation Program; an investigator in Dana-Farber's Department of Medical Oncology; a member of the affiliated faculty at Harvard Stem Cell Institute of Harvard University; and an associate professor of medicine at Harvard Medical School. Bradner is associate director of the Center for the Science of Therapeutics (CSofT) at the Broad Institute, and an associate member of the Broad's Chemical Biology Program.

    Dr. Bradner is the recipient of numerous awards, including the Damon Runyon-Rachleff Innovation Award, the Smith Family Award for Excellence in Biomedical Research, and the Dunkin Donuts Rising Star Award. He received his MD from the University of Chicago's Pritzker School of Medicine in 1999. He trained in Internal Medicine at Brigham and Women's Hospital and Hematology-Oncology at Dana-Farber, and he completed post-doctoral research training at Harvard University and the Broad Institute.

    Related resources

    Video: Researching stem cell transplants
    Video: Jay Bradner: Open-source cancer research (TEDX Boston)
    Scientists identify a roadmap to 'cancer dependencies' in lymph node cancer
    Crowd Sourcing: Sharing discoveries to speed new treatments
    New designer compound treats heart failure by targeting cell nucleus 

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