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About Acute Lymphoblastic Leukemia


  • David Steensma, MD, discusses his work caring for adult patients with leukemia, myelodysplasia, and myeloproliferative diseases, and the array of services available to patients to support them during and after their treatment at Dana-Farber.

  • Acute lymphoblastic leukemia (ALL) is a blood cancer in which the bone marrow starts to produce too many immature lymphocytes (a type of white blood cell), called lymphoblasts. This kind of cancer is called "acute" because it is usually a fast-growing kind of leukemia.

    Some people with ALL have chromosome abnormalities in the cancer cells (extra chromosomes or structural changes in chromosomes), but it is not clear what causes the mutations that can lead to ALL. Researchers have found that most cases of acute lymphoblastic leukemia are not inherited.

    Incidence

    ALL can develop at any age, but most commonly affects young children. About 1,000 new cases are diagnosed in adults each year in the United States.

    Risk Factors

    Risk factors include:

    • Past treatment with chemotherapy or radiation therapy
    • Being white
    • Having certain genetic disorders, such as Down syndrome
    • Having an identical twin with ALL
    • Having certain viral infections, such as human T-cell lymphoma/leukemia virus-1 (HTLV-1) – uncommon outside of Japan or the Caribbean

    Symptoms and Signs

    The most common symptoms include:

    • Fever
    • Unexplained weight or appetite loss
    • Weakness or fatigue
    • Pain or fullness below the ribs
    • Shortness of breath
    • Easy bruising
    • Night sweats
    • Enlarged lymph nodes

    Growth and Spread

    ALL is often an aggressive cancer. It can involve lymph nodes, spleen, bone marrow and blood, skin, or the central nervous system.

    Factors Affecting Prognosis

    As with any cancer, prognosis (chance of recovery) and long-term survival can vary greatly. The prognosis depends partly on:

    • Certain molecular mutations
    • Age — children (over the age of 1) with ALL have better prognoses than adults with the disease
    • Response to therapy