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About Adrenocortical Carcinoma

  • Adrenocortical carcinoma: a rare disease in which malignant (cancer) cells form in the cortex (outer layer) of the adrenal gland

    Adrenocortical carcinoma, also known as adrenal cortical carcinoma (ACC), is a rare and aggressive cancer that originates in the outer layer of the adrenal gland. There are two adrenal glands. One sits on top of each kidney. The adrenal cortex makes important hormones, including ones that keep water and salt in balance, control blood pressure, and help the body use energy. Adrenocortical tumors usually make extra amounts of one or more adrenal hormones, which may cause symptoms. Certain inherited disorders increase the risk of adrenocortical cancer; these include Li-Fraumeni syndrome, Beckwith-Wiedemann syndrome, and Carney complex.

    Learn about adrenocortical carcinoma, and find information on how we support and care for adults with adrenocortical carcinoma before, during, and after treatment.

    The following information is from the National Cancer Institute (NCI).


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