Chronic myelogenous leukemia (CML) is a cancer of the blood. It affects a particular type of white blood cells called myeloid cells, or “myeloblasts.”
- CML is uncommon in children.
- Unlike other forms of
childhood leukemia, CML progresses slowly, usually over a period of months or years.
- CML is often accompanied by a specific type of chromosome rearrangement:
- Part of chromosome #9 breaks off and attaches itself to chromosome #22
- There is an exchange of genetic material between these two chromosomes
- This rearrangement changes the position and functions of certain genes, which results in uncontrolled cell growth.
Leukemia treatment at Dana-Farber/Boston Children's
Children and teens with leukemia are treated through the
Leukemia Program at Dana-Farber/Boston Children's Cancer and Blood Disorders Center. Dana-Farber/Boston Children’s has played a key role in refining treatment for childhood leukemia, and we continue to be a world leader in
childhood leukemia clinical trials designed to increase cure rates, decrease treatment-related side effects and improve care for long-term survivors. The Leukemia Program also offers families the chance to have their child's leukemia cells molecularly profiled, which may help identify opportunities for
Learn more about CML
in-depth information on chronic myelogenous leukemia (CML) on the Dana-Farber/Boston Children's website, including details on CML symptoms, diagnosis and treatment.