Alejandro Gutierrez, MD

Alejandro Gutierrez, MD

Pediatric Hematology/Oncology

Contact Information

Fax

617-730-0934

Appointments

888-733-4662 (New Pediatric Patients)
617-632-3270 (Established Pediatric Patients)

Biography

Alejandro Gutierrez, MD

Dr. Gutierrez received an MD degree from the University of Pennsylvania School of Medicine and completed a pediatrics residency at The Children's Hospital of Philadelphia, followed by a fellowship in pediatric hematology/oncology at Boston Children's Hospital/Dana-Farber Cancer Institute. His postdoctoral research training was with Dr. A. Thomas Look at Dana-Farber Cancer Institute. Dr. Gutierrez is a Scholar of the American Society of Hematology-Harold Amos Medical Faculty Development Program and recipient of the 2010 Young Investigators Award from the American Society of Pediatric Hematology/Oncology.

Researcher

Physician

Physician
Associate Professor of Pediatrics, Harvard Medical School

Clinical Interests

Global health, Liposarcoma, T-cell acute lymphoblastic leukemia, Zebrafish drug screens

Board Certification

  • Pediatric Hematology/Oncology, 2009
  • Pediatrics, 2004

Fellowship

  • Boston Children's Hospital/Dana-Farber Cancer Institute, Pediatric Hematology/Oncology

Residency

  • Children's Hospital of Philadelphia, Pediatrics

Medical School

  • University of Pennsylvania School of Medicine

Recent Awards

  • Milagras para Niños Award, Boston Children's Hospital, 2019
  • Barry H. Paw Award for Excellence in Teaching, 2018
  • Clinical Investigator Award, Damon Runyon Cancer Research Foundation, 2014
  • Elected Member, Society for Pediatric Research, 2013
  • Young Investigator Award, American Society of Pediatric Hematology/Oncology, 2010
  • American Society of Hematology/Amos Medical Faculty Career Development Award, 2009

Research

    The Gutierrez laboratory is focused on discovery of molecular oncogenesis and novel therapeutic targets for chemoresistant human cancers, including high-risk T-cell acute lymphoblastic leukemia and treatment-resistant sarcomas. Our approach combines functional genetics, biochemistry, and small molecule screens, leveraging the zebrafish models of these high-risk human cancers we have recently developed.

    Publications

      • Supramolecular assembly of GSK3a as a cellular response to amino acid starvation. Mol Cell. 2022 08 04; 82(15):2858-2870.e8. View in: Pubmed

      • JAK3 mutations and mitochondrial apoptosis resistance in T-cell acute lymphoblastic leukemia. Leukemia. 2022 06; 36(6):1499-1507. View in: Pubmed

      • METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation. Mol Cell. 2021 08 19; 81(16):3323-3338.e14. View in: Pubmed

      • Ganglioneuromas are driven by activated AKT and can be therapeutically targeted with mTOR inhibitors. J Exp Med. 2020 10 05; 217(10). View in: Pubmed

      • Exploiting the Therapeutic Interaction of WNT Pathway Activation and Asparaginase for Colorectal Cancer Therapy. Cancer Discov. 2020 11; 10(11):1690-1705. View in: Pubmed

      • Fanconi-BRCA pathway mutations in childhood T-cell acute lymphoblastic leukemia. PLoS One. 2019; 14(11):e0221288. View in: Pubmed

      • Synthetic Lethality of Wnt Pathway Activation and Asparaginase in Drug-Resistant Acute Leukemias. Cancer Cell. 2019 04 15; 35(4):664-676.e7. View in: Pubmed

      • PRC2 loss induces chemoresistance by repressing apoptosis in T cell acute lymphoblastic leukemia. J Exp Med. 2018 12 03; 215(12):3094-3114. View in: Pubmed

      • JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia. J Exp Med. 2018 07 02; 215(7):1929-1945. View in: Pubmed

      • Hedgehog pathway mutations drive oncogenic transformation in high-risk T-cell acute lymphoblastic leukemia. Leukemia. 2018 10; 32(10):2126-2137. View in: Pubmed

      • An "off-the-shelf" fratricide-resistant CAR-T for the treatment of T cell hematologic malignancies. Leukemia. 2018 09; 32(9):1970-1983. View in: Pubmed

      • Acute myeloid/T-lymphoblastic leukaemia (AMTL): a distinct category of acute leukaemias with common pathogenesis in need of improved therapy. Br J Haematol. 2018 03; 180(6):919-924. View in: Pubmed

      • TOX Regulates Growth, DNA Repair, and Genomic Instability in T-cell Acute Lymphoblastic Leukemia. Cancer Discov. 2017 11; 7(11):1336-1353. View in: Pubmed

      • Inactivation of Capicua in adult mice causes T-cell lymphoblastic lymphoma. Genes Dev. 2017 07 15; 31(14):1456-1468. View in: Pubmed

      • The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice. Cancer Cell. 2016 07 11; 30(1):183. View in: Pubmed

      • The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice. Cancer Cell. 2016 04 11; 29(4):574-586. View in: Pubmed

      • Zebrafish Models of Human Leukemia: Technological Advances and Mechanistic Insights. Adv Exp Med Biol. 2016; 916:335-69. View in: Pubmed

      • Complete hematologic response of early T-cell progenitor acute lymphoblastic leukemia to the ?-secretase inhibitor BMS-906024: genetic and epigenetic findings in an outlier case. Cold Spring Harb Mol Case Stud. 2015 Oct; 1(1):a000539. View in: Pubmed

      • A strategy to improve treatment-related mortality and abandonment of therapy for childhood ALL in a developing country reveals the impact of treatment delays. Pediatr Blood Cancer. 2015 Aug; 62(8):1395-402. View in: Pubmed

      • An X-linked tumor suppressor in T-ALL. Blood. 2015 Jan 01; 125(1):3-4. View in: Pubmed

      • Oncogene regulation. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element. Science. 2014 Dec 12; 346(6215):1373-7. View in: Pubmed

      • Cyclin C is a haploinsufficient tumour suppressor. Nat Cell Biol. 2014 Nov; 16(11):1080-91. View in: Pubmed

      • Thymocyte transformation enhanced. Nat Med. 2014 Oct; 20(10):1096-7. View in: Pubmed

      • Maturation stage of T-cell acute lymphoblastic leukemia determines BCL-2 versus BCL-XL dependence and sensitivity to ABT-199. Cancer Discov. 2014 Sep; 4(9):1074-87. View in: Pubmed

      • Letter to the editor: Pseudopapillary tumor of the pancreas in a child with hemihypertrophy and a history of Wilms tumor. Pediatr Blood Cancer. 2014 Oct; 61(10):1901-2. View in: Pubmed

      • Loss of function tp53 mutations do not accelerate the onset of myc-induced T-cell acute lymphoblastic leukaemia in the zebrafish. Br J Haematol. 2014 Jul; 166(1):84-90. View in: Pubmed

      • Leukemia propagating cells Akt up. Cancer Cell. 2014 Mar 17; 25(3):263-5. View in: Pubmed

      • An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia. Nat Genet. 2014 Apr; 46(4):364-70. View in: Pubmed

      • Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia. J Clin Invest. 2014 Feb; 124(2):644-55. View in: Pubmed

      • c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells. Blood. 2014 Feb 13; 123(7):1040-50. View in: Pubmed

      • Immature MEF2C-dysregulated T-cell leukemia patients have an early T-cell precursor acute lymphoblastic leukemia gene signature and typically have non-rearranged T-cell receptors. Haematologica. 2014 Jan; 99(1):94-102. View in: Pubmed

      • The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia. J Exp Med. 2013 Jul 29; 210(8):1545-57. View in: Pubmed

      • TYK2-STAT1-BCL2 pathway dependence in T-cell acute lymphoblastic leukemia. Cancer Discov. 2013 May; 3(5):564-77. View in: Pubmed

      • Inactivation of ribosomal protein L22 promotes transformation by induction of the stemness factor, Lin28B. Blood. 2012 Nov 01; 120(18):3764-73. View in: Pubmed

      • Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia. Cancer Cell. 2012 Aug 14; 22(2):209-21. View in: Pubmed

      • NOTCH1 signaling promotes human T-cell acute lymphoblastic leukemia initiating cell regeneration in supportive niches. PLoS One. 2012; 7(6):e39725. View in: Pubmed

      • Aberrant AKT activation drives well-differentiated liposarcoma. Proc Natl Acad Sci U S A. 2011 Sep 27; 108(39):16386-91. View in: Pubmed

      • The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia. Blood. 2011 Oct 13; 118(15):4169-73. View in: Pubmed

      • Pten mediates Myc oncogene dependence in a conditional zebrafish model of T cell acute lymphoblastic leukemia. J Exp Med. 2011 Aug 01; 208(8):1595-603. View in: Pubmed

      • Shared acquired genomic changes in zebrafish and human T-ALL. Oncogene. 2011 Oct 13; 30(41):4289-96. View in: Pubmed

      • SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction. Nature. 2011 Mar 03; 471(7336):104-9. View in: Pubmed

      • T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation. Cancer Cell. 2010 Oct 19; 18(4):353-66. View in: Pubmed

      • Absence of biallelic TCRgamma deletion predicts early treatment failure in pediatric T-cell acute lymphoblastic leukemia. J Clin Oncol. 2010 Aug 20; 28(24):3816-23. View in: Pubmed

      • Inactivation of LEF1 in T-cell acute lymphoblastic leukemia. Blood. 2010 Apr 08; 115(14):2845-51. View in: Pubmed

      • Resolution of cerebral artery stenosis in a child with sickle cell anemia treated with hydroxyurea. Am J Hematol. 2010 Feb; 85(2):135-7. View in: Pubmed

      • Liquid chromatography-mass spectrometry (LC-MS) of steroid hormone metabolites and its applications. J Steroid Biochem Mol Biol. 2010 Aug; 121(3-5):546-55. View in: Pubmed

      • Interconnecting molecular pathways in the pathogenesis and drug sensitivity of T-cell acute lymphoblastic leukemia. Blood. 2010 Mar 04; 115(9):1735-45. View in: Pubmed

      • Emi1 maintains genomic integrity during zebrafish embryogenesis and cooperates with p53 in tumor suppression. Mol Cell Biol. 2009 Nov; 29(21):5911-22. View in: Pubmed

      • High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia. Blood. 2009 Jul 16; 114(3):647-50. View in: Pubmed

      • Cell and molecular biology of human leukaemias. Oxford Textbook of Medicine. 2009. View in: Pubmed

      • Pathobiology of Acute Lymphoblastic Leukemia. Hematology: Basic Principles and Practice. Editors: Hoffman R et al. 2009. View in: Pubmed

      • Alu elements mediate MYB gene tandem duplication in human T-ALL. J Exp Med. 2007 Dec 24; 204(13):3059-66. View in: Pubmed

      • NOTCH and PI3K-AKT pathways intertwined. Cancer Cell. 2007 Nov; 12(5):411-3. View in: Pubmed

      • Heat-shock induction of T-cell lymphoma/leukaemia in conditional Cre/lox-regulated transgenic zebrafish. Br J Haematol. 2007 Jul; 138(2):169-75. View in: Pubmed

      • Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers. Nature. 2007 Jun 21; 447(7147):966-71. View in: Pubmed

      • Liquid chromatography/electron capture atmospheric pressure chemical ionization/mass spectrometry: analysis of pentafluorobenzyl derivatives of biomolecules and drugs in the attomole range. Anal Chem. 2000 Jul 15; 72(14):3007-13. View in: Pubmed

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      Boston Children's Hospital

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      Dana-Farber Cancer Institute

      450 Brookline Avenue D322A Boston, MA 02215
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      Dana-Farber Cancer Institute

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      450 Brookline Avenue D322A Boston, MA 02215
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