Annick D. Van den Abbeele, MD, FACR

Annick D. Van den Abbeele, MD, FACR

Contact Information

Office Phone Number

617-632-3580

Fax

617-582-9702

Researcher

Physician

Chair Emeritus, Department of Imaging
Founding Director, Center for Biomedical Imaging in Oncology
Co-Director, Tumor Imaging Metrics Core, Dana-Farber/Harvard Cancer Care
Institute Physician
Professor of Radiology, Harvard Medical School

Centers/Programs

Clinical Interests

Cancer imaging, Molecular imaging, Quantitative tumor metrics, Radiotherapy with unsealed sources

Board Certification

  • Nuclear Medicine, 1993

Fellowship

  • Brigham and Women's Hospital/Harvard Medical School, Radiology & Nuclear Medicine
  • Vanderbilt University School of Medicine, Neonatology

Residency

  • Joint Program in Nuclear Medicine, Harvard Medical School
  • University of Louvain, Pediatrics

Medical School

  • Catholic University of Louvain

Publications

    • Report on the PET/CT Image-Based Radiation Dosimetry of [18F]FDHT in Women, a Validated Imaging Agent with New Applications for Evaluation of Androgen Receptor Status in Women with Metastatic Breast Cancer. J Nucl Med Technol. 2023 Sep; 51(3):204-210. View in: Pubmed

    • Perspectives on joint EANM/SNMMI/ANZSNM practice guidelines/procedure standards for [18F]FDG PET/CT imaging during immunomodulatory treatments in patients with solid tumors. Cancer Imaging. 2022 Dec 20; 22(1):73. View in: Pubmed

    • Will ultra-extended field-of-view scanners be an expensive folly or the next clinical standard for PET/CT? Cancer Imaging. 2022 09 06; 22(1):49. View in: Pubmed

    • Importance of 68Ga-FAPI PET/CT for Detection of Cancer. Radiology. 2022 04; 303(1):200-201. View in: Pubmed

    • Imaging Androgen Receptors in Breast Cancer with 18F-Fluoro-5a-Dihydrotestosterone PET: A Pilot Study. J Nucl Med. 2022 01; 63(1):22-28. View in: Pubmed

    • Noninvasive Imaging of Cancer Immunotherapy. Nanotheranostics. 2021; 5(1):90-112. View in: Pubmed

    • Theranostics: The Role of Quantitative Nuclear Medicine Imaging. Semin Radiat Oncol. 2021 01; 31(1):28-36. View in: Pubmed

    • Linsitinib (OSI-906) for the Treatment of Adult and Pediatric Wild-Type Gastrointestinal Stromal Tumors, a SARC Phase II Study. Clin Cancer Res. 2020 04 15; 26(8):1837-1845. View in: Pubmed

    • Evolution of Transarterial Chemoembolization for the Treatment of Liver Cancer. Radiology. 2019 12; 293(3):704-706. View in: Pubmed

    • Centralized Clinical Trial Imaging Data Management: Practical Guidance from a Comprehensive Cancer Center's Experience. J Digit Imaging. 2019 10; 32(5):849-854. View in: Pubmed

    • Guidance on 177Lu-DOTATATE Peptide Receptor Radionuclide Therapy from the Experience of a Single Nuclear Medicine Division. J Nucl Med Technol. 2018 Sep; 46(3):237-244. View in: Pubmed

    • Development and validation of a new MRI simulation technique that can reliably estimate optimal in vivo scanning parameters in a glioblastoma murine model. PLoS One. 2018; 13(7):e0200611. View in: Pubmed

    • Effects of hyperglycemia on fluorine-18-fluorodeoxyglucose biodistribution in a large oncology clinical practice. Nucl Med Commun. 2018 May; 39(5):417-422. View in: Pubmed

    • LesionTracker: Extensible Open-Source Zero-Footprint Web Viewer for Cancer Imaging Research and Clinical Trials. Cancer Res. 2017 11 01; 77(21):e119-e122. View in: Pubmed

    • Prognostic significance of supradiaphragmatic lymph nodes at initial presentation in patients with stage III high-grade serous ovarian cancer. Abdom Radiol (NY). 2017 10; 42(10):2513-2520. View in: Pubmed

    • Yield of bone scintigraphy for the detection of metastatic disease in treatment-naive prostate cancer: a systematic review and meta-analysis. Clin Radiol. 2018 02; 73(2):158-167. View in: Pubmed

    • Surveillance Imaging in Patients With Endometrial Cancer in First Remission. Curr Probl Diagn Radiol. 2018 Sep; 47(5):311-316. View in: Pubmed

    • Immune Modulation Therapy and Imaging: Workshop Report. J Nucl Med. 2018 03; 59(3):410-417. View in: Pubmed

    • Cancer Imaging Fellowship Training: Utility and Added Value in the Modern Era. J Am Coll Radiol. 2017 10; 14(10):1345-1348. View in: Pubmed

    • Ovarian Cancer: An Evidence-Based, Easy-to-Use Prediction Rule to Optimize the Use of Follow-up Chest CT. J Am Coll Radiol. 2017 Apr; 14(4):499-508. View in: Pubmed

    • Demonstration of DCE-MRI as an early pharmacodynamic biomarker of response to VEGF Trap in glioblastoma. J Neurooncol. 2016 12; 130(3):495-503. View in: Pubmed

    • Patterns and Prognostic Importance of Hepatic Involvement in Patients with Serous Ovarian Cancer: A Single-Institution Experience with 244 Patients. Radiology. 2017 Jan; 282(1):160-170. View in: Pubmed

    • Long-term follow-up results of the multicenter phase II trial of regorafenib in patients with metastatic and/or unresectable GI stromal tumor after failure of standard tyrosine kinase inhibitor therapy. Ann Oncol. 2016 09; 27(9):1794-9. View in: Pubmed

    • Cancer Imaging at the Crossroads of Precision Medicine: Perspective From an Academic Imaging Department in a Comprehensive Cancer Center. J Am Coll Radiol. 2016 Apr; 13(4):365-71. View in: Pubmed

    • Role of FDG-PET/CT in Extramedullary Multiple Myeloma: Correlation of FDG-PET/CT Findings With Clinical Outcome. Clin Nucl Med. 2016 Jan; 41(1):e7-13. View in: Pubmed

    • Glioblastoma Eradication Following Immune Checkpoint Blockade in an Orthotopic, Immunocompetent Model. Cancer Immunol Res. 2016 Feb; 4(2):124-35. View in: Pubmed

    • Pancreatitis Secondary to Anti-Programmed Death Receptor 1 Immunotherapy Diagnosed by FDG PET/CT. Clin Nucl Med. 2015 Nov; 40(11):e528-9. View in: Pubmed

    • Phase 2 study of sunitinib in patients with metastatic mucosal or acral melanoma. Cancer. 2015 Nov 15; 121(22):4007-15. View in: Pubmed

    • Phase II Study of Lapatinib in Combination With Trastuzumab in Patients With Human Epidermal Growth Factor Receptor 2-Positive Metastatic Breast Cancer: Clinical Outcomes and Predictive Value of Early [18F]Fluorodeoxyglucose Positron Emission Tomography Imaging (TBCRC 003). J Clin Oncol. 2015 Aug 20; 33(24):2623-31. View in: Pubmed

    • Cancer Imaging Training in the 21st Century: An Overview of Where We Are, and Where We Need To Be. J Am Coll Radiol. 2015 Jul; 12(7):714-20. View in: Pubmed

    • Advanced High-Grade Serous Ovarian Cancer: Frequency and Timing of Thoracic Metastases and the Implications for Chest Imaging Follow-up. Radiology. 2015 Dec; 277(3):733-40. View in: Pubmed

    • [(18)F]-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography of LAPC4-CR Castration-Resistant Prostate Cancer Xenograft Model in Soft Tissue Compartments. Transl Oncol. 2015 Jun; 8(3):147-53. View in: Pubmed

    • Cancer immunotherapy: imaging assessment of novel treatment response patterns and immune-related adverse events. Radiographics. 2015 Mar-Apr; 35(2):424-37. View in: Pubmed

    • Metabolic response by FDG-PET to imatinib correlates with exon 11 KIT mutation and predicts outcome in patients with mucosal melanoma. Cancer Imaging. 2014 Nov 12; 14:30. View in: Pubmed

    • A phase I study of everolimus and docetaxel in patients with castration-resistant prostate cancer. Clin Genitourin Cancer. 2015 Apr; 13(2):113-23. View in: Pubmed

    • 10% Tumor diameter shrinkage on the first follow-up computed tomography predicts clinical outcome in patients with advanced renal cell carcinoma treated with angiogenesis inhibitors: a follow-up validation study. Oncologist. 2014 May; 19(5):507-14. View in: Pubmed

    • Bevacizumab plus ipilimumab in patients with metastatic melanoma. Cancer Immunol Res. 2014 Jul; 2(7):632-42. View in: Pubmed

    • Stand up to cancer phase Ib study of pan-phosphoinositide-3-kinase inhibitor buparlisib with letrozole in estrogen receptor-positive/human epidermal growth factor receptor 2-negative metastatic breast cancer. J Clin Oncol. 2014 Apr 20; 32(12):1202-9. View in: Pubmed

    • Voxelwise single-subject analysis of imaging metabolic response to therapy in neuro-oncology. Stat. 2014 Jan 01; 3(1):172-186. View in: Pubmed

    • Metastatic mucosal melanoma: imaging patterns of metastasis and recurrence. Cancer Imaging. 2013 Dec 30; 13(4):626-32. View in: Pubmed

    • Intraobserver and interobserver variability in computed tomography size and attenuation measurements in patients with renal cell carcinoma receiving antiangiogenic therapy: implications for alternative response criteria. Cancer. 2014 Mar 01; 120(5):711-21. View in: Pubmed

    • What radiologists need to know about diagnosis and treatment of inflammatory breast cancer: a multidisciplinary approach. Radiographics. 2013 Nov-Dec; 33(7):2003-17. View in: Pubmed

    • End-therapy positron emission tomography for treatment response assessment in follicular lymphoma: a systematic review and meta-analysis. Clin Cancer Res. 2013 Dec 01; 19(23):6566-77. View in: Pubmed

    • Imatinib for melanomas harboring mutationally activated or amplified KIT arising on mucosal, acral, and chronically sun-damaged skin. J Clin Oncol. 2013 Sep 10; 31(26):3182-90. View in: Pubmed

    • Atypical metastases from prostate cancer: 10-year experience at a single institution. AJR Am J Roentgenol. 2012 Aug; 199(2):367-72. View in: Pubmed

    • Efficacy and safety of regorafenib in patients with metastatic and/or unresectable GI stromal tumor after failure of imatinib and sunitinib: a multicenter phase II trial. J Clin Oncol. 2012 Jul 01; 30(19):2401-7. View in: Pubmed

    • Combined modality treatment for PET-positive non-Hodgkin lymphoma: favorable outcomes of combined modality treatment for patients with non-Hodgkin lymphoma and positive interim or postchemotherapy FDG-PET. Int J Radiat Oncol Biol Phys. 2012 Aug 01; 83(5):e647-54. View in: Pubmed

    • Selective CDK4/6 inhibition with tumor responses by PD0332991 in patients with mantle cell lymphoma. Blood. 2012 May 17; 119(20):4597-607. View in: Pubmed

    • ACRIN 6665/RTOG 0132 phase II trial of neoadjuvant imatinib mesylate for operable malignant gastrointestinal stromal tumor: monitoring with 18F-FDG PET and correlation with genotype and GLUT4 expression. J Nucl Med. 2012 Apr; 53(4):567-74. View in: Pubmed

    • Hereditary cancer syndromes: a radiologist's perspective. AJR Am J Roentgenol. 2011 Dec; 197(6):W1001-7. View in: Pubmed

    • Imaging in renal cell carcinoma. Hematol Oncol Clin North Am. 2011 Aug; 25(4):687-715. View in: Pubmed

    • A multicenter phase II study of regorafenib in patients (pts) with advanced gastrointestinal stromal tumor (GIST), after therapy with imatinib (IM) and sunitinib (SU). J Clin Oncol. 2011 May 20; 29(15_suppl):10007. View in: Pubmed

    • Impact of RECIST 1.1 modifications on clinical trial eligibility. J Clin Oncol. 2011 May 20; 29(15_suppl):e16555. View in: Pubmed

    • TBCRC 003: Phase II trial of trastuzumab (T) and lapatinib (L) in patients (pts) with HER2+ metastatic breast cancer (MBC). J Clin Oncol. 2011 May 20; 29(15_suppl):527. View in: Pubmed

    • Assessment of regorafenib activity with FDG-PET/CT in a multicenter phase II study in patients (pts) with advanced gastrointestinal stromal tumor (GIST) following failure of standard therapy (Rx). J Clin Oncol. 2011 May 20; 29(15_suppl):10050. View in: Pubmed

    • A phase I trial of ipilimumab plus bevacizumab in patients with unresectable stage III or stage IV melanoma. J Clin Oncol. 2011 May 20; 29(15_suppl):8511. View in: Pubmed

    • Urothelial cancers of the upper urinary tract: metastatic pattern and its correlation with tumor histopathology and location. J Comput Assist Tomogr. 2011 Mar-Apr; 35(2):217-22. View in: Pubmed

    • Incidence of pulmonary embolism in oncologic outpatients at a tertiary cancer center. Cancer. 2011 Aug 15; 117(16):3860-6. View in: Pubmed

    • Comparison of four early posttherapy imaging changes (EPTIC; RECIST 1.0, tumor shrinkage, computed tomography tumor density, Choi criteria) in assessing outcome to vascular endothelial growth factor-targeted therapy in patients with advanced renal cell carcinoma. Eur Urol. 2011 May; 59(5):856-62. View in: Pubmed

    • Imaging of lung cancer in the era of molecular medicine. Acad Radiol. 2011 Apr; 18(4):424-36. View in: Pubmed

    • Metastatic pattern of bladder cancer: correlation with the characteristics of the primary tumor. AJR Am J Roentgenol. 2011 Jan; 196(1):117-22. View in: Pubmed

    • Imaging of extraosseous myeloma: CT, PET/CT, and MRI features. AJR Am J Roentgenol. 2010 Nov; 195(5):1057-65. View in: Pubmed

    • CT tumor volume measurement in advanced non-small-cell lung cancer: Performance characteristics of an emerging clinical tool. Acad Radiol. 2011 Jan; 18(1):54-62. View in: Pubmed

    • Adult extragonadal germ cell tumors. AJR Am J Roentgenol. 2010 Oct; 195(4):W274-80. View in: Pubmed

    • New Response Evaluation Criteria in Solid Tumors (RECIST) guidelines for advanced non-small cell lung cancer: comparison with original RECIST and impact on assessment of tumor response to targeted therapy. AJR Am J Roentgenol. 2010 Sep; 195(3):W221-8. View in: Pubmed

    • Surveillance imaging of Hodgkin lymphoma patients in first remission: a clinical and economic analysis. Cancer. 2010 Aug 15; 116(16):3835-42. View in: Pubmed

    • Revised RECIST guideline version 1.1: What oncologists want to know and what radiologists need to know. AJR Am J Roentgenol. 2010 Aug; 195(2):281-9. View in: Pubmed

    • Factorial validity of the Supports Intensity Scale (SIS). Am J Intellect Dev Disabil. 2010 Jul; 115(4):327-39. View in: Pubmed

    • Case report. PET/CT appearance of desmoid tumour of the chest wall. Br J Radiol. 2010 Feb; 83(986):e39-42. View in: Pubmed

    • Molecular target modulation, imaging, and clinical evaluation of gastrointestinal stromal tumor patients treated with sunitinib malate after imatinib failure. Clin Cancer Res. 2009 Sep 15; 15(18):5902-9. View in: Pubmed

    • Venous thrombosis in an outpatient oncologic center: distribution, type, and comorbidities. Ultrasound Q. 2009 Sep; 25(3):145-50. View in: Pubmed

    • Evaluation of low-density neutral oral contrast material in PET/CT for tumor imaging: results of a randomized clinical trial. AJR Am J Roentgenol. 2009 Aug; 193(2):326-32. View in: Pubmed

    • CT and PET/CT findings of T-cell lymphoma. AJR Am J Roentgenol. 2009 Aug; 193(2):349-58. View in: Pubmed

    • Sunitinib treatment in pediatric patients with advanced GIST following failure of imatinib. Pediatr Blood Cancer. 2009 Jul; 52(7):767-71. View in: Pubmed

    • Prognostic significance of mid- and post-ABVD PET imaging in Hodgkin's lymphoma: the importance of involved-field radiotherapy. Ann Oncol. 2009 Nov; 20(11):1848-53. View in: Pubmed

    • ACRIN 6665/RTOG 0132 phase II trial of neoadjuvant imatinib mesylate (IM) for primary and recurrent operable malignant GIST: Imaging findings and correlation with genotype and GLUT4 expression. J Clin Oncol. 2009 May 20; 27(15_suppl):10552. View in: Pubmed

    • Multicenter phase II trial of sunitinib in the treatment of nongastrointestinal stromal tumor sarcomas. J Clin Oncol. 2009 Jul 01; 27(19):3154-60. View in: Pubmed

    • Considerations for the use of imaging tools for phase II treatment trials in oncology. Clin Cancer Res. 2009 Mar 15; 15(6):1891-7. View in: Pubmed

    • Infrequent Tumors of the Gastrointestinal Tract Including Gastrointestinal Stromal Tumor (GIST). PET Clin. 2008 Apr; 3(2):207-15. View in: Pubmed

    • FDG-PET to Measure Response to Targeted Therapy: The Example of Gastrointestinal Stromal Tumor and Imatinib Mesylate (Gleevec). PET Clin. 2008 Jan; 3(1):77-87. View in: Pubmed

    • F-18 FDG PET/CT in the diagnosis and management of a pericardiac paraganglioma. Clin Nucl Med. 2008 Aug; 33(8):545-6. View in: Pubmed

    • Role of PET/CT scanning in initial and post-treatment assessment of Hodgkin disease. J Natl Compr Canc Netw. 2008 Jul; 6(6):623-32. View in: Pubmed

    • The impact of large lesions on the RECIST assessment criteria. J Clin Oncol. 2008 May 20; 26(15_suppl):17560. View in: Pubmed

    • Inhibition of heat shock protein 90 (Hsp90) with the novel agent IPI-504 in metastatic GIST following failure of tyrosine kinase inhibitors (TKIs) or other sarcomas: Clinical results from phase I trial. J Clin Oncol. 2008 May 20; 26(15_suppl):10503. View in: Pubmed

    • Phase I trial of RAD001 (R) and docetaxel (D) in castration resistant prostate cancer (CRPC) with FDG-PET assessment of RAD001 activity. J Clin Oncol. 2008 May 20; 26(15_suppl):5069. View in: Pubmed

    • Tumor imaging metrics core: A centralized service for standardized tumor measurements at a multi-institutional collaborative cancer center. J Clin Oncol. 2008 May 20; 26(15_suppl):20571. View in: Pubmed

    • Early metabolic response to continuous daily dosing of sunitinib in soft tissue sarcomas (STS) other than GIST using FDG- PET. J Clin Oncol. 2008 May 20; 26(15_suppl):10529. View in: Pubmed

    • Targeting the follicular lymphoma microenvironment through blockade of TNFalpha with etanercept. Leuk Lymphoma. 2008 May; 49(5):902-9. View in: Pubmed

    • Phase II trial of lapatinib for brain metastases in patients with human epidermal growth factor receptor 2-positive breast cancer. J Clin Oncol. 2008 Apr 20; 26(12):1993-9. View in: Pubmed

    • Major response to imatinib mesylate in KIT-mutated melanoma. J Clin Oncol. 2008 Apr 20; 26(12):2046-51. View in: Pubmed

    • Clinical, radiographic, and biochemical characterization of multiple myeloma patients with osteonecrosis of the jaw. Clin Cancer Res. 2008 Apr 15; 14(8):2387-95. View in: Pubmed

    • F18-fluorodeoxyglucose-positron emission tomography/computed tomography screening in Li-Fraumeni syndrome. JAMA. 2008 Mar 19; 299(11):1315-9. View in: Pubmed

    • The lessons of GIST--PET and PET/CT: a new paradigm for imaging. Oncologist. 2008; 13 Suppl 2:8-13. View in: Pubmed

    • Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib. Lancet. 2007 Dec 15; 370(9604):2011-9. View in: Pubmed

    • CT and PET: early prognostic indicators of response to imatinib mesylate in patients with gastrointestinal stromal tumor. AJR Am J Roentgenol. 2007 Dec; 189(6):W324-30. View in: Pubmed

    • Impact of acquisition geometry, image processing, and patient size on lesion detection in whole-body 18F-FDG PET. J Nucl Med. 2007 Dec; 48(12):1951-60. View in: Pubmed

    • Efficacy and safety of single-agent pertuzumab, a human epidermal receptor dimerization inhibitor, in patients with non small cell lung cancer. Clin Cancer Res. 2007 Oct 15; 13(20):6175-81. View in: Pubmed

    • Clonal evolution of resistance to imatinib in patients with metastatic gastrointestinal stromal tumors. Clin Cancer Res. 2007 Sep 15; 13(18 Pt 1):5398-405. View in: Pubmed

    • NCCN Task Force report: management of patients with gastrointestinal stromal tumor (GIST)--update of the NCCN clinical practice guidelines. J Natl Compr Canc Netw. 2007 Jul; 5 Suppl 2:S1-29; quiz S30. View in: Pubmed

    • Imaging of Venous Thrombosis in Oncologic Patients. American Journal of Roentgenology(AJR). 2007; 188(5):E136-A115. View in: Pubmed

    • Missed Metastases-Causes and Clinical Relevance. American Journal of Roentgenology(AJR). 2007; 188(5):E145-A115. View in: Pubmed

    • Malignant Melanoma - Not Just Skin Deep!. American Journal of Roentgenology(AJR). 2007; 188(5):E140-A115. View in: Pubmed

    • Deveolpment of a PET/CT database of patient information and scanning parameters. Journal of Nuclear Medicine(JNM). 2007; 48(Abstract Book):199P/701. View in: Pubmed

    • PET/CT quality assurance in clinical trials and good clinical practice. Journal of Nuclear Medicine(JNM). 2007; 48(Abstract Book):448P/2012. View in: Pubmed

    • Diagnosis of venous obstruction and thrombosis by radionuclinde venography in patients with central venous catheters. Journal of Nuclear Medicine(JNM). 2007; 48(Abstract Book):212P/1019. View in: Pubmed

    • Practical methods to minimize occupational radiation exposures in PET and nuclear medicine. Journal of Nuclear Medicine(JNM). 2007; 48(Abstract Book):452 p/2024. View in: Pubmed

    • Inhibition of the heat Shock Protein 90(Hsp90) chaperone with the novel agent PIP-504 to overcome resistance to tyrosine kinase inhibitors (TKIs) in metastatic GIST: Updated results of a phase 1 trial. Journal of Clinical Oncology (JCO). 2007; 25(18S Part 1 of 2):551s/10024. View in: Pubmed

    • Inhibition and flare patterns of metabolic response to the heat shock protein 90(Hsp90) inhibitor IPI-504 visualized by FDG-PET in patients (pts) with advanced gastrointestinal stromal tumors (GIST) resistant to tyrosine kinase inhibitor (TKI) therapy. Journal of Clinical Oncology (JCO). 2007; 25(18S Part 1 of 2):145s/3530. View in: Pubmed

    • Lymphoma: Differentiation of Lymphoma from Other Conditions. American Journal of Roentgenology(AJR). 2007; 188(5):A125. View in: Pubmed

    • 18FDG-PET/CT in Soft Tissue Sarcoma: Looking Beyond GIST. American Journal of Roentgenology(AJR). 2007; 188(5):E429-A191-A195. View in: Pubmed

    • Radiological Response and Toxicity of the New Targeted Molecular Therapies for Cancer-What the Radiologist Needs to Know. American Journal of Roentgenology(AJR). 2007; 188(5):E419 A191-A195. View in: Pubmed

    • Primary Malignant Neoplasms Mimicking Peritoneal Carcinomatosos: CT, MRI, and 18F FDG PET/CT Findings. American Journal of Roentgenology(AJR). 2007; 188(5):E207-A125-A140. View in: Pubmed

    • The Utility of 18F-FDG-PET in the Diagnosis and Management of Colorectal Carcinoma. Seminars in Colon and Rectal Surgery. 2007; In Press. View in: Pubmed

    • New core facility provides a common home for high-tech analysis of tumor images. Inside the Institute. 2007; 12(5):1. View in: Pubmed

    • Inhibiting TNFa with etanercept in relapsed/refractory follicular lymphoma. J Clin Oncol. 2006 Jun 20; 24(18_suppl):17525. View in: Pubmed

    • Patterns of PET response after long-term sunitinib therapy in patients (pts) with imatinib (IM)-resistant gastrointestinal stromal tumors (GIST). J Clin Oncol. 2006 Jun 20; 24(18_suppl):9547. View in: Pubmed

    • Phase II trial of lapatinib for brain metastases in patients with HER2+ breast cancer. J Clin Oncol. 2006 Jun 20; 24(18_suppl):503. View in: Pubmed

    • Assessment of response using FDG-PET and CT in a phase I study of AMN107 alone or in combination with imatinib (IM) in patients with imatinib-resistant (IM-R) gastrointestinal stromal tumors (GIST). J Clin Oncol. 2006 Jun 20; 24(18_suppl):3087. View in: Pubmed

    • Consensus recommendations for the use of 18F-FDG PET as an indicator of therapeutic response in patients in National Cancer Institute Trials. J Nucl Med. 2006 Jun; 47(6):1059-66. View in: Pubmed

    • Clonal Evolution of Resistance to Imatinib in Patients with Metastic GIST: Molecular and Radiologic Evaluation of New Lesions. 2006. View in: Pubmed

    • Results with AMN107, a novel kinase inhibitor, in gastrointestinal stromal tumor (GIST): preclinical rationale and early results in a patient (Pt) with imatinib (IM)-resistant GIST. American Society of Clinical Oncology (ASCO): Gastrointestinal Cancers Symposium; San Francisco, CA. 2006. View in: Pubmed

    • Inhibiting TNF with etanercept in relapsed/refractory follicular lymphoma. American Society of Clinical Oncology (ASCO). 2006; 24:682s. View in: Pubmed

    • Assessment of response using FDG-PET and CT in a phase I study of AMN107 alone or in combination with imatinib (IM) in patients with imatinib-resistant (IM-R) gastrointestinal stromal tumors (GIST). American Society of Clinical Oncology (ASCO). 2006; 24:142s. View in: Pubmed

    • FDG-PET imaging demonstrates metabolic response to SU11248 (sunitinib malate) within 7 days in GIST patients resistant to or intolerant of imatinib mesylate. ICACT. 2006; 17:241. View in: Pubmed

    • Pahe II trial of lapatinib for brain metastases in patients with HER2+ breast cancer. American Society of Clinical Oncology (ASCO). 2006; 24:3s. View in: Pubmed

    • Patterns of PET response after long-term sunitinib therapy in patients (pts) with imatinib (IM)-resistant gastrointestinal stromal tumors (GIST). American Society of Clinical Oncology. 2006; 24:531s. View in: Pubmed

    • Phase I dose-escalation study of the SRC and multi-kinase inhibitor BMS-354825 in patients (pts) with GIST and other solid tumors. J Clin Oncol. 2005 Jun; 23(16_suppl):3034. View in: Pubmed

    • Imaging kinase target inhibition with SU11248 by FDG-PET in patients (pts) with imatinib-resistant gastrointestinal stromal tumors (I-R GIST). J Clin Oncol. 2005 Jun; 23(16_suppl):9006. View in: Pubmed

    • 2-Deoxy-2-[F-18]fluoro-D-glucose-positron emission tomography of the head and neck: an atlas of normal uptake and variants. Mol Imaging Biol. 2005 May-Jun; 7(3):244-56. View in: Pubmed

    • Gastrointestinal stromal tumor: new nodule-within-a-mass pattern of recurrence after partial response to imatinib mesylate. Radiology. 2005 Jun; 235(3):892-8. View in: Pubmed

    • Tumor Ablation: Principles and Practice. 2005; 121-134.. View in: Pubmed

    • Qualitative assessment of FDG PET correlates with clinical benefit in patients with imatinib mesylate-resistant GIST treated with multi-targeted tyrosine kinase inhibitor SU11248. American Society of Clinical Oncology (ASCO): Gastrointestinal Cancers Symposium; Hollywood, FL. 2005. View in: Pubmed

    • Imaging kinase target inhibition with SU11248 by FDG-PET in patients (pts) with imatinib-resistant gastrointestinal stromal tumors (I-R GIST). American Society of Clinical Oncology (ASCO); Orlando, FL. 2005. View in: Pubmed

    • Seeing into cells: the promise of in vivo molecular imaging in oncology. 2005. View in: Pubmed

    • Positron Emission Tomography Imaging for Tumor Ablation. Tumor Ablation: Principles and Practice. 2005; 121-134.. View in: Pubmed

    • FDG-PET imaging demonstrates kinase target inhibition by sunitinib malate (SU11248) in GIST patients resistant to or intolerant of imatinib mesylate. The European Cancer Conference (ECCO 13); Paris, France. 2005. View in: Pubmed

    • Mid- and post-ABVD gallium scanning predicts for recurrence in early-stage Hodgkin's disease. Int J Radiat Oncol Biol Phys. 2005 Jan 01; 61(1):175-84. View in: Pubmed

    • Positron emission tomography with 18F-fluorodeoxyglucose to predict pathologic response after induction chemotherapy and definitive chemoradiotherapy in head and neck cancer. Head Neck. 2004 Oct; 26(10):890-6. View in: Pubmed

    • Phase II study of the antiangiogenic agent SU5416 in patients with advanced soft tissue sarcomas. Clin Cancer Res. 2004 Sep 01; 10(17):5732-40. View in: Pubmed

    • Use of computerized tomography (CT) as an early prognostic indicator of response to imatinib mesylate (IM) in patients with gastrointestinal stromal tumors (GIST). J Clin Oncol. 2004 Jul 15; 22(14_suppl):3011. View in: Pubmed

    • Combination signal transduction inhibition: a phase I/II trial of the oral mTOR-inhibitor everolimus (E, RAD001) and imatinib mesylate (IM) in patients (pts) with gastrointestinal stromal tumor (GIST) refractory to IM. J Clin Oncol. 2004 Jul 15; 22(14_suppl):3002. View in: Pubmed

    • Clonal evolution of resistance to imatinib (IM) in patients (pts) with gastrointestinal stromal tumor (GIST): molecular and radiologic evaluation of new lesions. J Clin Oncol. 2004 Jul 15; 22(14_suppl):3010. View in: Pubmed

    • Effects of cessation of imatinib mesylate (IM) therapy in patients (pts) with IM-refractory gastrointestinal stromal tumors (GIST) as visualized by FDG-PET scanning. J Clin Oncol. 2004 Jul 15; 22(14_suppl):3012. View in: Pubmed

    • Safety and efficacy of percutaneous radio-frequency ablation (RFA) in patients (pts) with metastatic gastrointestinal stromal tumor (GIST) with clonal evolution of lesions refractory to imatinib mesylate (IM). J Clin Oncol. 2004 Jul 15; 22(14_suppl):9024. View in: Pubmed

    • SU11248, a multi-targeted tyrosine kinase inhibitor, can overcome imatinib (IM) resistance caused by diverse genomic mechanisms in patients (pts) with metastatic gastrointestinal stromal tumor (GIST). J Clin Oncol. 2004 Jul 15; 22(14_suppl):3001. View in: Pubmed

    • Combination signal transduction inhibition: a phase I/II trial of the oral mTOR-inhibitor everolimus (E, RAD001)and imatinib mesylate (IM, Glivac/Gleevac) in patients with gastrointestinal stromal tumor (GIST)refractory to IM. American Society of Clinical Oncology (ASCO) Conference; New Orleans, LA. 2004. View in: Pubmed

    • SU11248, a multi-targeted tyrosine kinase inhibitor, can overcome Imatinib (IM) resistance caused by diverse genomic mechanisms in patients (pts) with metastatic gastrointestinal stromal tumor (GIST). New Orleans, LA. American Society of Clincal Oncology (ASCO) Conference. 2004. View in: Pubmed

    • Combination signal transduction inhibition: a phase 1 and 2 trial of the oral mTOR-inhibitor everolimus (ERAD001) and imatinib mesylate (IM, Glivac r/Gleevac r) in patients (pts) with gastrointestinal stromal tumor (GIST) refactory to IM. American Society of Clinical Oncology (ASCO) Conference. 2004. View in: Pubmed

    • Effects of cessation of imatinib mesylate therapy in patients with IM-refractory gastrointestinal stromal tumors (GIST)as visualized by FDG-PET scanning. American Society of Clinical Oncology (ASCO) Conference; New Orleans, LA. 2004. View in: Pubmed

    • Safety and efficacy of percutaneous Radio-Frequency Ablation (RFA)in patients (pts) with metastatic gastrointestinal stromal tumor (GIST)with clonal evolution of lesions refractory to imatinib mesylate (IM). American Society of Clinical Oncology (ASCO) Conference; New Orleans, LA. 2004. View in: Pubmed

    • Effects of cesssation of imatinib mesylate (IM) therapy in patients (pts) with IM-refactory gastrointestinal stromal tumors (GIST)as visualized by FDG-PET scanning. American Soceity of Clinical Oncology (ASCO) Conference. 2004. View in: Pubmed

    • Clonal evaluation of resistance to imatinib in patients with gastrointestinal stromal tumor (GIST): Molecular and radiologic evaluation of new lesions. American Society of Clinical Oncology (ASCO)Conference. New Orleans, LA. 2004. View in: Pubmed

    • The era of molecular therapy: redifining the treatment of gastrointestinal stromal tumors (GIST). 2004. View in: Pubmed

    • Safety and efficacy of percutaneous Radio-Frequency Ablation (RFA)in patients (Pts) with metastatic gastrointestinal stromal tumor (GIST)with clonal evolution of lesions refractory to imatinib mesylate (IM). American Society of Clinical Oncology (ASCO) Conference. 2004. View in: Pubmed

    • SU11248, a multi-targeted tyrosine kinase inhibitor, can overcome Imatinib (IM) resistance caused by stromal tumor (GIST). American Society of Clinical Oncology (ASCO)Conference. 2004. View in: Pubmed

    • Clonal evolution of resistance to imatinib (IM) in patients (pts) with gastrointestinal stromal tumor (GIST). Molecular and radiologic evalution of new lesions. American Society of clinical Oncology (ASCO) Conference. 2004. View in: Pubmed

    • Optimal management of patients with gastrointestinal stromal tumors (GIST). 2004. View in: Pubmed

    • NCCN Task Force report: optimal management of patients with gastrointestinal stromal tumor (GIST)--expansion and update of NCCN clinical practice guidelines. J Natl Compr Canc Netw. 2004 May; 2 Suppl 1:S-1-26; quiz 27-30. View in: Pubmed

    • Long-term follow up of advanced gastrointestinal stromal tumor (GIST) patients treated with imatinib mesylate. Gastrointestinal Cancers Symposium; San Francisco, CA. 2004. View in: Pubmed

    • Long-term follow upof advanced gastrointestinal stromal tumors (GIST) patients treated with imatinib mesylate. Gastointestinal Cancers Symposium . 2004. View in: Pubmed

    • FDG-PET is superior to gallium scintigraphy in staging and more sensitive in the follow-up of patients with de novo Hodgkin lymphoma: a blinded comparison. Leuk Lymphoma. 2004 Jan; 45(1):85-92. View in: Pubmed

    • A CME newsletter publication covering key clinical issues in the management of GIST, including highlights from the 2003 CTOS annual meeting and Helsinki GIST symposium. 2004. View in: Pubmed

    • Use of Computerized Tomography as an Early Prognostic Indicator of Response to Imatinib Mesylate in Patient with Gastrointestinal Stromal Tumors (GIST). Annual Meeting of the American Society of Clinical Oncology, New Orleans, LA. 2004. View in: Pubmed

    • Non-Hodgkin's Lymphomas. 2004; 155-169. View in: Pubmed

    • Activity and tolerability of the multi-targeted tyrosine kinase inhibitor SU011248 in patients (pts) with metastatic gastrointestinal stromal tumor (GIST) refractory to imatinib mesylate. American Society of Clinical Oncology (ASCO): Gastrointestinal Cancers Symposium; San Francisco, CA. 2004. View in: Pubmed

    • Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor. J Clin Oncol. 2003 Dec 01; 21(23):4342-9. View in: Pubmed

    • Physiologic and benign causes of FDG uptake in oncologic FDG-PET imaging. Radiological Society of North America (RSNA) Conference. Chicago, IL. 2003. View in: Pubmed

    • Physiologic and benign causes of FDG uptake in oncologic FDG-PET imaging. Radiological Society of North America (RSNA)Conference. 2003. View in: Pubmed

    • Evaluation of a Model Based Scatter Correction in Clinical 3D PET. IEEE Medical Imaging Conference. Portland, OR. 2003. View in: Pubmed

    • Prospective comparison of imaging findings in the lung, hilum and spleen on FDG-PET and GA-67 scintigraphy in patients with hodgkin's disease prior to and following chemotherapy with ABVD. Radiological Society of North America (RSNA) Conference. Chicago, IL. 2003. View in: Pubmed

    • Impact of patient size, acquisition mode, reconstruction algorithm, and randoms and attenuation corrections on lesion detection and activity estimation in whole-body FDG-PET. IEEE Medical Imaging Conference. Portland, OR. 2003. View in: Pubmed

    • Prospective comparison of imaging finding in the lung, hilum and spleen on FDG-PET and GA-67 scintigraphy in patients with hodgkin's disease prior to and following chemotherapy with ABVD. Radiological Society of North America (RSNA) Conference. . 2003. View in: Pubmed

    • Impact of patient size, aquisition mode, reconstruction algorithm, and randoms and attenuation corrections on lesion detection and activity estmiation in whole-body FDG-PET. IEEE Medical Imaging Conference. 2003. View in: Pubmed

    • Evaluation of a Monte Carlo scatter correction in clinical 3D PET. IEEE Medical Imaging Conference. 2003. View in: Pubmed

    • Impact of patients size, Acquisition mode, reconstruction algorithm, and random and attenuation corrections on lesion detection and activity estimation in whole-body FDG-PET. IEEE Medical Imaging Conference. 2003. View in: Pubmed

    • Assessing biological responses to SU11248 in a Phase I clinical trial of patients with imatinib -resistant gastrointestinal stromal tumors (GIST):. Pharmacodynamic evaluation using 18 FDG-PET functional imaging, pharmacokinetics, and modulation of blood biomarkers. 2003. View in: Pubmed

    • Assessing biological responses to SU11248 in a Phase I clinical trial of patients with imatinib-resistant gastrointestinal stromal tumors (GIST): Pharmacodynamic evaluation using FDG-PET functional imaging, pharmacokinetics, and modulation of blood biomarkers. ISMRM Workshop on Cellular and Molecular Imaging in Diagnostics and Therapy. Orlando, FL. 2003. View in: Pubmed

    • Medical Progress, Esophageal Cancer. New Engl. J. Med. 2003. View in: Pubmed

    • Biological activity of the multi-targeted tyrosine kinase inhibitor SU11248 in patients with malignant gastrointestinal Stromal tumor (GIST)refractory to imatinib mesylate. AACR. 2003; 44:967. View in: Pubmed

    • Dependence of performace of whole-body-FDG-PET lesion detection and activity estimation on patient size, randoms, variance reduction, and acquisition geometry. J Nucl Med. 2003; 44(5):61. View in: Pubmed

    • Clinical activity and tolerability of the multi-targeted tyrosine kinase inhibitor SU11248 in patients with malignant gastrointestinal stromal tumor (GIST) refractory to imatinib mesylate. Proc Am Soc Clin Oncol. 2003; 22:814A. View in: Pubmed

    • Molecular-genetic imaging: current and future perspective. 2003. View in: Pubmed

    • Pharmacokinetic and pharmacodynamic evaluation of SU11248 in a phase I clinical trial of patients with imatinib-resistant gastrointestinal stromal tumor (GIST). Proc Am Soc Clin Oncol. 2003; 22:192A. View in: Pubmed

    • Novel patterns of progression following initial response to Imatinib in patients with malignant gastrointestinal stromal tumors (GIST). Proc Am Soc Clin Oncol. 2003; 22:230A. View in: Pubmed

    • FDG-PET as a Surrogate Marker for the Response to Gleevec (Imatinib Mesylate) in Patients with Advanced Gastrointestinal Stromal Tumors (GIST). J Nucl Med. 2003; 44(5):24-25. View in: Pubmed

    • Radiographic Evaluation of Cancer. Atlas of Diagnostic Oncology. 2003; 5-26. View in: Pubmed

    • Non-Hodgkin's Lymphomas. Nuclear Medicine. 2003. View in: Pubmed

    • Pet Imaging: Tumor Ablation: Principles and Practice. 2003. View in: Pubmed

    • A New Role for PET Scanning. The American Journal of Oncology Reivew. 2003; 367-368. View in: Pubmed

    • Decreases in circulating levels of soluble KIT in patients with imatinib-resistant gastrointestinal Stromal tumor (GIST) receiving the novel kinases inhibitor SU11248: Correlative analysis of blood and plasma biomarkers. AACR. 2003; 44:587. View in: Pubmed

    • Use of positron emission tomography in oncology and its potential role to assess response to imatinib mesylate therapy in gastrointestinal stromal tumors (GISTs). Eur J Cancer. 2002 Sep; 38 Suppl 5:S60-5. View in: Pubmed

    • Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N Engl J Med. 2002 Aug 15; 347(7):472-80. View in: Pubmed

    • A Pilot study of Imatinib Mesylate (Gleevec) prior to prostatectomy in men with newly diagnosed prostate cancer. CaPCURE Scientific Retreat. 2002. View in: Pubmed

    • The role of FDG-PET in patients with squamous cell cancer of the head and neck after sequential induction chemotherapy and definitive chemoradiotherapy. J Nucl Med. 2002; 43:P73. View in: Pubmed

    • FDG-PET as a key tool in the diagnosis and monitoring of GIST. In first Successful Treatment for GIST. 2002. View in: Pubmed

    • A Pilot study Imatinib Mesylate prior to prostatectomy in men with newly diagnosed prostate cancer. 2002. View in: Pubmed

    • The use of FDG-PET to detect residual disease after induction chemotherapy and definite chemoradiotherapy for squamous cell cancer of the head and neck. Sixth Research Workshop on the Biology,Prevention, and Treatment of Head and Neck Cancer. 2002. View in: Pubmed

    • FDG-PET is superior to gallium-67 scintigraphy in the staging and follow-up of patients with Hodgkin's disease: a prospective, blinded comparison. J Nucl Med. 2002; 43:P30-P31. View in: Pubmed

    • PET imaging and treatment evaluation in cancer patients. 2002. View in: Pubmed

    • Impact of acquisition geometry and lesion size on tumor detectability in patient whole body PET: A channelized hotelling observer study. IEEE meeting. 2002. View in: Pubmed

    • PET. Medstar. 2002. View in: Pubmed

    • A comparison of 2D and 3D FDG-PET images on a high performance BGO scanner using an interleaved septa-in/septa-out acquisition protocol. Molecular Imaging and Biology. 2002; 4:44S. View in: Pubmed

    • Impact of acquisition geometry and size on tumor detectability in patient whole body PET:. A Channelized hotelling observer study. 2002. View in: Pubmed

    • Response to imatinib mesylate (Gleevec) therapy in patients with advanced gastrointestinal stromal tumors (GIST) is demonstrated by F-18-FDG-PET prior to anatomic imaging with CT. Radiology. 2002; 225:P424. View in: Pubmed

    • F-FDG-PET predicts response to Imatinib mesylate (Gleevec) in patients with advanced gastrointestinal stromal tumors (GIST). Proc Am Soc Clin Oncol. 2002; 21:P403a. View in: Pubmed

    • A day in the life of the Dana-Farber Cancer Institute. 2001. View in: Pubmed

    • The use of FDG-PET to detect residual disease after sequential therapy with induction chemotherapy and definitive chemoradiotherapy for squamous cell cancer of the head and neck. The second International Chicago Symposium on Malignancies of the Chest and Head and neck. 2001. View in: Pubmed

    • The use of FDG-PET to detect residual disease after sequential therapy with induction chemotherapy and definitive chemoradiotherapy for squamous cell cancer of the head and neck. The Second International Chicago Symposium on Malginancies of the Chest and Head & Neck. 2001; abst. 76. View in: Pubmed

    • A prospective blinded comparison of positron emission tomography(PET)with gallium/SPECT scintigraphy in the staging and follow-up of patients with de novo Hodgkin's disease. International Lymphoma Conference, Lausanne. 2001. View in: Pubmed

    • A prospective blind comparison of positron emission tomography (PET) with gallium/SPECT scintigraphy in the staging and follow up of patients with de novo Hodgkin's disease. 2001. View in: Pubmed

    • GIST tumors and Glivec. 2001. View in: Pubmed

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    • A potential murine model for flap-related investigations. Plast Reconstr Surg. 2001 May; 107(6):1504-8. View in: Pubmed

    • Breast Cancer. 2001. View in: Pubmed

    • F18-FDG-PET provides early evidence of biological response to ST1571 in patients with malignant gastrointestinal stromal tumors (GIST). Proc Am Soc Clin Oncol. 2001; 20:P362a. View in: Pubmed

    • PET documents Gleevec tumor-fighting power. Diagnostic Imaging. 2001; 1(2):4. View in: Pubmed

    • Prognostic significance of the number of bone scan abnormalities at the time of initial bone metastatic recurrence in breast carcinoma. Cancer. 2001 Jan 01; 91(1):17-24. View in: Pubmed

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    • The treatment and outcome of cancer patients with thromboses on central venous catheters. J Thromb Thrombolysis. 2000 Dec; 10(3):271-5. View in: Pubmed

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    • When is hilar uptake of 67Ga-citrate indicative of residual disease after CHOP chemotherapy? J Nucl Med. 2000 Feb; 41(2):269-74. View in: Pubmed

    • Relative Lesion detectability in 3D vs. 2D dedicated multi-ring PET. 2000. View in: Pubmed

    • The use of FDG-PET to detect residual disease after induction chemotherapy and definite chemoradiotherapy for squamous cell cancer of the head and neck. Sixth Research Workshop on the Biology, Prevention, and Treatment of Head and Neck Cancer. Virginia. 2000. View in: Pubmed

    • Relative lesion detectability in 3D vs. 2D dedicated multi-ring PET. IEEE meeting 2000, Lyon, France. 2000. View in: Pubmed

    • Advances at the Frontier of Cancer Diagnosis: PET scanner opens a window on cancer. Paths of Progress. 2000. View in: Pubmed

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    • Lymphoscintigraphy. Teaching Atlas of Nuclear Medicine. Donohoe K, Van den Abbeele A. 2000; 369-374. View in: Pubmed

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    • Primary cardiac angiosarcoma presenting as a malignant pericardial effusion. J Clin Oncol. 1998 Dec; 16(12):3913-5. View in: Pubmed

    • 5-[125I]iodo-2'-deoxyuridine in the radiotherapy of brain tumors in rats. J Nucl Med. 1998 Jul; 39(7):1148-54. View in: Pubmed

    • Biodistribution of radiolabeled MOv18 in nude mice bearing ovarian cancer xenografts. Proceeding of the Fourth International Conference on Monoclonal Antibody lmmunoconjugates for Cancer. 1998; 97. View in: Pubmed

    • Comparison of Dual-Head Gamma Camera System Sensitivity at 511 keV using a Distance-Dependent Method. American Association of Physicists in Medicine 39th Annual Meeting and Exhibition. Milwaukee, WI. 1997. View in: Pubmed

    • Comparison of Dual-Head Gamma Camera System Sensitivity at 511 KeV using a Distance-Dependent Method. American Association of Physicists in Medicine a 39th Annual Meeting and Exhibition. 1997. View in: Pubmed

    • Procedure guideline for gallium scintigraphy in the evaluation of malignant disease. Society of Nuclear Medicine. J Nucl Med. 1997 Jun; 38(6):990-4. View in: Pubmed

    • An investigation of lymphatic function following free-tissue transfer. Plast Reconstr Surg. 1997 Mar; 99(3):730-41; discussion 742-3. View in: Pubmed

    • Quantification of gallium-67 avidity as a function of the histology in patients with non-Hodgkin's lymphoma. J Nucl Med. 1997; 38:P238. View in: Pubmed

    • The role of SPECT in the evaluation of the abdomen on gallium-67 scintigraphy. J Nucl Med. 1997; 38:P115. View in: Pubmed

    • Determinination of the visibility of simulated lesions in background with 511 KeV SPECT. Proceedings of the European Conference on Research and Application of Positron Emission Tomography in Oncology PET and Cancer. 1996. View in: Pubmed

    • Determination of the visibility of simulated lesions in background with 511 keV SPECT. European Conference on Research and Application of Positron Emission Tomography in Oncology PET and Cancer, Groningen University Hospital, The Netherlands. 1996. View in: Pubmed

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