Arnold S. Freedman, MD

Arnold S. Freedman, MD

Medical Oncology

Contact Information

Office Phone Number

617-582-9086

Fax

617-632-6590

Appointments

617-632-6246 (new)

Biography

Arnold S. Freedman, MD

Dr. Freedman is a Professor of Medicine at Harvard Medical School, a member of Dana-Farber Cancer Institute's Department of Medical Oncology, and an attending physician at Brigham and Women's Hospital. Dr. Freedman has focused on clinical and laboratory research in non-Hodgkin's lymphomas. A graduate of Brandeis University, Dr. Freedman received his M.D. from University of Massachusetts Medical School, and came to Dana-Farber as a fellow in medical oncology in 1982. Dr. Freedman's research interests have focused on the development of new therapies for non-Hodgkin's lymphoma. This includes efforts are toward enhancing the effects of antibody based therapies and understanding how the tumor microenvironment can be manipulated in the treatment of lymphomas.

Researcher

Physician

Institute Physician
Professor of Medicine, Harvard Medical School

Centers/Programs

Stem Cell Transplantation
Lymphoma Program
CNS Lymphoma Center

Clinical Interests

CAR T-cell therapy, Chronic lymphocytic leukemia, Hodgkin disease, Lymphoma, Stem cell/bone marrow transplantation

Board Certification

  • Internal Medicine, 1982
  • Medical Oncology, 1985

Fellowship

  • Dana-Farber Cancer Institute, Hematology & Oncology

Residency

  • Memorial Hospital, Worcester, Internal Medicine

Medical School

  • University of Massachusetts Medical School

Research

    Non-Hodgkin's Lymphomas: Biology and New Therapies

    In our laboratory, we used cDNA arrays to compare the gene expression of germinal center (GC) B cells with follicular lymphoma (FL) cells, and confirmed differentially expressed genes by qRT-PCR. Among the genes upregulated in FL were cell cycle regulator proteins CDK10, p120, p21CIP1, and p16INK4a; transcription factors/regulators Pax-5 and Id-2; and genes involved in cell-cell interactions: TNF-alpha, IL-2R,-g and IL-4R. We also demonstrated that cytogenetic changes in FL cells correlates with the altered expression of some of these genes at their known loci. These findings provide a basis for future studies of the pathogenesis and pathophysiology of follicular lymphoma, and may lead to the identification of potential therapeutic targets as well as antigens for immunotherapeutic strategies. Based upon our array studies and other work, we are focusing on TNF-alpha, which is overexpressed by FL cells, as a therapeutic target in FL. TNF-alpha upregulates expression of adhesion molecules, cytokines, and chemokines that are critical to interactions between FL cells and follicular dendritic cells (FDC). We are currently conducting a clinical trial of etanercept - which binds to TNF-alpha, reducing its biological activities - in patients with relapsed and refractory follicular lymphoma, and also evaluating a variety of surrogate markers of the microenvironment and T cell function in these patients.In other research, we are attempting to modulate the effects of the anti-CD20 monoclonal antibody (mAb) rituximab. We completed a trial of low dose IL-2 with rituximab in which the numbers of natural killer cells increased in the peripheral blood of treated patients. We have also investigated the combination of rituximab with immunostimulatory DNA sequences (ISS), which enhance antigen presentation and costimulatory molecule expression, stimulate dendritic cell maturation, and induce cytokines, resulting in increased cell-mediated cytotoxicity. Through these effects on both the adaptive and innate immune response, ISS are excellent candidates to enhance the cytotoxicity of mAbs such as rituximab. We completed a phase I study of 1018 ISS in combination with rituximab in patients with relapsed non-Hodgkin's lymphoma (NHL), demonstrating safety and biological activity. Given this favorable data, we plan to test the efficacy of combination immunotherapy in a phase II study in patients with relapsed follicular NHL, and to further analyze the immunologic effects of this combination in vitro and in vivo.

    Publications

      • A multi-cohort phase 1b trial of rituximab in combination with immunotherapy doublets in relapsed/refractory follicular lymphoma. Ann Hematol. 2024 Jan; 103(1):185-198. View in: Pubmed

      • Minimal residual disease in patients with diffuse large B-cell lymphoma undergoing autologous stem cell transplantation. Blood Adv. 2023 09 12; 7(17):4748-4759. View in: Pubmed

      • Targeting constitutively active STAT3 in chronic lymphocytic leukemia: A clinical trial of the STAT3 inhibitor pyrimethamine with pharmacodynamic analyses. Am J Hematol. 2021 04 01; 96(4):E95-E98. View in: Pubmed

      • A prospective study of minimal residual disease in patients with diffuse large B-cell lymphoma using an Ig-NGS assay. Leuk Lymphoma. 2021 02; 62(2):478-481. View in: Pubmed

      • Rituximab/bendamustine and rituximab/cytarabine induction therapy for transplant-eligible mantle cell lymphoma. Blood Adv. 2020 03 10; 4(5):858-867. View in: Pubmed

      • PD-1 blockade for diffuse large B-cell lymphoma after autologous stem cell transplantation. Blood Adv. 2020 01 14; 4(1):122-126. View in: Pubmed

      • Follicular lymphoma: 2020 update on diagnosis and management. Am J Hematol. 2020 03; 95(3):316-327. View in: Pubmed

      • Efficacy results of a phase 2 trial of first-line idelalisib plus ofatumumab in chronic lymphocytic leukemia. Blood Adv. 2019 04 09; 3(7):1167-1174. View in: Pubmed

      • PD-1 blockade with pembrolizumab for classical Hodgkin lymphoma after autologous stem cell transplantation. Blood. 2019 07 04; 134(1):22-29. View in: Pubmed

      • Increased Risk of Infectious Complications in Older Patients With Indolent Non-Hodgkin Lymphoma Exposed to Bendamustine. Clin Infect Dis. 2019 01 07; 68(2):247-255. View in: Pubmed

      • Safety, tolerability, and preliminary activity of IMGN529, a CD37-targeted antibody-drug conjugate, in patients with relapsed or refractory B-cell non-Hodgkin lymphoma: a dose-escalation, phase I study. Invest New Drugs. 2018 10; 36(5):869-876. View in: Pubmed

      • Follicular lymphoma: 2018 update on diagnosis and management. Am J Hematol. 2018 Feb; 93(2):296-305. View in: Pubmed

      • Persistence of dysphagia and odynophagia after mediastinal radiation and chemotherapy in patients with lung cancer or lymphoma. Dis Esophagus. 2017 02 01; 30(2):1-8. View in: Pubmed

      • Clonal Hematopoiesis Associated With Adverse Outcomes After Autologous Stem-Cell Transplantation for Lymphoma. J Clin Oncol. 2017 May 10; 35(14):1598-1605. View in: Pubmed

      • Relapsed or Refractory Double-Expressor and Double-Hit Lymphomas Have Inferior Progression-Free Survival After Autologous Stem-Cell Transplantation. J Clin Oncol. 2017 Jan; 35(1):24-31. View in: Pubmed

      • The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice. Cancer Cell. 2016 07 11; 30(1):183. View in: Pubmed

      • Is There a Best Initial Treatment for a New Patient With Low Grade Follicular Lymphoma. Curr Hematol Malig Rep. 2016 06; 11(3):218-23. View in: Pubmed

      • Idelalisib given front-line for treatment of chronic lymphocytic leukemia causes frequent immune-mediated hepatotoxicity. Blood. 2016 07 14; 128(2):195-203. View in: Pubmed

      • The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice. Cancer Cell. 2016 04 11; 29(4):574-586. View in: Pubmed

      • A phase 2 study of Rituximab-Bendamustine and Rituximab-Cytarabine for transplant-eligible patients with mantle cell lymphoma. Br J Haematol. 2016 Apr; 173(1):89-95. View in: Pubmed

      • Follicular lymphoma: 2015 update on diagnosis and management. Am J Hematol. 2015 Dec; 90(12):1171-8. View in: Pubmed

      • Rethinking Prognosis and Therapy for Follicular Lymphoma. J Clin Oncol. 2015 Aug 10; 33(23):2489-91. View in: Pubmed

      • Obatoclax in combination with fludarabine and rituximab is well-tolerated and shows promising clinical activity in relapsed chronic lymphocytic leukemia. Leuk Lymphoma. 2015; 56(12):3336-42. View in: Pubmed

      • Is observation dead in follicular lymphoma? Still appropriate. J Natl Compr Canc Netw. 2015 Mar; 13(3):367-70. View in: Pubmed

      • Early lymphoid lesions: conceptual, diagnostic and clinical challenges. Haematologica. 2014 Sep; 99(9):1421-32. View in: Pubmed

      • Imatinib mesylate lacks efficacy in relapsed/refractory peripheral T cell lymphoma. Leuk Lymphoma. 2015 Apr; 56(4):993-8. View in: Pubmed

      • Genetic variation in DNA repair pathways and risk of non-Hodgkin's lymphoma. PLoS One. 2014; 9(7):e101685. View in: Pubmed

      • Active idiotypic vaccination versus control immunotherapy for follicular lymphoma. J Clin Oncol. 2014 Jun 10; 32(17):1797-803. View in: Pubmed

      • Follicular lymphoma: 2014 update on diagnosis and management. Am J Hematol. 2014 Apr; 89(4):429-36. View in: Pubmed

      • Phase IA/II, multicentre, open-label study of the CD40 antagonistic monoclonal antibody lucatumumab in adult patients with advanced non-Hodgkin or Hodgkin lymphoma. Br J Haematol. 2014 Jan; 164(2):258-65. View in: Pubmed

      • One size does not fit all in follicular lymphoma. J Clin Oncol. 2013 Sep 20; 31(27):3307-8. View in: Pubmed

      • Detection of circulating tumour DNA in patients with aggressive B-cell non-Hodgkin lymphoma. Br J Haematol. 2013 Oct; 163(1):123-6. View in: Pubmed

      • A phase I study of escalated dose subcutaneous alemtuzumab given weekly with rituximab in relapsed chronic lymphocytic leukemia/small lymphocytic lymphoma. Haematologica. 2013 Jun; 98(6):964-70. View in: Pubmed

      • First-line treatment of indolent lymphoma: axing CHOP? Lancet. 2013 Apr 06; 381(9873):1163-5. View in: Pubmed

      • Low-dose involved-field radiation in the treatment of non-hodgkin lymphoma: predictors of response and treatment failure. Int J Radiat Oncol Biol Phys. 2013 May 01; 86(1):121-7. View in: Pubmed

      • Prognostic factors for patients with diffuse large B cell lymphoma and transformed indolent lymphoma undergoing autologous stem cell transplantation in the positron emission tomography era. Br J Haematol. 2013 Mar; 160(5):608-17. View in: Pubmed

      • Everolimus in combination with rituximab induces complete responses in heavily pretreated diffuse large B-cell lymphoma. Haematologica. 2013 Apr; 98(4):615-9. View in: Pubmed

      • Follicular lymphoma: 2012 update on diagnosis and management. Am J Hematol. 2012 Oct; 87(10):988-95. View in: Pubmed

      • Early stage follicular lymphoma, current management and controversies. Curr Opin Oncol. 2012 Sep; 24(5):475-9. View in: Pubmed

      • Primary bone lymphoma involving bilateral tibia. Am J Hematol. 2012 Sep; 87(9):924-5. View in: Pubmed

      • Integrative genomic analysis implicates gain of PIK3CA at 3q26 and MYC at 8q24 in chronic lymphocytic leukemia. Clin Cancer Res. 2012 Jul 15; 18(14):3791-802. View in: Pubmed

      • Germline copy number variation associated with Mendelian inheritance of CLL in two families. Leukemia. 2012 Jul; 26(7):1710-3. View in: Pubmed

      • Risk factors for development of pneumonitis after high-dose chemotherapy with cyclophosphamide, BCNU and etoposide followed by autologous stem cell transplant. Leuk Lymphoma. 2012 Jun; 53(6):1130-6. View in: Pubmed

      • Predictive factors for radiation pneumonitis in Hodgkin lymphoma patients receiving combined-modality therapy. Int J Radiat Oncol Biol Phys. 2012 May 01; 83(1):277-83. View in: Pubmed

      • Follicular lymphoma: 2011 update on diagnosis and management. Am J Hematol. 2011 Sep; 86(9):768-75. View in: Pubmed

      • Expression of mesenchyme-specific gene signatures by follicular dendritic cells: insights from the meta-analysis of microarray data from multiple mouse cell populations. Immunology. 2011 Aug; 133(4):482-98. View in: Pubmed

      • Early initial therapy of advanced follicular lymphoma: the need for vigilance. Leuk Lymphoma. 2011 Mar; 52(3):355-7. View in: Pubmed

      • A phase III study of anti-B4-blocked ricin as adjuvant therapy post-autologous bone marrow transplant: CALGB 9254. Leuk Lymphoma. 2011 Apr; 52(4):587-96. View in: Pubmed

      • (90)Y-ibritumomab tiuxetan followed by reduced-intensity conditioning and allo-SCT in patients with advanced follicular lymphoma. Bone Marrow Transplant. 2011 Dec; 46(12):1503-9. View in: Pubmed

      • A large single-center experience with allogeneic stem-cell transplantation for peripheral T-cell non-Hodgkin lymphoma and advanced mycosis fungoides/Sezary syndrome. Ann Oncol. 2011 Jul; 22(7):1608-1613. View in: Pubmed

      • A phase I study of lenalidomide in combination with fludarabine and rituximab in previously untreated CLL/SLL. Leukemia. 2010 Nov; 24(11):1972-5. View in: Pubmed

      • Comparison of familial and sporadic chronic lymphocytic leukaemia using high resolution array comparative genomic hybridization. Br J Haematol. 2010 Nov; 151(4):336-45. View in: Pubmed

      • Down-regulation of CD9 expression and its correlation to tumor progression in B lymphomas. Am J Pathol. 2010 Jul; 177(1):377-86. View in: Pubmed

      • Epstein-barr virus-associated diffuse large B-cell lymphoma in an immunocompetent woman. J Clin Oncol. 2010 Feb 10; 28(5):e75-8. View in: Pubmed

      • ASCT in follicular lymphoma. Nat Rev Clin Oncol. 2009 Jul; 6(7):380-2. View in: Pubmed

      • Phase II study of a TLR-9 agonist (1018 ISS) with rituximab in patients with relapsed or refractory follicular lymphoma. Br J Haematol. 2009 Aug; 146(3):282-91. View in: Pubmed

      • Placebo-controlled phase III trial of patient-specific immunotherapy with mitumprotimut-T and granulocyte-macrophage colony-stimulating factor after rituximab in patients with follicular lymphoma. J Clin Oncol. 2009 Jun 20; 27(18):3036-43. View in: Pubmed

      • A phase 2 study of concurrent fludarabine and rituximab for the treatment of marginal zone lymphomas. Br J Haematol. 2009 Jun; 145(6):741-8. View in: Pubmed

      • Improved survival in lymphoma patients receiving sirolimus for graft-versus-host disease prophylaxis after allogeneic hematopoietic stem-cell transplantation with reduced-intensity conditioning. J Clin Oncol. 2008 Dec 10; 26(35):5767-74. View in: Pubmed

      • Systematic genomic screen for tyrosine kinase mutations in CLL. Leukemia. 2008 Oct; 22(10):1966-9. View in: Pubmed

      • Prevalence of familial malignancy in a prospectively screened cohort of patients with lymphoproliferative disorders. Br J Haematol. 2008 Nov; 143(3):361-8. View in: Pubmed

      • Response to low-dose involved-field radiotherapy in patients with non-Hodgkin's lymphoma. Ann Oncol. 2008 Dec; 19(12):2043-7. View in: Pubmed

      • Targeting the follicular lymphoma microenvironment through blockade of TNFalpha with etanercept. Leuk Lymphoma. 2008 May; 49(5):902-9. View in: Pubmed

      • Allogeneic transplantation with reduced-intensity conditioning for Hodgkin and non-Hodgkin lymphoma: importance of histology for outcome. Biol Blood Marrow Transplant. 2008 Apr; 14(4):418-25. View in: Pubmed

      • Antibody and immunomodulatory agents in the treatment of indolent non-Hodgkin's lymphoma. Semin Hematol. 2008 Apr; 45(2):85-9. View in: Pubmed

      • Long-term survival after autologous bone marrow transplantation for follicular lymphoma in first remission. Biol Blood Marrow Transplant. 2007 Sep; 13(9):1057-65. View in: Pubmed

      • Myeloablative therapy with autologous bone marrow transplantation for follicular lymphoma at the time of second or subsequent remission: long-term follow-up. J Clin Oncol. 2007 Jun 20; 25(18):2554-9. View in: Pubmed

      • Novel presentation of intraneural nodular fasciitis of the sciatic nerve. J Peripher Nerv Syst. 2007 Mar; 12(1):61-3. View in: Pubmed

      • Antibody and immunomodulatory agents in treatment of indolent non-Hodgkin's lymphoma. Curr Treat Options Oncol. 2006 Jul; 7(4):276-84. View in: Pubmed

      • Inhibiting TNFa with etanercept in relapsed/refractory follicular lymphoma. J Clin Oncol. 2006 Jun 20; 24(18_suppl):17525. View in: Pubmed

      • Non-transplant-related treatment options in follicular lymphoma. Biol Blood Marrow Transplant. 2006 Jan; 12(1 Suppl 1):53-8. View in: Pubmed

      • CD34(+) CD38(-) and CD34(+) HLA-DR(-) cells in BM stem cell grafts correlate with short-term engraftment but have no influence on long-term hematopoietic reconstitution after autologous transplantation. Cytotherapy. 2006; 8(4):399-407. View in: Pubmed

      • Follicular lymphoma with bilateral testicular and epididymal involvement: case report and review of the literature. Leuk Lymphoma. 2005 Nov; 46(11):1663-6. View in: Pubmed

      • Autologous and allogeneic stem cell transplantations for poor-risk chronic lymphocytic leukemia. Blood. 2005 Dec 15; 106(13):4389-96. View in: Pubmed

      • Increasing incidence of late second malignancies after conditioning with cyclophosphamide and total-body irradiation and autologous bone marrow transplantation for non-Hodgkin's lymphoma. J Clin Oncol. 2005 Apr 01; 23(10):2208-14. View in: Pubmed

      • Biology and management of histologic transformation of indolent lymphoma. Hematology Am Soc Hematol Educ Program. 2005; 314-20. View in: Pubmed

      • TGFbeta-mediated activation of Smad1 in B-cell non-Hodgkin's lymphoma and effect on cell proliferation. Leukemia. 2004 Dec; 18(12):2015-25. View in: Pubmed

      • B-cell purging in autologous stem-cell transplantation for non-Hodgkin lymphoma. Lancet Oncol. 2004 Dec; 5(12):711-7. View in: Pubmed

      • Combination immunotherapy with a CpG oligonucleotide (1018 ISS) and rituximab in patients with non-Hodgkin lymphoma: increased interferon-alpha/beta-inducible gene expression, without significant toxicity. Blood. 2005 Jan 15; 105(2):489-95. View in: Pubmed

      • Hodgkin disease associated with T-cell non-Hodgkin lymphomas: case reports and review of the literature. Am J Clin Pathol. 2004 May; 121(5):701-8. View in: Pubmed

      • Integrins regulate survival of pre-B-ALL cells through differential IAP and caspase-7 ubiquitination and degradation. Leukemia. 2004 Apr; 18(4):873-5. View in: Pubmed

      • An update on the role of high-dose therapy with autologous or allogeneic stem cell transplantation in mantle cell lymphoma. Curr Opin Oncol. 2004 Mar; 16(2):106-13. View in: Pubmed

      • Engraftment of autologous and allogeneic marrow HPCs after myeloablative therapy. Transfusion. 2004 Feb; 44(2):253-61. View in: Pubmed

      • Autologous bone marrow transplantation for marginal zone non-Hodgkin's lymphoma. Leuk Lymphoma. 2004 Feb; 45(2):315-20. View in: Pubmed

      • Oral fludarabine has significant activity in patients with previously untreated chronic lymphocytic leukemia, and leads to increased STAT1 levels in vivo. Leuk Res. 2004 Feb; 28(2):139-47. View in: Pubmed

      • Ex vivo B cell depletion using the Eligix B Cell SC system and autologous peripheral blood stem cell transplantation in patients with follicular non-Hodgkin's lymphoma. Bone Marrow Transplant. 2003 Oct; 32(7):681-6. View in: Pubmed

      • Multicolour fluorescence in situ hybridization analysis of t(14;18)-positive follicular lymphoma and correlation with gene expression data and clinical outcome. Br J Haematol. 2003 Sep; 122(5):745-59. View in: Pubmed

      • Early neutrophil engraftment following autologous BMT provides a functional predictor of long-term hematopoietic reconstitution. Transfusion. 2003 May; 43(5):614-21. View in: Pubmed

      • CXCL13 (BCA-1) is produced by follicular lymphoma cells: role in the accumulation of malignant B cells. Br J Haematol. 2002 Nov; 119(2):492-5. View in: Pubmed

      • Temporal gene expression profile of human precursor B leukemia cells induced by adhesion receptor: identification of pathways regulating B-cell survival. Blood. 2003 Feb 01; 101(3):1118-27. View in: Pubmed

      • The role of Aktand RAFTK in beta1 integrin mediated survival of precursor B-acute lymphoblastic leukemia cells. Leuk Lymphoma. 2002 Aug; 43(8):1663-71. View in: Pubmed

      • Combination immunotherapy with rituximab and interleukin 2 in patients with relapsed or refractory follicular non-Hodgkin's lymphoma. Br J Haematol. 2002 Jun; 117(4):828-34. View in: Pubmed

      • Effect of total body irradiation dose escalation on outcome following T-cell-depleted allogeneic bone marrow transplantation. Biol Blood Marrow Transplant. 2002; 8(3):139-44. View in: Pubmed

      • Gene expression profiling of follicular lymphoma and normal germinal center B cells using cDNA arrays. Blood. 2002 Jan 01; 99(1):282-9. View in: Pubmed

      • Effective purging of autologous hematopoietic stem cells using anti-B-cell monoclonal antibody-coated high-density microparticles prior to high-dose therapy for patients with non-Hodgkin's lymphoma. Biol Blood Marrow Transplant. 2002; 8(8):429-34. View in: Pubmed

      • Breast lymphoma associated with breast implants: two case-reports and a review of the literature. Leuk Lymphoma. 2002 Jan; 43(1):115-9. View in: Pubmed

      • Comparable outcome with T-cell-depleted unrelated-donor versus related-donor allogeneic bone marrow transplantation. Biol Blood Marrow Transplant. 2002; 8(11):601-7. View in: Pubmed

      • Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells. J Exp Med. 2001 Dec 03; 194(11):1625-38. View in: Pubmed

      • MCP-1 modulates chemotaxis by follicular lymphoma cells. Br J Haematol. 2001 Dec; 115(3):554-62. View in: Pubmed

      • CD6+ donor marrow T-cell depletion as the sole form of graft-versus-host disease prophylaxis in patients undergoing allogeneic bone marrow transplant from unrelated donors. J Clin Oncol. 2001 Feb 15; 19(4):1152-9. View in: Pubmed

      • The impact of external beam radiation therapy prior to autologous bone marrow transplantation in patients with non-Hodgkin's lymphoma. Biol Blood Marrow Transplant. 2001; 7(8):446-53. View in: Pubmed

      • Loss of marrow reserve from dose-intensified chemotherapy results in impaired hematopoietic reconstitution after autologous transplantation: CD34(+), CD34(+)38(-), and week-6 CAFC assays predict poor engraftment. Exp Hematol. 2000 Dec; 28(12):1325-33. View in: Pubmed

      • Functional effects of TNF and lymphotoxin alpha1beta2 on FDC-like cells. Cell Immunol. 2000 Aug 01; 203(2):134-43. View in: Pubmed

      • High-dose therapy for follicular lymphoma. Oncology (Williston Park). 2000 Mar; 14(3):321-6, 329; discussion 330-2, 338. View in: Pubmed

      • Long-term follow-up of autologous bone marrow transplantation in patients with relapsed follicular lymphoma. Blood. 1999 Nov 15; 94(10):3325-33. View in: Pubmed

      • Outcome in patients with myelodysplastic syndrome after autologous bone marrow transplantation for non-Hodgkin's lymphoma. J Clin Oncol. 1999 Oct; 17(10):3128-35. View in: Pubmed

      • A Phase II study of adjuvant therapy with anti-B4-blocked ricin after autologous bone marrow transplantation for patients with relapsed B-cell non-Hodgkin's lymphoma. Clin Cancer Res. 1999 Sep; 5(9):2392-8. View in: Pubmed

      • High-dose therapy and stem cell transplantation in follicular lymphoma. Ann Hematol. 1999 May; 78(5):203-11. View in: Pubmed

      • Bone marrow transplantation for low-grade lymphoma and chronic lymphocytic leukemia. Semin Hematol. 1999 Apr; 36(2):209-16. View in: Pubmed

      • PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanismsin haematological malignancies. Hum Mol Genet. 1999 Feb; 8(2):185-93. View in: Pubmed

      • Autologous bone marrow transplantation after histologic transformation of indolent B cell malignancies. Biol Blood Marrow Transplant. 1999; 5(4):262-8. View in: Pubmed

      • Predictive value of clonality assays in patients with non-Hodgkin's lymphoma undergoing autologous bone marrow transplant: a single institution study. Blood. 1998 Jun 15; 91(12):4496-503. View in: Pubmed

      • CD6+ T cell-depleted allogeneic bone marrow transplantation for non-Hodgkin's lymphoma. Bone Marrow Transplant. 1998 Jun; 21(12):1177-81. View in: Pubmed

      • High dose therapy and autologous stem cell transplantation in follicular non-Hodgkin's lymphoma. Leuk Lymphoma. 1998 Jan; 28(3-4):219-30. View in: Pubmed

      • Unbalanced expression of bcl-2 family proteins in follicular lymphoma: contribution of CD40 signaling in promoting survival. Blood. 1998 Jan 01; 91(1):244-51. View in: Pubmed

      • High-dose chemoradiotherapy and anti-B-cell monoclonal antibody-purged autologous bone marrow transplantation in mantle-cell lymphoma: no evidence for long-term remission. J Clin Oncol. 1998 Jan; 16(1):13-8. View in: Pubmed

      • Cyclophosphamide, doxorubicin, vincristine, prednisone dose intensification with granulocyte colony-stimulating factor markedly depletes stem cell reserve for autologous bone marrow transplantation. Blood. 1997 Dec 15; 90(12):4996-5001. View in: Pubmed

      • Association of the Cas-like molecule HEF1 with CrkL following integrin and antigen receptor signaling in human B-cells: potential relevance to neoplastic lymphohematopoietic cells. Leuk Lymphoma. 1997 Dec; 28(1-2):65-72. View in: Pubmed

      • Failure of immunologic purging in mantle cell lymphoma assessed by polymerase chain reaction detection of minimal residual disease. Blood. 1997 Nov 15; 90(10):4212-21. View in: Pubmed

      • The related adhesion focal tyrosine kinase differentially phosphorylates p130Cas and the Cas-like protein, p105HEF1. J Biol Chem. 1997 Aug 08; 272(32):19719-24. View in: Pubmed

      • Regulation of integrin-mediated p130(Cas) tyrosine phosphorylation in human B cells. A role for p59(Fyn) and SHP2. J Biol Chem. 1997 Jun 20; 272(25):15636-41. View in: Pubmed

      • CD6-depleted allogeneic bone marrow transplantation for acute leukemia in first complete remission. Blood. 1997 Apr 15; 89(8):3039-47. View in: Pubmed

      • CD6+ T cell depleted allogeneic bone marrow transplantation from genotypically HLA nonidentical related donors. Biol Blood Marrow Transplant. 1997 Apr; 3(1):11-7. View in: Pubmed

      • Involvement of p130(Cas) and p105(HEF1), a novel Cas-like docking protein, in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells. J Biol Chem. 1997 Feb 14; 272(7):4230-6. View in: Pubmed

      • The related adhesion focal tyrosine kinase is tyrosine-phosphorylated after beta1-integrin stimulation in B cells and binds to p130cas. J Biol Chem. 1997 Jan 03; 272(1):228-32. View in: Pubmed

      • Tyrosine phosphorylation of the product of the c-cbl protooncogene is [corrected] induced after integrin stimulation. Exp Hematol. 1997 Jan; 25(1):45-50. View in: Pubmed

      • High-dose therapy and autologous bone marrow transplantation in patients with follicular lymphoma during first remission. Blood. 1996 Oct 01; 88(7):2780-6. View in: Pubmed

      • Stimulation of tyrosine phosphorylation after ligation of beta7 and beta1 integrins on human B cells. Blood. 1996 Mar 01; 87(5):1855-61. View in: Pubmed

      • Cell surface antigens in leukemias and lymphomas. Cancer Invest. 1996; 14(3):252-76. View in: Pubmed

      • Expression of vascular cell adhesion molecule-1 by follicular dendritic cells. Leuk Lymphoma. 1995 Jul; 18(3-4):259-64. View in: Pubmed

      • Monoclonal antibody-purged bone marrow transplantation therapy for multiple myeloma. Leuk Lymphoma. 1995 Mar; 17(1-2):87-93. View in: Pubmed

      • Role of follicular dendritic cells in the regulation of B cell proliferation. Curr Top Microbiol Immunol. 1995; 201:83-92. View in: Pubmed

      • Myelodysplastic syndrome as a late complication following autologous bone marrow transplantation for non-Hodgkin's lymphoma. J Clin Oncol. 1994 Dec; 12(12):2535-42. View in: Pubmed

      • Detection of residual lymphoma cells by polymerase chain reaction in peripheral blood is significantly less predictive for relapse than detection in bone marrow. Blood. 1994 Jun 15; 83(12):3800-7. View in: Pubmed

      • A phase II study of continuous infusion recombinant human granulocyte-macrophage colony-stimulating factor as an adjunct to autologous bone marrow transplantation for patients with non-Hodgkin's lymphoma in first remission. Blood. 1994 May 01; 83(9):2707-14. View in: Pubmed

      • Selective ablation of rat brain tumors by boron neutron capture therapy. Int J Radiat Oncol Biol Phys. 1994 Mar 30; 28(5):1067-77. View in: Pubmed

      • Adhesion of follicular lymphoma cells to lymphoid germinal centers--a potential mechanism of tumor cell homing following autologous transplantation. Leuk Lymphoma. 1994 Mar; 13(1-2):47-52. View in: Pubmed

      • In vivo expression of the B7 costimulatory molecule by subsets of antigen-presenting cells and the malignant cells of Hodgkin's disease. Blood. 1994 Feb 01; 83(3):793-8. View in: Pubmed

      • Myeloablative therapy with autologous bone marrow transplantation as consolidation therapy for follicular lymphoma. Ann Oncol. 1994; 5 Suppl 2:143-6. View in: Pubmed

      • Monoclonal antibody-purged bone marrow transplantation therapy for multiple myeloma. Blood. 1993 Oct 15; 82(8):2568-76. View in: Pubmed

      • Expression and function of adhesion receptors on normal B cells and B cell non-Hodgkin's lymphomas. Semin Hematol. 1993 Oct; 30(4):318-28. View in: Pubmed

      • Which patients with relapsed non-Hodgkin's lymphoma benefit from high-dose therapy and hematopoietic stem-cell transplantation? J Clin Oncol. 1993 Oct; 11(10):1841-3. View in: Pubmed

      • Monoclonal antibody-purged autologous bone marrow transplantation in adults with acute lymphoblastic leukemia at high risk of relapse. Bone Marrow Transplant. 1993 Sep; 12(3):243-51. View in: Pubmed

      • Autologous and allogeneic bone marrow transplantation for poor prognosis patients with B-cell chronic lymphocytic leukemia. Blood. 1993 Aug 15; 82(4):1366-76. View in: Pubmed

      • Detection by polymerase chain reaction of residual cells with the bcl-2 translocation is associated with increased risk of relapse after autologous bone marrow transplantation for B-cell lymphoma. Blood. 1993 Jun 15; 81(12):3449-57. View in: Pubmed

      • Developments in purging in autotransplantation. Hematol Oncol Clin North Am. 1993 Jun; 7(3):687-715. View in: Pubmed

      • Autologous bone marrow transplantation in poor-prognosis intermediate-grade and high-grade B-cell non-Hodgkin's lymphoma in first remission: a pilot study. J Clin Oncol. 1993 May; 11(5):931-6. View in: Pubmed

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      • Serotherapy of B-cell neoplasms with anti-B4-blocked ricin: a phase I trial of daily bolus infusion. Blood. 1992 Feb 01; 79(3):576-85. View in: Pubmed

      • The gene for B7, a costimulatory signal for T-cell activation, maps to chromosomal region 3q13.3-3q21. Blood. 1992 Jan 15; 79(2):489-94. View in: Pubmed

      • Follicular non-Hodgkin's lymphoma cell adhesion to normal germinal centers and neoplastic follicles involves very late antigen-4 and vascular cell adhesion molecule-1. Blood. 1992 Jan 01; 79(1):206-12. View in: Pubmed

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      • Selective induction of B7/BB-1 on interferon-gamma stimulated monocytes: a potential mechanism for amplification of T cell activation through the CD28 pathway. Cell Immunol. 1991 Oct 15; 137(2):429-37. View in: Pubmed

      • Immunologic markers in non-Hodgkin's lymphoma. Hematol Oncol Clin North Am. 1991 Oct; 5(5):871-89. View in: Pubmed

      • Endothelial cell lymphocyte function-associated antigen-3 and an unidentified ligand act in concert to provide costimulation to human peripheral blood CD4+ T cells. Cell Immunol. 1991 Oct 01; 137(1):150-63. View in: Pubmed

      • B-cell surface antigen B7 provides a costimulatory signal that induces T cells to proliferate and secrete interleukin 2. Proc Natl Acad Sci U S A. 1991 Aug 01; 88(15):6575-9. View in: Pubmed

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      • Autologous bone marrow transplantation in 69 patients with a history of low-grade B-cell non-Hodgkin's lymphoma. Blood. 1991 Jun 01; 77(11):2524-9. View in: Pubmed

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      • Total lymphoid irradiation to prevent graft rejection in recipients of HLA non-identical T cell-depleted allogeneic marrow. Bone Marrow Transplant. 1991 Jan; 7(1):23-33. View in: Pubmed

      • Acute and chronic pulmonary complications following autologous bone marrow transplantation in non-Hodgkin's lymphoma. Bone Marrow Transplant. 1990 Nov; 6(5):329-31. View in: Pubmed

      • A chronic "postinfectious" fatigue syndrome associated with benign lymphoproliferation, B-cell proliferation, and active replication of human herpesvirus-6. J Clin Immunol. 1990 Nov; 10(6):335-44. View in: Pubmed

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      • Further characterization of prolymphocytic leukemia cells as a tumor of activated B cells. Am J Hematol. 1990 Jul; 34(3):181-5. View in: Pubmed

      • Autologous bone marrow transplantation in B-cell non-Hodgkin's lymphoma: very low treatment-related mortality in 100 patients in sensitive relapse. J Clin Oncol. 1990 May; 8(5):784-91. View in: Pubmed

      • Expression and state of phosphorylation of the retinoblastoma susceptibility gene product in cycling and noncycling human hematopoietic cells. Proc Natl Acad Sci U S A. 1990 Apr; 87(7):2770-4. View in: Pubmed

      • mAb 104, a new monoclonal antibody, recognizes the B7 antigen that is expressed on activated B cells and HTLV-1-transformed T cells. Immunology. 1990 Apr; 69(4):531-5. View in: Pubmed

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      • Molecular cloning of the B-cell-restricted activation antigen B7 identifies a new member of the immunoglobulin gene family. Leukocyte Typing IV. 1990; 141-2. View in: Pubmed

      • The relationship of chronic lymphocytic leukemia to normal activated B cells. Leuk Lymphoma. 1990; 1(5-6):293-300. View in: Pubmed

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      • Anti-B-cell monoclonal antibody-purged autologous bone marrow transplantation for B-cell non-Hodgkin's lymphoma: phenotypic reconstitution and B-cell function. Blood. 1989 Nov 01; 74(6):2203-11. View in: Pubmed

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      • B7, a new member of the Ig superfamily with unique expression on activated and neoplastic B cells. J Immunol. 1989 Oct 15; 143(8):2714-22. View in: Pubmed

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      Dana-Farber Cancer Institute

      Location Avtar

      Dana-Farber Cancer Institute

      450 Brookline Avenue Dana Building D1B30 Boston, MA 02215
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      42.3374, -71.1082

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      Arnold S. Freedman, MD

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