David Reardon, MD

David Reardon, MD

Neuro-oncology

Contact Information

Office Phone Number

617-632-2166

Fax

617-632-4773

Appointments

617-632-2166

Biography

David Reardon, MD

Researcher

Physician

Clinical Director, Center for Neuro-Oncology
Institute Physician
Professor of Medicine, Harvard Medical School

Centers/Programs

CNS Lymphoma Center

Clinical Interests

Anti-angiogenic treatments, Brain and spinal tumors, Clinical trials in neuro-oncology, Convection-enhanced delivery, Immunotherapy, Targeted therapies

Board Certification

  • Neuro-Oncology
  • Pediatric Hematology/Oncology

Fellowship

  • University of Michigan Hospital, MOTT Children's Hospital, Pediatric Hematology/Oncology

Residency

  • Johns Hopkins Hospital, Pediatrics

Medical School

  • Tufts Medical School

Research

    The goals of my research are to: 1) identify exciting new treatments for brain cancer in the laboratory using animal models; 2) understand how these treatment approaches are working to fight cancer cells in order to optimize their effectiveness; and 3) move these promising approaches as quickly as possible to the clinic via clinical trials to help brain cancer patients. My laboratory focuses primarily on innovative and cutting-edge immunotherapies as single agents and in rationally designed, combinational approaches that include a wide array of additional therapies. We utilize a variety of brain tumor models that are grown intracranially and treatments that are applied systemically and/or locally. We have access to state-of-the-art imaging systems including MRI, PET scans and bioluminescence to help us evaluate the "success" of our treatments in our animal models. We collaborate with several outstanding cancer immunology scientists who can help us comprehensively evaluate mechanisms of action of our therapies by applying advanced techniques to evaluate harvested intracranial tumors, draining lymph nodes, other lymphatic organs and peripheral blood. Results of our work continue to drive new clinical trials evaluating promising approaches for brain cancer patients. My research effort also extends into the clinic and specifically includes designing and implementing clinical trials to effectively evaluate promising new therapies as quickly as possible for our patients.

    Publications

      • Auto-segmentation of Adult-Type Diffuse Gliomas: Comparison of Transfer Learning-Based Convolutional Neural Network Model vs. Radiologists. J Imaging Inform Med. 2024 Feb 21. View in: Pubmed

      • Lessons learned from phase 3 trials of immunotherapy for glioblastoma: Time for longitudinal sampling? Neuro Oncol. 2024 02 02; 26(2):211-225. View in: Pubmed

      • Glioma genetic profiles associated with electrophysiologic hyperexcitability. Neuro Oncol. 2024 02 02; 26(2):323-334. View in: Pubmed

      • Clinical and genomic predictors of adverse events in newly diagnosed glioblastoma. Clin Cancer Res. 2024 Jan 22. View in: Pubmed

      • Investigative needle core biopsies for multi-omics in Glioblastoma. medRxiv. 2023 Dec 31. View in: Pubmed

      • Antigen presentation deficiency, mesenchymal differentiation, and resistance to immunotherapy in the murine syngeneic CT2A tumor model. Front Immunol. 2023; 14:1297932. View in: Pubmed

      • A new era for glioma therapy - targeting mutant IDH. Nat Rev Clin Oncol. 2023 11; 20(11):737-738. View in: Pubmed

      • Re-irradiation of recurrent IDH-wildtype glioblastoma in the bevacizumab and immunotherapy era: Target delineation, outcomes and patterns of recurrence. Clin Transl Radiat Oncol. 2024 Jan; 44:100697. View in: Pubmed

      • Clinical trial links oncolytic immunoactivation to survival in glioblastoma. Nature. 2023 Nov; 623(7985):157-166. View in: Pubmed

      • RANO 2.0: Update to the Response Assessment in Neuro-Oncology Criteria for High- and Low-Grade Gliomas in Adults. J Clin Oncol. 2023 Nov 20; 41(33):5187-5199. View in: Pubmed

      • Inaugural Results of the Individualized Screening Trial of Innovative Glioblastoma Therapy: A Phase II Platform Trial for Newly Diagnosed Glioblastoma Using Bayesian Adaptive Randomization. J Clin Oncol. 2023 Dec 20; 41(36):5524-5535. View in: Pubmed

      • Bavituximab Decreases Immunosuppressive Myeloid-Derived Suppressor Cells in Newly Diagnosed Glioblastoma Patients. Clin Cancer Res. 2023 Aug 15; 29(16):3017-3025. View in: Pubmed

      • Erdafitinib in patients with advanced solid tumours with FGFR alterations (RAGNAR): an international, single-arm, phase 2 study. Lancet Oncol. 2023 08; 24(8):925-935. View in: Pubmed

      • Metastatic pituitary tumors: an institutional case series. Pituitary. 2023 Oct; 26(5):561-572. View in: Pubmed

      • ALK Amplification and Rearrangements Are Recurrent Targetable Events in Congenital and Adult Glioblastoma. Clin Cancer Res. 2023 Jul 14; 29(14):2651-2667. View in: Pubmed

      • BRAF-MEK Inhibition in Newly Diagnosed Papillary Craniopharyngiomas. N Engl J Med. 2023 Jul 13; 389(2):118-126. View in: Pubmed

      • Evaluating hematologic parameters in newly diagnosed and recurrent glioblastoma: Prognostic utility and clinical trial implications of myelosuppression. Neurooncol Adv. 2023 Jan-Dec; 5(1):vdad083. View in: Pubmed

      • Clinical Importance of the lncRNA NEAT1 in Cancer Patients Treated with Immune Checkpoint Inhibitors. Clin Cancer Res. 2023 06 13; 29(12):2226-2238. View in: Pubmed

      • Trotabresib, an oral potent bromodomain and extraterminal inhibitor, in patients with high-grade gliomas: A phase I, "window-of-opportunity" study. Neuro Oncol. 2023 06 02; 25(6):1113-1122. View in: Pubmed

      • Phase I study of a novel glioblastoma radiation therapy schedule exploiting cell-state plasticity. Neuro Oncol. 2023 06 02; 25(6):1100-1112. View in: Pubmed

      • Long-term survival with IDH wildtype glioblastoma: first results from the ETERNITY Brain Tumor Funders' Collaborative Consortium (EORTC 1419). Eur J Cancer. 2023 08; 189:112913. View in: Pubmed

      • An expanded role for surgery in grade 3 1p/19q co-deleted oligodendroglioma. Neurooncol Adv. 2023 Jan-Dec; 5(1):vdad046. View in: Pubmed

      • Evaluation of Standard Response Assessment in Neuro-Oncology, Modified Response Assessment in Neuro-Oncology, and Immunotherapy Response Assessment in Neuro-Oncology in Newly Diagnosed and Recurrent Glioblastoma. J Clin Oncol. 2023 06 10; 41(17):3160-3171. View in: Pubmed

      • Glioma genetic profiles associated with electrophysiologic hyperexcitability. medRxiv. 2023 Feb 24. View in: Pubmed

      • Losartan controls immune checkpoint blocker-induced edema and improves survival in glioblastoma mouse models. Proc Natl Acad Sci U S A. 2023 02 07; 120(6):e2219199120. View in: Pubmed

      • The Blood-Brain Barrier: Implications for Experimental Cancer Therapeutics. Annu Rev Cancer Biol. 2023 Apr; 7:265-289. View in: Pubmed

      • PARP inhibition utilized in combination therapy with Olaparib-Temozolomide to achieve disease stabilization in a rare case of BRCA1-mutant, metastatic myxopapillary ependymoma. Rare Tumors. 2023; 15:20363613231152333. View in: Pubmed

      • Isocitrate dehydrogenase (IDH) mutant gliomas: A Society for Neuro-Oncology (SNO) consensus review on diagnosis, management, and future directions. Neuro Oncol. 2023 01 05; 25(1):4-25. View in: Pubmed

      • Radiotherapy combined with nivolumab or temozolomide for newly diagnosed glioblastoma with unmethylated MGMT promoter: An international randomized phase III trial. Neuro Oncol. 2023 01 05; 25(1):123-134. View in: Pubmed

      • Bifunctional cancer cell-based vaccine concomitantly drives direct tumor killing and antitumor immunity. Sci Transl Med. 2023 01 04; 15(677):eabo4778. View in: Pubmed

      • Phase IIa Study of SurVaxM Plus Adjuvant Temozolomide for Newly Diagnosed Glioblastoma. J Clin Oncol. 2023 03 01; 41(7):1453-1465. View in: Pubmed

      • Phase III trial of chemoradiotherapy with temozolomide plus nivolumab or placebo for newly diagnosed glioblastoma with methylated MGMT promoter. Neuro Oncol. 2022 11 02; 24(11):1935-1949. View in: Pubmed

      • Immunotherapy approaches for adult glioma: knowledge gained from recent clinical trials. Curr Opin Neurol. 2022 12 01; 35(6):803-813. View in: Pubmed

      • Spatial maps of T cell receptors and transcriptomes reveal distinct immune niches and interactions in the adaptive immune response. Immunity. 2022 10 11; 55(10):1940-1952.e5. View in: Pubmed

      • Brain metastases: A Society for Neuro-Oncology (SNO) consensus review on current management and future directions. Neuro Oncol. 2022 10 03; 24(10):1613-1646. View in: Pubmed

      • A multi-institutional phase II trial of bevacizumab for recurrent and refractory meningioma. Neurooncol Adv. 2022 Jan-Dec; 4(1):vdac123. View in: Pubmed

      • Isatuximab plus atezolizumab in patients with advanced solid tumors: results from a phase I/II, open-label, multicenter study. ESMO Open. 2022 10; 7(5):100562. View in: Pubmed

      • Cell-penetrating peptides enhance peptide vaccine accumulation and persistence in lymph nodes to drive immunogenicity. Proc Natl Acad Sci U S A. 2022 08 09; 119(32):e2204078119. View in: Pubmed

      • Safety, tolerability and efficacy of agonist anti-CD27 antibody (varlilumab) administered in combination with anti-PD-1 (nivolumab) in advanced solid tumors. J Immunother Cancer. 2022 08; 10(8). View in: Pubmed

      • Clinical utility of targeted next-generation sequencing assay in IDH-wildtype glioblastoma for therapy decision-making. Neuro Oncol. 2022 07 01; 24(7):1140-1149. View in: Pubmed

      • The current state of glioma data registries. Neurooncol Adv. 2022 Jan-Dec; 4(1):vdac099. View in: Pubmed

      • Circulating Immune Cell and Outcome Analysis from the Phase II Study of PD-L1 Blockade with Durvalumab for Newly Diagnosed and Recurrent Glioblastoma. Clin Cancer Res. 2022 06 13; 28(12):2567-2578. View in: Pubmed

      • Combined immunotherapy with controlled interleukin-12 gene therapy and immune checkpoint blockade in recurrent glioblastoma: An open-label, multi-institutional phase I trial. Neuro Oncol. 2022 06 01; 24(6):951-963. View in: Pubmed

      • A molecularly integrated grade for meningioma. Neuro Oncol. 2022 05 04; 24(5):796-808. View in: Pubmed

      • Radiomics-Based Machine Learning for Outcome Prediction in a Multicenter Phase II Study of Programmed Death-Ligand 1 Inhibition Immunotherapy for Glioblastoma. AJNR Am J Neuroradiol. 2022 05; 43(5):675-681. View in: Pubmed

      • Genomic Analysis of Tumors from Patients with Glioblastoma with Long-Term Response to Afatinib. Onco Targets Ther. 2022; 15:367-380. View in: Pubmed

      • Nivolumab plus radiotherapy with or without temozolomide in newly diagnosed glioblastoma: Results from exploratory phase I cohorts of CheckMate 143. Neurooncol Adv. 2022 Jan-Dec; 4(1):vdac025. View in: Pubmed

      • Designing Clinical Trials for Combination Immunotherapy: A Framework for Glioblastoma. Clin Cancer Res. 2022 02 15; 28(4):585-593. View in: Pubmed

      • Glioblastoma Clinical Trials: Current Landscape and Opportunities for Improvement. Clin Cancer Res. 2022 02 15; 28(4):594-602. View in: Pubmed

      • Is There a Role for Immunotherapy in Central Nervous System Cancers? Hematol Oncol Clin North Am. 2022 02; 36(1):237-252. View in: Pubmed

      • Hematol Oncol Clin North Am. 2022 02; 36(1):xv-xvi. View in: Pubmed

      • Clinical Trial Enrollment Among Adolescent and Young Adults with Primary Central Nervous System Tumors Treated at the Dana-Farber Cancer Institute. J Adolesc Young Adult Oncol. 2022 Dec; 11(6):543-549. View in: Pubmed

      • Short-term outcomes associated with temozolomide or PCV chemotherapy for 1p/19q-codeleted WHO grade 3 oligodendrogliomas: A national evaluation. Neurooncol Pract. 2022 May; 9(3):201-207. View in: Pubmed

      • Activity of PD-1 blockade with nivolumab among patients with recurrent atypical/anaplastic meningioma: phase II trial results. Neuro Oncol. 2022 01 05; 24(1):101-113. View in: Pubmed

      • Long-term outcomes of patients with active melanoma brain metastases treated with combination nivolumab plus ipilimumab (CheckMate 204): final results of an open-label, multicentre, phase 2 study. Lancet Oncol. 2021 12; 22(12):1692-1704. View in: Pubmed

      • Safety and efficacy of the combination of nivolumab plus ipilimumab in patients with melanoma and asymptomatic or symptomatic brain metastases (CheckMate 204). Neuro Oncol. 2021 11 02; 23(11):1961-1973. View in: Pubmed

      • Temporal Muscle Thickness as a Prognostic Marker in Patients with Newly Diagnosed Glioblastoma: Translational Imaging Analysis of the CENTRIC EORTC 26071-22072 and CORE Trials. Clin Cancer Res. 2022 01 01; 28(1):129-136. View in: Pubmed

      • Glial and myeloid heterogeneity in the brain tumour microenvironment. Nat Rev Cancer. 2021 12; 21(12):786-802. View in: Pubmed

      • Glioblastoma as an age-related neurological disorder in adults. Neurooncol Adv. 2021 Jan-Dec; 3(1):vdab125. View in: Pubmed

      • The combined use of steroids and immune checkpoint inhibitors in brain metastasis patients: a systematic review and meta-analysis. Neuro Oncol. 2021 08 02; 23(8):1261-1272. View in: Pubmed

      • Consensus disease definitions for neurologic immune-related adverse events of immune checkpoint inhibitors. J Immunother Cancer. 2021 07; 9(7). View in: Pubmed

      • Systematic review of combinations of targeted or immunotherapy in advanced solid tumors. J Immunother Cancer. 2021 07; 9(7). View in: Pubmed

      • A Comparative Retrospective Study of Immunotherapy RANO Versus Standard RANO Criteria in Glioblastoma Patients Receiving Immune Checkpoint Inhibitor Therapy. Front Oncol. 2021; 11:679331. View in: Pubmed

      • Vaccination for IDH-mutant tumors: A novel therapeutic approach applied to glioma. Med (N Y). 2021 05 14; 2(5):450-452. View in: Pubmed

      • Improved outcomes associated with maximal extent of resection for butterfly glioblastoma: insights from institutional and national data. Acta Neurochir (Wien). 2021 07; 163(7):1883-1894. View in: Pubmed

      • Bintrafusp alfa (M7824), a bifunctional fusion protein targeting TGF-ß and PD-L1: results from a phase I expansion cohort in patients with recurrent glioblastoma. Neurooncol Adv. 2021 Jan-Dec; 3(1):vdab058. View in: Pubmed

      • Assessment of tumor hypoxia and perfusion in recurrent glioblastoma following bevacizumab failure using MRI and 18F-FMISO PET. Sci Rep. 2021 04 07; 11(1):7632. View in: Pubmed

      • The Current Landscape of Immune Checkpoint Blockade in Glioblastoma. Neurosurg Clin N Am. 2021 Apr; 32(2):235-248. View in: Pubmed

      • IDH-mutant gliomas with additional class-defining molecular events. Mod Pathol. 2021 07; 34(7):1236-1244. View in: Pubmed

      • Unique challenges for glioblastoma immunotherapy-discussions across neuro-oncology and non-neuro-oncology experts in cancer immunology. Meeting Report from the 2019 SNO Immuno-Oncology Think Tank. Neuro Oncol. 2021 03 25; 23(3):356-375. View in: Pubmed

      • Clinical, radiological and genomic features and targeted therapy in BRAF V600E mutant adult glioblastoma. J Neurooncol. 2021 May; 152(3):515-522. View in: Pubmed

      • Adolescent and young adult neuro-oncology: a comprehensive review. Neurooncol Pract. 2021 Jun; 8(3):236-246. View in: Pubmed

      • Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis. Cell. 2021 03 04; 184(5):1281-1298.e26. View in: Pubmed

      • Phase 2 trial of hypoxia activated evofosfamide (TH302) for treatment of recurrent bevacizumab-refractory glioblastoma. Sci Rep. 2021 01 27; 11(1):2306. View in: Pubmed

      • Treatment with pembrolizumab in programmed death ligand 1-positive recurrent glioblastoma: Results from the multicohort phase 1 KEYNOTE-028 trial. Cancer. 2021 05 15; 127(10):1620-1629. View in: Pubmed

      • Socioeconomic Disparities Associated With MGMT Promoter Methylation Testing for Patients With Glioblastoma. JAMA Oncol. 2020 12 01; 6(12):1972-1974. View in: Pubmed

      • Appropriate Analysis of Duration of Response Data in Cancer Trials-Reply. JAMA Oncol. 2020 12 01; 6(12):1978-1979. View in: Pubmed

      • Phase 0 and window of opportunity clinical trial design in neuro-oncology: a RANO review. Neuro Oncol. 2020 11 26; 22(11):1568-1579. View in: Pubmed

      • Concurrent Dexamethasone Limits the Clinical Benefit of Immune Checkpoint Blockade in Glioblastoma. Clin Cancer Res. 2021 01 01; 27(1):276-287. View in: Pubmed

      • Randomized Phase II and Biomarker Study of Pembrolizumab plus Bevacizumab versus Pembrolizumab Alone for Patients with Recurrent Glioblastoma. Clin Cancer Res. 2021 02 15; 27(4):1048-1057. View in: Pubmed

      • Emerging immunotherapies for malignant glioma: from immunogenomics to cell therapy. Neuro Oncol. 2020 10 14; 22(10):1425-1438. View in: Pubmed

      • Adult immuno-oncology: using past failures to inform the future. Neuro Oncol. 2020 09 29; 22(9):1249-1261. View in: Pubmed

      • Higher risk of urinary tract infections in renal transplant recipients receiving pentamidine versus trimethoprim-sulfamethoxazole (TMP-SMX) for Pneumocystis pneumonia prophylaxis. Clin Transplant. 2020 11; 34(11):e14067. View in: Pubmed

      • Glioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions. Neuro Oncol. 2020 08 17; 22(8):1073-1113. View in: Pubmed

      • Effect of Nivolumab vs Bevacizumab in Patients With Recurrent Glioblastoma: The CheckMate 143 Phase 3 Randomized Clinical Trial. JAMA Oncol. 2020 07 01; 6(7):1003-1010. View in: Pubmed

      • PD-1 Inhibitors: Do they have a Future in the Treatment of Glioblastoma? Clin Cancer Res. 2020 10 15; 26(20):5287-5296. View in: Pubmed

      • Exploring Predictors of Response to Dacomitinib in EGFR-Amplified Recurrent Glioblastoma. JCO Precis Oncol. 2020; 4. View in: Pubmed

      • Tumor Interferon Signaling Is Regulated by a lncRNA INCR1 Transcribed from the PD-L1 Locus. Mol Cell. 2020 06 18; 78(6):1207-1223.e8. View in: Pubmed

      • Blood-brain barrier disruption and delivery of irinotecan in a rat model using a clinical transcranial MRI-guided focused ultrasound system. Sci Rep. 2020 05 29; 10(1):8766. View in: Pubmed

      • A phase 1 study of PF-06840003, an oral indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor in patients with recurrent malignant glioma. Invest New Drugs. 2020 12; 38(6):1784-1795. View in: Pubmed

      • Optimizing eligibility criteria and clinical trial conduct to enhance clinical trial participation for primary brain tumor patients. Neuro Oncol. 2020 05 15; 22(5):601-612. View in: Pubmed

      • Mechanisms and therapeutic implications of hypermutation in gliomas. Nature. 2020 04; 580(7804):517-523. View in: Pubmed

      • Glioblastoma infiltration of both tumor- and virus-antigen specific cytotoxic T cells correlates with experimental virotherapy responses. Sci Rep. 2020 03 20; 10(1):5095. View in: Pubmed

      • Deep-Learning Detection of Cancer Metastases to the Brain on MRI. J Magn Reson Imaging. 2020 10; 52(4):1227-1236. View in: Pubmed

      • NRG/RTOG 1122: A phase 2, double-blinded, placebo-controlled study of bevacizumab with and without trebananib in patients with recurrent glioblastoma or gliosarcoma. Cancer. 2020 06 15; 126(12):2821-2828. View in: Pubmed

      • Predictors and early survival outcomes of maximal resection in WHO grade II 1p/19q-codeleted oligodendrogliomas. Neuro Oncol. 2020 03 05; 22(3):369-380. View in: Pubmed

      • Rindopepimut with Bevacizumab for Patients with Relapsed EGFRvIII-Expressing Glioblastoma (ReACT): Results of a Double-Blind Randomized Phase II Trial. Clin Cancer Res. 2020 04 01; 26(7):1586-1594. View in: Pubmed

      • Correction: Arming an Oncolytic Herpes Simplex Virus Type 1 with a Single-chain Fragment Variable Antibody against PD-1 for Experimental Glioblastoma Therapy. Clin Cancer Res. 2020 Feb 01; 26(3):758. View in: Pubmed

      • An Online Calculator for the Prediction of Survival in Glioblastoma Patients Using Classical Statistics and Machine Learning. Neurosurgery. 2020 02 01; 86(2):E184-E192. View in: Pubmed

      • Contemporary assessment of extent of resection in molecularly defined categories of diffuse low-grade glioma: a volumetric analysis. J Neurosurg. 2019 Oct 25; 1-11. View in: Pubmed

      • Molecular targeted therapy of glioblastoma. Cancer Treat Rev. 2019 Nov; 80:101896. View in: Pubmed

      • Barriers to accrual and enrollment in brain tumor trials. Neuro Oncol. 2019 09 06; 21(9):1100-1117. View in: Pubmed

      • Author Correction: Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39. Nat Neurosci. 2019 Sep; 22(9):1533. View in: Pubmed

      • Letter: When Less is More: Dexamethasone Dosing for Brain Tumors. Neurosurgery. 2019 09 01; 85(3):E607-E608. View in: Pubmed

      • Phase II trial of ponatinib in patients with bevacizumab-refractory glioblastoma. Cancer Med. 2019 10; 8(13):5988-5994. View in: Pubmed

      • Acoustic feedback enables safe and reliable carboplatin delivery across the blood-brain barrier with a clinical focused ultrasound system and improves survival in a rat glioma model. Theranostics. 2019; 9(21):6284-6299. View in: Pubmed

      • Regulatable interleukin-12 gene therapy in patients with recurrent high-grade glioma: Results of a phase 1 trial. Sci Transl Med. 2019 08 14; 11(505). View in: Pubmed

      • A Randomized Double-Blind Placebo-Controlled Phase II Trial of Dendritic Cell Vaccine ICT-107 in Newly Diagnosed Patients with Glioblastoma. Clin Cancer Res. 2019 10 01; 25(19):5799-5807. View in: Pubmed

      • Safety, tolerability, and pharmacokinetics of anti-EGFRvIII antibody-drug conjugate AMG 595 in patients with recurrent malignant glioma expressing EGFRvIII. Cancer Chemother Pharmacol. 2019 08; 84(2):327-336. View in: Pubmed

      • Survival and prognostic factors in surgically treated brain metastases. J Neurooncol. 2019 Jun; 143(2):359-367. View in: Pubmed

      • Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39. Nat Neurosci. 2019 05; 22(5):729-740. View in: Pubmed

      • Efficacy and safety of immune checkpoint blockade for brain metastases. CNS Oncol. 2019 06; 8(2):CNS33. View in: Pubmed

      • Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma. Nat Med. 2019 03; 25(3):477-486. View in: Pubmed

      • Buparlisib in Patients With Recurrent Glioblastoma Harboring Phosphatidylinositol 3-Kinase Pathway Activation: An Open-Label, Multicenter, Multi-Arm, Phase II Trial. J Clin Oncol. 2019 03 20; 37(9):741-750. View in: Pubmed

      • The Misclassification of Diffuse Gliomas: Rates and Outcomes. Clin Cancer Res. 2019 04 15; 25(8):2656-2663. View in: Pubmed

      • Proposed response assessment and endpoints for meningioma clinical trials: report from the Response Assessment in Neuro-Oncology Working Group. Neuro Oncol. 2019 01 01; 21(1):26-36. View in: Pubmed

      • Safety and efficacy of depatuxizumab mafodotin + temozolomide in patients with EGFR-amplified, recurrent glioblastoma: results from an international phase I multicenter trial. Neuro Oncol. 2019 01 01; 21(1):106-114. View in: Pubmed

      • Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial. Nature. 2019 01; 565(7738):234-239. View in: Pubmed

      • Pseudoprogression: fact or wishful thinking in neuro-oncology? Lancet Oncol. 2018 12; 19(12):1561-1563. View in: Pubmed

      • Mismatch repair deficiency in high-grade meningioma: a rare but recurrent event associated with dramatic immune activation and clinical response to PD-1 blockade. JCO Precis Oncol. 2018; 2018. View in: Pubmed

      • Voxel-Wise Analysis of Fluoroethyltyrosine PET and MRI in the Assessment of Recurrent Glioblastoma During Antiangiogenic Therapy. AJR Am J Roentgenol. 2018 12; 211(6):1342-1347. View in: Pubmed

      • Arming an Oncolytic Herpes Simplex Virus Type 1 with a Single-chain Fragment Variable Antibody against PD-1 for Experimental Glioblastoma Therapy. Clin Cancer Res. 2019 01 01; 25(1):290-299. View in: Pubmed

      • Volumetric response quantified using T1 subtraction predicts long-term survival benefit from cabozantinib monotherapy in recurrent glioblastoma. Neuro Oncol. 2018 09 03; 20(10):1411-1418. View in: Pubmed

      • PD-1 inhibition has only limited clinical benefit in patients with recurrent high-grade glioma. Neurology. 2018 10 02; 91(14):e1355-e1359. View in: Pubmed

      • Combined Nivolumab and Ipilimumab in Melanoma Metastatic to the Brain. N Engl J Med. 2018 Aug 23; 379(8):722-730. View in: Pubmed

      • Validation of postoperative residual contrast-enhancing tumor volume as an independent prognostic factor for overall survival in newly diagnosed glioblastoma. Neuro Oncol. 2018 08 02; 20(9):1240-1250. View in: Pubmed

      • Diagnostic accuracy of 2-hydroxyglutarate magnetic resonance spectroscopy in newly diagnosed brain mass and suspected recurrent gliomas. Neuro Oncol. 2018 08 02; 20(9):1262-1271. View in: Pubmed

      • Immunotherapy for glioblastoma: going viral. Nat Med. 2018 08; 24(8):1094-1096. View in: Pubmed

      • Associations of anticoagulant use with outcome in newly diagnosed glioblastoma. Eur J Cancer. 2018 09; 101:95-104. View in: Pubmed

      • Improved Risk-Adjusted Survival for Melanoma Brain Metastases in the Era of Checkpoint Blockade Immunotherapies: Results from a National Cohort. Cancer Immunol Res. 2018 09; 6(9):1039-1045. View in: Pubmed

      • Epidermal Growth Factor Receptor Extracellular Domain Mutations in Glioblastoma Present Opportunities for Clinical Imaging and Therapeutic Development. Cancer Cell. 2018 07 09; 34(1):163-177.e7. View in: Pubmed

      • Multiplexed immunofluorescence reveals potential PD-1/PD-L1 pathway vulnerabilities in craniopharyngioma. Neuro Oncol. 2018 07 05; 20(8):1101-1112. View in: Pubmed

      • Phase I and Biomarker Study of Plerixafor and Bevacizumab in Recurrent High-Grade Glioma. Clin Cancer Res. 2018 10 01; 24(19):4643-4649. View in: Pubmed

      • Corticosteroid use endpoints in neuro-oncology: Response Assessment in Neuro-Oncology Working Group. Neuro Oncol. 2018 06 18; 20(7):897-906. View in: Pubmed

      • Safety, pharmacokinetics, and antitumor response of depatuxizumab mafodotin as monotherapy or in combination with temozolomide in patients with glioblastoma. Neuro Oncol. 2018 05 18; 20(6):838-847. View in: Pubmed

      • Bevacizumab biosimilars: scientific justification for extrapolation of indications. Future Oncol. 2018 Oct; 14(24):2507-2520. View in: Pubmed

      • Nivolumab with or without ipilimumab in patients with recurrent glioblastoma: results from exploratory phase I cohorts of CheckMate 143. Neuro Oncol. 2018 04 09; 20(5):674-686. View in: Pubmed

      • Concepts for Immunotherapies in Gliomas. Semin Neurol. 2018 02; 38(1):62-72. View in: Pubmed

      • Toxicity and Efficacy of a Novel GADD34-expressing Oncolytic HSV-1 for the Treatment of Experimental Glioblastoma. Clin Cancer Res. 2018 06 01; 24(11):2574-2584. View in: Pubmed

      • Do statins, ACE inhibitors or sartans improve outcome in primary glioblastoma? J Neurooncol. 2018 May; 138(1):163-171. View in: Pubmed

      • Preclinical investigation of combined gene-mediated cytotoxic immunotherapy and immune checkpoint blockade in glioblastoma. Neuro Oncol. 2018 01 22; 20(2):225-235. View in: Pubmed

      • Phase II study of cabozantinib in patients with progressive glioblastoma: subset analysis of patients with prior antiangiogenic therapy. Neuro Oncol. 2018 01 22; 20(2):259-267. View in: Pubmed

      • Phase II study of cabozantinib in patients with progressive glioblastoma: subset analysis of patients naive to antiangiogenic therapy. Neuro Oncol. 2018 01 22; 20(2):249-258. View in: Pubmed

      • Modeling tumor immunity of mouse glioblastoma by exhausted CD8+ T cells. Sci Rep. 2018 01 09; 8(1):208. View in: Pubmed

      • Phase I/II trial of vorinostat, bevacizumab, and daily temozolomide for recurrent malignant gliomas. J Neurooncol. 2018 Apr; 137(2):349-356. View in: Pubmed

      • Phase 2 and biomarker study of trebananib, an angiopoietin-blocking peptibody, with and without bevacizumab for patients with recurrent glioblastoma. Cancer. 2018 04 01; 124(7):1438-1448. View in: Pubmed

      • High-grade Gliomas. Continuum (Minneap Minn). 2017 Dec; 23(6, Neuro-oncology):1548-1563. View in: Pubmed

      • Quantitative imaging biomarkers for risk stratification of patients with recurrent glioblastoma treated with bevacizumab. Neuro Oncol. 2017 Nov 29; 19(12):1688-1697. View in: Pubmed

      • Phase II Study of Bevacizumab and Vorinostat for Patients with Recurrent World Health Organization Grade 4 Malignant Glioma. Oncologist. 2018 02; 23(2):157-e21. View in: Pubmed

      • Immunotherapy for glioblastoma: on the sidelines or in the game? Discov Med. 2017 11; 24(133):201-208. View in: Pubmed

      • Efficacy of depatuxizumab mafodotin (ABT-414) monotherapy in patients with EGFR-amplified, recurrent glioblastoma: results from a multi-center, international study. Cancer Chemother Pharmacol. 2017 Dec; 80(6):1209-1217. View in: Pubmed

      • Salvage re-irradiation for recurrent high-grade glioma and comparison to bevacizumab alone. J Neurooncol. 2017 Dec; 135(3):581-591. View in: Pubmed

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      • Metronomic chemotherapy with daily, oral etoposide plus bevacizumab for recurrent malignant glioma: a phase II study. Br J Cancer. 2009 Dec 15; 101(12):1986-94. View in: Pubmed

      • Multicentre phase II studies evaluating imatinib plus hydroxyurea in patients with progressive glioblastoma. Br J Cancer. 2009 Dec 15; 101(12):1995-2004. View in: Pubmed

      • An epidermal growth factor receptor variant III-targeted vaccine is safe and immunogenic in patients with glioblastoma multiforme. Mol Cancer Ther. 2009 Oct; 8(10):2773-9. View in: Pubmed

      • Overall survival of newly diagnosed glioblastoma patients receiving carmustine wafers followed by radiation and concurrent temozolomide plus rotational multiagent chemotherapy. Cancer. 2009 Aug 01; 115(15):3501-11. View in: Pubmed

      • Current available therapies and future directions in the treatment of malignant gliomas. Biologics. 2009; 3:15-25. View in: Pubmed

      • Phase 1 trial of temozolomide plus irinotecan plus O6-benzylguanine in adults with recurrent malignant glioma. Cancer. 2009 Jul 01; 115(13):2964-70. View in: Pubmed

      • Will integrin inhibitors have proangiogenic effects in the clinic? Nat Med. 2009 Jul; 15(7):726; author reply 727. View in: Pubmed

      • Phase 2 trial of erlotinib plus sirolimus in adults with recurrent glioblastoma. J Neurooncol. 2010 Jan; 96(2):219-30. View in: Pubmed

      • Phase II trial of temozolomide (TMZ) plus irinotecan (CPT-11) in adults with newly diagnosed glioblastoma multiforme before radiotherapy. J Neurooncol. 2009 Dec; 95(3):393-400. View in: Pubmed

      • Phase I trial of vendetanib and oral etoposide for recurrent malignant gliomas. J Clin Oncol. 2009 May 20; 27(15_suppl):e13016. View in: Pubmed

      • Safety and efficacy of the addition of bevacizumab (BV) to temozolomide (TMZ) and radiation therapy (RT) followed by BV, TMZ, and irinotecan (CPT-11) for newly diagnosed glioblastoma multiforme (GBM). J Clin Oncol. 2009 May 20; 27(15_suppl):2015. View in: Pubmed

      • Effect of daclizumab on TReg counts and EGFRvIII-specific immune responses in GBM. J Clin Oncol. 2009 May 20; 27(15_suppl):2034. View in: Pubmed

      • Temozolomide (TMZ) and bevacizumab (BV) as initial treatment for unresectable or multifocal glioblastoma multiforme (GBM). J Clin Oncol. 2009 May 20; 27(15_suppl):e13025. View in: Pubmed

      • Phase II study of bevacizumab plus erlotinib for recurrent malignant gliomas. J Clin Oncol. 2009 May 20; 27(15_suppl):2045. View in: Pubmed

      • A phase I study of sunitinib plus irinotecan in the treatment of patients with recurrent malignant glioma. J Clin Oncol. 2009 May 20; 27(15_suppl):e13024. View in: Pubmed

      • Phase I study of vandetanib, imatinib mesylate, and hydroxyurea for recurrent malignant glioma. J Clin Oncol. 2009 May 20; 27(15_suppl):e13007. View in: Pubmed

      • Pazopanib and lapatinib in patients with relapsed malignant glioma: Results of a phase I/II study. J Clin Oncol. 2009 May 20; 27(15_suppl):2040. View in: Pubmed

      • Quantitative assessment of cardiorespiratory fitness, skeletal muscle function, and body composition in adults with primary malignant glioma. J Clin Oncol. 2009 May 20; 27(15_suppl):e13002. View in: Pubmed

      • Bevacizumab plus etoposide among recurrent malignant glioma patients: Phase II study final results. J Clin Oncol. 2009 May 20; 27(15_suppl):2046. View in: Pubmed

      • Phase I trial combining SCH 66336 to temozolomide (TMZ) for patients with grade 3 or 4 malignant gliomas (MG). J Clin Oncol. 2009 May 20; 27(15_suppl):e13004. View in: Pubmed

      • Epidermal growth factor receptor variant III (EGFRvIII) vaccine (CDX-110) in GBM. J Clin Oncol. 2009 May 20; 27(15_suppl):2021. View in: Pubmed

      • Phase I pharmacokinetic study of the vascular endothelial growth factor receptor tyrosine kinase inhibitor vatalanib (PTK787) plus imatinib and hydroxyurea for malignant glioma. Cancer. 2009 May 15; 115(10):2188-98. View in: Pubmed

      • Tinzaparin prophylaxis against venous thromboembolic complications in brain tumor patients. J Neurooncol. 2009 Oct; 95(1):129-134. View in: Pubmed

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      • Phase I trial of temozolomide plus O6-benzylguanine 5-day regimen with recurrent malignant glioma. Neuro Oncol. 2009 Oct; 11(5):556-61. View in: Pubmed

      • Targeting multiple kinases in glioblastoma multiforme. Expert Opin Investig Drugs. 2009 Mar; 18(3):277-92. View in: Pubmed

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      • Phase II trial of temozolomide plus o6-benzylguanine in adults with recurrent, temozolomide-resistant malignant glioma. J Clin Oncol. 2009 Mar 10; 27(8):1262-7. View in: Pubmed

      • Phase II trial of Gliadel plus O6-benzylguanine in adults with recurrent glioblastoma multiforme. Clin Cancer Res. 2009 Feb 01; 15(3):1064-8. View in: Pubmed

      • Computerized assessment of vessel morphological changes during treatment of glioblastoma multiforme: report of a case imaged serially by MRA over four years. Neuroimage. 2009 Aug; 47 Suppl 2:T143-51. View in: Pubmed

      • Randomized phase II study of cilengitide, an integrin-targeting arginine-glycine-aspartic acid peptide, in recurrent glioblastoma multiforme. J Clin Oncol. 2008 Dec 01; 26(34):5610-7. View in: Pubmed

      • Bevacizumab plus irinotecan in recurrent WHO grade 3 malignant gliomas. Clin Cancer Res. 2008 Nov 01; 14(21):7068-73. View in: Pubmed

      • Experience with irinotecan for the treatment of malignant glioma. Neuro Oncol. 2009 Feb; 11(1):80-91. View in: Pubmed

      • Efficacy of high-dose chemotherapy or standard salvage therapy in patients with recurrent medulloblastoma. Neuro Oncol. 2008 Oct; 10(5):745-51. View in: Pubmed

      • Cilengitide: an integrin-targeting arginine-glycine-aspartic acid peptide with promising activity for glioblastoma multiforme. Expert Opin Investig Drugs. 2008 Aug; 17(8):1225-35. View in: Pubmed

      • Phase II study of AMG 102, a fully human neutralizing antibody against hepatocyte growth factor/scatter factor, in patients with recurrent glioblastoma multiforme. J Clin Oncol. 2008 May 20; 26(15_suppl):2051. View in: Pubmed

      • Bevacizumab and daily temozolomide for recurrent glioblastoma multiforme (GBM). J Clin Oncol. 2008 May 20; 26(15_suppl):2074. View in: Pubmed

      • Phase I trial of temozolomide plus O6-benzylguanine on three different 5-day temozolomide regimens for patients with progressive glioblastoma multiforme. J Clin Oncol. 2008 May 20; 26(15_suppl):2084. View in: Pubmed

      • Efficacy of a phase II vaccine targeting Cytomegalovirus antigens in newly diagnosed GBM. J Clin Oncol. 2008 May 20; 26(15_suppl):2042. View in: Pubmed

      • Treatment of adults with recurrent progressive low-grade glioma using imatinib mesylate and hydroxyurea. J Clin Oncol. 2008 May 20; 26(15_suppl):2071. View in: Pubmed

      • Effect of EGFRvIII-targeted vaccine (CDX-110) on immune response and TTP when given with simultaneous standard and continuous temozolomide in patients with GBM. J Clin Oncol. 2008 May 20; 26(15_suppl):2011. View in: Pubmed

      • Phase II study of bevacizumab and erlotinib in patients with recurrent glioblastoma multiforme. J Clin Oncol. 2008 May 20; 26(15_suppl):13008. View in: Pubmed

      • Effect of bevacizumab (BEV) and irinotecan (CPT-11) on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in glioblastoma (GBM) patients. J Clin Oncol. 2008 May 20; 26(15_suppl):2026. View in: Pubmed

      • Final report: Phase I trial of imatinib mesylate, hydroxyurea, and vatalanib for patients with recurrent malignant glioma (MG). J Clin Oncol. 2008 May 20; 26(15_suppl):2057. View in: Pubmed

      • Update on survival from the original phase II trial of bevacizumab and irinotecan in recurrent malignant gliomas. J Clin Oncol. 2008 May 20; 26(15_suppl):2021. View in: Pubmed

      • Immunotherapy against angiogenesis-associated targets: evidence and implications for the treatment of malignant glioma. Expert Rev Anticancer Ther. 2008 May; 8(5):717-32. View in: Pubmed

      • Intracerebral infusion of an EGFR-targeted toxin in recurrent malignant brain tumors. Neuro Oncol. 2008 Jun; 10(3):320-9. View in: Pubmed

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      • Safety and pharmacokinetics of dose-intensive imatinib mesylate plus temozolomide: phase 1 trial in adults with malignant glioma. Neuro Oncol. 2008 Jun; 10(3):330-40. View in: Pubmed

      • A pilot study: 131I-antitenascin monoclonal antibody 81c6 to deliver a 44-Gy resection cavity boost. Neuro Oncol. 2008 Apr; 10(2):182-9. View in: Pubmed

      • The emerging role of anti-angiogenic therapy for malignant glioma. Curr Treat Options Oncol. 2008 Feb; 9(1):1-22. View in: Pubmed

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      • Diagnosis and treatment of high-grade astrocytoma. Neurol Clin. 2007 Nov; 25(4):1111-39, x. View in: Pubmed

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      • Molecularly targeted therapy for malignant glioma. Cancer. 2007 Jul 01; 110(1):13-24. View in: Pubmed

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      • Clinical utility of a patient-specific algorithm for simulating intracerebral drug infusions. Neuro Oncol. 2007 Jul; 9(3):343-53. View in: Pubmed

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      • Neurofibromatosis type 2. Neurology. 2007 Mar 27; 68(13):E14. View in: Pubmed

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      • Using the theory of planned behavior to understand the determinants of exercise intention in patients diagnosed with primary brain cancer. Psychooncology. 2007 Mar; 16(3):232-40. View in: Pubmed

      • Induction of hyperintense signal on T2-weighted MR images correlates with infusion distribution from intracerebral convection-enhanced delivery of a tumor-targeted cytotoxin. AJR Am J Roentgenol. 2007 Mar; 188(3):703-9. View in: Pubmed

      • Phase II trial of bevacizumab and irinotecan in recurrent malignant glioma. Clin Cancer Res. 2007 Feb 15; 13(4):1253-9. View in: Pubmed

      • Phase II study of imatinib mesylate and hydroxyurea for recurrent grade III malignant gliomas. J Neurooncol. 2007 May; 83(1):53-60. View in: Pubmed

      • Phase II study of Cloretazine for the treatment of adults with recurrent glioblastoma multiforme. Neuro Oncol. 2007 Jan; 9(1):70-4. View in: Pubmed

      • 3'-Deoxy-3'-[F-18]fluorothymidine positron emission tomography in patients with recurrent glioblastoma multiforme: comparison with Gd-DTPA enhanced magnetic resonance imaging. Mol Imaging Biol. 2006 Nov-Dec; 8(6):340-7. View in: Pubmed

      • Exercise interest and preferences among patients diagnosed with primary brain cancer. Support Care Cancer. 2007 Jan; 15(1):47-55. View in: Pubmed

      • An update on phase I study of dose-escalating imatinib mesylate plus standard-dosed temozolomide for the treatment of patients with malignant glioma. J Clin Oncol. 2006 Jun 20; 24(18_suppl):1560. View in: Pubmed

      • Combination of bevacizumab, a monoclonal antibody to vascular endothelial growth factor (VEGF), and temozolomide: Study of cases. J Clin Oncol. 2006 Jun 20; 24(18_suppl):11522. View in: Pubmed

      • Phase II trial of imatinib mesylate and hydroxyurea for grade III malignant gliomas. J Clin Oncol. 2006 Jun 20; 24(18_suppl):1573. View in: Pubmed

      • A phase I trial of imatinib, hydroxyurea and RAD001 for patients with recurrent malignant glioma. J Clin Oncol. 2006 Jun 20; 24(18_suppl):1580. View in: Pubmed

      • Phase II trial of Gliadel plus O6-benzylguanine (O6-BG) for patients with recurrent glioblastoma multiforme. J Clin Oncol. 2006 Jun 20; 24(18_suppl):1568. View in: Pubmed

      • Bevacizumab, a monoclonal antibody to vascular endothelial growth factor (VEGF), and irinotecan for treatment of malignant gliomas. J Clin Oncol. 2006 Jun 20; 24(18_suppl):1506. View in: Pubmed

      • Acute toxicity analysis of patients receiving surgery, Gliadel wafer implantation, and postoperative daily temozolomide with radiation therapy for primary high-grade glioma. J Clin Oncol. 2006 Jun 20; 24(18_suppl):11504. View in: Pubmed

      • Tinzaparin prophylaxis against thromboembolic complications in brain tumor patients. J Clin Oncol. 2006 Jun 20; 24(18_suppl):1539. View in: Pubmed

      • Tumor-specific peptide vaccination in newly-diagnosed patients with GBM. J Clin Oncol. 2006 Jun 20; 24(18_suppl):2529. View in: Pubmed

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      • Incidence and patterns of neuraxis metastases in children with diffuse pontine glioma. J Neurooncol. 2006 Apr; 77(2):207-12. View in: Pubmed

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      • Phase II study of imatinib mesylate plus hydroxyurea in adults with recurrent glioblastoma multiforme. J Clin Oncol. 2005 Dec 20; 23(36):9359-68. View in: Pubmed

      • ZD6474, a novel tyrosine kinase inhibitor of vascular endothelial growth factor receptor and epidermal growth factor receptor, inhibits tumor growth of multiple nervous system tumors. Clin Cancer Res. 2005 Nov 15; 11(22):8145-57. View in: Pubmed

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      • Results of a phase II study of 131 Iodine-labeled anti-tenascin murine monoclonal antibody 81C6 (m81C6) administered to deliver a targeted radiation boost dose of 44 Gy to the surgically created cystic resection cavity perimeter in the treatment of patients with newly diagnosed primary and metastatic brain tumors. J Clin Oncol. 2005 Jun; 23(16_suppl):1510. View in: Pubmed

      • A phase I study of AEE788, a novel multitargeted inhibitor of ErbB and VEGF receptor family tyrosine kinases, in recurrent GBM patients. J Clin Oncol. 2005 Jun; 23(16_suppl):3063. View in: Pubmed

      • A phase I dose escalation study of imatinib mesylate plus standard-dosed temozolomide in the treatment of patients with malignant glioma. J Clin Oncol. 2005 Jun; 23(16_suppl):1540. View in: Pubmed

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      • Phase II study of thalidomide and daily cyclophosphamide for adults with malignant glioma. J Clin Oncol. 2004 Jul 15; 22(14_suppl):1554. View in: Pubmed

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      • A methods study to define the performance specifications of MHC tetramer assays for immune monitoring of tumor immunotherapy. J Clin Oncol. 2004 Jul 15; 22(14_suppl):9682. View in: Pubmed

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