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David Takeda, MD, PhD


Medical Oncology

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Physician

  • Physician
  • Instructor in Medicine, Harvard Medical School

Centers/Programs

Clinical Interests

  • Bladder cancer
  • Hormone and chemotherapy
  • Kidney cancer
  • Prostate cancer
  • Testicular cancer

Contact Information

  • Appointments617-582-9725 (follow-up)
  • Office Phone Number617-632-6328
    877-332-4294 (new)
  • Fax617-632-2165

Bio

Harvard Medical School, MD PhD, 2007



Internal Medicine Residency, Brigham and Women's Hospital, 2009



Hematology/Oncology Fellowship, Dana Farber Cancer Institute, 2013



Instructor in Medicine, Harvard Medical School, Dana Farber Cancer Institute

Board Certification:

  • Internal Medicine, 2010

Fellowship:

  • Dana-Farber/Partners CancerCare, Hematology/Oncology

Residency:

  • Brigham and Women's Hospital, Internal Medicine

Medical School:

  • Harvard Medical School

Recent Awards:

  • Prostate Cancer Foundation Young Investigator Award 2012

Research

Targeting the TMPRSS2-ERG Translocation in Prostate Cancer

Approximately half of all prostate cancers contain a translocation involving the transcription factor ERG with the androgen regulated gene TMPRSS2.  The TMPRSS2-ERG fusion results in androgen dependent overexpression of ERG which is not normally expressed in the prostate.  Several lines of evidence demonstrate that aberrant overexpression of ERG contributes to the development of prostate cancer making it an attractive therapeutic target.  However, transcription factors have historically been difficult to inhibit by conventional means.  Furthermore, identifying critical TMPRSS2-ERG dependent pathways to target is difficult as ERG regulates many cellular processes.  To address these challenges Dr. Takeda has developed a strategy to use gene expression signatures as a readout for TMPRSS2-ERG activity.  This novel gene expression signature assay was combined with recent advances in genetics, proteomics, and chemistry to identify genes and small molecules that modulate TMPRSS2-ERG activity in prostate cancer cells.  These findings will be important for understanding TMPRSS2-ERG function in prostate cancer and developing new therapeutics targeting its function.

Research Departments:

Location

Dana-Farber Cancer Institute
450 Brookline Avenue
Dana 1230
Boston MA, 02215
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