Donna S. Neuberg, ScD

Donna S. Neuberg, ScD

Researcher

Contact Information

Office Phone Number

(617) 632-2448

Fax

(617) 632-2444

Appointments

617-632-3012

Biography

Donna S. Neuberg, ScD

Dr. Neuberg received her ScD in Biostatistics from Harvard School of Public Health in 1988. She became a biostatistician at DFCI in 1987. She serves as the senior statistician for the Leukemia, Lymphoma, and Benign Hematology Programs at DFCI. She is also very involved in mentoring and teaching clinical and laboratory investigators.

Researcher

Physician

Senior Lecturer in Biostatistics, Harvard School of Public Health

Research

    Analysis of clinical trials with correlative laboratory data

    Analysis of laboratory and animal data

    There exists a substantial statistical literature exists on the design and analysis of clinical trials with response or time-to-event end points. However, early-stage trials with biologic end points, such as vaccine studies or investigations of targeted therapies, require alternative approaches. It is crucial that in the planning stage, the unique aspects of a biologic or molecular therapy be taken into account. This principle extends to the design of laboratory studies, and especially to those correlative laboratory studies that embedded in clinical investigations.

    An aspect of the complexity of laboratory studies—whether in basic science, animals, or humans--is the abundance of data. With the advent of whole genome or whole exome sequencing in conjunction with epigenetic or proteomic studies on the same patient, the number of laboratory values collected far exceeds the number of patients. Dr. Neuberg's current interests concern the planning and analysis of studies that integrate laboratory outcomes at the genome, transcriptome, or proteome level with clinical and demographic information.

    Research Departments

    Publications

      • Influence of thrombocytopenia on bleeding and vascular events in atrial fibrillation. Blood Adv. 2023 Sep 27. View in: Pubmed

      • Effect of BMI on toxicities and survival among adolescents and young adults treated on DFCI Consortium ALL trials. Blood Adv. 2023 09 26; 7(18):5234-5245. View in: Pubmed

      • FLT3-ITD does not predict inferior prognosis in acute myeloid leukemia patients aged =60 years. Blood Adv. 2023 09 26; 7(18):5354-5358. View in: Pubmed

      • ZNF683 marks a CD8+ T cell population associated with anti-tumor immunity following anti-PD-1 therapy for Richter syndrome. Cancer Cell. 2023 Sep 21. View in: Pubmed

      • Higher abatacept exposure after transplant decreases acute GVHD risk without increasing adverse events. Blood. 2023 08 24; 142(8):700-710. View in: Pubmed

      • Loss-of-function lesions impact B-cell development and fitness but are insufficient to drive CLL in mouse models. Blood Adv. 2023 08 22; 7(16):4514-4517. View in: Pubmed

      • Abatacept for the prevention of graft versus host disease in pediatric patients receiving 7/8 HLA-mismatched unrelated transplant for hematologic malignancies: a real-world analysis. Bone Marrow Transplant. 2023 Aug 14. View in: Pubmed

      • Atorvastatin for Anthracycline-Associated Cardiac Dysfunction: The STOP-CA Randomized Clinical Trial. JAMA. 2023 08 08; 330(6):528-536. View in: Pubmed

      • Mapping the evolution of T cell states during response and resistance to adoptive cellular therapy. Cell Rep. 2023 Aug 29; 42(8):113011. View in: Pubmed

      • Correcting the record on anemia of aging: a statistical reanalysis. Blood Adv. 2023 07 25; 7(14):3642-3643. View in: Pubmed

      • Impairment of health-related quality of life for children with acute lymphoblastic leukemia over the first year of therapy: A report from the DFCI ALL Consortium. Pediatr Blood Cancer. 2023 Nov; 70(11):e30560. View in: Pubmed

      • Clonal Hematopoiesis in Young Women Treated for Breast Cancer. Clin Cancer Res. 2023 07 05; 29(13):2551-2558. View in: Pubmed

      • Impact of cytoreduction and remission status on hematopoietic cell transplantation outcomes in pediatric myelodysplastic syndrome and related disorders. Pediatr Blood Cancer. 2023 Jun 27; e30530. View in: Pubmed

      • Prediction of risk for myeloid malignancy in clonal hematopoiesis. NEJM Evid. 2023 May; 2(5). View in: Pubmed

      • Mechanisms of response and resistance to combined decitabine and ipilimumab for advanced myeloid disease. Blood. 2023 04 13; 141(15):1817-1830. View in: Pubmed

      • Ipilimumab plus decitabine for patients with MDS or AML in posttransplant or transplant-naïve settings. Blood. 2023 04 13; 141(15):1884-1888. View in: Pubmed

      • Nelarabine combination therapy for relapsed or refractory T-cell acute lymphoblastic lymphoma/leukemia. Blood Adv. 2023 04 11; 7(7):1092-1102. View in: Pubmed

      • Mitochondrial DNA Mutations as Natural Barcodes for Lineage Tracing of Murine Tumor Models. Cancer Res. 2023 03 02; 83(5):667-672. View in: Pubmed

      • Targeting MET and FGFR in Relapsed or Refractory Acute Myeloid Leukemia: Preclinical and Clinical Findings, and Signal Transduction Correlates. Clin Cancer Res. 2023 03 01; 29(5):878-887. View in: Pubmed

      • In Vivo Modeling of CLL Transformation to Richter Syndrome Reveals Convergent Evolutionary Paths and Therapeutic Vulnerabilities. Blood Cancer Discov. 2023 03 01; 4(2):150-169. View in: Pubmed

      • Absolute neutrophil count by Duffy status among healthy Black and African American adults. Blood Adv. 2023 02 14; 7(3):317-320. View in: Pubmed

      • Antiplatelet medications and intracranial hemorrhage in patients with primary brain tumors. J Thromb Haemost. 2023 05; 21(5):1148-1155. View in: Pubmed

      • Enhancing CAR-T cell functionality in a patient-specific manner. Nat Commun. 2023 01 31; 14(1):506. View in: Pubmed

      • Evolutionary history of transformation from chronic lymphocytic leukemia to Richter syndrome. Nat Med. 2023 01; 29(1):158-169. View in: Pubmed

      • Persistence of Unequal Access to Classical Hematology Telemedicine Visits by Race and Other Demographics During the COVID-19 Pandemic. Telemed J E Health. 2023 08; 29(8):1266-1271. View in: Pubmed

      • Intensity of induction regimen and outcomes among adults with Ph+ALL undergoing allogeneic hematopoietic stem cell transplantation. Leuk Res. 2023 02; 125:107004. View in: Pubmed

      • Immune recall improves antibody durability and breadth to SARS-CoV-2 variants. Sci Immunol. 2022 12 23; 7(78):eabp8328. View in: Pubmed

      • Pagophagia and restless legs syndrome are highly associated with iron deficiency and should be included in histories evaluating anemia. Am J Hematol. 2023 01; 98(1):E8-E10. View in: Pubmed

      • Clonal hematopoiesis of indeterminate potential and risk of death from COVID-19. Blood. 2022 11 03; 140(18):1993-1997. View in: Pubmed

      • Enrollment Lessons from a Biological Assignment Study of Marrow Transplantation versus Standard Care for Adolescents and Young Adults with Sickle Cell Disease: Considerations for Future Gene and Cellular Therapy Trials. Transplant Cell Ther. 2023 04; 29(4):217-221. View in: Pubmed

      • Pulmonary hypertension is associated with poor cardiovascular and hematologic outcomes in patients with myeloproliferative neoplasms and cardiovascular disease. Int J Hematol. 2022 Oct 02. View in: Pubmed

      • Patient perspectives on testing for clonal hematopoiesis of indeterminate potential. Blood Adv. 2022 Sep 21. View in: Pubmed

      • TET2-mutant clonal hematopoiesis and risk of gout. Blood. 2022 09 08; 140(10):1094-1103. View in: Pubmed

      • Molecular map of chronic lymphocytic leukemia and its impact on outcome. Nat Genet. 2022 11; 54(11):1664-1674. View in: Pubmed

      • Improved T-cell Immunity Following Neoadjuvant Chemotherapy in Ovarian Cancer. Clin Cancer Res. 2022 08 02; 28(15):3356-3366. View in: Pubmed

      • Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment. Nat Genet. 2022 08; 54(8):1178-1191. View in: Pubmed

      • Impact of the Types and Relative Quantities of IGHV Gene Mutations in Predicting Prognosis of Patients With Chronic Lymphocytic Leukemia. Front Oncol. 2022; 12:897280. View in: Pubmed

      • Reversal of viral and epigenetic HLA class I repression in Merkel cell carcinoma. J Clin Invest. 2022 07 01; 132(13). View in: Pubmed

      • Peripheral blood CD3+ T-cell gene expression biomarkers correlate with clinical frailty in patients with haematological malignancies. Br J Haematol. 2022 10; 199(1):100-105. View in: Pubmed

      • Survival outcomes with warfarin compared with direct oral anticoagulants in cancer-associated venous thromboembolism in the United States: A population-based cohort study. PLoS Med. 2022 05; 19(5):e1004012. View in: Pubmed

      • Prediction of life-threatening and disabling bleeding in patients with AML receiving intensive induction chemotherapy. Blood Adv. 2022 05 10; 6(9):2835-2846. View in: Pubmed

      • Landscape of helper and regulatory antitumour CD4+ T cells in melanoma. Nature. 2022 05; 605(7910):532-538. View in: Pubmed

      • Genomic profiling of a randomized trial of interferon-a vs hydroxyurea in MPN reveals mutation-specific responses. Blood Adv. 2022 04 12; 6(7):2107-2119. View in: Pubmed

      • Single-cell analysis reveals immune dysfunction from the earliest stages of CLL that can be reversed by ibrutinib. Blood. 2022 04 07; 139(14):2252-2256. View in: Pubmed

      • Predictors of thrombosis in children receiving therapy for acute lymphoblastic leukemia: Results from Dana-Farber Cancer Institute ALL Consortium trial 05-001. Pediatr Blood Cancer. 2022 08; 69(8):e29581. View in: Pubmed

      • Outcomes of antifungal prophylaxis for newly diagnosed AML patients treated with a hypomethylating agent and venetoclax. Leuk Lymphoma. 2022 08; 63(8):1934-1941. View in: Pubmed

      • Antiplatelet medications and risk of intracranial hemorrhage in patients with metastatic brain tumors. Blood Adv. 2022 03 08; 6(5):1559-1565. View in: Pubmed

      • A nonrandomized phase I and biomarker trial of regorafenib in advanced myeloid malignancies. EJHaem. 2022 May; 3(2):434-442. View in: Pubmed

      • Antibody and T-cell responses to SARS-CoV-2 vaccination in myeloproliferative neoplasm patients. Leukemia. 2022 04; 36(4):1176-1179. View in: Pubmed

      • Ixazomib in addition to chemotherapy for the treatment of acute lymphoblastic leukemia in older adults. Leuk Lymphoma. 2022 06; 63(6):1428-1435. View in: Pubmed

      • Association of clonal hematopoiesis with chronic obstructive pulmonary disease. Blood. 2022 01 20; 139(3):357-368. View in: Pubmed

      • Anticoagulation in cancer-associated thromboembolism with thrombocytopenia: a prospective, multicenter cohort study. Blood Adv. 2021 12 28; 5(24):5546-5553. View in: Pubmed

      • ASH Research Collaborative: a real-world data infrastructure to support real-world evidence development and learning healthcare systems in hematology. Blood Adv. 2021 12 14; 5(23):5429-5438. View in: Pubmed

      • Longitudinal Single-Cell Dynamics of Chromatin Accessibility and Mitochondrial Mutations in Chronic Lymphocytic Leukemia Mirror Disease History. Cancer Discov. 2021 12 01; 11(12):3048-3063. View in: Pubmed

      • Coevolving JAK2V617F+relapsed AML and donor T cells with PD-1 blockade after stem cell transplantation: an index case. Blood Adv. 2021 11 23; 5(22):4701-4709. View in: Pubmed

      • Mapping the evolution of T cell states during response and resistance to adoptive cellular therapy. Cell Rep. 2021 11 09; 37(6):109992. View in: Pubmed

      • Practice patterns and outcomes of direct oral anticoagulant use in myeloproliferative neoplasm patients. Blood Cancer J. 2021 11 05; 11(11):176. View in: Pubmed

      • Erratum to: Analysis, identification and visualization of subgroups in genomics. Brief Bioinform. 2021 Nov 05; 22(6). View in: Pubmed

      • Activation of Notch and Myc Signaling via B-cell-Restricted Depletion of Dnmt3a Generates a Consistent Murine Model of Chronic Lymphocytic Leukemia. Cancer Res. 2021 12 15; 81(24):6117-6130. View in: Pubmed

      • Impact of sickle cell trait on morbidity and mortality from SARS-CoV-2 infection. Blood Adv. 2021 09 28; 5(18):3690-3693. View in: Pubmed

      • Overall survival with warfarin vs. low-molecular-weight heparin in cancer-associated thrombosis. J Thromb Haemost. 2021 11; 19(11):2825-2834. View in: Pubmed

      • Multi-platform profiling characterizes molecular subgroups and resistance networks in chronic lymphocytic leukemia. Nat Commun. 2021 09 13; 12(1):5395. View in: Pubmed

      • The clinical and functional effects of TERT variants in myelodysplastic syndrome. Blood. 2021 09 09; 138(10):898-911. View in: Pubmed

      • Clonal hematopoiesis in patients receiving chimeric antigen receptor T-cell therapy. Blood Adv. 2021 08 10; 5(15):2982-2986. View in: Pubmed

      • Memory B cell repertoire for recognition of evolving SARS-CoV-2 spike. Cell. 2021 09 16; 184(19):4969-4980.e15. View in: Pubmed

      • Phenotype, specificity and avidity of antitumour CD8+ T cells in melanoma. Nature. 2021 08; 596(7870):119-125. View in: Pubmed

      • ZBTB33 is mutated in clonal hematopoiesis and myelodysplastic syndromes and impacts RNA splicing. Blood Cancer Discov. 2021 09; 2(5):500-517. View in: Pubmed

      • Multifunctional barcoding with ClonMapper enables high-resolution study of clonal dynamics during tumor evolution and treatment. Nat Cancer. 2021 07; 2(7):758-772. View in: Pubmed

      • Multiplex Tissue Imaging Harmonization: A Multicenter Experience from CIMAC-CIDC Immuno-Oncology Biomarkers Network. Clin Cancer Res. 2021 09 15; 27(18):5072-5083. View in: Pubmed

      • Efficacy and Toxicity of Pegaspargase and Calaspargase Pegol in Childhood Acute Lymphoblastic Leukemia: Results of DFCI 11-001. J Clin Oncol. 2021 11 01; 39(31):3496-3505. View in: Pubmed

      • Molecular and cellular features of CTLA-4 blockade for relapsed myeloid malignancies after transplantation. Blood. 2021 06 10; 137(23):3212-3217. View in: Pubmed

      • Analysis, identification and visualization of subgroups in genomics. Brief Bioinform. 2021 05 20; 22(3). View in: Pubmed

      • Author Correction: Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes. Nat Med. 2021 May; 27(5):927. View in: Pubmed

      • Pretreatment clinical and genetic factors predict early post-treatment mortality in fit AML patients following induction. Am J Hematol. 2021 07 01; 96(7):E259-E262. View in: Pubmed

      • Spatial signatures identify immune escape via PD-1 as a defining feature of T-cell/histiocyte-rich large B-cell lymphoma. Blood. 2021 03 11; 137(10):1353-1364. View in: Pubmed

      • Memory B cell repertoire for recognition of evolving SARS-CoV-2 spike. bioRxiv. 2021 Mar 10. View in: Pubmed

      • A hotspot mutation in transcription factor IKZF3 drives B cell neoplasia via transcriptional dysregulation. Cancer Cell. 2021 03 08; 39(3):380-393.e8. View in: Pubmed

      • Author Correction: Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes. Nat Med. 2021 Mar; 27(3):562. View in: Pubmed

      • Intermediate-dose anticoagulation, aspirin, and in-hospital mortality in COVID-19: A propensity score-matched analysis. Am J Hematol. 2021 04 01; 96(4):471-479. View in: Pubmed

      • Genomic and evolutionary portraits of disease relapse in acute myeloid leukemia. Leukemia. 2021 09; 35(9):2688-2692. View in: Pubmed

      • Personal neoantigen vaccines induce persistent memory T cell responses and epitope spreading in patients with melanoma. Nat Med. 2021 03; 27(3):515-525. View in: Pubmed

      • Intermediate-dose anticoagulation, aspirin, and in-hospital mortality in COVID-19: a propensity score-matched analysis. medRxiv. 2021 Jan 15. View in: Pubmed

      • Corrigendum. Pediatr Blood Cancer. 2021 Mar; 68(3):e28885. View in: Pubmed

      • Short telomere length predicts nonrelapse mortality after stem cell transplantation for myelodysplastic syndrome. Blood. 2020 12 24; 136(26):3070-3081. View in: Pubmed

      • Cross-Site Concordance Evaluation of Tumor DNA and RNA Sequencing Platforms for the CIMAC-CIDC Network. Clin Cancer Res. 2021 09 15; 27(18):5049-5061. View in: Pubmed

      • Outcomes of patients with hematologic malignancies and COVID-19: a report from the ASH Research Collaborative Data Hub. Blood Adv. 2020 12 08; 4(23):5966-5975. View in: Pubmed

      • Preneoplastic Alterations Define CLL DNA Methylome and Persist through Disease Progression and Therapy. Blood Cancer Discov. 2021 01; 2(1):54-69. View in: Pubmed

      • High throughput single-cell detection of multiplex CRISPR-edited gene modifications. Genome Biol. 2020 10 20; 21(1):266. View in: Pubmed

      • Identification of prognostic factors in childhood T-cell acute lymphoblastic leukemia: Results from DFCI ALL Consortium Protocols 05-001 and 11-001. Pediatr Blood Cancer. 2021 01; 68(1):e28719. View in: Pubmed

      • Pregnancy outcomes, risk factors, and cell count trends in pregnant women with essential thrombocythemia. Leuk Res. 2020 11; 98:106459. View in: Pubmed

      • Distinct evolutionary paths in chronic lymphocytic leukemia during resistance to the graft-versus-leukemia effect. Sci Transl Med. 2020 09 16; 12(561). View in: Pubmed

      • Endogenous Glucocorticoid Signaling Regulates CD8+ T Cell Differentiation and Development of Dysfunction in the Tumor Microenvironment. Immunity. 2020 09 15; 53(3):658-671.e6. View in: Pubmed

      • Short Telomere Length Predicts Non-Relapse Mortality after Stem Cell Transplantation for Myelodysplastic Syndrome. Blood. 2020 Aug 17. View in: Pubmed

      • A peripheral immune signature of responsiveness to PD-1 blockade in patients with classical Hodgkin lymphoma. Nat Med. 2020 09; 26(9):1468-1479. View in: Pubmed

      • Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes. Nat Med. 2020 10; 26(10):1549-1556. View in: Pubmed

      • Heparin induced thrombocytopenia antibodies in Covid-19. Am J Hematol. 2020 Jul 13. View in: Pubmed

      • SF3B1-mutant MDS as a distinct disease subtype: a proposal from the International Working Group for the Prognosis of MDS. Blood. 2020 07 09; 136(2):157-170. View in: Pubmed

      • Anticoagulation after intracranial hemorrhage in brain tumors: Risk of recurrent hemorrhage and venous thromboembolism. Res Pract Thromb Haemost. 2020 Jul; 4(5):860-865. View in: Pubmed

      • Clonal hematopoiesis is associated with adverse outcomes in multiple myeloma patients undergoing transplant. Nat Commun. 2020 06 12; 11(1):2996. View in: Pubmed

      • Interplay of somatic alterations and immune infiltration modulates response to PD-1 blockade in advanced clear cell renal cell carcinoma. Nat Med. 2020 06; 26(6):909-918. View in: Pubmed

      • Dose-adjusted enoxaparin thromboprophylaxis in hospitalized cancer patients: a randomized, double-blinded multicenter phase 2 trial. Blood Adv. 2020 05 26; 4(10):2254-2260. View in: Pubmed

      • BCR selection and affinity maturation in Peyer's patch germinal centres. Nature. 2020 06; 582(7812):421-425. View in: Pubmed

      • HLA alleles associated with asparaginase hypersensitivity in childhood ALL: a report from the DFCI Consortium. Pharmacogenomics. 2020 06; 21(8):541-547. View in: Pubmed

      • Sensitive Detection of Minimal Residual Disease in Patients Treated for Early-Stage Breast Cancer. Clin Cancer Res. 2020 06 01; 26(11):2556-2564. View in: Pubmed

      • Mind the gap: Expediting gender parity in MD-PhD admissions. JCI Insight. 2020 02 27; 5(4). View in: Pubmed

      • Automated Flow Synthesis of Tumor Neoantigen Peptides for Personalized Immunotherapy. Sci Rep. 2020 01 20; 10(1):723. View in: Pubmed

      • Increased mitochondrial apoptotic priming with targeted therapy predicts clinical response to re-induction chemotherapy. Am J Hematol. 2020 03; 95(3):245-250. View in: Pubmed

      • A phase 1 study of the antibody-drug conjugate brentuximab vedotin with re-induction chemotherapy in patients with CD30-expressing relapsed/refractory acute myeloid leukemia. Cancer. 2020 03 15; 126(6):1264-1273. View in: Pubmed

      • Alisertib plus induction chemotherapy in previously untreated patients with high-risk, acute myeloid leukaemia: a single-arm, phase 2 trial. Lancet Haematol. 2020 Feb; 7(2):e122-e133. View in: Pubmed

      • Sudden death in sickle cell disease: current experience. Br J Haematol. 2020 02; 188(4):e43-e45. View in: Pubmed

      • Genes identified through genome-wide association studies of osteonecrosis in childhood acute lymphoblastic leukemia patients. Pharmacogenomics. 2019 11; 20(17):1189-1197. View in: Pubmed

      • Dissecting the web of ischemic stroke, sickle cell trait, and chronic kidney disease. Am J Hematol. 2019 12; 94(12):1302. View in: Pubmed

      • Pembrolizumab in Relapsed or Refractory Primary Mediastinal Large B-Cell Lymphoma. J Clin Oncol. 2019 12 01; 37(34):3291-3299. View in: Pubmed

      • Mitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies. Cancer Cell. 2019 10 14; 36(4):369-384.e13. View in: Pubmed

      • CXCR4 upregulation is an indicator of sensitivity to B-cell receptor/PI3K blockade and a potential resistance mechanism in B-cell receptor-dependent diffuse large B-cell lymphomas. Haematologica. 2020 05; 105(5):1361-1368. View in: Pubmed

      • A dominant-negative effect drives selection of TP53 missense mutations in myeloid malignancies. Science. 2019 08 09; 365(6453):599-604. View in: Pubmed

      • Contrast-enhanced ultrasound detects changes in microvascular blood flow in adults with sickle cell disease. PLoS One. 2019; 14(7):e0218783. View in: Pubmed

      • Severe CD4+ T-cell lymphopenia is not observed in frequent plateletpheresis donors collected on the Fenwal Amicus. Transfusion. 2019 09; 59(9):2783-2787. View in: Pubmed

      • Multicenter analysis of outcomes in blastic plasmacytoid dendritic cell neoplasm offers a pretargeted therapy benchmark. Blood. 2019 08 22; 134(8):678-687. View in: Pubmed

      • Brentuximab vedotin, doxorubicin, vinblastine, and dacarbazine for nonbulky limited-stage classical Hodgkin lymphoma. Blood. 2019 08 15; 134(7):606-613. View in: Pubmed

      • Growth dynamics in naturally progressing chronic lymphocytic leukaemia. Nature. 2019 06; 570(7762):474-479. View in: Pubmed

      • Phase 1 study of lenalidomide, bendamustine, and rituximab in previously untreated patients with chronic lymphocytic leukemia. Leuk Lymphoma. 2019 12; 60(12):2931-2938. View in: Pubmed

      • Synthetic Lethality of Wnt Pathway Activation and Asparaginase in Drug-Resistant Acute Leukemias. Cancer Cell. 2019 04 15; 35(4):664-676.e7. View in: Pubmed

      • Activation of hedgehog signaling associates with early disease progression in chronic lymphocytic leukemia. Blood. 2019 06 20; 133(25):2651-2663. View in: Pubmed

      • Targeting protein disulfide isomerase with the flavonoid isoquercetin to improve hypercoagulability in advanced cancer. JCI Insight. 2019 02 21; 4(4). View in: Pubmed

      • CD4+ T-cell lymphopenia in frequent platelet donors who have ceased platelet donation for at least 1 year. Transfusion. 2019 05; 59(5):1644-1647. View in: Pubmed

      • Bone marrow transplantation for adolescents and young adults with sickle cell disease: Results of a prospective multicenter pilot study. Am J Hematol. 2019 04; 94(4):446-454. View in: Pubmed

      • A Murine Model of Chronic Lymphocytic Leukemia Based on B Cell-Restricted Expression of Sf3b1 Mutation and Atm Deletion. Cancer Cell. 2019 02 11; 35(2):283-296.e5. View in: Pubmed

      • TP53 mutation status divides myelodysplastic syndromes with complex karyotypes into distinct prognostic subgroups. Leukemia. 2019 07; 33(7):1747-1758. View in: Pubmed

      • Postoperative bridging anticoagulation and left ventricular assist system thrombosis. J Thromb Thrombolysis. 2019 Jan; 47(1):57-66. View in: Pubmed

      • Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial. Nature. 2019 01; 565(7738):234-239. View in: Pubmed

      • Intracranial hemorrhage with direct oral anticoagulants in patients with brain tumors. J Thromb Haemost. 2019 01; 17(1):72-76. View in: Pubmed

      • Plateletpheresis-associated lymphopenia in frequent platelet donors. Blood. 2019 02 07; 133(6):605-614. View in: Pubmed

      • Isocitrate dehydrogenase 1 and 2 mutations, 2-hydroxyglutarate levels, and response to standard chemotherapy for patients with newly diagnosed acute myeloid leukemia. Cancer. 2019 02 15; 125(4):541-549. View in: Pubmed

      • PRC2 loss induces chemoresistance by repressing apoptosis in T cell acute lymphoblastic leukemia. J Exp Med. 2018 12 03; 215(12):3094-3114. View in: Pubmed

      • Phase I Trial of Autologous CAR T Cells Targeting NKG2D Ligands in Patients with AML/MDS and Multiple Myeloma. Cancer Immunol Res. 2019 01; 7(1):100-112. View in: Pubmed

      • Characteristics of myeloproliferative neoplasms in patients exposed to ionizing radiation following the Chernobyl nuclear accident. Am J Hematol. 2019 01; 94(1):62-73. View in: Pubmed

      • Prospective feasibility and safety assessment of surgical biopsy for patients with newly diagnosed diffuse intrinsic pontine glioma. Neuro Oncol. 2018 10 09; 20(11):1547-1555. View in: Pubmed

      • Splicing modulation sensitizes chronic lymphocytic leukemia cells to venetoclax by remodeling mitochondrial apoptotic dependencies. JCI Insight. 2018 10 04; 3(19). View in: Pubmed

      • A cloning and expression system to probe T-cell receptor specificity and assess functional avidity to neoantigens. Blood. 2018 11 01; 132(18):1911-1921. View in: Pubmed

      • Author Correction: Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes. Nat Med. 2018 Aug; 24(8):1290-1291. View in: Pubmed

      • Publisher Correction: Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes. Nat Med. 2018 Aug; 24(8):1292. View in: Pubmed

      • The Benefits of TRTHing along. Hemasphere. 2018 08; 2(4):e138. View in: Pubmed

      • Panobinostat in combination with rituximab in heavily pretreated diffuse large B-cell lymphoma: Results of a phase II study. Hematol Oncol. 2018 Oct; 36(4):633-637. View in: Pubmed

      • Refining risk classification in childhood B acute lymphoblastic leukemia: results of DFCI ALL Consortium Protocol 05-001. Blood Adv. 2018 06 26; 2(12):1449-1458. View in: Pubmed

      • JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia. J Exp Med. 2018 07 02; 215(7):1929-1945. View in: Pubmed

      • CDK6 Antagonizes p53-Induced Responses during Tumorigenesis. Cancer Discov. 2018 07; 8(7):884-897. View in: Pubmed

      • Outcome of children and adolescents with Down syndrome treated on Dana-Farber Cancer Institute Acute Lymphoblastic Leukemia Consortium protocols 00-001 and 05-001. Pediatr Blood Cancer. 2018 10; 65(10):e27256. View in: Pubmed

      • Mass cytometry of Hodgkin lymphoma reveals a CD4+ regulatory T-cell-rich and exhausted T-effector microenvironment. Blood. 2018 08 23; 132(8):825-836. View in: Pubmed

      • Reply to Z. Wu et al. J Clin Oncol. 2018 09 01; 36(25):2657. View in: Pubmed

      • Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes. Nat Med. 2018 05; 24(5):679-690. View in: Pubmed

      • Reply to comment on: Effectiveness of antibacterial prophylaxis during induction chemotherapy in children with acute lymphoblastic leukemia. Pediatr Blood Cancer. 2018 08; 65(8):e27082. View in: Pubmed

      • Wnt5a induces ROR1 to recruit DOCK2 to activate Rac1/2 in chronic lymphocytic leukemia. Blood. 2018 07 12; 132(2):170-178. View in: Pubmed

      • PPAR? Contributes to Immunity Induced by Cancer Cell Vaccines That Secrete GM-CSF. Cancer Immunol Res. 2018 06; 6(6):723-732. View in: Pubmed

      • Cancer-Germline Antigen Expression Discriminates Clinical Outcome to CTLA-4 Blockade. Cell. 2018 04 19; 173(3):624-633.e8. View in: Pubmed

      • Increased neutrophil extracellular trap formation promotes thrombosis in myeloproliferative neoplasms. Sci Transl Med. 2018 04 11; 10(436). View in: Pubmed

      • Autochthonous tumors driven by Rb1 loss have an ongoing requirement for the RBP2 histone demethylase. Proc Natl Acad Sci U S A. 2018 04 17; 115(16):E3741-E3748. View in: Pubmed

      • Phase I trial of the mTOR inhibitor everolimus in combination with multi-agent chemotherapy in relapsed childhood acute lymphoblastic leukemia. Pediatr Blood Cancer. 2018 07; 65(7):e27062. View in: Pubmed

      • Microbial symbionts regulate the primary Ig repertoire. J Exp Med. 2018 05 07; 215(5):1397-1415. View in: Pubmed

      • Hedgehog pathway mutations drive oncogenic transformation in high-risk T-cell acute lymphoblastic leukemia. Leukemia. 2018 10; 32(10):2126-2137. View in: Pubmed

      • Corrigendum: An immunogenic personal neoantigen vaccine for patients with melanoma. Nature. 2018 03 14; 555(7696):402. View in: Pubmed

      • Prognostic impact of kinase-activating fusions and IKZF1 deletions in pediatric high-risk B-lineage acute lymphoblastic leukemia. Blood Adv. 2018 03 13; 2(5):529-533. View in: Pubmed

      • Statistics Everywhere. Hemasphere. 2018 Jan-Feb; 2(1):e30. View in: Pubmed

      • Major Histocompatibility Complex Class II and Programmed Death Ligand 1 Expression Predict Outcome After Programmed Death 1 Blockade in Classic Hodgkin Lymphoma. J Clin Oncol. 2018 04 01; 36(10):942-950. View in: Pubmed

      • The use of prophylactic anticoagulation during induction and consolidation chemotherapy in adults with acute lymphoblastic leukemia. J Thromb Thrombolysis. 2018 Feb; 45(2):306-314. View in: Pubmed

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      • The frequency and management of asparaginase-related thrombosis in paediatric and adult patients with acute lymphoblastic leukaemia treated on Dana-Farber Cancer Institute consortium protocols. Br J Haematol. 2011 Feb; 152(4):452-9. View in: Pubmed

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      • CCL3 (MIP-1a) plasma levels and the risk for disease progression in chronic lymphocytic leukemia. Blood. 2011 Feb 03; 117(5):1662-9. View in: Pubmed

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      • Assessment of dexrazoxane as a cardioprotectant in doxorubicin-treated children with high-risk acute lymphoblastic leukaemia: long-term follow-up of a prospective, randomised, multicentre trial. Lancet Oncol. 2010 Oct; 11(10):950-61. View in: Pubmed

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      • Self-administered, subcutaneous alemtuzumab to treat residual disease in patients with chronic lymphocytic leukemia. Cancer. 2011 Jan 01; 117(1):116-24. View in: Pubmed

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      • Characteristics and outcomes after autologous stem cell transplant for patients with relapsed or refractory diffuse large B-cell lymphoma who failed initial rituximab, cyclophosphamide, adriamycin, vincristine, and prednisone therapy compared to patients who failed cyclophosphamide, adriamycin, vincristine, and prednisone. Leuk Lymphoma. 2010 May; 51(5):789-96. View in: Pubmed

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      • Erwinia asparaginase after allergy to E. coli asparaginase in children with acute lymphoblastic leukemia. Pediatr Blood Cancer. 2010 Feb; 54(2):199-205. View in: Pubmed

      • Generation of tumor-specific T lymphocytes using dendritic cell/tumor fusions and anti-CD3/CD28. J Immunother. 2010 Feb-Mar; 33(2):155-66. View in: Pubmed

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      • Long-term results of Dana-Farber Cancer Institute ALL Consortium protocols for children with newly diagnosed acute lymphoblastic leukemia (1985-2000). Leukemia. 2010 Feb; 24(2):320-34. View in: Pubmed

      • Intravenous PEG-asparaginase during remission induction in children and adolescents with newly diagnosed acute lymphoblastic leukemia. Blood. 2010 Feb 18; 115(7):1351-3. View in: Pubmed

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      • Sonographic scoring index for prenatal detection of chromosomal abnormalities. J Ultrasound Med. 1992 Sep; 11(9):449-58. View in: Pubmed

      • Environmental endotoxin measurement: the Kinetic Limulus Assay with Resistant-parallel-line Estimation. Environ Res. 1992 Apr; 57(2):212-30. View in: Pubmed

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      • Humeral shortening in second-trimester fetuses with Down syndrome. Obstet Gynecol. 1991 Feb; 77(2):223-7. View in: Pubmed

      • A pilot study of three sequential chemotherapeutic regimens in metastatic breast cancer. Am J Clin Oncol. 1991 Feb; 14(1):45-8. View in: Pubmed

      • Making cocktails versus making soup. J Clin Oncol. 1991 Feb; 9(2):200-3. View in: Pubmed

      • Phase II study of lonidamine in patients with metastatic breast cancer. An Eastern Cooperative Oncology Group study. Invest New Drugs. 1990 Nov; 8(4):397-9. View in: Pubmed

      • Prevalence and significance of acquired immunodeficiency syndrome-related retinal microvasculopathy. Am J Ophthalmol. 1989 Mar 15; 107(3):229-35. View in: Pubmed

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      Dana-Farber Cancer Institute

      450 Brookline Avenue CLSB 11004 Boston, MA 02215
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      Dana-Farber Cancer Institute

      Location Avtar

      Dana-Farber Cancer Institute

      450 Brookline Avenue CLSB 11004 Boston, MA 02215
      Get Direction
      42.3374, -71.1082