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Edward J. Benz Jr., MD


Medical Oncology

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Physician

  • President and CEO Emeritus, Dana-Farber Cancer Institute
  • Richard and Susan Smith Distinguished Professor of Medicine, Professor of Pediatrics, Professor of Genetics, Harvard Medical School

Contact Information

  • Office Phone Number617-632-2015
  • Fax617-632-2161

Bio

Dr. Benz graduated from Harvard Medical School in 1973 and received his training at Brigham and Women's Hospital and the National Institutes of Health. He is president and CEO emeritus of Dana-Farber Cancer Institute, director emeritus and principal investigator of Dana-Farber/Harvard Cancer Center, and a member of the Governing Board of Dana-Farber/Children's Cancer Center. He is also a clinical hematologist and an active NIH-funded investigator.

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Board Certification:

  • Hematology
  • Internal Medicine

Fellowship:

  • Yale University, Hematology

Residency:

  • Brigham and Women's Hospital, Internal Medicine

Medical School:

  • Harvard Medical School

Recent Awards:

  • President, American Association of Cancer Institutes 2005
  • Elected Fellow, American Association for the Advancement of Science 2004
  • Member, American Academy of Arts and Sciences 2004
  • Member, Institute of Medicine 2004

Location

Dana-Farber Cancer Institute
450 Brookline Avenue
Dana 1628
Boston MA, 02215
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Research

The Molecular Pathology of Hemolytic Anemias

Our laboratory continues to focus on the molecular pathology and physiology of red cell development, the molecular basis of inherited hemolytic anemias, and the use of the red cell homeostatic system as a model to study gene regulation and growth control in other tissues.

During the past five years, we have focused on the structure, function, gene regulation, and molecular pathology of protein 4.1. This cytoskeletal protein, originally described in the red cell, forms a ternary complex with spectrin-actin, and attaches the spectrin latticework to membranes by binding to the cytoplasmic domains of key transmembrane proteins. Defects in this protein are associated with hereditary erythrocytosis. Our laboratory has shown that many isoforms of protein 4.1 arise from a single protein 4.1R gene by tissue-specific alternative mRNA splicing pathways, a number of which we have characterized. Our group has identified at least three target sequence areas and one putative splicing factor involved in tissue-specific regulation of red cell isoforms during erythroid differentiation.

Isoforms of protein 4.1R are expressed in many tissues and exhibit complex patterns of intracellular localization. We have shown that some forms associate with NuMa, a key mitotic protein, and are components of the mitotic apparatus. Other domains of protein 4.1R participate in tight junction formation by binding the proteins ZO-2. Moreover, as cells approach the state of terminal differentiation, there is a clear shift from the intranuclear localization of protein 4.1R to peripheral localization. Current studies are pursuing the hypothesis that this complex shift in localization and association is indicative of a role for protein 4.1R in signaling terminal differentiation and initiating shutdown of cell proliferation and division.

Huang SC, Zhang HS, Yu B, McMahon E, Nguyen DT, Yu FH, Ou AC, Ou JP, Benz EJ. Protein 4.1R Exon 16 3' Splice Site Activation Requires Coordination among TIA1, Pcbp1, and RBM39 during Terminal Erythropoiesis. Mol Cell Biol. 2017 May 01; 37(9).
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Benz EJ. The Jeremiah Metzger Lecture Cancer in the Twenty-First Century: An Inside View from an Outsider. Trans Am Clin Climatol Assoc. 2017; 128:275-297.
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Huang SC, Zhou A, Nguyen DT, Zhang HS, Benz EJ. Protein 4.1R Influences Myogenin Protein Stability and Skeletal Muscle Differentiation. J Biol Chem. 2016 Dec 02; 291(49):25591-25607.
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Nardi EA, Wolfson JA, Rosen ST, Diasio RB, Gerson SL, Parker BA, Alvarnas JC, Levine HA, Fong Y, Weisenburger DD, Fitzgerald CL, Egan M, Stranford S, Carlson RW, Benz EJ. Value, Access, and Cost of Cancer Care Delivery at Academic Cancer Centers. J Natl Compr Canc Netw. 2016 Jul; 14(7):837-47.
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Benz EJ. BERNARD GREGOIRE FORGET, MD: 1939 - 2015. Trans Am Clin Climatol Assoc. 2016; 127:lxxxviii-xci.
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Tefferi A, Kantarjian H, Rajkumar SV, Baker LH, Abkowitz JL, Adamson JW, Advani RH, Allison J, Antman KH, Bast RC, Bennett JM, Benz EJ, Berliner N, Bertino J, Bhatia R, Bhatia S, Bhojwani D, Blanke CD, Bloomfield CD, Bosserman L, Broxmeyer HE, Byrd JC, Cabanillas F, Canellos GP, Chabner BA, Chanan-Khan A, Cheson B, Clarkson B, Cohn SL, Colon-Otero G, Cortes J, Coutre S, Cristofanilli M, Curran WJ, Daley GQ, DeAngelo DJ, Deeg HJ, Einhorn LH, Erba HP, Esteva FJ, Estey E, Fidler IJ, Foran J, Forman S, Freireich E, Fuchs C, George JN, Gertz MA, Giralt S, Golomb H, Greenberg P, Gutterman J, Handin RI, Hellman S, Hoff PM, Hoffman R, Hong WK, Horowitz M, Hortobagyi GN, Hudis C, Issa JP, Johnson BE, Kantoff PW, Kaushansky K, Khayat D, Khuri FR, Kipps TJ, Kripke M, Kyle RA, Larson RA, Lawrence TS, Levine R, Link MP, Lippman SM, Lonial S, Lyman GH, Markman M, Mendelsohn J, Meropol NJ, Messinger Y, Mulvey TM, O'Brien S, Perez-Soler R, Pollock R, Prchal J, Press O, Radich J, Rai K, Rosenberg SA, Rowe JM, Rugo H, Runowicz CD, Sandmaier BM, Saven A, Schafer AI, Schiffer C, Sekeres MA, Silver RT, Siu LL, Steensma DP, Stewart FM, Stock W, Stone R, Storb R, Strong LC, Tallman MS, Thompson M, Ueno NT, Van Etten RA, Vose JM, Wiernik PH, Winer EP, Younes A, Zelenetz AD, LeMaistre CA. In Support of a Patient-Driven Initiative and Petition to Lower the High Price of Cancer Drugs. Mayo Clin Proc. 2015 Aug; 90(8):996-1000.
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Benz EJ, Nathan DG. A tribute to Emil Frei III. J Clin Invest. 2013 Aug 1; 123(8):3188-9.
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Benz EJ. Presidential address: doing our part to ensure the future of academic medicine. Trans Am Clin Climatol Assoc. 2013; 124:1-13.
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Huang SC, Ou AC, Park J, Yu F, Yu B, Lee A, Yang G, Zhou A, Benz EJ. RBFOX2 promotes protein 4.1R exon 16 selection via U1 snRNP recruitment. Mol Cell Biol. 2012 Jan; 32(2):513-26.
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Gao G, Xie A, Huang SC, Zhou A, Zhang J, Herman AM, Ghassemzadeh S, Jeong EM, Kasturirangan S, Raicu M, Sobieski MA, Bhat G, Tatooles A, Benz EJ, Kamp TJ, Dudley SC. Role of RBM25/LUC7L3 in abnormal cardiac sodium channel splicing regulation in human heart failure. Circulation. 2011 Sep 06; 124(10):1124-31.
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Benz EJ, Wu CC, Sohani AR. Case records of the Massachusetts General Hospital. Case 25-2011. A 62-year-old woman with anemia and paraspinal masses. N Engl J Med. 2011 Aug 18; 365(7):648-58.
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Kwak LW, Goldenberg DM, Benz EJ, Yi Q, Müschen M, Wang D. American Journal of Blood Research: Editorial Board (2011) e-Century Publishing Corporation. Am J Blood Res. 2011; 1(1):106-9.
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Kwak LW, Goldenberg DM, Benz EJ, Yi Q, Muschen M, Wang D. Launching of american journal of blood research. Am J Blood Res. 2011; 1(1):i.
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Benz EJ. Newborn screening for a-thalassemia--keeping up with globalization. N Engl J Med. 2011 Feb 24; 364(8):770-1.
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Benz EJ. Learning about genomics and disease from the anucleate human red blood cell. J Clin Invest. 2010 Dec; 120(12):4204-6.
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Levit L, Smith AP, Benz EJ, Ferrell B. Ensuring quality cancer care through the oncology workforce. J Oncol Pract. 2010 Jan; 6(1):7-11.
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Huang SC, Cho A, Norton S, Liu ES, Park J, Zhou A, Munagala ID, Ou AC, Yang G, Wickrema A, Tang TK, Benz EJ. Coupled transcription-splicing regulation of mutually exclusive splicing events at the 5' exons of protein 4.1R gene. Blood. 2009 Nov 05; 114(19):4233-42.
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Bates SE, Benz EJ. Commentary: troublesome words, linguistic precision, and medical oncology. Oncologist. 2009 Apr; 14(4):445-7.
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Mattagajasingh SN, Huang SC, Benz EJ. Inhibition of protein 4.1 R and NuMA interaction by mutagenization of their binding-sites abrogates nuclear localization of 4.1 R. Clin Transl Sci. 2009 Apr; 2(2):102-11.
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Zhou A, Ou AC, Cho A, Benz EJ, Huang SC. Novel splicing factor RBM25 modulates Bcl-x pre-mRNA 5' splice site selection. Mol Cell Biol. 2008 Oct; 28(19):5924-36.
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Benz EJ. Paroxysmal nocturnal hemoglobinuria (PNH): an historical perspective. Hematology Am Soc Hematol Educ Program. 2008; 92.
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Benz EJ, Nathan DG, Amaravadi RK, Danial NN. Targeting the cell death-survival equation. Clin Cancer Res. 2007 Dec 15; 13(24):7250-3.
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Emmons KM, Burns White K, Benz EJ. Development of an integrated approach to cancer disparities: one cancer center's experience. Cancer Epidemiol Biomarkers Prev. 2007 Nov; 16(11):2186-92.
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Yang G, Huang SC, Wu JY, Benz EJ. Regulated Fox-2 isoform expression mediates protein 4.1R splicing during erythroid differentiation. Blood. 2008 Jan 01; 111(1):392-401.
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Benz EJ. 2006 Association of American Physicians George M. Kober Medal. Introduction of David G. Nathan, MD. J Clin Invest. 2007 Apr; 117(4):1107-11.
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Benz EJ, Countryman GL. Partnerships with patients. Trustee. 2006 Oct; 59(9):40, 56.
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Feldman AM, Benz EJ. Restructuring the academic department of internal medicine. Am J Med. 2005 Dec; 118(12):1430-5.
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Huang SC, Liu ES, Chan SH, Munagala ID, Cho HT, Jagadeeswaran R, Benz EJ. Mitotic regulation of protein 4.1R involves phosphorylation by cdc2 kinase. Mol Biol Cell. 2005 Jan; 16(1):117-27.
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Yang G, Huang SC, Wu JY, Benz EJ. An erythroid differentiation-specific splicing switch in protein 4.1R mediated by the interaction of SF2/ASF with an exonic splicing enhancer. Blood. 2005 Mar 01; 105(5):2146-53.
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Benz EJ. Genotypes and phenotypes--another lesson from the hemoglobinopathies. N Engl J Med. 2004 Oct 07; 351(15):1490-2.
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Huang SC, Jagadeeswaran R, Liu ES, Benz EJ. Protein 4.1R, a microtubule-associated protein involved in microtubule aster assembly in mammalian mitotic extract. J Biol Chem. 2004 Aug 13; 279(33):34595-602.
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Delhommeau F, Vasseur-Godbillon C, Leclerc P, Schischmanoff PO, Croisille L, Rince P, Morinière M, Benz EJ, Tchernia G, Tamagnini G, Ribeiro L, Delaunay J, Baklouti F. A splicing alteration of 4.1R pre-mRNA generates 2 protein isoforms with distinct assembly to spindle poles in mitotic cells. Blood. 2002 Oct 01; 100(7):2629-36.
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Deguillien M, Huang SC, Morinière M, Dreumont N, Benz EJ, Baklouti F. Multiple cis elements regulate an alternative splicing event at 4.1R pre-mRNA during erythroid differentiation. Blood. 2001 Dec 15; 98(13):3809-16.
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Nathan D, Benz EJ. Comprehensive cancer centres and the war on cancer. Nat Rev Cancer. 2001 Dec; 1(3):240-5.
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Huang S, Lichtenauer UD, Pack S, Wang C, Kim AC, Lutchman M, Koch CA, Torres-Cruz J, Huang SC, Benz EJ, Christiansen H, Dockhorn-Dworniczak B, Poremba C, Vortmeyer AO, Chishti AH, Zhuang Z. Reassignment of the EPB4.1 gene to 1p36 and assessment of its involvement in neuroblastomas. Eur J Clin Invest. 2001 Oct; 31(10):907-14.
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Kontrogianni-Konstantopoulos A, Frye CS, Benz EJ, Huang SC. The prototypical 4.1R-10-kDa domain and the 4.1g-10-kDa paralog mediate fodrin-actin complex formation. J Biol Chem. 2001 Jun 08; 276(23):20679-87.
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Devarajan P, Benz EJ. Translational regulation of Na-K-ATPase subunit mRNAs by glucocorticoids. Am J Physiol Renal Physiol. 2000 Dec; 279(6):F1132-8.
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Benz EJ. Edward J. Benz, Jr, MD. J Investig Med. 2000 Nov; 48(6):381-4.
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Kontrogianni-Konstantopoulos A, Huang SC, Benz EJ. A nonerythroid isoform of protein 4.1R interacts with components of the contractile apparatus in skeletal myofibers. Mol Biol Cell. 2000 Nov; 11(11):3805-17.
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Mattagajasingh SN, Huang SC, Hartenstein JS, Benz EJ. Characterization of the interaction between protein 4.1R and ZO-2. A possible link between the tight junction and the actin cytoskeleton. J Biol Chem. 2000 Sep 29; 275(39):30573-85.
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Benz EJ. Clonal variation, autoimmunity, and neoplasia: an ecology lesson from paroxysmal nocturnal hemoglobinuria. Ann Intern Med. 1999 Sep 21; 131(6):467-8.
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Mattagajasingh SN, Huang SC, Hartenstein JS, Snyder M, Marchesi VT, Benz EJ. A nonerythroid isoform of protein 4.1R interacts with the nuclear mitotic apparatus (NuMA) protein. J Cell Biol. 1999 Apr 05; 145(1):29-43.
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Benz EJ, Clayton CP, Costa ST. Increasing academic internal medicine's investment in female faculty. Am J Med. 1998 Dec; 105(6):459-63.
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Chishti AH, Kim AC, Marfatia SM, Lutchman M, Hanspal M, Jindal H, Liu SC, Low PS, Rouleau GA, Mohandas N, Chasis JA, Conboy JG, Gascard P, Takakuwa Y, Huang SC, Benz EJ, Bretscher A, Fehon RG, Gusella JF, Ramesh V, Solomon F, Marchesi VT, Tsukita S, Tsukita S, Hoover KB, et al. The FERM domain: a unique module involved in the linkage of cytoplasmic proteins to the membrane. Trends Biochem Sci. 1998 Aug; 23(8):281-2.
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Baklouti F, Huang SC, Vulliamy TJ, Delaunay J, Benz EJ. Organization of the human protein 4.1 genomic locus: new insights into the tissue-specific alternative splicing of the pre-mRNA. Genomics. 1997 Feb 01; 39(3):289-302.
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Benz EJ, Huang SC. Role of tissue specific alternative pre-mRNA splicing in the differentiation of the erythrocyte membrane. Trans Am Clin Climatol Assoc. 1997; 108:78-95.
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Zahler R, Gilmore-Hebert M, Sun W, Benz EJ. Na, K-ATPase isoform gene expression in normal and hypertrophied dog heart. Basic Res Cardiol. 1996 May-Jun; 91(3):256-66.
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Baklouti F, Huang SC, Tang TK, Delaunay J, Marchesi VT, Benz EJ. Asynchronous regulation of splicing events within protein 4.1 pre-mRNA during erythroid differentiation. Blood. 1996 May 01; 87(9):3934-41.
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Benz EJ. The thalassemia syndromes: lessons from molecular medicines index case. Trans Am Clin Climatol Assoc. 1996; 107:20-36; discussion 35-6.
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Benz EJ, Bank A. Gene therapy in hematology. Rev Invest Clin. 1994 Apr; Suppl:143-6.
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Xu JC, Lytle C, Zhu TT, Payne JA, Benz E, Forbush B. Molecular cloning and functional expression of the bumetanide-sensitive Na-K-Cl cotransporter. Proc Natl Acad Sci U S A. 1994 Mar 15; 91(6):2201-5.
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Horne WC, Huang SC, Becker PS, Tang TK, Benz EJ. Tissue-specific alternative splicing of protein 4.1 inserts an exon necessary for formation of the ternary complex with erythrocyte spectrin and F-actin. Blood. 1993 Oct 15; 82(8):2558-63.
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Chambers SK, Gilmore-Hebert M, Wang Y, Rodov S, Benz EJ, Kacinski BM. Posttranscriptional regulation of colony-stimulating factor-1 (CSF-1) and CSF-1 receptor gene expression during inhibition of phorbol-ester-induced monocytic differentiation by dexamethasone and cyclosporin A: potential involvement of a destabilizing protein. Exp Hematol. 1993 Sep; 21(10):1328-34.
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Zahler R, Gilmore-Hebert M, Baldwin JC, Franco K, Benz EJ. Expression of alpha isoforms of the Na,K-ATPase in human heart. Biochim Biophys Acta. 1993 Jul 04; 1149(2):189-94.
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Huang JP, Tang CJ, Kou GH, Marchesi VT, Benz EJ, Tang TK. Genomic structure of the locus encoding protein 4.1. Structural basis for complex combinational patterns of tissue-specific alternative RNA splicing. J Biol Chem. 1993 Feb 15; 268(5):3758-66.
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Feddal S, Hayette S, Baklouti F, Rimokh R, Wilmotte R, Magaud JP, Maréchal J, Benz EJ, Girot R, Delaunay J, et al. Prevalent skipping of an individual exon accounts for shortened protein 4.1 Presles. Blood. 1992 Dec 01; 80(11):2925-30.
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Devarajan P, Gilmore-Hebert M, Benz EJ. Differential translation of the Na,K-ATPase subunit mRNAs. J Biol Chem. 1992 Nov 05; 267(31):22435-9.
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Dalla Venezia N, Gilsanz F, Alloisio N, Ducluzeau MT, Benz EJ, Delaunay J. Homozygous 4.1(-) hereditary elliptocytosis associated with a point mutation in the downstream initiation codon of protein 4.1 gene. J Clin Invest. 1992 Nov; 90(5):1713-7.
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Benz E. Presidential address to the American Society for Clinical Investigation, Baltimore, Maryland, 2-6 May 1992. J Clin Invest. 1992 Oct; 90(4):1177-9.
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Chambers SK, Gilmore-Hebert M, Kacinski BM, Benz EJ. Changes in Na,K-ATPase gene expression during granulocytic differentiation of HL60 cells. Blood. 1992 Sep 15; 80(6):1559-64.
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Inaba M, Gupta KC, Kuwabara M, Takahashi T, Benz EJ, Maede Y. Deamidation of human erythrocyte protein 4.1: possible role in aging. Blood. 1992 Jun 15; 79(12):3355-61.
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Johnston JJ, Rintels P, Chung J, Sather J, Benz EJ, Berliner N. Lactoferrin gene promoter: structural integrity and nonexpression in HL60 cells. Blood. 1992 Jun 01; 79(11):2998-3006.
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Kolansky DM, Brines ML, Gilmore-Hebert M, Benz EJ. The A2 isoform of rat Na+,K(+)-adenosine triphosphatase is active and exhibits high ouabain affinity when expressed in transfected fibroblasts. FEBS Lett. 1992 Jun 01; 303(2-3):147-53.
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Baserga SJ, Benz EJ. Beta-globin nonsense mutation: deficient accumulation of mRNA occurs despite normal cytoplasmic stability. Proc Natl Acad Sci U S A. 1992 Apr 01; 89(7):2935-9.
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Abraham NG, Benz EJ, Karlsson S, Lutton J, Clark SC. The stem cell mavens had a blast. Second International Symposium on the Molecular Biology of Hematopoiesis, Innsbruck, Austria, July 14-18, 1991. New Biol. 1992 Jan; 4(1):42-7.
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Zahler R, Brines M, Kashgarian M, Benz EJ, Gilmore-Hebert M. The cardiac conduction system in the rat expresses the alpha 2 and alpha 3 isoforms of the Na+,K(+)-ATPase. Proc Natl Acad Sci U S A. 1992 Jan 01; 89(1):99-103.
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Huang SC, Baklouti F, Tang TK, Benz EJ. Differential utilization of translation initiation sites in alternatively spliced mRNAs arising from the protein 4.1 gene. Trans Assoc Am Physicians. 1992; 105:165-71.
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Feddal S, Brunet G, Roda L, Chabanis S, Alloisio N, Morlé L, Ducluzeau MT, Maréchal J, Robert JM, Benz EJ, et al. Molecular analysis of hereditary elliptocytosis with reduced protein 4.1 in the French Northern Alps. Blood. 1991 Oct 15; 78(8):2113-9.
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Brines ML, Gulanski BI, Gilmore-Hebert M, Greene AL, Benz EJ, Robbins RJ. Cytoarchitectural relationships between [3H]ouabain binding and mRNA for isoforms of the sodium pump catalytic subunit in rat brain. Brain Res Mol Brain Res. 1991 May; 10(2):139-50.
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Vignery A, Wang F, Qian HY, Benz EJ, Gilmore-Hebert M. Detection of the Na(+)-K(+)-ATPase alpha 3-isoform in multinucleated macrophages. Am J Physiol. 1991 May; 260(5 Pt 2):F704-9.
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Takeshita K, Benz EJ. Gene expression during erythropoiesis. Int J Cell Cloning. 1991 Mar; 9(2):109-22.
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Tang TK, Qin Z, Leto T, Marchesi VT, Benz EJ. Heterogeneity of mRNA and protein products arising from the protein 4.1 gene in erythroid and nonerythroid tissues. J Cell Biol. 1990 Mar; 110(3):617-24.
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Benz EJ. The molecular genetics of cancer. Introduction to principles of recombinant DNA technology. Cancer. 1990 Feb 01; 65(3 Suppl):731-41.
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Stolle CA, Penny LA, Ivory S, Forget BG, Benz EJ. Sequence analysis of the gamma-globin gene locus from a patient with the deletion form of hereditary persistence of fetal hemoglobin. Blood. 1990 Jan 15; 75(2):499-504.
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Magnus T, Baserga SJ, Stolle C, Takeshita K, Benz EJ. Metabolism of non-translatable globin mRNAs arising from premature translation termination codons. Ann N Y Acad Sci. 1990; 612:55-66.
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Váradi A, Gilmore-Heber M, Benz EJ. Amplification of the phosphorylation site-ATP-binding site cDNA fragment of the Na+,K(+)-ATPase and the Ca2(+)-ATPase of Drosophila melanogaster by polymerase chain reaction. FEBS Lett. 1989 Dec 04; 258(2):203-7.
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Gilmore-Hebert M, Schneider JW, Greene AL, Berliner N, Stolle CA, Lomax K, Mercer RW, Benz EJ. Expression of multiple Na+,K+-adenosine triphosphatase isoform genes in human hematopoietic cells. Behavior of the novel A3 isoform during induced maturation of HL60 cells. J Clin Invest. 1989 Jul; 84(1):347-51.
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Leto TL, Pleasic S, Forget BG, Benz EJ, Marchesi VT. Characterization of the calmodulin-binding site of nonerythroid alpha-spectrin. Recombinant protein and model peptide studies. J Biol Chem. 1989 Apr 05; 264(10):5826-30.
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Lomax KJ, Gallin JI, Rotrosen D, Raphael GD, Kaliner MA, Benz EJ, Boxer LA, Malech HL. Selective defect in myeloid cell lactoferrin gene expression in neutrophil specific granule deficiency. J Clin Invest. 1989 Feb; 83(2):514-9.
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Tang TK, Leto TL, Correas I, Alonso MA, Marchesi VT, Benz EJ. Selective expression of an erythroid-specific isoform of protein 4.1. Proc Natl Acad Sci U S A. 1988 Jun; 85(11):3713-7.
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Baserga SJ, Benz EJ. Nonsense mutations in the human beta-globin gene affect mRNA metabolism. Proc Natl Acad Sci U S A. 1988 Apr; 85(7):2056-60.
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Yang-Feng TL, Schneider JW, Lindgren V, Shull MM, Benz EJ, Lingrel JB, Francke U. Chromosomal localization of human Na+, K+-ATPase alpha- and beta-subunit genes. Genomics. 1988 Feb; 2(2):128-38.
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Mercer RW, Schneider JW, Benz EJ. Molecular cloning and characterization of alpha-subunit isoforms of the Na,K-ATPase. Prog Clin Biol Res. 1988; 268B:119-26.
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Schneider JW, Mercer RW, Benz EJ, Levenson R. Molecular cloning of Na+,K+-ATPase alpha subunit gene using antibody probes. Methods Enzymol. 1988; 156:379-92.
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Gilmore-Hebert M, Mercer RW, Schneider JW, Benz EJ. In vitro expression of the alpha and beta subunits of the Na,K-ATPase. Prog Clin Biol Res. 1988; 268B:71-6.
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Radin AI, Benz EJ. Antenatal diagnosis of the hemoglobinopathies. Hematol Pathol. 1988; 2(4):199-220.
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Schneider JW, Mercer RW, Gilmore-Hebert M, Utset MF, Lai C, Greene A, Benz EJ. Tissue specificity, localization in brain, and cell-free translation of mRNA encoding the A3 isoform of Na+,K+-ATPase. Proc Natl Acad Sci U S A. 1988 Jan; 85(1):284-8.
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Tang TK, Leto TL, Marchesi VT, Benz EJ. Expression of specific isoforms of protein 4.1 in erythroid and non-erythroid tissues. Adv Exp Med Biol. 1988; 241:81-95.
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Stolle CA, Benz EJ. Cellular factor affecting the stability of beta-globin mRNA. Gene. 1988; 62(1):65-74.
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Leto TL, Fortugno-Erikson D, Barton D, Yang-Feng TL, Francke U, Harris AS, Morrow JS, Marchesi VT, Benz EJ. Comparison of nonerythroid alpha-spectrin genes reveals strict homology among diverse species. Mol Cell Biol. 1988 Jan; 8(1):1-9.
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Rado TA, Wei XP, Benz EJ. Isolation of lactoferrin cDNA from a human myeloid library and expression of mRNA during normal and leukemic myelopoiesis. Blood. 1987 Oct; 70(4):989-93.
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Stolle CA, Payne MS, Benz EJ. Equal stabilities of normal beta globin and nontranslatable beta0 -39 thalassemic transcripts in cell-free extracts. Blood. 1987 Jul; 70(1):293-300.
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Benz EJ. Hospital cardiology, cardiac surgery program reported. Physician Exec. 1987 Mar-Apr; 13(2):28.
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High KA, Stolle CA, Schneider JW, Hu W, Benz EJ. c-myc gene inactivation during induced maturation of HL-60 cells. Transcriptional repression and loss of a specific DNAse I hypersensitive site. J Clin Invest. 1987 Jan; 79(1):93-9.
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Schneider JW, Mercer RW, Emanuel J, Levenson RM, Benz EJ. Expression of genes for the alpha and beta subunits of the Na,K-ATPase in normal and drug resistant cells. Blood Cells. 1987; 13(1-2):299-307.
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Mercer RW, Schneider JW, Savitz A, Emanuel J, Benz EJ, Levenson R. Rat-brain Na,K-ATPase beta-chain gene: primary structure, tissue-specific expression, and amplification in ouabain-resistant HeLa C+ cells. Mol Cell Biol. 1986 Nov; 6(11):3884-90.
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Hager KM, Mandala SM, Davenport JW, Speicher DW, Benz EJ, Slayman CW. Amino acid sequence of the plasma membrane ATPase of Neurospora crassa: deduction from genomic and cDNA sequences. Proc Natl Acad Sci U S A. 1986 Oct; 83(20):7693-7.
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Emanuel JR, Garetz S, Schneider J, Ash JF, Benz EJ, Levenson R. Amplification of DNA sequences coding for the Na,K-ATPase alpha-subunit in ouabain-resistant C+ cells. Mol Cell Biol. 1986 Jul; 6(7):2476-81.
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Schneider JW, Mercer RW, Caplan M, Emanuel JR, Sweadner KJ, Benz EJ, Levenson R. Molecular cloning of rat brain Na,K-ATPase alpha-subunit cDNA. Proc Natl Acad Sci U S A. 1985 Sep; 82(18):6357-61.
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Lambert SR, High KA, Cotlier E, Benz EJ. Serous retinal detachments in thrombotic thrombocytopenic purpura. Arch Ophthalmol. 1985 Aug; 103(8):1172-4.
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Baserga SJ, Linnenbach AJ, Malcolm S, Ghosh P, Malcolm AD, Takeshita K, Forget BG, Benz EJ. Polyadenylation of a human mitochondrial ribosomal RNA transcript detected by molecular cloning. Gene. 1985; 35(3):305-12.
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Benz EJ, Takeshita K, Scarpa AL. Metabolism of structurally abnormal mRNAs resulting from beta-thalassemia mutations. Ann N Y Acad Sci. 1985; 445:57-67.
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Takeshita K, Benz EJ. Analysis of gene expression during hematopoiesis: present and future applications. Crit Rev Oncol Hematol. 1985; 4(1):67-102.
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Rado TA, Bollekens J, St Laurent G, Parker L, Benz EJ. Lactoferrin biosynthesis during granulocytopoiesis. Blood. 1984 Nov; 64(5):1103-9.
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Takeshita K, Forget BG, Scarpa A, Benz EJ. Intranuclear defect in beta-globin mRNA accumulation due to a premature translation termination codon. Blood. 1984 Jul; 64(1):13-22.
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Benz EJ, Pritchard J, Hillman D, Glass J, Forget BG. Beta globin messenger RNA content of bone marrow erythroblasts in heterozygous beta-thalassemia. Am J Hematol. 1984 Jan; 16(1):33-45.
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Molthan L, Matulewicz TJ, Bansal-Carver B, Benz EJ. An immediate hemolytic transfusion reaction due to anti-C and a delayed hemolytic transfusion reaction due to anti-Ce+e: hemoglobinemia, hemoglobinuria and transient impaired renal function. Vox Sang. 1984; 47(5):348-53.
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Benz EJ. Molecular genetics of the sickling syndromes: evolution of new strategies for improved diagnosis. Am J Pediatr Hematol Oncol. 1984; 6(1):59-66.
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Hoffman R, McPhedran P, Benz EJ, Duffy TP. Isoniazid-induced pure red cell aplasia. Am J Med Sci. 1983 Jul-Aug; 286(1):2-9.
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Benz EJ. Clinical management of gene expression. N Engl J Med. 1982 Dec 09; 307(24):1515-6.
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Gewirtz AM, Burger D, Rado TA, Benz EJ, Hoffman R. Constitutive expression of platelet glycoproteins by the human leukemia cell line K562. Blood. 1982 Sep; 60(3):785-9.
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Tonkonow BL, Hoffman R, Burger D, Elder JT, Mazur EM, Murnane MJ, Benz EJ. Differing responses of globin and glycophorin gene expression to hemin in the human leukemia cell line K562. Blood. 1982 Apr; 59(4):738-46.
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Fukumaki Y, Ghosh PK, Benz EJ, Reddy VB, Lebowitz P, Forget BG, Weissman SM. Abnormally spliced messenger RNA in erythroid cells from patients with beta+ thalassemia and monkey cells expressing a cloned beta+-thalassemic gene. Cell. 1982 Mar; 28(3):585-93.
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Benz EJ, Scarpa AL, Forget BG. Defective processing of beta mRNA in different forms of beta +-thalassemia. Trans Assoc Am Physicians. 1982; 95:325-33.
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Benz EJ, Forget BG. The thalassemia syndromes: models for the molecular analysis of human disease. Annu Rev Med. 1982; 33:363-73.
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Forget BG, Benz EJ, Spritz RA, Weissman SM. Globin mRNA metabolism and gene structure in beta +-thalassemia. Birth Defects Orig Artic Ser. 1982; 18(7):51-9.
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Benz EJ, Scarpa AL, Tonkonow BL, Pearson HA, Ritchey AK. Posttranscriptional defects in beta-globin messenger RNA metabolism in beta-thalassemia: abnormal accumulation of beta-messenger RNA precursor sequences. J Clin Invest. 1981 Dec; 68(6):1529-38.
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Benz EJ, Berman BW, Tonkonow BL, Coupal E, Coates T, Boxer LA, Altman A, Adams JG. Molecular analysis of the beta-thalassemia phenotype associated with inheritance of hemoglobin E (alpha 2 beta2(26)Glu leads to Lys). J Clin Invest. 1981 Jul; 68(1):118-26.
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Adams JG, Steinberg MH, Newman MV, Morrison WT, Benz EJ, Iyer R. beta-Thalassemia present in cis to a new beta-chain structural variant, Hb Vicksburg [beta 75 (E19)Leu leads to 0]. Proc Natl Acad Sci U S A. 1981 Jan; 78(1):469-73.
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Benz EJ, Murnane MJ, Tonkonow BL, Berman BW, Mazur EM, Cavallesco C, Jenko T, Snyder EL, Forget BG, Hoffman R. Embryonic-fetal erythroid characteristics of a human leukemic cell line. Proc Natl Acad Sci U S A. 1980 Jun; 77(6):3509-13.
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Benz EJ, Forget BG. Pathogenesis of the thalassemia syndromes. Pathobiol Annu. 1980; 10:1-33.
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Benz EJ, Glass J, Tsistrakis GA, Hillman DG, Cavallesco C, Coupal E, Forget BG, Turner PA, Kantor JA, Nienhuis AW. Heterogeneity of messenger RNA defects in the thalassemia syndromes. Ann N Y Acad Sci. 1980; 344:101-12.
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Benz EJ. Hemoglobin switching in animals. Tex Rep Biol Med. 1980-1981; 40:111-23.
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Leon MB, Borer JS, Bacharach SL, Green MV, Benz EJ, Griffith P, Nienhuis AW. Detection of early cardiac dysfunction in patients with severe beta-thalassemia and chronic iron overload. N Engl J Med. 1979 Nov 22; 301(21):1143-8.
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Hoffman R, Murnane MJ, Benz EJ, Prohaska R, Floyd V, Dainiak N, Forget BG, Furthmayr H. Induction of erythropoietic colonies in a human chronic myelogenous leukemia cell line. Blood. 1979 Nov; 54(5):1182-7.
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Benz EJ, Kretschmer PJ, Geist CE, Kantor JA, Turner PH, Nienhuis AW. Hemoglobin switching in sheep. Synthesis, cloning, and characterization of DNA sequences coding for the beta B, beta C, and gamma-globin mRNAs. J Biol Chem. 1979 Aug 10; 254(15):6880-8.
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Young NS, Benz EJ, Kantor JA, Kretschmer P, Nienhuis AW. Hemoglobin switching in sheep: only the gamma gene is in the active conformation in fetal liver but all the beta and gamma genes are in the active conformation in bone marrow. Proc Natl Acad Sci U S A. 1978 Dec; 75(12):5884-8.
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Benz EJ, Steggles AW, Geist CE, Nienhuis AW. Hemoglobin switching in sheep. Quantitation of betaA- and betaC-mRNA sequences in nuclear and cytoplasmic RNA during the HbA to HbC switch. J Biol Chem. 1978 Jul 25; 253(14):5025-32.
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Benz EJ, Barker JE, Pierce JE, Turner PA, Nienhuis AW. Hemoglobin switching in sheep: commitment of erythroid stem cells to expression of the betaC-globin gene and accumulation of betaC-globin mRNA. Cell. 1978 Jul; 14(3):733-40.
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Benz EJ, Forget BG, Hillman DG, Cohen-Solal M, Pritchard J, Cavallesco C, Prensky W, Housman D. Variability in the amount of beta-globin mRNA in beta0 thalassemia. Cell. 1978 Jun; 14(2):299-312.
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Forget BG, Cavallesco C, Benz EJ, McClure PD, Hillman DG, Krieger H, Clarke B, Housman D. Studies of globin chain synthesis and globin mRNA content in a patient homozygous for hemoglobin Lepore. Hemoglobin. 1978; 2(2):117-28.
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Nienhuis AW, Benz EJ. Regulation of hemoglobin synthesis during the development of the red cell (third of three parts). N Engl J Med. 1977 Dec 29; 297(26):1430-6.
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Nienhuis AW, Benz EJ. Regulation of hemoglobin synthesis during the development of the red cell. (Second of three parts). N Engl J Med. 1977 Dec 22; 297(25):1371-81.
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Nienhuis AW, Benz EJ. Regulation of hemoglobin synthesis during the development of the red cell (first of three parts). N Engl J Med. 1977 Dec 15; 297(24):1318-28.
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Nienhuis AW, Turner P, Benz EJ. Relative stability of alpha- and beta-globin messenger RNAs in homozygous beta+ thalassemia. Proc Natl Acad Sci U S A. 1977 Sep; 74(9):3960-4.
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Benz E, Turner P, Barker J, Nienhuis A. Stability of the individual globin genes during erythroid differentiation. Science. 1977 Jun 10; 196(4295):1213-4.
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Benz EJ, Geist CE, Steggles AW, Barker JE, Nienhuis AW. Hemoglobin switching in sheep and goats. Preparation and characterization of complementary DNAs specific for the alpha-, beta-, and gamma-globin messenger RNAs of sheep. J Biol Chem. 1977 Mar 25; 252(6):1908-16.
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Forget BG, Housman D, Benz EJ, McCaffrey RP. Synthesis of DNA complementary to separated human alpha and beta globin messenger RNAs. Proc Natl Acad Sci U S A. 1975 Mar; 72(3):984-8.
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Benz EJ, Forget BG. The molecular genetics of the thalassemia syndromes. Prog Hematol. 1975; 9:107-55.
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Benz EJ, Swerdlow PS, Forget BG. Absence of functional messenger RNA activity for beta globin chain synthesis in beta 0-thalassemia. Blood. 1975 Jan; 45(1):1-10.
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Housman D, Skoultchi A, Forget BG, Benz EJ. Use of globin cDNA as a hybridization probe for globin mRNA. Ann N Y Acad Sci. 1974 Nov 29; 241(0):280-9.
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Benz EJ, Forget BG. The biosynthesis of hemoglobin. Semin Hematol. 1974 Oct; 11(4):463-523.
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Forget BG, Benz EJ, Skoultchi A, Baglioni C, Housman D. Absence of messenger RNA for beta globin chain in beta(0) thalassaemia. Nature. 1974 Feb 08; 247(5440):379-81.
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Forget BG, Baltimore D, Benz EJ, Housman D, Lebowitz P, Marotta CA, McCaffrey RP, Skoultchi A, Swerdlow PS, Verma IM, Weissman SM. Globin messenger RNA in the thalassemia syndromes. Ann N Y Acad Sci. 1974; 232(0):76-87.
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Benz EJ, Swerdlow PS, Forget BG. Globin messenger RNA in hemoglobin H disease. Blood. 1973 Dec; 42(6):825-33.
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Housman D, Forget BG, Skoultchi A, Benz EJ. Quantitative deficiency of chain-specific globin messenger ribonucleic acids in the thalassemia syndromes. Proc Natl Acad Sci U S A. 1973 Jun; 70(6):1809-13.
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Zervanos NJ, Benz EJ, Aho WR. Family and community medicine in a general hospital. Putting principles to work. JAMA. 1972 Jul 03; 221(1):54-7.
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Benz EJ, Forget BG. Defect in messenger RNA for human hemoglobin synthesis in beta thalassemia. J Clin Invest. 1971 Dec; 50(12):2755-60.
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Pardee AB, Benz EJ, St Peter DA, Krieger JN, Meuth M, Trieshmann HW. Hyperproduction and purification of nicotinamide deamidase, a microconstitutive enzyme of Escherichia coli. J Biol Chem. 1971 Nov 25; 246(22):6792-6.
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FLOR FS, SCHADT DC, BENZ EJ. Gonadal dysgenesis with male chromatin pattern: testicular feminization syndrome. Clinical and pathological findings in two cases in siblings. JAMA. 1962 Aug 04; 181:375-9.
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KOEHLER LH, BENZ EJ. Serum adenosine deaminase: methodology and clinical applications. Clin Chem. 1962 Apr; 8:133-40.
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GROSS P, BENZ EJ. The concept of organizing pneumonia. Arch Pathol. 1961 Dec; 72:607-19.
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BENZ EJ, BAGGENSTOSS AH. Focal cirrhosis of the liver: its relation to the so-called hamartoma (adenoma, benign hepatoma). Cancer. 1953 Jul; 6(4):743-55.
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BENZ EJ, BAGGENSTOSS AH. Solitary nodules (focal cirrhosis) of liver. Proc Staff Meet Mayo Clin. 1953 Apr 22; 28(8):245-7.
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BENZ EJ, BAGGENSTOSS AH. Atrophy of the left lobe of the liver. Proc Staff Meet Mayo Clin. 1953 Apr 22; 28(8):232-8.
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BENZ EJ, BAGGENSTOSS AH, WOLLAEGER EE. The pathogenesis of atrophy of the left lobe of the liver of man. Gastroenterology. 1952 Sep; 22(1):34-51.
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BENZ EJ, DOCKERTY MB, DIXON CF. Polypoid endometrioma of the colon: report of case in which unusual pathologic features were present. Proc Staff Meet Mayo Clin. 1952 May 07; 27(10):201-8.
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BENZ EJ, BAGGENSTOSS AH, WOLLAEGER EE. Atrophy of the left lobe of the liver. AMA Arch Pathol. 1952 Apr; 53(4):315-30.
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GROSS P, BENZ EJ. Pulmonary embolism by amniotic fluid; report of three cases with a new diagnostic procedure. Surg Gynecol Obstet. 1947 Sep; 85(3):315-20.
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