Jennifer R. Brown, MD, PhD

Jennifer R. Brown, MD, PhD

Medical Oncology

Contact Information

Office Phone Number

617-632-5847

Fax

617-582-7890

Appointments

617-632-6246 (new)

Biography

Jennifer R. Brown, MD, PhD

Jennifer R. Brown, MD, PhD is the Director of the CLL Center of the Division of Hematologic Malignancies at Dana-Farber Cancer Institute and the Worthington and Margaret Collette Professor of Medicine in the Field of Hematologic Oncology at Harvard Medical School in Boston, Massachusetts. Dr. Brown completed a B.S. and M.S. simultaneously in molecular biophysics and biochemistry (MB&B) at Yale, graduating summa cum laude with distinction. She proceeded to Harvard Medical School where she received her MD and PhD in molecular genetics in 1998 and was awarded the James Tolbert Shipley Prize. She then served as an intern and resident in Internal Medicine at Massachusetts General Hospital followed by fellowship in Hematology and Medical Oncology at DFCI. Dr. Brown joined the faculty of DFCI and Harvard Medical School in 2004, where she has an active clinical-translational research program in CLL.

Her interests include the development of novel targeted therapeutics for CLL, as well as CLL genomics. She has been instrumental in the clinical development of idelalisib and ibrutinib, leading to their regulatory approvals in CLL. Her genomics work has characterized the somatic mutation profile of CLL, and she is now particularly interested in the implementation of genomic technology in the clinic. She also has a longstanding research interest in the inherited predisposition to CLL. To date she has published about 250 papers in the scientific literature, predominantly in CLL. In 2014 she was the recipient of two awards from DFCI, the Clinical Innovation Award, as well as the George Canellos Award. She is a member of the International Workshop on CLL (iwCLL) and enjoys a worldwide reputation as a CLL expert having made the Highly Cited Researchers list by Clarivate, with multiple papers ranking in the top 1% by citations for their field and year of publication.

Researcher

Physician

Director, Chronic Lymphocytic Leukemia (CLL) Center
Institute Physician
Worthington and Margaret Collette Professor of Medicine in the Field of Hematologic Oncology, Harvard Medical School

Centers/Programs

Center for Chronic Lymphocytic Lymphoma (CLL)
Stem Cell Transplantation
Lymphoma Program

Clinical Interests

Chronic lymphocytic leukemia, Lymphoma, Stem cell/bone marrow transplant

Board Certification

  • Hematology, 2004
  • Internal Medicine, 2001
  • Medical Oncology, 2004

Fellowship

  • Dana-Farber/Partners CancerCare, Medical Oncology

Residency

  • Massachusetts General Hospital, Internal Medicine

Medical School

  • Harvard Medical School

Research

    Novel therapeutics in CLL Familial Predisposition to CLL and lymphoma

    Publications

      • ERBB4-Mediated Signaling Is a Mediator of Resistance to PI3K and BTK Inhibitors in B-cell Lymphoid Neoplasms. Mol Cancer Ther. 2024 Mar 04; 23(3):368-380. View in: Pubmed

      • Characterization of zanubrutinib safety and tolerability profile and comparison with ibrutinib safety profile in patients with B-cell malignancies: post-hoc analysis of a large clinical trial safety database. Haematologica. 2024 Feb 29. View in: Pubmed

      • Five-year follow-up of a phase 2 study of ibrutinib plus fludarabine, cyclophosphamide, and rituximab as initial therapy in CLL. Blood Adv. 2024 Feb 27; 8(4):832-841. View in: Pubmed

      • Long-term Follow-up from A041202 Shows Continued Efficacy of Ibrutinib Regimens for Older Adults with CLL. Blood. 2024 Jan 12. View in: Pubmed

      • Plain language summary of zanubrutinib or ibrutinib in chronic lymphocytic leukemia that is resistant to treatment or has come back after treatment. Future Oncol. 2023 Dec 13. View in: Pubmed

      • A multi-cohort phase 1b trial of rituximab in combination with immunotherapy doublets in relapsed/refractory follicular lymphoma. Ann Hematol. 2024 Jan; 103(1):185-198. View in: Pubmed

      • Health-related quality-of-life in treatment-naive CLL/SLL patients treated with zanubrutinib versus bendamustine plus rituximab. Curr Med Res Opin. 2023 Sep 27; 1-7. View in: Pubmed

      • Health-related quality of life outcomes associated with zanubrutinib versus ibrutinib monotherapy in patients with relapsed/refractory chronic lymphocytic leukemia and small lymphocytic lymphoma: results from the ALPINE Trial. Curr Med Res Opin. 2023 Sep 27; 1-7. View in: Pubmed

      • Minimal residual disease in patients with diffuse large B-cell lymphoma undergoing autologous stem cell transplantation. Blood Adv. 2023 09 12; 7(17):4748-4759. View in: Pubmed

      • Optimization of Advanced Molecular Genetic Testing Utilization in Hematopathology: A Goldilocks Approach to Bone Marrow Testing. JCO Oncol Pract. 2024 Feb; 20(2):220-227. View in: Pubmed

      • Localized upper extremity edema secondary to Bruton's tyrosine kinase inhibition. Leuk Lymphoma. 2023 12; 64(12):2047-2050. View in: Pubmed

      • Detailed safety profile of acalabrutinib vs ibrutinib in previously treated chronic lymphocytic leukemia in the ELEVATE-RR trial. Blood. 2023 08 24; 142(8):687-699. View in: Pubmed

      • PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer. Mol Cancer. 2023 08 18; 22(1):138. View in: Pubmed

      • Genetic events associated with venetoclax resistance in CLL identified by whole-exome sequencing of patient samples. Blood. 2023 08 03; 142(5):421-433. View in: Pubmed

      • Pirtobrutinib after a Covalent BTK Inhibitor in Chronic Lymphocytic Leukemia. N Engl J Med. 2023 Jul 06; 389(1):33-44. View in: Pubmed

      • Pirtobrutinib targets BTK C481S in ibrutinib-resistant CLL but second-site BTK mutations lead to resistance. Blood Adv. 2023 05 09; 7(9):1929-1943. View in: Pubmed

      • Zanubrutinib in Chronic Lymphocytic Leukemia. Reply. N Engl J Med. 2023 May 04; 388(18):1720-1721. View in: Pubmed

      • METTL3-Mediated m6A Modification Controls Splicing Factor Abundance and Contributes to Aggressive CLL. Blood Cancer Discov. 2023 05 01; 4(3):228-245. View in: Pubmed

      • Treatment Discontinuation Patterns for Patients With Chronic Lymphocytic Leukemia in Real-World Settings: Results From a Multi-Center International Study. Clin Lymphoma Myeloma Leuk. 2023 07; 23(7):515-526. View in: Pubmed

      • Circulating Th17 T cells at treatment onset predict autoimmune toxicity of PI3Kd inhibitors. Blood Cancer J. 2023 02 02; 13(1):22. View in: Pubmed

      • A phase 1b study of ibrutinib in combination with obinutuzumab in patients with relapsed or refractory chronic lymphocytic leukemia. Leukemia. 2023 04; 37(4):835-842. View in: Pubmed

      • Interim Positron Emission Tomography During Frontline Chemoimmunotherapy for Follicular Lymphoma. Hemasphere. 2023 Feb; 7(2):e826. View in: Pubmed

      • Evolutionary history of transformation from chronic lymphocytic leukemia to Richter syndrome. Nat Med. 2023 01; 29(1):158-169. View in: Pubmed

      • PI3K inhibitors in chronic lymphocytic leukemia: where do we go from here? Haematologica. 2023 01 01; 108(1):9-21. View in: Pubmed

      • Zanubrutinib or Ibrutinib in Relapsed or Refractory Chronic Lymphocytic Leukemia. N Engl J Med. 2023 01 26; 388(4):319-332. View in: Pubmed

      • Selecting initial therapy in CLL. Hematology Am Soc Hematol Educ Program. 2022 Dec 09; 2022(1):323-328. View in: Pubmed

      • Zanubrutinib Versus Ibrutinib in Relapsed/Refractory Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma: Interim Analysis of a Randomized Phase III Trial. J Clin Oncol. 2023 02 10; 41(5):1035-1045. View in: Pubmed

      • Resistance to PI3Kd inhibitors in marginal zone lymphoma can be reverted by targeting the IL-6/PDGFRA axis. Haematologica. 2022 11 01; 107(11):2685-2697. View in: Pubmed

      • Rare Germline ATM Variants Influence the Development of Chronic Lymphocytic Leukemia. J Clin Oncol. 2023 02 10; 41(5):1116-1128. View in: Pubmed

      • Functional Testing to Characterize and Stratify PI3K Inhibitor Responses in Chronic Lymphocytic Leukemia. Clin Cancer Res. 2022 10 14; 28(20):4444-4455. View in: Pubmed

      • EXABS-179-CLL DEBATE: Sequencing Small Molecules Is the Way to Go. Clin Lymphoma Myeloma Leuk. 2022 Oct; 22 Suppl 2:S81-S82. View in: Pubmed

      • Molecular map of chronic lymphocytic leukemia and its impact on outcome. Nat Genet. 2022 11; 54(11):1664-1674. View in: Pubmed

      • PI3K inhibitors in haematological malignancies. Lancet Oncol. 2022 08; 23(8):e364. View in: Pubmed

      • Impact of the Types and Relative Quantities of IGHV Gene Mutations in Predicting Prognosis of Patients With Chronic Lymphocytic Leukemia. Front Oncol. 2022; 12:897280. View in: Pubmed

      • Zanubrutinib versus bendamustine and rituximab in untreated chronic lymphocytic leukaemia and small lymphocytic lymphoma (SEQUOIA): a randomised, controlled, phase 3 trial. Lancet Oncol. 2022 08; 23(8):1031-1043. View in: Pubmed

      • Response to Comment on: "Cardiovascular adverse events in patients with chronic lymphocytic leukemia receiving acalabrutinib monotherapy: pooled analysis of 762 patients". Haematologica. 2022 06 01; 107(6):1491-1492. View in: Pubmed

      • Cardiovascular adverse events in patients with chronic lymphocytic leukemia receiving acalabrutinib monotherapy: pooled analysis of 762 patients. Haematologica. 2022 06 01; 107(6):1335-1346. View in: Pubmed

      • Idelalisib activates AKT via increased recruitment of PI3Kd/PI3Kß to BCR signalosome while reducing PDK1 in post-therapy CLL cells. Leukemia. 2022 07; 36(7):1806-1817. View in: Pubmed

      • Editorial: Targeting Bruton Tyrosine Kinase. Front Cell Dev Biol. 2022; 10:909655. View in: Pubmed

      • Odronextamab, a human CD20×CD3 bispecific antibody in patients with CD20-positive B-cell malignancies (ELM-1): results from the relapsed or refractory non-Hodgkin lymphoma cohort in a single-arm, multicentre, phase 1 trial. Lancet Haematol. 2022 May; 9(5):e327-e339. View in: Pubmed

      • Phase Ib dose-escalation study of the selective, non-covalent, reversible Bruton's tyrosine kinase inhibitor vecabrutinib in B-cell malignancies. Haematologica. 2022 04 01; 107(4):984-987. View in: Pubmed

      • Idelalisib reduces regulatory T cells and activates T helper 17 cell differentiation in relapsed refractory patients with chronic lymphocytic leukaemia. Br J Haematol. 2022 04; 197(2):207-211. View in: Pubmed

      • Recognizing Unmet Need in the Era of Targeted Therapy for CLL/SLL: "What's Past Is Prologue" (Shakespeare). Clin Cancer Res. 2022 02 15; 28(4):603-608. View in: Pubmed

      • Venetoclax plus dose-adjusted R-EPOCH for Richter syndrome. Blood. 2022 02 03; 139(5):686-689. View in: Pubmed

      • Allogeneic hematopoietic cell transplantation outcomes in patients with Richter's transformation. Haematologica. 2021 12 01; 106(12):3219-3222. View in: Pubmed

      • Longitudinal Single-Cell Dynamics of Chromatin Accessibility and Mitochondrial Mutations in Chronic Lymphocytic Leukemia Mirror Disease History. Cancer Discov. 2021 12 01; 11(12):3048-3063. View in: Pubmed

      • Editorial: New Insights on Bruton's Tyrosine Kinase Inhibitors. Front Immunol. 2021; 12:804735. View in: Pubmed

      • Monitoring and Managing BTK Inhibitor Treatment-Related Adverse Events in Clinical Practice. Front Oncol. 2021; 11:720704. View in: Pubmed

      • A T cell inflammatory phenotype is associated with autoimmune toxicity of the PI3K inhibitor duvelisib in chronic lymphocytic leukemia. Leukemia. 2022 03; 36(3):723-732. View in: Pubmed

      • Acalabrutinib monotherapy for treatment of chronic lymphocytic leukaemia (ACE-CL-001): analysis of the Richter transformation cohort of an open-label, single-arm, phase 1-2 study. Lancet Haematol. 2021 Dec; 8(12):e912-e921. View in: Pubmed

      • IL4-STAT6 signaling induces CD20 in chronic lymphocytic leukemia and this axis is repressed by PI3Kd inhibitor idelalisib. Haematologica. 2021 11 01; 106(11):2995-2999. View in: Pubmed

      • Activation of Notch and Myc Signaling via B-cell-Restricted Depletion of Dnmt3a Generates a Consistent Murine Model of Chronic Lymphocytic Leukemia. Cancer Res. 2021 12 15; 81(24):6117-6130. View in: Pubmed

      • Immune Reconstitution following High-Dose Chemotherapy and Autologous Stem Cell Transplantation with or without Pembrolizumab Maintenance Therapy in Patients with Lymphoma. Transplant Cell Ther. 2022 01; 28(1):32.e1-32.e10. View in: Pubmed

      • Acalabrutinib, venetoclax, and obinutuzumab as frontline treatment for chronic lymphocytic leukaemia: a single-arm, open-label, phase 2 study. Lancet Oncol. 2021 10; 22(10):1391-1402. View in: Pubmed

      • Activity of mRNA COVID-19 vaccines in patients with lymphoid malignancies. Blood Adv. 2021 08 24; 5(16):3062-3065. View in: Pubmed

      • The future of antibody therapy in chronic lymphocytic leukemia. Expert Opin Emerg Drugs. 2021 09; 26(3):323-336. View in: Pubmed

      • Idelalisib immune-related toxicity is associated with improved treatment response. Leuk Lymphoma. 2021 12; 62(12):2915-2920. View in: Pubmed

      • Adverse event burden in older patients with CLL receiving bendamustine plus rituximab or ibrutinib regimens: Alliance A041202. Leukemia. 2021 10; 35(10):2854-2861. View in: Pubmed

      • Activation of the MAPK pathway mediates resistance to PI3K inhibitors in chronic lymphocytic leukemia. Blood. 2021 07 08; 138(1):44-56. View in: Pubmed

      • Measurable residual disease in chronic lymphocytic leukemia: expert review and consensus recommendations. Leukemia. 2021 11; 35(11):3059-3072. View in: Pubmed

      • Targeting Bruton's Tyrosine Kinase in CLL. Front Immunol. 2021; 12:687458. View in: Pubmed

      • Acalabrutinib in treatment-naive chronic lymphocytic leukemia. Blood. 2021 06 17; 137(24):3327-3338. View in: Pubmed

      • The Evolving Use of Phosphatidylinositol 3-Kinase Inhibitors for the Treatment of Chronic Lymphocytic Leukemia. Hematol Oncol Clin North Am. 2021 08; 35(4):807-826. View in: Pubmed

      • Post-Transformation IGHV-IGHD-IGHJ Mutations in Chronic Lymphocytic Leukemia B Cells: Implications for Mutational Mechanisms and Impact on Clinical Course. Front Oncol. 2021; 11:640731. View in: Pubmed

      • Chronic Lymphocytic Leukemia: So Much Progress, Still Challenges Ahead. Hematol Oncol Clin North Am. 2021 08; 35(4):xiii-xiv. View in: Pubmed

      • miR-29 modulates CD40 signaling in chronic lymphocytic leukemia by targeting TRAF4: an axis affected by BCR inhibitors. Blood. 2021 05 06; 137(18):2481-2494. View in: Pubmed

      • Pooled analysis of safety data from clinical trials evaluating acalabrutinib monotherapy in mature B-cell malignancies. Leukemia. 2021 11; 35(11):3201-3211. View in: Pubmed

      • Multi-Factor Clustering Incorporating Cell Motility Predicts T Cell Expansion Potential. Front Cell Dev Biol. 2021; 9:648925. View in: Pubmed

      • High-grade heart block associated with ibrutinib therapy. HeartRhythm Case Rep. 2021 Jun; 7(6):391-394. View in: Pubmed

      • A phase Ib, open label, dose escalation trial of the anti-CD37 monoclonal antibody, BI 836826, in combination with ibrutinib in patients with relapsed/refractory chronic lymphocytic leukemia. Invest New Drugs. 2021 08; 39(4):1099-1105. View in: Pubmed

      • Pirtobrutinib in relapsed or refractory B-cell malignancies (BRUIN): a phase 1/2 study. Lancet. 2021 03 06; 397(10277):892-901. View in: Pubmed

      • AKT: a key to RT? Blood. 2021 02 04; 137(5):582-584. View in: Pubmed

      • Targeting constitutively active STAT3 in chronic lymphocytic leukemia: A clinical trial of the STAT3 inhibitor pyrimethamine with pharmacodynamic analyses. Am J Hematol. 2021 04 01; 96(4):E95-E98. View in: Pubmed

      • Mechanism of EBV inducing anti-tumour immunity and its therapeutic use. Nature. 2021 02; 590(7844):157-162. View in: Pubmed

      • Changes in Bcl-2 members after ibrutinib or venetoclax uncover functional hierarchy in determining resistance to venetoclax in CLL. Blood. 2020 12 17; 136(25):2918-2926. View in: Pubmed

      • Preneoplastic Alterations Define CLL DNA Methylome and Persist through Disease Progression and Therapy. Blood Cancer Discov. 2021 01; 2(1):54-69. View in: Pubmed

      • A prospective study of minimal residual disease in patients with diffuse large B-cell lymphoma using an Ig-NGS assay. Leuk Lymphoma. 2021 02; 62(2):478-481. View in: Pubmed

      • Zanubrutinib monotherapy for patients with treatment naïve chronic lymphocytic leukemia and 17p deletion. Haematologica. 2020 10 13; 106(9):2354-2363. View in: Pubmed

      • Distinct evolutionary paths in chronic lymphocytic leukemia during resistance to the graft-versus-leukemia effect. Sci Transl Med. 2020 09 16; 12(561). View in: Pubmed

      • Allogeneic hematopoietic cell transplantation after prior targeted therapy for high-risk chronic lymphocytic leukemia. Blood Adv. 2020 09 08; 4(17):4113-4123. View in: Pubmed

      • Outcomes of COVID-19 in patients with CLL: a multicenter international experience. Blood. 2020 09 03; 136(10):1134-1143. View in: Pubmed

      • Allogeneic stem cell transplantation for chronic lymphocytic leukemia in the era of novel agents. Blood Adv. 2020 08 25; 4(16):3977-3989. View in: Pubmed

      • A phase 1b/2 study of duvelisib in combination with FCR (DFCR) for frontline therapy for younger CLL patients. Leukemia. 2021 04; 35(4):1064-1072. View in: Pubmed

      • How We Manage Patients With Chronic Lymphocytic Leukemia During the SARS-CoV-2 Pandemic. Hemasphere. 2020 Aug; 4(4):e432. View in: Pubmed

      • Risk factors for grade 3/4 transaminase elevation in patients with chronic lymphocytic leukemia treated with idelalisib. Leukemia. 2020 12; 34(12):3404-3407. View in: Pubmed

      • Pneumocystis jirovecii pneumonia and institutional prophylaxis practices in CLL patients treated with BTK inhibitors. Blood Adv. 2020 04 14; 4(7):1458-1463. View in: Pubmed

      • Acalabrutinib monotherapy in patients with relapsed/refractory chronic lymphocytic leukemia: updated phase 2 results. Blood. 2020 04 09; 135(15):1204-1213. View in: Pubmed

      • ALPINE: zanubrutinib versus ibrutinib in relapsed/refractory chronic lymphocytic leukemia/small lymphocytic lymphoma. Future Oncol. 2020 Apr; 16(10):517-523. View in: Pubmed

      • Rituximab/bendamustine and rituximab/cytarabine induction therapy for transplant-eligible mantle cell lymphoma. Blood Adv. 2020 03 10; 4(5):858-867. View in: Pubmed

      • Preliminary Safety and Efficacy Results from a Phase 2 Study of Acalabrutinib, Venetoclax and Obinutuzumab in Patients with Previously Untreated Chronic Lymphocytic Leukemia (CLL). Blood. 2019 Nov 13; 134(Supplement_1):32. View in: Pubmed

      • Evolving Strategies in First-Line Chronic Lymphocytic Leukemia: Is There a Role for Chemoimmunotherapy? J Natl Compr Canc Netw. 2019 11; 17(11.5):1408-1410. View in: Pubmed

      • Phosphatidylinositol 3 Kinase d Inhibitors: Present and Future. Cancer J. 2019 Nov/Dec; 25(6):394-400. View in: Pubmed

      • Ibrutinib-associated invasive fungal diseases in patients with chronic lymphocytic leukaemia and non-Hodgkin lymphoma: An observational study. Mycoses. 2019 Dec; 62(12):1140-1147. View in: Pubmed

      • Final analysis from RESONATE: Up to six years of follow-up on ibrutinib in patients with previously treated chronic lymphocytic leukemia or small lymphocytic lymphoma. Am J Hematol. 2019 12; 94(12):1353-1363. View in: Pubmed

      • Cardiovascular Toxicities Associated With Ibrutinib. J Am Coll Cardiol. 2019 10 01; 74(13):1667-1678. View in: Pubmed

      • Mitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies. Cancer Cell. 2019 10 14; 36(4):369-384.e13. View in: Pubmed

      • For CLL cells, there's no place like home. Leuk Lymphoma. 2019 12; 60(14):3347-3349. View in: Pubmed

      • Long-Term Studies Assessing Outcomes of Ibrutinib Therapy in Patients With Del(11q) Chronic Lymphocytic Leukemia. Clin Lymphoma Myeloma Leuk. 2019 11; 19(11):715-722.e6. View in: Pubmed

      • Developmental subtypes assessed by DNA methylation-iPLEX forecast the natural history of chronic lymphocytic leukemia. Blood. 2019 08 22; 134(8):688-698. View in: Pubmed

      • Prognostic Score and Cytogenetic Risk Classification for Chronic Lymphocytic Leukemia Patients: Center for International Blood and Marrow Transplant Research Report. Clin Cancer Res. 2019 08 15; 25(16):5143-5155. View in: Pubmed

      • Ibrutinib plus fludarabine, cyclophosphamide, and rituximab as initial treatment for younger patients with chronic lymphocytic leukaemia: a single-arm, multicentre, phase 2 trial. Lancet Haematol. 2019 Aug; 6(8):e419-e428. View in: Pubmed

      • Growth dynamics in naturally progressing chronic lymphocytic leukaemia. Nature. 2019 06; 570(7762):474-479. View in: Pubmed

      • Acalabrutinib monotherapy in patients with chronic lymphocytic leukemia who are intolerant to ibrutinib. Blood Adv. 2019 05 14; 3(9):1553-1562. View in: Pubmed

      • Phase 1 study of lenalidomide, bendamustine, and rituximab in previously untreated patients with chronic lymphocytic leukemia. Leuk Lymphoma. 2019 12; 60(12):2931-2938. View in: Pubmed

      • Efficacy results of a phase 2 trial of first-line idelalisib plus ofatumumab in chronic lymphocytic leukemia. Blood Adv. 2019 04 09; 3(7):1167-1174. View in: Pubmed

      • Perceived risk for cancer progression and psychological status in chronic lymphocytic leukemia patients: CALGB 70603 (Alliance). Leuk Lymphoma. 2019 10; 60(10):2580-2583. View in: Pubmed

      • Outcomes with ibrutinib by line of therapy and post-ibrutinib discontinuation in patients with chronic lymphocytic leukemia: Phase 3 analysis. Am J Hematol. 2019 05; 94(5):554-562. View in: Pubmed

      • Long-term follow-up of the RESONATE phase 3 trial of ibrutinib vs ofatumumab. Blood. 2019 05 09; 133(19):2031-2042. View in: Pubmed

      • Durable remissions with obinutuzumab-based chemoimmunotherapy: long-term follow-up of the phase 1b GALTON trial in CLL. Blood. 2019 02 28; 133(9):990-992. View in: Pubmed

      • Umbralisib in combination with ibrutinib in patients with relapsed or refractory chronic lymphocytic leukaemia or mantle cell lymphoma: a multicentre phase 1-1b study. Lancet Haematol. 2019 Jan; 6(1):e38-e47. View in: Pubmed

      • MYD88 L265P mutations identify a prognostic gene expression signature and a pathway for targeted inhibition in CLL. Br J Haematol. 2019 03; 184(6):925-936. View in: Pubmed

      • Ibrutinib: searching for a partner drug. Lancet Oncol. 2019 01; 20(1):3-5. View in: Pubmed

      • Incidence of and risk factors for major haemorrhage in patients treated with ibrutinib: An integrated analysis. Br J Haematol. 2019 02; 184(4):558-569. View in: Pubmed

      • Ibrutinib Regimens versus Chemoimmunotherapy in Older Patients with Untreated CLL. N Engl J Med. 2018 12 27; 379(26):2517-2528. View in: Pubmed

      • Relapsed CLL: sequencing, combinations, and novel agents. Hematology Am Soc Hematol Educ Program. 2018 11 30; 2018(1):248-255. View in: Pubmed

      • Enhancer Architecture and Essential Core Regulatory Circuitry of Chronic Lymphocytic Leukemia. Cancer Cell. 2018 12 10; 34(6):982-995.e7. View in: Pubmed

      • PI3K p110d inactivation antagonizes chronic lymphocytic leukemia and reverses T cell immune suppression. J Clin Invest. 2019 01 02; 129(1):122-136. View in: Pubmed

      • Ofatumumab plus high dose methylprednisolone followed by ofatumumab plus alemtuzumab to achieve maximal cytoreduction prior to allogeneic transplantation for 17p deleted or TP53 mutated chronic lymphocytic leukemia. Leuk Lymphoma. 2019 05; 60(5):1312-1315. View in: Pubmed

      • Improvement in Parameters of Hematologic and Immunologic Function and Patient Well-being in the Phase III RESONATE Study of Ibrutinib Versus Ofatumumab in Patients With Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma. Clin Lymphoma Myeloma Leuk. 2018 12; 18(12):803-813.e7. View in: Pubmed

      • Vigilance for ibrutinib-associated ventricular arrhythmias: rare but be aware. Leuk Lymphoma. 2018 12; 59(12):2767-2768. View in: Pubmed

      • Still a role for second-line chemoimmunotherapy in chronic lymphocytic leukemia? Haematologica. 2018 07; 103(7):1096-1098. View in: Pubmed

      • Ibrutinib: coming of age? Blood. 2018 04 26; 131(17):1880-1882. View in: Pubmed

      • Voxtalisib (XL765) in patients with relapsed or refractory non-Hodgkin lymphoma or chronic lymphocytic leukaemia: an open-label, phase 2 trial. Lancet Haematol. 2018 Apr; 5(4):e170-e180. View in: Pubmed

      • Subtype assignment of CLL based on B-cell subset associated gene signatures from normal bone marrow - A proof of concept study. PLoS One. 2018; 13(3):e0193249. View in: Pubmed

      • Are BTK and PLCG2 mutations necessary and sufficient for ibrutinib resistance in chronic lymphocytic leukemia? Expert Rev Hematol. 2018 03; 11(3):185-194. View in: Pubmed

      • Enhanced activation and expansion of T cells using mechanically soft elastomer fibers. Adv Biosyst. 2018 Feb; 2(2). View in: Pubmed

      • How I treat CLL patients with ibrutinib. Blood. 2018 01 25; 131(4):379-386. View in: Pubmed

      • The Role of Rituximab in Chronic Lymphocytic Leukemia Treatment and the Potential Utility of Biosimilars. Oncologist. 2018 03; 23(3):288-296. View in: Pubmed

      • Experience with ibrutinib for first-line use in patients with chronic lymphocytic leukemia. Ther Adv Hematol. 2018 Jan; 9(1):3-19. View in: Pubmed

      • Minimal residual disease detected by immunoglobulin sequencing predicts CLL relapse more effectively than flow cytometry. Leuk Lymphoma. 2018 08; 59(8):1986-1989. View in: Pubmed

      • Reply to S. Opat et al. J Clin Oncol. 2017 12 20; 35(36):4094-4095. View in: Pubmed

      • Analysis of ITGB2 rare germ line variants in chronic lymphocytic leukemia. Blood. 2017 11 30; 130(22):2443-2444. View in: Pubmed

      • FCR achieves long-term durable remissions in patients with IGHV-mutated CLL. Blood. 2017 11 23; 130(21):2278-2282. View in: Pubmed

      • PI3Kd-selective and PI3Ka/d-combinatorial inhibitors in clinical development for B-cell non-Hodgkin lymphoma. Expert Opin Investig Drugs. 2017 Nov; 26(11):1267-1279. View in: Pubmed

      • Targeting B Cell Signaling in Chronic Lymphocytic Leukemia. Curr Oncol Rep. 2017 Sep; 19(9):61. View in: Pubmed

      • Characterization of atrial fibrillation adverse events reported in ibrutinib randomized controlled registration trials. Haematologica. 2017 10; 102(10):1796-1805. View in: Pubmed

      • Chemoimmunotherapy Is Not Dead Yet in Chronic Lymphocytic Leukemia. J Clin Oncol. 2017 09 10; 35(26):2989-2992. View in: Pubmed

      • Bendamustine hydrochloride in patients with B-cell malignancies who have comorbidities - is there an optimal dose? Expert Rev Hematol. 2017 08; 10(8):707-718. View in: Pubmed

      • Integrated single-cell genetic and transcriptional analysis suggests novel drivers of chronic lymphocytic leukemia. Genome Res. 2017 08; 27(8):1300-1311. View in: Pubmed

      • Current Status of Bruton's Tyrosine Kinase Inhibitor Development and Use in B-Cell Malignancies. Drugs Aging. 2017 07; 34(7):509-527. View in: Pubmed

      • Changes in Bcl-2 Family Protein Profile During Idelalisib Therapy Mimic Those During Duvelisib Therapy in Chronic Lymphocytic Leukemia Lymphocytes. JCO Precis Oncol. 2017; 1. View in: Pubmed

      • The potential combination of BCL-2 inhibitors and ibrutinib as frontline therapy in chronic lymphocytic leukemia. Leuk Lymphoma. 2017 Oct; 58(10):2287-2297. View in: Pubmed

      • Lenalidomide in the treatment of chronic lymphocytic leukemia. Expert Opin Investig Drugs. 2017 May; 26(5):633-650. View in: Pubmed

      • Impact of ibrutinib dose adherence on therapeutic efficacy in patients with previously treated CLL/SLL. Blood. 2017 05 11; 129(19):2612-2615. View in: Pubmed

      • Efficacy and safety of idelalisib in combination with ofatumumab for previously treated chronic lymphocytic leukaemia: an open-label, randomised phase 3 trial. Lancet Haematol. 2017 Mar; 4(3):e114-e126. View in: Pubmed

      • Ventricular arrhythmias and sudden death in patients taking ibrutinib. Blood. 2017 05 04; 129(18):2581-2584. View in: Pubmed

      • Phosphatidylinositol 3-kinase d blockade increases genomic instability in B cells. Nature. 2017 02 23; 542(7642):489-493. View in: Pubmed

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      450 Brookline Avenue Boston, MA 02215
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      42.3374, -71.1082

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