Jerome Ritz, MD

Jerome Ritz, MD

Medical Oncology

Contact Information

Office Phone Number

617-632-3465

Fax

617-632-5167

Biography

Jerome Ritz, MD

Dr. Ritz received his MD from Chicago Medical School in 1972, followed by residency in internal medicine at the University of Wisconsin Hospital and Clinics, Madison. He completed a clinical fellowship in hematology and oncology at Beth Israel Hospital, and a research fellowship at DFCI, where he joined the staff in 1980. Since 1996, he has been director of the Connell and O'Reilly Families Cell Manipulation Core.

Researcher

Physician

Executive Director, Connell and O'Reilly Families Cell Manipulation Core Facility
Professor of Medicine, Harvard Medical School

Centers/Programs

Stem Cell Transplantation
Older Adult Hematologic Malignancy (OHM) Program

Clinical Interests

Stem cell/bone marrow transplant, Tumor immunology

Board Certification

  • Hematology, 1980
  • Internal Medicine, 1975

Fellowship

  • Beth Israel Deaconess Medical Center, Hematology & Oncology
  • Dana-Farber Cancer Institute, Tumor Immunology

Residency

  • University of Wisconsin Hospitals, Internal Medicine

Medical School

  • Chicago Medical School

Recent Awards

  • Stohlman Scholar Award, Leukemia Society of America 1988
  • Elected Member, American Society for Clinical Investigation 1990

Research

    Hematopoietic Stem Cell Transplantation, Graft versus Host Disease, Graft versus Leukemia, Cellular Therapy and Immunotherapy

    Allogeneic hematopoietic stem cell transplantation (HSCT) is an effective treatment for patients with hematologic malignancies, but continues to be associated with severe toxicities. Both the efficacy and toxicity of HSCT are mediated by donor immune cells. Immune responses that target antigens expressed on recipient leukemia cells (termed graft versus leukemia – GVL) play an important role in eradicating residual tumor cells and preventing leukemia relapse after transplant. In contrast, immune responses that target antigens expressed by normal tissues in the recipient are the primary mediators of graft versus host disease (GVHD) and thus lead to substantial toxicities. 

    Although donor T cells are the primary immune cells responsible for GVL and GVHD, studies from our laboratory demonstrated that donor B cells also play a role in these responses. To examine the role of B cells we determined whether patients developed antibodies specific for minor histocompatibility antigens such as Y-chromosome encoded proteins (H-Y antigens) after HSCT. While males are tolerant to these self-proteins, female T cells develop strong responses to these antigens after transplantation into male recipients. Our studies demonstrated that antibodies specific for H-Y antigens developed in approximately 50% of male recipients with female donors but not in male patients with male donors. Importantly, the incidence of chronic GVHD was significantly higher and the risk of relapse was significantly lower in patients with H-Y antibodies. These studies provided evidence that B cell responses contribute to GVHD as well as GVL and also suggested that targeting donor B cells might offer a new therapeutic approach for chronic GVHD. This was confirmed by clinical trials demonstrating the efficacy of rituximab in patients with persistent chronic GVHD.  Further studies evaluating the efficacy of rituximab for prevention of chronic GVHD are also underway. Current studies in my laboratory focus on defining the mechanisms whereby donor B cells and antibodies specific for recipient antigens contribute to GVL and GVHD.

    Regulatory T cells (Treg) are known to play a critical role in immune tolerance and deficiencies of Treg contribute to the development of autoimmune diseases. Studies from our laboratory demonstrated that patients with chronic GVHD were deficient in Treg and inadequate reconstitution of Treg after transplant helps explain the inability of some patients to become immunologically tolerant to their own tissues. These findings also suggested that enhancement of Treg might restore immune tolerance and control GVHD. This was recently confirmed in clinical trials showing that administration of low doses of IL-2, a critical cytokine required for maintenance of Treg, resulted in the selective expansion of Treg and significant clinical improvement in approximately 50% of patients with active chronic GVHD. Current studies in my laboratory focus on the identification of critical factors that regulate homeostasis of Treg in normal individuals and in patients after HSCT. These studies also examine the effects of exogenous IL-2 on Treg homeostasis and characterization of the mechanisms whereby IL-2 enhances Treg numbers and function in patients with GVHD.

    In addition to the specific projects described above, my laboratory is also interested in developing other novel immune therapies for hematologic malignancies. These would include cytokines, immune modulating antibodies or other agents, cancer vaccines and adoptive cellular therapies. Our laboratory has the ability to develop novel therapies of many types and to evaluate the immunologic effects of these new approaches in patients enrolled on the clinical trials conducted to evaluate these methods. 

    Publications

      • Chronic GvHD NIH Consensus Project Biology Task Force: evolving path to personalized treatment of chronic GvHD. Blood Adv. 2023 09 12; 7(17):4886-4902. View in: Pubmed

      • Epitope editing enables targeted immunotherapy of acute myeloid leukaemia. Nature. 2023 Sep; 621(7978):404-414. View in: Pubmed

      • Necessity of routine perioperative epidural catheter placement in laparoscopic colorectal resections: a retrospective data analysis. Langenbecks Arch Surg. 2023 Aug 25; 408(1):335. View in: Pubmed

      • Real-world experience with low-dose IL-2 for children and young adults with refractory chronic graft-versus-host disease. Blood Adv. 2023 08 22; 7(16):4647-4657. View in: Pubmed

      • Cultivated autologous limbal epithelial cell (CALEC) transplantation: Development of manufacturing process and clinical evaluation of feasibility and safety. Sci Adv. 2023 08 18; 9(33):eadg6470. View in: Pubmed

      • Mapping the evolution of T cell states during response and resistance to adoptive cellular therapy. Cell Rep. 2023 Aug 29; 42(8):113011. View in: Pubmed

      • Cytokine release syndrome in haploidentical stem cell transplant may impact T-cell recovery and relapse. Blood Adv. 2023 08 08; 7(15):4080-4088. View in: Pubmed

      • Posttransplant cyclophosphamide vs tacrolimus-based GVHD prophylaxis: lower incidence of relapse and chronic GVHD. Blood Adv. 2023 08 08; 7(15):3903-3915. View in: Pubmed

      • Lower incidence of chronic GVHD observed after transplantation with cryopreserved unrelated allogeneic stem cells. Blood Adv. 2023 06 13; 7(11):2431-2435. View in: Pubmed

      • Real-world experience with low-dose IL-2 for children and young adults with refractory chronic graft-versus-host disease. Blood Adv. 2023 May 24. View in: Pubmed

      • Robotic colorectal resection in combination with a multimodal enhanced recovery program - results of the first 100 cases. Int J Colorectal Dis. 2023 Apr 13; 38(1):95. View in: Pubmed

      • Mechanisms of response and resistance to combined decitabine and ipilimumab for advanced myeloid disease. Blood. 2023 04 13; 141(15):1817-1830. View in: Pubmed

      • Ipilimumab plus decitabine for patients with MDS or AML in posttransplant or transplant-naïve settings. Blood. 2023 04 13; 141(15):1884-1888. View in: Pubmed

      • Editorial: Regulatory T cells in graft versus host disease. Front Immunol. 2022; 13:1085220. View in: Pubmed

      • A phase 1 study of donor regulatory T-cell infusion plus low-dose interleukin-2 for steroid-refractory chronic graft-vs-host disease. Blood Adv. 2022 11 08; 6(21):5786-5796. View in: Pubmed

      • Phenotypic and functional characterization of the CD6-ALCAM T-cell co-stimulatory pathway after allogeneic cell transplantation. Haematologica. 2022 11 01; 107(11):2617-2629. View in: Pubmed

      • Durability of clinical and immunologic responses to extended low-dose interleukin-2 therapy in patients with refractory chronic graft-versus-host disease. Front Immunol. 2022; 13:954966. View in: Pubmed

      • Organ-specific response after low-dose interleukin-2 therapy for steroid-refractory chronic graft-versus-host disease. Blood Adv. 2022 08 09; 6(15):4392-4402. View in: Pubmed

      • Impact of diagnostic genetics on remission MRD and transplantation outcomes in older patients with AML. Blood. 2022 06 16; 139(24):3546-3557. View in: Pubmed

      • Memory-like NK cells armed with a neoepitope-specific CAR exhibit potent activity against NPM1 mutated acute myeloid leukemia. Proc Natl Acad Sci U S A. 2022 06 21; 119(25):e2122379119. View in: Pubmed

      • Expansion, persistence, and efficacy of donor memory-like NK cells infused for posttransplant relapse. J Clin Invest. 2022 06 01; 132(11). View in: Pubmed

      • BET-bromodomain and EZH2 inhibitor-treated chronic GVHD mice have blunted germinal centers with distinct transcriptomes. Blood. 2022 05 12; 139(19):2983-2997. View in: Pubmed

      • GM-CSF secreting leukemia cell vaccination for MDS/AML after allogeneic HSCT: a randomized, double-blinded, phase 2 trial. Blood Adv. 2022 04 12; 6(7):2183-2194. View in: Pubmed

      • Microbiota dynamics in a randomized trial of gut decontamination during allogeneic hematopoietic cell transplantation. JCI Insight. 2022 04 08; 7(7). View in: Pubmed

      • [First 18 months as certified ERAS® center for colorectal cancer : Lessons learned and results of the first 261 patients]. Chirurgie (Heidelb). 2022 Jul; 93(7):687-693. View in: Pubmed

      • Cell-free DNA profiling informs all major complications of hematopoietic cell transplantation. Proc Natl Acad Sci U S A. 2022 01 25; 119(4). View in: Pubmed

      • Impact of cryopreservation and transit times of allogeneic grafts on hematopoietic and immune reconstitution. Blood Adv. 2021 12 14; 5(23):5140-5149. View in: Pubmed

      • Allogeneic hematopoietic cell transplantation outcomes in patients with Richter's transformation. Haematologica. 2021 12 01; 106(12):3219-3222. View in: Pubmed

      • Donor Clonal Hematopoiesis and Recipient Outcomes After Transplantation. J Clin Oncol. 2022 01 10; 40(2):189-201. View in: Pubmed

      • Mapping the evolution of T cell states during response and resistance to adoptive cellular therapy. Cell Rep. 2021 11 09; 37(6):109992. View in: Pubmed

      • Author Correction: Blockade of IL-22 signaling reverses erythroid dysfunction in stress-induced anemias. Nat Immunol. 2021 Nov; 22(11):1465. View in: Pubmed

      • Immune Reconstitution following High-Dose Chemotherapy and Autologous Stem Cell Transplantation with or without Pembrolizumab Maintenance Therapy in Patients with Lymphoma. Transplant Cell Ther. 2022 01; 28(1):32.e1-32.e10. View in: Pubmed

      • Monitoring PD-1 Phosphorylation to Evaluate PD-1 Signaling during Antitumor Immune Responses. Cancer Immunol Res. 2021 12; 9(12):1465-1475. View in: Pubmed

      • Molecular and cellular features of CTLA-4 blockade for relapsed myeloid malignancies after transplantation. Blood. 2021 06 10; 137(23):3212-3217. View in: Pubmed

      • NKTR-358: A novel regulatory T-cell stimulator that selectively stimulates expansion and suppressive function of regulatory T cells for the treatment of autoimmune and inflammatory diseases. J Transl Autoimmun. 2021; 4:100103. View in: Pubmed

      • Blockade of IL-22 signaling reverses erythroid dysfunction in stress-induced anemias. Nat Immunol. 2021 04; 22(4):520-529. View in: Pubmed

      • National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. The 2020 Etiology and Prevention Working Group Report. Transplant Cell Ther. 2021 06; 27(6):452-466. View in: Pubmed

      • Global Perspective on the Development of Genetically Modified Immune Cells for Cancer Therapy. Front Immunol. 2020; 11:608485. View in: Pubmed

      • Comparative analysis of cell therapy infusion workflows at clinical sites. Cytotherapy. 2021 04; 23(4):285-292. View in: Pubmed

      • Impaired T- and NK-cell reconstitution after haploidentical HCT with posttransplant cyclophosphamide. Blood Adv. 2021 01 26; 5(2):352-364. View in: Pubmed

      • Maturation and Phenotypic Heterogeneity of Human CD4+ Regulatory T Cells From Birth to Adulthood and After Allogeneic Stem Cell Transplantation. Front Immunol. 2020; 11:570550. View in: Pubmed

      • Cell-free DNA tissues of origin by methylation profiling reveals significant cell, tissue, and organ-specific injury related to COVID-19 severity. Med (N Y). 2021 04 09; 2(4):411-422.e5. View in: Pubmed

      • Mechanism of EBV inducing anti-tumour immunity and its therapeutic use. Nature. 2021 02; 590(7844):157-162. View in: Pubmed

      • Chimeric Antigen Receptor T Cells Targeting NKG2D-Ligands Show Robust Efficacy Against Acute Myeloid Leukemia and T-Cell Acute Lymphoblastic Leukemia. Front Immunol. 2020; 11:580328. View in: Pubmed

      • Post-Transcriptional Genetic Silencing of BCL11A to Treat Sickle Cell Disease. N Engl J Med. 2021 01 21; 384(3):205-215. View in: Pubmed

      • Distinct evolutionary paths in chronic lymphocytic leukemia during resistance to the graft-versus-leukemia effect. Sci Transl Med. 2020 09 16; 12(561). View in: Pubmed

      • Allogeneic hematopoietic cell transplantation after prior targeted therapy for high-risk chronic lymphocytic leukemia. Blood Adv. 2020 09 08; 4(17):4113-4123. View in: Pubmed

      • Peripheral host T cells survive hematopoietic stem cell transplantation and promote graft-versus-host disease. J Clin Invest. 2020 09 01; 130(9):4624-4636. View in: Pubmed

      • Cell-Free DNA in Blood Reveals Significant Cell, Tissue and Organ Specific injury and Predicts COVID-19 Severity. medRxiv. 2020 Jul 29. View in: Pubmed

      • Axicabtagene Ciloleucel in the Non-Trial Setting: Outcomes and Correlates of Response, Resistance, and Toxicity. J Clin Oncol. 2020 09 20; 38(27):3095-3106. View in: Pubmed

      • Clonal hematopoiesis is associated with adverse outcomes in multiple myeloma patients undergoing transplant. Nat Commun. 2020 06 12; 11(1):2996. View in: Pubmed

      • A multicenter phase 1 study of nivolumab for relapsed hematologic malignancies after allogeneic transplantation. Blood. 2020 06 11; 135(24):2182-2191. View in: Pubmed

      • T Cell Clonal Dynamics Determined by High-Resolution TCR-ß Sequencing in Recipients after Allogeneic Hematopoietic Cell Transplantation. Biol Blood Marrow Transplant. 2020 09; 26(9):1567-1574. View in: Pubmed

      • Personalized iPSC-Derived Dopamine Progenitor Cells for Parkinson's Disease. N Engl J Med. 2020 05 14; 382(20):1926-1932. View in: Pubmed

      • BK virus-specific T-cell immune reconstitution after allogeneic hematopoietic cell transplantation. Blood Adv. 2020 05 12; 4(9):1881-1893. View in: Pubmed

      • PD-1 blockade for diffuse large B-cell lymphoma after autologous stem cell transplantation. Blood Adv. 2020 01 14; 4(1):122-126. View in: Pubmed

      • Inhibition of inositol kinase B controls acute and chronic graft-versus-host disease. Blood. 2020 01 02; 135(1):28-40. View in: Pubmed

      • A phase II study of reduced intensity double umbilical cord blood transplantation using fludarabine, melphalan, and low dose total body irradiation. Bone Marrow Transplant. 2020 04; 55(4):804-810. View in: Pubmed

      • Assessment of a multi-cytokine profile by a novel biochip-based assay allows correlation of cytokine profiles with clinical outcomes in adult recipients of umbilical cord blood transplantation. Bone Marrow Transplant. 2020 09; 55(9):1821-1823. View in: Pubmed

      • Dose-escalated interleukin-2 therapy for refractory chronic graft-versus-host disease in adults and children. Blood Adv. 2019 09 10; 3(17):2550-2561. View in: Pubmed

      • Elevated Galectin-3 Plasma Concentrations in Recipients of Allogeneic Hematopoietic Cell Transplantation. Clin Hematol Int. 2019 Dec; 1(4):201-204. View in: Pubmed

      • Recurrent genetic HLA loss in AML relapsed after matched unrelated allogeneic hematopoietic cell transplantation. Blood Adv. 2019 07 23; 3(14):2199-2204. View in: Pubmed

      • Effect of Sirolimus on Immune Reconstitution Following Myeloablative Allogeneic Stem Cell Transplantation: An Ancillary Analysis of a Randomized Controlled Trial Comparing Tacrolimus/Sirolimus and Tacrolimus/Methotrexate (Blood and Marrow Transplant Clinical Trials Network/BMT CTN 0402). Biol Blood Marrow Transplant. 2019 11; 25(11):2143-2151. View in: Pubmed

      • Reactivation of BK virus after double umbilical cord blood transplantation in adults correlates with impaired reconstitution of CD4+ and CD8+ T effector memory cells and increase of T regulatory cells. Clin Immunol. 2019 10; 207:18-23. View in: Pubmed

      • Efficacy and immunologic effects of extracorporeal photopheresis plus interleukin-2 in chronic graft-versus-host disease. Blood Adv. 2019 04 09; 3(7):969-979. View in: Pubmed

      • Functional analysis of clinical response to low-dose IL-2 in patients with refractory chronic graft-versus-host disease. Blood Adv. 2019 04 09; 3(7):984-994. View in: Pubmed

      • PD-1 blockade with pembrolizumab for classical Hodgkin lymphoma after autologous stem cell transplantation. Blood. 2019 07 04; 134(1):22-29. View in: Pubmed

      • Targeting PI3Kd function for amelioration of murine chronic graft-versus-host disease. Am J Transplant. 2019 06; 19(6):1820-1830. View in: Pubmed

      • Clinical Metabolomics Identifies Blood Serum Branched Chain Amino Acids as Potential Predictive Biomarkers for Chronic Graft vs. Host Disease. Front Oncol. 2019; 9:141. View in: Pubmed

      • Naive and Stem Cell Memory T Cell Subset Recovery Reveals Opposing Reconstitution Patterns in CD4 and CD8 T Cells in Chronic Graft vs. Host Disease. Front Immunol. 2019; 10:334. View in: Pubmed

      • A confirmation of chronic graft-versus-host disease prediction using allogeneic HY antibodies following sex-mismatched hematopoietic cell transplantation. Haematologica. 2019 07; 104(7):e314-e317. View in: Pubmed

      • Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial. Nature. 2019 01; 565(7738):234-239. View in: Pubmed

      • Phase I Trial of Autologous CAR T Cells Targeting NKG2D Ligands in Patients with AML/MDS and Multiple Myeloma. Cancer Immunol Res. 2019 01; 7(1):100-112. View in: Pubmed

      • Small-molecule BCL6 inhibitor effectively treats mice with nonsclerodermatous chronic graft-versus-host disease. Blood. 2019 01 03; 133(1):94-99. View in: Pubmed

      • Effect of Antihuman T Lymphocyte Globulin on Immune Recovery after Myeloablative Allogeneic Stem Cell Transplantation with Matched Unrelated Donors: Analysis of Immune Reconstitution in a Double-Blind Randomized Controlled Trial. Biol Blood Marrow Transplant. 2018 11; 24(11):2216-2223. View in: Pubmed

      • Manufacturing development and clinical production of NKG2D chimeric antigen receptor-expressing T cells for autologous adoptive cell therapy. Cytotherapy. 2018 07; 20(7):952-963. View in: Pubmed

      • NK-cell activation is associated with increased HIV transcriptional activity following allogeneic hematopoietic cell transplantation. Blood Adv. 2018 06 26; 2(12):1412-1416. View in: Pubmed

      • Biomanufacturing for clinically advanced cell therapies. Nat Biomed Eng. 2018 06; 2(6):362-376. View in: Pubmed

      • Impact of Thrombotic Microangiopathy on Renal Outcomes and Survival after Hematopoietic Stem Cell Transplantation. Biol Blood Marrow Transplant. 2018 11; 24(11):2344-2353. View in: Pubmed

      • A Comparison of the Myeloablative Conditioning Regimen Fludarabine/Busulfan with Cyclophosphamide/Total Body Irradiation, for Allogeneic Stem Cell Transplantation in the Modern Era: A Cohort Analysis. Biol Blood Marrow Transplant. 2018 08; 24(8):1733-1740. View in: Pubmed

      • Corrigendum: An immunogenic personal neoantigen vaccine for patients with melanoma. Nature. 2018 03 14; 555(7696):402. View in: Pubmed

      • Bortezomib-based immunosuppression after reduced-intensity conditioning hematopoietic stem cell transplantation: randomized phase II results. Haematologica. 2018 03; 103(3):522-530. View in: Pubmed

      • Immunophenotyping of pediatric brain tumors: correlating immune infiltrate with histology, mutational load, and survival and assessing clonal T cell response. J Neurooncol. 2018 Apr; 137(2):269-278. View in: Pubmed

      • Signaling by the Epstein-Barr virus LMP1 protein induces potent cytotoxic CD4+ and CD8+ T cell responses. Proc Natl Acad Sci U S A. 2018 01 23; 115(4):E686-E695. View in: Pubmed

      • Vaccination with autologous myeloblasts admixed with GM-K562 cells in patients with advanced MDS or AML after allogeneic HSCT. Blood Adv. 2017 Nov 14; 1(24):2269-2279. View in: Pubmed

      • Antibodies targeting surface membrane antigens in patients with chronic graft-versus-host disease. Blood. 2017 12 28; 130(26):2889-2899. View in: Pubmed

      • CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation. Cancer Discov. 2018 02; 8(2):216-233. View in: Pubmed

      • Prospective, Randomized, Double-Blind, Phase III Clinical Trial of Anti-T-Lymphocyte Globulin to Assess Impact on Chronic Graft-Versus-Host Disease-Free Survival in Patients Undergoing HLA-Matched Unrelated Myeloablative Hematopoietic Cell Transplantation. J Clin Oncol. 2017 Dec 20; 35(36):4003-4011. View in: Pubmed

      • An immunogenic personal neoantigen vaccine for patients with melanoma. Nature. 2017 07 13; 547(7662):217-221. View in: Pubmed

      • An activated Th17-prone T cell subset involved in chronic graft-versus-host disease sensitive to pharmacological inhibition. JCI Insight. 2017 Jun 15; 2(12). View in: Pubmed

      • Phase 1 multicenter trial of brentuximab vedotin for steroid-refractory acute graft-versus-host disease. Blood. 2017 06 15; 129(24):3256-3261. View in: Pubmed

      • Research Techniques Made Simple: Mass Cytometry Analysis Tools for Decrypting the Complexity of Biological Systems. J Invest Dermatol. 2017 05; 137(5):e43-e51. View in: Pubmed

      • Donor-engrafted CHIP is common among stem cell transplant recipients with unexplained cytopenias. Blood. 2017 07 06; 130(1):91-94. View in: Pubmed

      • Synergistic Immunostimulatory Effects and Therapeutic Benefit of Combined Histone Deacetylase and Bromodomain Inhibition in Non-Small Cell Lung Cancer. Cancer Discov. 2017 08; 7(8):852-867. View in: Pubmed

      • Research Techniques Made Simple: Experimental Methodology for Single-Cell Mass Cytometry. J Invest Dermatol. 2017 04; 137(4):e31-e38. View in: Pubmed

      • Pirfenidone ameliorates murine chronic GVHD through inhibition of macrophage infiltration and TGF-ß production. Blood. 2017 05 04; 129(18):2570-2580. View in: Pubmed

      • Epstein-Barr virus-specific adoptive immunotherapy for recurrent, metastatic nasopharyngeal carcinoma. Cancer. 2017 Jul 15; 123(14):2642-2650. View in: Pubmed

      • Adoptive Transfer of Invariant NKT Cells as Immunotherapy for Advanced Melanoma: A Phase I Clinical Trial. Clin Cancer Res. 2017 Jul 15; 23(14):3510-3519. View in: Pubmed

      • PD-1 modulates regulatory T-cell homeostasis during low-dose interleukin-2 therapy. Blood. 2017 04 13; 129(15):2186-2197. View in: Pubmed

      • Safety and efficacy of allogeneic hematopoietic stem cell transplant after PD-1 blockade in relapsed/refractory lymphoma. Blood. 2017 03 09; 129(10):1380-1388. View in: Pubmed

      • Clonal Hematopoiesis Associated With Adverse Outcomes After Autologous Stem-Cell Transplantation for Lymphoma. J Clin Oncol. 2017 May 10; 35(14):1598-1605. View in: Pubmed

      • Lack of impact of umbilical cord blood unit processing techniques on clinical outcomes in adult double cord blood transplant recipients. Cytotherapy. 2017 02; 19(2):272-284. View in: Pubmed

      • Mechanistic approaches for the prevention and treatment of chronic GVHD. Blood. 2017 01 05; 129(1):22-29. View in: Pubmed

      • Low-dose IL-2 selectively activates subsets of CD4+ Tregs and NK cells. JCI Insight. 2016 11 03; 1(18):e89278. View in: Pubmed

      • Risk factors for reoperation after ileostomy reversal - Results from a prospective cohort study. Int J Surg. 2016 Dec; 36(Pt A):233-239. View in: Pubmed

      • Angiogenic Factors Correlate with T Cell Immune Reconstitution and Clinical Outcomes after Double-Unit Umbilical Cord Blood Transplantation in Adults. Biol Blood Marrow Transplant. 2017 01; 23(1):103-112. View in: Pubmed

      • Next-generation sequencing-based detection of circulating tumour DNA After allogeneic stem cell transplantation for lymphoma. Br J Haematol. 2016 Dec; 175(5):841-850. View in: Pubmed

      • The Biology of Chronic Graft-versus-Host Disease: A Task Force Report from the National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease. Biol Blood Marrow Transplant. 2017 Feb; 23(2):211-234. View in: Pubmed

      • CD95-Mediated Calcium Signaling Promotes T Helper 17 Trafficking to Inflamed Organs in Lupus-Prone Mice. Immunity. 2016 07 19; 45(1):209-23. View in: Pubmed

      • Ipilimumab for Patients with Relapse after Allogeneic Transplantation. N Engl J Med. 2016 Jul 14; 375(2):143-53. View in: Pubmed

      • The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice. Cancer Cell. 2016 07 11; 30(1):183. View in: Pubmed

      • Therapeutic regulatory T-cell adoptive transfer ameliorates established murine chronic GVHD in a CXCR5-dependent manner. Blood. 2016 08 18; 128(7):1013-7. View in: Pubmed

      • A phase I study of CD25/regulatory T-cell-depleted donor lymphocyte infusion for relapse after allogeneic stem cell transplantation. Haematologica. 2016 10; 101(10):1251-1259. View in: Pubmed

      • Idelalisib given front-line for treatment of chronic lymphocytic leukemia causes frequent immune-mediated hepatotoxicity. Blood. 2016 07 14; 128(2):195-203. View in: Pubmed

      • Necessity of subcutaneous suction drains in ileostomy reversal (DRASTAR)-a randomized, controlled bi-centered trial. Langenbecks Arch Surg. 2016 Jun; 401(4):409-18. View in: Pubmed

      • Efficacy, durability, and response predictors of low-dose interleukin-2 therapy for chronic graft-versus-host disease. Blood. 2016 07 07; 128(1):130-7. View in: Pubmed

      • The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice. Cancer Cell. 2016 04 11; 29(4):574-586. View in: Pubmed

      • Targeted Rho-associated kinase 2 inhibition suppresses murine and human chronic GVHD through a Stat3-dependent mechanism. Blood. 2016 04 28; 127(17):2144-54. View in: Pubmed

      • Circulating T follicular helper cells with increased function during chronic graft-versus-host disease. Blood. 2016 05 19; 127(20):2489-97. View in: Pubmed

      • Enhancement of tumor cell susceptibility to natural killer cell activity through inhibition of the PI3K signaling pathway. Cancer Immunol Immunother. 2016 Mar; 65(3):355-66. View in: Pubmed

      • Infused total nucleated cell dose is a better predictor of transplant outcomes than CD34+ cell number in reduced-intensity mobilized peripheral blood allogeneic hematopoietic cell transplantation. Haematologica. 2016 Apr; 101(4):499-505. View in: Pubmed

      • Dramatic Expansion of HSCs: New Possibilities for HSC Transplants? Cell Stem Cell. 2016 Jan 07; 18(1):10-2. View in: Pubmed

      • Unbalanced recovery of regulatory and effector T cells after allogeneic stem cell transplantation contributes to chronic GVHD. Blood. 2016 Feb 04; 127(5):646-57. View in: Pubmed

      • Presensitization to HY antigens in female donors prior to transplant is not associated with male recipient post-transplant HY antibody development nor with clinical outcomes. Haematologica. 2016 Jan; 101(1):e30-3. View in: Pubmed

      • IL-7 and SCF Levels Inversely Correlate with T Cell Reconstitution and Clinical Outcomes after Cord Blood Transplantation in Adults. PLoS One. 2015; 10(7):e0132564. View in: Pubmed

      • A Bortezomib-Based Regimen Offers Promising Survival and Graft-versus-Host Disease Prophylaxis in Myeloablative HLA-Mismatched and Unrelated Donor Transplantation: A Phase II Trial. Biol Blood Marrow Transplant. 2015 Nov; 21(11):1907-13. View in: Pubmed

      • Reconstitution of T Cell Immunity after Umbilical Cord Blood Transplantation. Biol Blood Marrow Transplant. 2015 Jul; 21(7):1151-2. View in: Pubmed

      • Targeting Syk-activated B cells in murine and human chronic graft-versus-host disease. Blood. 2015 Jun 25; 125(26):4085-94. View in: Pubmed

      • Biologic Activity of Autologous, Granulocyte-Macrophage Colony-Stimulating Factor Secreting Alveolar Soft-Part Sarcoma and Clear Cell Sarcoma Vaccines. Clin Cancer Res. 2015 Jul 15; 21(14):3178-86. View in: Pubmed

      • Interferon-?-induced activation of JAK1 and JAK2 suppresses tumor cell susceptibility to NK cells through upregulation of PD-L1 expression. Oncoimmunology. 2015 Jun; 4(6):e1008824. View in: Pubmed

      • Aberrant B-cell homeostasis in chronic GVHD. Blood. 2015 Mar 12; 125(11):1703-7. View in: Pubmed

      • Reprint of: B cells in chronic graft-versus-host disease. Biol Blood Marrow Transplant. 2015 Feb; 21(2 Suppl):S11-8. View in: Pubmed

      • Absolute lymphocyte count recovery after allogeneic hematopoietic stem cell transplantation predicts clinical outcome. Biol Blood Marrow Transplant. 2015 May; 21(5):873-80. View in: Pubmed

      • Angiogenic cytokines are antibody targets during graft-versus-leukemia reactions. Clin Cancer Res. 2015 Mar 01; 21(5):1010-8. View in: Pubmed

      • B cells in chronic graft-versus-host disease. Biol Blood Marrow Transplant. 2015 Jan; 21(1):16-23. View in: Pubmed

      • A modified ?-retrovirus vector for X-linked severe combined immunodeficiency. N Engl J Med. 2014 Oct 09; 371(15):1407-17. View in: Pubmed

      • Ibrutinib treatment ameliorates murine chronic graft-versus-host disease. J Clin Invest. 2014 Nov; 124(11):4867-76. View in: Pubmed

      • Sequential infusion of donor-derived dendritic cells with donor lymphocyte infusion for relapsed hematologic cancers after allogeneic hematopoietic stem cell transplantation. Am J Hematol. 2014 Dec; 89(12):1092-6. View in: Pubmed

      • Somatic mutations predict poor outcome in patients with myelodysplastic syndrome after hematopoietic stem-cell transplantation. J Clin Oncol. 2014 Sep 01; 32(25):2691-8. View in: Pubmed

      • A phase II study of bortezomib plus prednisone for initial therapy of chronic graft-versus-host disease. Biol Blood Marrow Transplant. 2014 Nov; 20(11):1737-43. View in: Pubmed

      • Current issues in chronic graft-versus-host disease. Blood. 2014 Jul 17; 124(3):374-84. View in: Pubmed

      • Donor chimerism early after reduced-intensity conditioning hematopoietic stem cell transplantation predicts relapse and survival. Biol Blood Marrow Transplant. 2014 Oct; 20(10):1516-21. View in: Pubmed

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      • A phase I study of escalated dose subcutaneous alemtuzumab given weekly with rituximab in relapsed chronic lymphocytic leukemia/small lymphocytic lymphoma. Haematologica. 2013 Jun; 98(6):964-70. View in: Pubmed

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      Dana-Farber Cancer Institute

      450 Brookline Avenue Mayer 530 Boston, MA 02215
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      Dana-Farber Cancer Institute

      Location Avtar

      Dana-Farber Cancer Institute

      450 Brookline Avenue Mayer 530 Boston, MA 02215
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      42.3374, -71.1082