Matthew B. Yurgelun, MD

A Randomized Trial of Two Remote Health Care Delivery Models on the Uptake of Genetic Testing and Impact on Patient-Reported Psychological Outcomes in Families With Pancreatic Cancer: The Genetic Education, Risk Assessment, and Testing (GENERATE) Study. Gastroenterology. 2024 Feb 05. View in: Pubmed

Biomarkers of pembrolizumab efficacy in advanced anal squamous cell carcinoma: analysis of a phase II clinical trial and a cohort of long-term responders. J Immunother Cancer. 2024 01 25; 12(1). View in: Pubmed

Development and evaluation of INT2GRATE: a platform for comprehensive assessment of the role of germline variants informed by tumor signature profile in Lynch syndrome. Front Oncol. 2023; 13:1284690. View in: Pubmed

Oncogenic Drivers and Therapeutic Vulnerabilities in KRAS Wild-Type Pancreatic Cancer. Clin Cancer Res. 2023 11 14; 29(22):4627-4643. View in: Pubmed

NCCN Guidelines® Insights: Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic, Version 2.2024. J Natl Compr Canc Netw. 2023 10; 21(10):1000-1010. View in: Pubmed

PREMM5 distinguishes sporadic from Lynch syndrome-associated MMR-deficient/MSI-high colorectal cancer. Fam Cancer. 2023 10; 22(4):459-465. View in: Pubmed

Adipose tissue and skeletal muscle wasting precede clinical diagnosis of pancreatic cancer. Nat Commun. 2023 07 18; 14(1):4317. View in: Pubmed

Serendipity Strikes: How Pursuing Novel Hypotheses Shifted the Paradigm Regarding the Genetic Basis of Colorectal Cancer and Changed Cancer Therapy. Dig Dis Sci. 2023 09; 68(9):3504-3513. View in: Pubmed

Is Appendiceal Cancer a Lynch Syndrome-Associated Cancer? JAMA Oncol. 2023 06 01; 9(6):869. View in: Pubmed

G-CSF rescue of FOLFIRINOX-induced neutropenia leads to systemic immune suppression in mice and humans. J Immunother Cancer. 2023 06; 11(6). View in: Pubmed

Phase Ib and Expansion Study of Gemcitabine, Nab-Paclitaxel, and Ficlatuzumab in Patients With Metastatic Pancreatic Cancer. Oncologist. 2023 05 08; 28(5):425-432. View in: Pubmed

Aberrant cell state plasticity mediated by developmental reprogramming precedes colorectal cancer initiation. Sci Adv. 2023 03 29; 9(13):eadf0927. View in: Pubmed

Clinical factors associated with skin neoplasms in individuals with Lynch syndrome in a longitudinal observational cohort. J Am Acad Dermatol. 2023 06; 88(6):1282-1290. View in: Pubmed

Combined PD-1, BRAF and MEK inhibition in BRAFV600E colorectal cancer: a phase 2 trial. Nat Med. 2023 02; 29(2):458-466. View in: Pubmed

MyLynch: A Patient-Facing Clinical Decision Support Tool for Genetically-Guided Personalized Medicine in Lynch Syndrome. Cancers (Basel). 2023 Jan 06; 15(2). View in: Pubmed

Programmatic Precision Oncology Decision Support for Patients With Gastrointestinal Cancer. JCO Precis Oncol. 2023 01; 7:e2200342. View in: Pubmed

Delphi Initiative for Early-Onset Colorectal Cancer (DIRECt) International Management Guidelines. Clin Gastroenterol Hepatol. 2023 03; 21(3):581-603.e33. View in: Pubmed

Prevalence of Mismatch-Repair Deficiency in Rectal Adenocarcinomas. N Engl J Med. 2022 11 03; 387(18):1714-1716. View in: Pubmed

An updated counseling framework for moderate-penetrance colorectal cancer susceptibility genes. Genet Med. 2022 Dec; 24(12):2587-2590. View in: Pubmed

Preface. Hematol Oncol Clin North Am. 2022 Oct; 36(5):xiii-xiv. View in: Pubmed

An integrated somatic and germline approach to aid interpretation of germline variants of uncertain significance in cancer susceptibility genes. Front Oncol. 2022; 12:942741. View in: Pubmed

Development and Validation of the PREMMplus Model for Multigene Hereditary Cancer Risk Assessment. J Clin Oncol. 2022 12 10; 40(35):4083-4094. View in: Pubmed

The Evolving Paradigm of Germline Testing in Pancreatic Ductal Adenocarcinoma and Implications for Clinical Practice. Surg Pathol Clin. 2022 Sep; 15(3):491-502. View in: Pubmed

Building on More Than 20 Years of Progress in Pancreatic Cancer Surveillance for High-Risk Individuals. J Clin Oncol. 2022 10 01; 40(28):3230-3234. View in: Pubmed

Point/Counterpoint: Is It Time for Universal Germline Genetic Testing for All GI Cancers? J Clin Oncol. 2022 08 20; 40(24):2681-2692. View in: Pubmed

Identification and Management of Pathogenic Variants in BRCA1, BRCA2, and PALB2 in a Tumor-Only Genomic Testing Program. Clin Cancer Res. 2022 06 01; 28(11):2349-2360. View in: Pubmed

Physical activity in older adults with metastatic gastrointestinal cancer: a pilot and feasibility study. BMJ Open Sport Exerc Med. 2022; 8(2):e001353. View in: Pubmed

Cetuximab and Irinotecan With or Without Bevacizumab in Refractory Metastatic Colorectal Cancer: BOND-3, an ACCRU Network Randomized Clinical Trial. Oncologist. 2022 04 05; 27(4):292-298. View in: Pubmed

Risk assessment and genetic counseling for Lynch syndrome - Practice resource of the National Society of Genetic Counselors and the Collaborative Group of the Americas on Inherited Gastrointestinal Cancer. J Genet Couns. 2022 06; 31(3):568-583. View in: Pubmed

Lynch Syndrome-Associated Cancers Beyond Colorectal Cancer. Gastrointest Endosc Clin N Am. 2022 Jan; 32(1):75-93. View in: Pubmed

Surveillance Imaging in Individuals at High Risk for Pancreatic Cancer: Not a Ceiling, but Rather a Floor Upon Which to Build. Gastroenterology. 2022 03; 162(3):700-702. View in: Pubmed

Durable clinical benefit from PARP inhibition in a platinum-sensitive, BRCA2-mutated pancreatic cancer patient after earlier progression on placebo treatment on the POLO trial: a case report. J Gastrointest Oncol. 2021 Dec; 12(6):3133-3140. View in: Pubmed

A Case of Microsatellite Instability-High Colon Cancer in a Young Woman With Familial Adenomatous Polyposis. J Natl Compr Canc Netw. 2021 12; 19(12):1377-1381. View in: Pubmed

Clinical Implications of Pathogenic Germline Variants in Small Intestine Neuroendocrine Tumors (SI-NETs). JCO Precis Oncol. 2021 11; 5:808-816. View in: Pubmed

NCCN Guidelines® Insights: Genetic/Familial High-Risk Assessment: Colorectal, Version 1.2021. J Natl Compr Canc Netw. 2021 10 15; 19(10):1122-1132. View in: Pubmed

Novel Models of Genetic Education and Testing for Pancreatic Cancer Interception: Preliminary Results from the GENERATE Study. Cancer Prev Res (Phila). 2021 11; 14(11):1021-1032. View in: Pubmed

Correction to: Letter to the Editor-Recent advances in Lynch syndrome: response to Møller et al. Fam Cancer. 2021 Apr; 20(2):123. View in: Pubmed

Letter to the Editor-Recent advances in Lynch syndrome: response to Møller et al. Fam Cancer. 2021 04; 20(2):121-122. View in: Pubmed

Familial Burden and Other Clinical Factors Associated With Various Types of Cancer in Individuals With Lynch Syndrome. Gastroenterology. 2021 07; 161(1):143-150.e4. View in: Pubmed

A Case-Based Approach to Understanding Complex Genetic Information in an Evolving Landscape. Am Soc Clin Oncol Educ Book. 2021 Mar; 41:1-11. View in: Pubmed

Managing gastric cancer risk in lynch syndrome: controversies and recommendations. Fam Cancer. 2022 01; 21(1):75-78. View in: Pubmed

Implementing Systematic Genetic Counseling and Multigene Germline Testing for Individuals With Pancreatic Cancer. JCO Oncol Pract. 2021 02; 17(2):e236-e247. View in: Pubmed

Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2021 01 06; 19(1):77-102. View in: Pubmed

Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Body Composition among Patients with Advanced or Metastatic Colorectal Cancer: A Randomized Trial. Cancers (Basel). 2020 Nov 20; 12(11). View in: Pubmed

Phenotypic Differences in Juvenile Polyposis Syndrome With or Without a Disease-causing SMAD4/BMPR1A Variant. Cancer Prev Res (Phila). 2021 02; 14(2):215-222. View in: Pubmed

Comparison of Colorectal and Endometrial Microsatellite Instability Tumor Analysis and Premm5 Risk Assessment for Predicting Pathogenic Germline Variants on Multigene Panel Testing. J Clin Oncol. 2020 12 01; 38(34):4086-4094. View in: Pubmed

Characterizing germline APC and MUTYH variants in Ashkenazi Jews compared to other individuals. Fam Cancer. 2021 04; 20(2):111-116. View in: Pubmed

Collaborative Group of the Americas on Inherited Gastrointestinal Cancer Position statement on multigene panel testing for patients with colorectal cancer and/or polyposis. Fam Cancer. 2020 07; 19(3):223-239. View in: Pubmed

Aspirin for Lynch syndrome: a legacy of prevention. Lancet. 2020 06 13; 395(10240):1817-1818. View in: Pubmed

NCCN Guidelines Insights: Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic, Version 1.2020. J Natl Compr Canc Netw. 2020 04; 18(4):380-391. View in: Pubmed

A Multi-Institutional Cohort of Therapy-Associated Polyposis in Childhood and Young Adulthood Cancer Survivors. Cancer Prev Res (Phila). 2020 03; 13(3):291-298. View in: Pubmed

Correction to: Health Care Provider Perceptions of Caring for Individuals with Inherited Pancreatic Cancer Risk. J Cancer Educ. 2020 Feb; 35(1):204. View in: Pubmed

Identification of Lynch syndrome by microsatellite instability and mismatch repair deficiency testing on colorectal adenomas. Eur J Hum Genet. 2020 03; 28(3):275-276. View in: Pubmed

Clinical Factors Associated with Urinary Tract Cancer in Individuals with Lynch Syndrome. Cancer Epidemiol Biomarkers Prev. 2020 01; 29(1):193-199. View in: Pubmed

Precision Treatment and Prevention of Colorectal Cancer-Hope or Hype? Gastroenterology. 2020 01; 158(2):441-446. View in: Pubmed

Health behaviours and beliefs in individuals with familial pancreatic cancer. Fam Cancer. 2019 10; 18(4):457-464. View in: Pubmed

Clinical Factors Associated With Gastric Cancer in Individuals With Lynch Syndrome. Clin Gastroenterol Hepatol. 2020 04; 18(4):830-837.e1. View in: Pubmed

Targeted Cancer Next-Generation Sequencing as a Primary Screening Tool for Microsatellite Instability and Lynch Syndrome in Upper Gastrointestinal Tract Cancers. Cancer Epidemiol Biomarkers Prev. 2019 07; 28(7):1246-1251. View in: Pubmed

Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Progression-Free Survival Among Patients With Advanced or Metastatic Colorectal Cancer: The SUNSHINE Randomized Clinical Trial. JAMA. 2019 04 09; 321(14):1370-1379. View in: Pubmed

Recent advances in Lynch syndrome. Fam Cancer. 2019 04; 18(2):211-219. View in: Pubmed

FOLFOX plus ziv-aflibercept or placebo in first-line metastatic esophagogastric adenocarcinoma: A double-blind, randomized, multicenter phase 2 trial. Cancer. 2019 07 01; 125(13):2213-2221. View in: Pubmed

Family history of cancer, Ashkenazi Jewish ancestry, and pancreatic cancer risk. Br J Cancer. 2019 04; 120(8):848-854. View in: Pubmed

Multigene panel testing versus syndrome-specific germline testing for inherited cancer risk: 'a somewhat different way'. Per Med. 2019 03; 16(2):83-86. View in: Pubmed

Genetics of Familial and Sporadic Pancreatic Cancer. Gastroenterology. 2019 05; 156(7):2041-2055. View in: Pubmed

Tumor Testing for Microsatellite Instability to Identify Lynch Syndrome: New Insights Into an Old Diagnostic Strategy. J Clin Oncol. 2019 02 01; 37(4):263-265. View in: Pubmed

Evaluating Susceptibility to Pancreatic Cancer: ASCO Provisional Clinical Opinion. J Clin Oncol. 2019 01 10; 37(2):153-164. View in: Pubmed

A Phase II and Biomarker Study of Sorafenib Combined with Modified FOLFOX in Patients with Advanced Hepatocellular Carcinoma. Clin Cancer Res. 2019 01 01; 25(1):80-89. View in: Pubmed

Germline cancer susceptibility gene variants, somatic second hits, and survival outcomes in patients with resected pancreatic cancer. Genet Med. 2019 01; 21(1):213-223. View in: Pubmed

Validation of a targeted next-generation sequencing approach to detect mismatch repair deficiency in colorectal adenocarcinoma. Mod Pathol. 2018 12; 31(12):1882-1890. View in: Pubmed

Precision Prevention and Early Detection of Cancer: Fundamental Principles. Cancer Discov. 2018 07; 8(7):803-811. View in: Pubmed

Real-time Genomic Characterization of Advanced Pancreatic Cancer to Enable Precision Medicine. Cancer Discov. 2018 09; 8(9):1096-1111. View in: Pubmed

Recent Advances in Lynch Syndrome: Diagnosis, Treatment, and Cancer Prevention. Am Soc Clin Oncol Educ Book. 2018 May 23; 38:101-109. View in: Pubmed

A counseling framework for moderate-penetrance colorectal cancer susceptibility genes. Genet Med. 2018 11; 20(11):1324-1327. View in: Pubmed

Recent progress in Lynch syndrome and other familial colorectal cancer syndromes. CA Cancer J Clin. 2018 05; 68(3):217-231. View in: Pubmed

Inherited DNA-Repair Defects in Colorectal Cancer. Am J Hum Genet. 2018 03 01; 102(3):401-414. View in: Pubmed

The Role of Genetic Counseling in Familial and Sporadic Cancer: Considerations, Challenges, and Collaboration. Ann Intern Med. 2017 12 19; 167(12):884-885. View in: Pubmed

Germline Testing for Individuals With Pancreatic Cancer: The Benefits and Challenges to Casting a Wider Net. J Clin Oncol. 2017 10 20; 35(30):3375-3377. View in: Pubmed

Community Practice Implementation of a Self-administered Version of PREMM1,2,6 to Assess Risk for Lynch Syndrome. Clin Gastroenterol Hepatol. 2018 Jan; 16(1):49-58. View in: Pubmed

Mutational cascades in cancer. Oncotarget. 2017 Jun 27; 8(26):41784-41785. View in: Pubmed

Reply to M.S. Daniels et al. J Clin Oncol. 2017 08 01; 35(22):2588-2589. View in: Pubmed

Development and Validation of the PREMM5 Model for Comprehensive Risk Assessment of Lynch Syndrome. J Clin Oncol. 2017 Jul 01; 35(19):2165-2172. View in: Pubmed

Precancer Atlas to Drive Precision Prevention Trials. Cancer Res. 2017 04 01; 77(7):1510-1541. View in: Pubmed

Universal Screening for Mismatch-Repair Deficiency in Endometrial Cancers to Identify Patients With Lynch Syndrome and Lynch-like Syndrome. Int J Gynecol Pathol. 2017 Mar; 36(2):115-127. View in: Pubmed

Historical Perspective on Familial Gastric Cancer. Cell Mol Gastroenterol Hepatol. 2017 Mar; 3(2):192-200. View in: Pubmed

A phase 2 and biomarker study of cabozantinib in patients with advanced cholangiocarcinoma. Cancer. 2017 06 01; 123(11):1979-1988. View in: Pubmed

Translating Germline Cancer Risk into Precision Prevention. Cell. 2017 02 09; 168(4):566-570. View in: Pubmed

Cancer Susceptibility Gene Mutations in Individuals With Colorectal Cancer. J Clin Oncol. 2017 Apr 01; 35(10):1086-1095. View in: Pubmed

"New" Cancer Genes and Inherited Colorectal Cancer Risk: Caveat Emptor. Gastroenterology. 2017 01; 152(1):12-13. View in: Pubmed

Detection of Mismatch Repair Deficiency and Microsatellite Instability in Colorectal Adenocarcinoma by Targeted Next-Generation Sequencing. J Mol Diagn. 2017 01; 19(1):84-91. View in: Pubmed

Leveraging premalignant biology for immune-based cancer prevention. Proc Natl Acad Sci U S A. 2016 09 27; 113(39):10750-8. View in: Pubmed

Genetic predisposition to colorectal cancer: Implications for treatment and prevention. Semin Oncol. 2016 Oct; 43(5):536-542. View in: Pubmed

Advances in Hereditary Colorectal and Pancreatic Cancers. Clin Ther. 2016 Jul; 38(7):1600-21. View in: Pubmed

Population-Wide Screening for Germline BRCA1 and BRCA2 Mutations: Too Much of a Good Thing? J Clin Oncol. 2015 Oct 01; 33(28):3092-5. View in: Pubmed

Identification of a Variety of Mutations in Cancer Predisposition Genes in Patients With Suspected Lynch Syndrome. Gastroenterology. 2015 Sep; 149(3):604-13.e20. View in: Pubmed

Germline TP53 Mutations in Patients With Early-Onset Colorectal Cancer in the Colon Cancer Family Registry. JAMA Oncol. 2015 May; 1(2):214-21. View in: Pubmed

Next-generation strategies for hereditary colorectal cancer risk assessment. J Clin Oncol. 2015 Feb 10; 33(5):388-93. View in: Pubmed

Phase II study of gemcitabine, oxaliplatin in combination with panitumumab in KRAS wild-type unresectable or metastatic biliary tract and gallbladder cancer. Br J Cancer. 2014 Jul 29; 111(3):430-6. View in: Pubmed

Therapy-associated polyposis as a late sequela of cancer treatment. Clin Gastroenterol Hepatol. 2014 Jun; 12(6):1046-50. View in: Pubmed

Impact of genetic testing on endometrial cancer risk-reducing practices in women at risk for Lynch syndrome. Gynecol Oncol. 2012 Dec; 127(3):544-51. View in: Pubmed

Microsatellite instability and DNA mismatch repair protein deficiency in Lynch syndrome colorectal polyps. Cancer Prev Res (Phila). 2012 Apr; 5(4):574-82. View in: Pubmed

Recruitment of osteoclast precursors by stromal cell derived factor-1 (SDF-1) in giant cell tumor of bone. J Orthop Res. 2005 Jan; 23(1):203-9. View in: Pubmed