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Myles A. Brown, MD


Researcher


Researcher

  • Physician
  • Director, Center for Functional Cancer Epigenetics
  • Emil Frei III Professor of Medicine, Harvard Medical School

Contact Information

  • Office Phone Number(617) 632-3948
  • Fax(617) 582-8501

Bio

Dr. Brown obtained his undergraduate degree in Biology from Yale University and his M.D. from the Johns Hopkins University School of Medicine. He completed training in Internal Medicine at the Brigham and Women's Hospital while doing research with David Livingston at the Dana-Farber. He went on to complete training in Medical Oncology at the Dana-Farber and postdoctoral research with Phillip Sharp at MIT. Following the completion of his training he joined the faculty of the Dana-Farber and Harvard Medical School. From 2002-2010 he served as Chief of the Division of Molecular and Cellular Oncology at the Dana-Farber. In 2010 together with Shirley Liu he founded the Center for Functional Cancer Epigenetics at the Dana-Farber.

Board Certification:

  • Internal Medicine, 1986
  • Medical Oncology, 1989

Fellowship:

  • Dana-Farber Cancer Institute, Medical Oncology
  • Massachusetts Institute Of Technology, Cancer Biology

Residency:

  • Brigham and Women's Hospital, Internal Medicine

Medical School:

  • Johns Hopkins University School of Medicine

Recent Awards:

  • American Society for Clinical Investigation 1997
  • Edwin B. Astwood Award, The Endocrine Society 2010
  • Tisch Family Outstanding Achievement Award, DFCI 2006
  • NAMS/Wyeth Pharmaceuticals SERM Research Award 2005
  • Elected to the Association of American Physicians 2003

Research

Epigenomics of hormone action

Dr. Brown’s research laboratory focuses on elucidating the epigenetic factors underlying the action of steroid hormones. This work has important implications both for normal physiology and for the treatment of hormone dependent malignancies including breast and prostate cancer. He is recognized for three seminal discoveries. His lab opened the steroid receptor coregulator field, illuminated the dynamic nature of receptor and coregulator interaction with the genome and elucidated the importance of epigenetically determined distant cis-regulatory steroid receptor binding sites. His contributions have uniquely reformulated the understanding of steroid hormone action in normal physiology and in hormone-dependent cancer.

Location

Dana-Farber Cancer Institute
450 Brookline Avenue
Dana 730
Boston MA, 02215
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