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Pere Puigserver, PhD


Researcher


Researcher

  • Professor of Cell Biology, Harvard Medical School

Contact Information

  • Office Phone Number617-582-7977
  • Fax617-632-5363

Bio

Pere Puigserver is a Professor of Cell Biology at Harvard Medical School. His laboratory is based in the Department of Cancer Biology at Dana-Farber Cancer Institute, located in the Center for Life Sciences Boston (CLSB).

Dr. Puigserver received his B.S. in Biological Sciences and Ph.D. in Biochemistry at the University of Illes Balears, Spain. His graduate work focused on mitochondrial energetics using in-vitro and in-vivo approaches, and included research at the University of Stockholm. He pursued postdoctoral training in molecular and cellular biology at the Dana-Farber Cancer Institute and Harvard Medical School. In 2002, he was appointed Assistant Professor of Cell Biology at Johns Hopkins University School of Medicine. In 2006, he was recruited back to the Dana-Farber Cancer Institute and Harvard Medical School to continue his research program in cell metabolism.

Research

Nutrient Sensing, Mitochondrial Biology and Cancer Metabolism

The Puigserver Laboratory investigates broad aspects of fundamental metabolic and energetic processes in mammals that are necessary for cell survival and specific biological function. We focus on the molecular mechanisms by which mammalian cells sense, communicate, and respond to nutrients.

Studies from our group have identified new basic and evolutionary conserved metabolic circuitries that involve nutrient signaling to gene expression programs associated with cellular metabolic reprogramming. Components of these circuitries are dysregulated in metabolic diseases, cancer, and age-associated diseases and represent therapeutic targets.

The Lab’s research program pursues fundamental biological and disease-relevant questions such as:





  • What are the molecular components that sense and transmit nutrient signals to reprogram mammalian cells?


  • What are the molecular components that sense signals to coordinate the supply of proteins for mitochondrial biogenesis, dynamics, and function?


  • What are the genetic and epigenetic mechanisms underlying metabolic reprogramming and plasticity in tumor cells?




The Puigserver Lab’s research combines and applies a variety of biochemical, cellular, genetic, chemical biology, metabolic, and screening approaches both in cell culture and whole animals to identify the molecular mechanisms by which mammalian cells sense, communicate, and respond to nutrients. In particular, we have a close collaboration with the Broad Institute in chemical biology to identify small compounds involved in nutrient sensing and metabolic reprogramming in a variety of mammalian cell types.



 

Hatting M, Tavares CDJ, Sharabi K, Rines AK, Puigserver P. Insulin regulation of gluconeogenesis. Ann N Y Acad Sci. 2018 Jan; 1411(1):21-35.
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Luo C, Balsa E, Thomas A, Hatting M, Jedrychowski M, Gygi SP, Widlund HR, Puigserver P. ERRa Maintains Mitochondrial Oxidative Metabolism and Constitutes an Actionable Target in PGC1a-Elevated Melanomas. Mol Cancer Res. 2017 Oct; 15(10):1366-1375.
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Sharabi K, Lin H, Tavares CDJ, Dominy JE, Camporez JP, Perry RJ, Schilling R, Rines AK, Lee J, Hickey M, Bennion M, Palmer M, Nag PP, Bittker JA, Perez J, Jedrychowski MP, Ozcan U, Gygi SP, Kamenecka TM, Shulman GI, Schreiber SL, Griffin PR, Puigserver P. Selective Chemical Inhibition of PGC-1a Gluconeogenic Activity Ameliorates Type 2 Diabetes. Cell. 2017 Mar 23; 169(1):148-160.e15.
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Pan Y, Tian T, Park CO, Lofftus SY, Mei S, Liu X, Luo C, O'Malley JT, Gehad A, Teague JE, Divito SJ, Fuhlbrigge R, Puigserver P, Krueger JG, Hotamisligil GS, Clark RA, Kupper TS. Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism. Nature. 2017 03 09; 543(7644):252-256.
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Hatting M, Rines AK, Luo C, Tabata M, Sharabi K, Hall JA, Verdeguer F, Trautwein C, Puigserver P. Adipose Tissue CLK2 Promotes Energy Expenditure during High-Fat Diet Intermittent Fasting. Cell Metab. 2017 Feb 07; 25(2):428-437.
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Luo C, Widlund HR, Puigserver P. PGC-1 Coactivators: Shepherding the Mitochondrial Biogenesis of Tumors. Trends Cancer. 2016 10; 2(10):619-631.
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Barrow JJ, Balsa E, Verdeguer F, Tavares CD, Soustek MS, Hollingsworth LR, Jedrychowski M, Vogel R, Paulo JA, Smeitink J, Gygi SP, Doench J, Root DE, Puigserver P. Bromodomain Inhibitors Correct Bioenergetic Deficiency Caused by Mitochondrial Disease Complex I Mutations. Mol Cell. 2016 Oct 06; 64(1):163-175.
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Luo C, Lim JH, Lee Y, Granter SR, Thomas A, Vazquez F, Widlund HR, Puigserver P. A PGC1a-mediated transcriptional axis suppresses melanoma metastasis. Nature. 2016 09 15; 537(7620):422-426.
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Rines AK, Sharabi K, Tavares CD, Puigserver P. Targeting hepatic glucose metabolism in the treatment of type 2 diabetes. Nat Rev Drug Discov. 2016 11; 15(11):786-804.
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Luo C, Puigserver P, Widlund HR. Breaking BRAF(V600E)-drug resistance by stressing mitochondria. Pigment Cell Melanoma Res. 2016 Jul; 29(4):401-3.
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Tavares CD, Sharabi K, Dominy JE, Lee Y, Isasa M, Orozco JM, Jedrychowski MP, Kamenecka TM, Griffin PR, Gygi SP, Puigserver P. The Methionine Transamination Pathway Controls Hepatic Glucose Metabolism through Regulation of the GCN5 Acetyltransferase and the PGC-1a Transcriptional Coactivator. J Biol Chem. 2016 May 13; 291(20):10635-45.
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Luo C, Puigserver P. Stem cells: Dietary fat promotes intestinal dysregulation. Nature. 2016 Mar 03; 531(7592):42-3.
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Lee G, Won HS, Lee YM, Choi JW, Oh TI, Jang JH, Choi DK, Lim BO, Kim YJ, Park JW, Puigserver P, Lim JH. Oxidative Dimerization of PHD2 is Responsible for its Inactivation and Contributes to Metabolic Reprogramming via HIF-1a Activation. Sci Rep. 2016 Jan 07; 6:18928.
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Balsa-Martinez E, Puigserver P. Cancer Cells Hijack Gluconeogenic Enzymes to Fuel Cell Growth. Mol Cell. 2015 Nov 19; 60(4):509-11.
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Sharabi K, Tavares CD, Rines AK, Puigserver P. Molecular pathophysiology of hepatic glucose production. Mol Aspects Med. 2015 Dec; 46:21-33.
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Verdeguer F, Soustek MS, Hatting M, Blättler SM, McDonald D, Barrow JJ, Puigserver P. Brown Adipose YY1 Deficiency Activates Expression of Secreted Proteins Linked to Energy Expenditure and Prevents Diet-Induced Obesity. Mol Cell Biol. 2015 Oct 26; 36(1):184-96.
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Soustek MS, Puigserver P. Interrupting synoviolin play at the ER: a plausible action to elevate mitochondrial energetics and silence obesity. EMBO J. 2015 Apr 15; 34(8):981-3.
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Rines AK, Verdeguer F, Puigserver P. Adenosine activates thermogenic adipocytes. Cell Res. 2015 Feb; 25(2):155-6.
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Lee Y, Dominy JE, Choi YJ, Jurczak M, Tolliday N, Camporez JP, Chim H, Lim JH, Ruan HB, Yang X, Vazquez F, Sicinski P, Shulman GI, Puigserver P. Cyclin D1-Cdk4 controls glucose metabolism independently of cell cycle progression. Nature. 2014 Jun 26; 510(7506):547-51.
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Lim JH, Luo C, Vazquez F, Puigserver P. Targeting mitochondrial oxidative metabolism in melanoma causes metabolic compensation through glucose and glutamine utilization. Cancer Res. 2014 Jul 01; 74(13):3535-45.
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Kraus D, Yang Q, Kong D, Banks AS, Zhang L, Rodgers JT, Pirinen E, Pulinilkunnil TC, Gong F, Wang YC, Cen Y, Sauve AA, Asara JM, Peroni OD, Monia BP, Bhanot S, Alhonen L, Puigserver P, Kahn BB. Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. Nature. 2014 Apr 10; 508(7495):258-62.
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Hall JA, Tabata M, Rodgers JT, Puigserver P. USP7 attenuates hepatic gluconeogenesis through modulation of FoxO1 gene promoter occupancy. Mol Endocrinol. 2014 Jun; 28(6):912-24.
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Chow JD, Lawrence RT, Healy ME, Dominy JE, Liao JA, Breen DS, Byrne FL, Kenwood BM, Lackner C, Okutsu S, Mas VR, Caldwell SH, Tomsig JL, Cooney GJ, Puigserver PB, Turner N, James DE, Villén J, Hoehn KL. Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation. Mol Metab. 2014 Jul; 3(4):419-31.
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Verdeguer F, Blättler SM, Cunningham JT, Hall JA, Chim H, Puigserver P. Decreased genetic dosage of hepatic Yin Yang 1 causes diabetic-like symptoms. Mol Endocrinol. 2014 Mar; 28(3):308-16.
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Tabata M, Rodgers JT, Hall JA, Lee Y, Jedrychowski MP, Gygi SP, Puigserver P. Cdc2-like kinase 2 suppresses hepatic fatty acid oxidation and ketogenesis through disruption of the PGC-1a and MED1 complex. Diabetes. 2014 May; 63(5):1519-32.
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Dominy JE, Puigserver P. Mitochondrial biogenesis through activation of nuclear signaling proteins. Cold Spring Harb Perspect Biol. 2013 Jul 01; 5(7).
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Hall JA, Dominy JE, Lee Y, Puigserver P. The sirtuin family's role in aging and age-associated pathologies. J Clin Invest. 2013 Mar; 123(3):973-9.
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Vazquez F, Lim JH, Chim H, Bhalla K, Girnun G, Pierce K, Clish CB, Granter SR, Widlund HR, Spiegelman BM, Puigserver P. PGC1a expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress. Cancer Cell. 2013 Mar 18; 23(3):287-301.
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Lim JH, Gerhart-Hines Z, Dominy JE, Lee Y, Kim S, Tabata M, Xiang YK, Puigserver P. Oleic acid stimulates complete oxidation of fatty acids through protein kinase A-dependent activation of SIRT1-PGC1a complex. J Biol Chem. 2013 Mar 08; 288(10):7117-26.
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Dominy J, Puigserver P, Cantó C. In vivo measurement of the acetylation state of sirtuin substrates as a proxy for sirtuin activity. Methods Mol Biol. 2013; 1077:217-37.
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Dominy JE, Lee Y, Jedrychowski MP, Chim H, Jurczak MJ, Camporez JP, Ruan HB, Feldman J, Pierce K, Mostoslavsky R, Denu JM, Clish CB, Yang X, Shulman GI, Gygi SP, Puigserver P. The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis. Mol Cell. 2012 Dec 28; 48(6):900-13.
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Ye L, Kleiner S, Wu J, Sah R, Gupta RK, Banks AS, Cohen P, Khandekar MJ, Boström P, Mepani RJ, Laznik D, Kamenecka TM, Song X, Liedtke W, Mootha VK, Puigserver P, Griffin PR, Clapham DE, Spiegelman BM. TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. Cell. 2012 Sep 28; 151(1):96-110.
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Carracedo A, Weiss D, Leliaert AK, Bhasin M, de Boer VC, Laurent G, Adams AC, Sundvall M, Song SJ, Ito K, Finley LS, Egia A, Libermann T, Gerhart-Hines Z, Puigserver P, Haigis MC, Maratos-Flier E, Richardson AL, Schafer ZT, Pandolfi PP. A metabolic prosurvival role for PML in breast cancer. J Clin Invest. 2012 Sep; 122(9):3088-100.
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Blättler SM, Verdeguer F, Liesa M, Cunningham JT, Vogel RO, Chim H, Liu H, Romanino K, Shirihai OS, Vazquez F, Rüegg MA, Shi Y, Puigserver P. Defective mitochondrial morphology and bioenergetic function in mice lacking the transcription factor Yin Yang 1 in skeletal muscle. Mol Cell Biol. 2012 Aug; 32(16):3333-46.
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Blättler SM, Cunningham JT, Verdeguer F, Chim H, Haas W, Liu H, Romanino K, Rüegg MA, Gygi SP, Shi Y, Puigserver P. Yin Yang 1 deficiency in skeletal muscle protects against rapamycin-induced diabetic-like symptoms through activation of insulin/IGF signaling. Cell Metab. 2012 Apr 04; 15(4):505-17.
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Dominy JE, Gerhart-Hines Z, Puigserver P. Nutrient-dependent acetylation controls basic regulatory metabolic switches and cellular reprogramming. Cold Spring Harb Symp Quant Biol. 2011; 76:203-9.
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Dominy JE, Vazquez F, Puigserver P. Glycine decarboxylase cleaves a "malignant" metabolic path to promote tumor initiation. Cancer Cell. 2012 Feb 14; 21(2):143-5.
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Gerhart-Hines Z, Dominy JE, Blättler SM, Jedrychowski MP, Banks AS, Lim JH, Chim H, Gygi SP, Puigserver P. The cAMP/PKA pathway rapidly activates SIRT1 to promote fatty acid oxidation independently of changes in NAD(+). Mol Cell. 2011 Dec 23; 44(6):851-63.
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Romanino K, Mazelin L, Albert V, Conjard-Duplany A, Lin S, Bentzinger CF, Handschin C, Puigserver P, Zorzato F, Schaeffer L, Gangloff YG, Rüegg MA. Myopathy caused by mammalian target of rapamycin complex 1 (mTORC1) inactivation is not reversed by restoring mitochondrial function. Proc Natl Acad Sci U S A. 2011 Dec 20; 108(51):20808-13.
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Bhalla K, Hwang BJ, Dewi RE, Ou L, Twaddel W, Fang HB, Vafai SB, Vazquez F, Puigserver P, Boros L, Girnun GD. PGC1a promotes tumor growth by inducing gene expression programs supporting lipogenesis. Cancer Res. 2011 Nov 01; 71(21):6888-98.
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Kelly TJ, Souza AL, Clish CB, Puigserver P. A hypoxia-induced positive feedback loop promotes hypoxia-inducible factor 1alpha stability through miR-210 suppression of glycerol-3-phosphate dehydrogenase 1-like. Mol Cell Biol. 2011 Jul; 31(13):2696-706.
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Rodgers JT, Vogel RO, Puigserver P. Clk2 and B56ß mediate insulin-regulated assembly of the PP2A phosphatase holoenzyme complex on Akt. Mol Cell. 2011 Feb 18; 41(4):471-9.
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Dominy JE, Puigserver P. Nuclear FoxO1 inflames insulin resistance. EMBO J. 2010 Dec 15; 29(24):4068-9.
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Walker AK, Yang F, Jiang K, Ji JY, Watts JL, Purushotham A, Boss O, Hirsch ML, Ribich S, Smith JJ, Israelian K, Westphal CH, Rodgers JT, Shioda T, Elson SL, Mulligan P, Najafi-Shoushtari H, Black JC, Thakur JK, Kadyk LC, Whetstine JR, Mostoslavsky R, Puigserver P, Li X, Dyson NJ, Hart AC, Näär AM. Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP. Genes Dev. 2010 Jul 01; 24(13):1403-17.
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Rodgers JT, Haas W, Gygi SP, Puigserver P. Cdc2-like kinase 2 is an insulin-regulated suppressor of hepatic gluconeogenesis. Cell Metab. 2010 Jan; 11(1):23-34.
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Dominy JE, Lee Y, Gerhart-Hines Z, Puigserver P. Nutrient-dependent regulation of PGC-1alpha's acetylation state and metabolic function through the enzymatic activities of Sirt1/GCN5. Biochim Biophys Acta. 2010 Aug; 1804(8):1676-83.
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Cheng Z, Guo S, Copps K, Dong X, Kollipara R, Rodgers JT, Depinho RA, Puigserver P, White MF. Foxo1 integrates insulin signaling with mitochondrial function in the liver. Nat Med. 2009 Nov; 15(11):1307-11.
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Schafer ZT, Grassian AR, Song L, Jiang Z, Gerhart-Hines Z, Irie HY, Gao S, Puigserver P, Brugge JS. Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment. Nature. 2009 Sep 03; 461(7260):109-13.
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Kelly TJ, Lerin C, Haas W, Gygi SP, Puigserver P. GCN5-mediated transcriptional control of the metabolic coactivator PGC-1beta through lysine acetylation. J Biol Chem. 2009 Jul 24; 284(30):19945-52.
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Cantó C, Gerhart-Hines Z, Feige JN, Lagouge M, Noriega L, Milne JC, Elliott PJ, Puigserver P, Auwerx J. AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature. 2009 Apr 23; 458(7241):1056-60.
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Rodgers JT, Puigserver P. Insulin resistance: beta-arrestin development. Cell Res. 2009 Mar; 19(3):275-6.
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Housley MP, Udeshi ND, Rodgers JT, Shabanowitz J, Puigserver P, Hunt DF, Hart GW. A PGC-1alpha-O-GlcNAc transferase complex regulates FoxO transcription factor activity in response to glucose. J Biol Chem. 2009 Feb 20; 284(8):5148-57.
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Suchankova G, Nelson LE, Gerhart-Hines Z, Kelly M, Gauthier MS, Saha AK, Ido Y, Puigserver P, Ruderman NB. Concurrent regulation of AMP-activated protein kinase and SIRT1 in mammalian cells. Biochem Biophys Res Commun. 2009 Jan 23; 378(4):836-41.
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Coste A, Louet JF, Lagouge M, Lerin C, Antal MC, Meziane H, Schoonjans K, Puigserver P, O'Malley BW, Auwerx J. The genetic ablation of SRC-3 protects against obesity and improves insulin sensitivity by reducing the acetylation of PGC-1{alpha}. Proc Natl Acad Sci U S A. 2008 Nov 04; 105(44):17187-92.
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Housley MP, Rodgers JT, Udeshi ND, Kelly TJ, Shabanowitz J, Hunt DF, Puigserver P, Hart GW. O-GlcNAc regulates FoxO activation in response to glucose. J Biol Chem. 2008 Jun 13; 283(24):16283-92.
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J. T. Rodgers, C. Lerin, Z. Gerhart-Hines and P. Puigserver. Metabolic Adaptations Through PGC-1α and SIRT1 Pathways. FEBS Letters. 2008; 582:46-53.
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Cunningham JT, Rodgers JT, Arlow DH, Vazquez F, Mootha VK, Puigserver P. mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex. Nature. 2007 Nov 29; 450(7170):736-40.
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Rodgers JT, Lerin C, Gerhart-Hines Z, Puigserver P. Metabolic adaptations through the PGC-1 alpha and SIRT1 pathways. FEBS Lett. 2008 Jan 09; 582(1):46-53.
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Rodgers JT, Puigserver P. Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1. Proc Natl Acad Sci U S A. 2007 Jul 31; 104(31):12861-6.
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Kim D, Nguyen MD, Dobbin MM, Fischer A, Sananbenesi F, Rodgers JT, Delalle I, Baur JA, Sui G, Armour SM, Puigserver P, Sinclair DA, Tsai LH. SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. EMBO J. 2007 Jul 11; 26(13):3169-79.
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Gerhart-Hines Z, Rodgers JT, Bare O, Lerin C, Kim SH, Mostoslavsky R, Alt FW, Wu Z, Puigserver P. Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha. EMBO J. 2007 Apr 04; 26(7):1913-23.
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Rodgers JT, Puigserver P. Receptor feasts on sugar and cholesterol. Nat Med. 2007 Feb; 13(2):128-9.
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J.T. Rodgers and P. Puigserver. Fasting-Dependent Glucose and Lipid Metabolic Response through Hepatic SIRT1. Proc. Natl. Acad. Sci. USA. 2007; 104(31):12861-66.
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P. Puigserver and C.R. Kahn. Mammalian Metabolism in Aging. Molecular Biology of Aging. Edited by L. Guarente, L. Partridge and D.C. Wallace. Cold Spring Harbor Monograph Series. 2007; 51.
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Z. Gerhart-Hines, J.T. Rodgers, O. Bare, C. Lerin, S.H. Kim, R. Mostoslavsky, F.W. Alt, Z. Wu and P. Puigserver. Metabolic Control of Mitochondrial Function and Fatty Acid Oxidation Through PGC-1α/SIRT1. EMBO J. 2007; 26:1913-1923.
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J.T. Cunningham, J.T. Rodgers, D. Arlow, F. Vazquez, V.K. Mootha and P. Puigserver. mTOR controls mitochondrial oxidative function through a YY1/PGC-1α complex. Nature. 2007; 450:736-740.
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Lagouge M, Argmann C, Gerhart-Hines Z, Meziane H, Lerin C, Daussin F, Messadeq N, Milne J, Lambert P, Elliott P, Geny B, Laakso M, Puigserver P, Auwerx J. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell. 2006 Dec 15; 127(6):1109-22.
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Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Prabhu VV, Allard JS, Lopez-Lluch G, Lewis K, Pistell PJ, Poosala S, Becker KG, Boss O, Gwinn D, Wang M, Ramaswamy S, Fishbein KW, Spencer RG, Lakatta EG, Le Couteur D, Shaw RJ, Navas P, Puigserver P, Ingram DK, de Cabo R, Sinclair DA. Resveratrol improves health and survival of mice on a high-calorie diet. Nature. 2006 Nov 16; 444(7117):337-42.
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Cha SH, Rodgers JT, Puigserver P, Chohnan S, Lane MD. Hypothalamic malonyl-CoA triggers mitochondrial biogenesis and oxidative gene expression in skeletal muscle: Role of PGC-1alpha. Proc Natl Acad Sci U S A. 2006 Oct 17; 103(42):15410-5.
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Qin W, Yang T, Ho L, Zhao Z, Wang J, Chen L, Zhao W, Thiyagarajan M, MacGrogan D, Rodgers JT, Puigserver P, Sadoshima J, Deng H, Pedrini S, Gandy S, Sauve AA, Pasinetti GM. Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction. J Biol Chem. 2006 Aug 04; 281(31):21745-54.
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Lerin C, Rodgers JT, Kalume DE, Kim SH, Pandey A, Puigserver P. GCN5 acetyltransferase complex controls glucose metabolism through transcriptional repression of PGC-1alpha. Cell Metab. 2006 Jun; 3(6):429-38.
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Rodgers JT, Puigserver P. Certainly can't live without this: SIRT6. Cell Metab. 2006 Feb; 3(2):77-8.
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Puigserver P, Rodgers JT. Foxa2, a novel transcriptional regulator of insulin sensitivity. Nat Med. 2006 Jan; 12(1):38-9.
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S.H. Cha, Rodgers J.T., Puigserver, P., Chohnan, S. and Lane, M.D. Hypothalamic malonyl-CoA triggers mitochondrial biogenesis and oxidative gene expression in skeletal muscle: Role of PGC-1α. Proc. Natl. Acad. Sci. 2006; 103(42):15410-5.
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M. Lagouge, Argmann, C., Gerhart-Hines, Z., Meziane, H., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., Lerin, C., Geny, B., Laakso, M., Puigserver, P., Auwerx, J. Resveratrol promotes mitochondrial biogenesis and protects against metabolic disease through activating SIRT1 and PGC-1α activity. Cell. 2006; 127(6):1109-22.
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J. T. Rodgers and P. Puigserver. Certainly you can’t live without it: SIRT6. Cell Metabolism. 2006; 3(2):77-8.
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Pere Puigserver, Joseph T. Rodgers, Jill Milne and Karl Normington. Modulators of cdc2-like kinases (CLKs) and methods of use thereof. 2005.
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Rodgers JT, Lerin C, Haas W, Gygi SP, Spiegelman BM, Puigserver P. Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature. 2005 Mar 03; 434(7029):113-8.
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Puigserver P. Tissue-specific regulation of metabolic pathways through the transcriptional coactivator PGC1-alpha. Int J Obes (Lond). 2005 Mar; 29 Suppl 1:S5-9.
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P. Puigserver. Tissue-Specific Regulation of Metabolic Pathways Through the Transcriptional Coactivator PGC-1α. Int. J. Obes. Relat. Metab. Disord. 2005; 29:S5-9.
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J.T. Rodgers, C. Lerin, W. Haas, S.P. Gygi, B.M. Spiegelman and P.Puigserver. Nutrient Control of Gluconeogenesis Through PGC-1α/SIRT1 Deacetylase Complex. Nature. 2005; 434:113-8.
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Mootha VK, Handschin C, Arlow D, Xie X, St Pierre J, Sihag S, Yang W, Altshuler D, Puigserver P, Patterson N, Willy PJ, Schulman IG, Heyman RA, Lander ES, Spiegelman BM. Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle. Proc Natl Acad Sci U S A. 2004 Apr 27; 101(17):6570-5.
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Cao W, Daniel KW, Robidoux J, Puigserver P, Medvedev AV, Bai X, Floering LM, Spiegelman BM, Collins S. p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene. Mol Cell Biol. 2004 Apr; 24(7):3057-67.
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Fan M, Rhee J, St-Pierre J, Handschin C, Puigserver P, Lin J, Jäeger S, Erdjument-Bromage H, Tempst P, Spiegelman BM. Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK. Genes Dev. 2004 Feb 01; 18(3):278-89.
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V.K. Mootha, C. Handschin, D. Arlow, X. Xie, J. St Pierre, S. Sihag, W. Yang, D. Altshuler, P. Puigserver, N. Patterson, P.J. Willy, I.G. Schulman, R.A. Heyman, E.S. Lander, B.M. Spiegelman. ERRalpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle. Proc. Natl. Acad. Sci. USA. 2004; 101:6570-5.
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M. Fan, J. Rhee, J. St-Pierre, C. Handshin, P. Puigserver, J. Lin, S. Jaeger, H. Erdjument-Bromage, P. Tempst and B. M. Spiegelman. Suppression of Mitochondrial Respiration via p160 Myb Binding Protein Docking on PGC-1α: Modulation by p38 MAPK. Genes Dev. 2004; 18:278-289.
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W. Cao, K.W. Daniel, J. Rabidoux, P. Puigserver, A.V. Medvedev, X. Bai, L.M. Floering, B.M. Spiegelman and S. Collins. p38 Mitogen-Activated Protein Kinase is the Central Regulator of cAMP-Dependent Transcription of the Brown Fat Uncoupling Protein 1 Gene. Mol.Cell Biol. 2004; 24:3057-3067.
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Mootha VK, Lindgren CM, Eriksson KF, Subramanian A, Sihag S, Lehar J, Puigserver P, Carlsson E, Ridderstråle M, Laurila E, Houstis N, Daly MJ, Patterson N, Mesirov JP, Golub TR, Tamayo P, Spiegelman B, Lander ES, Hirschhorn JN, Altshuler D, Groop LC. PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet. 2003 Jul; 34(3):267-73.
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Yoon JC, Xu G, Deeney JT, Yang SN, Rhee J, Puigserver P, Levens AR, Yang R, Zhang CY, Lowell BB, Berggren PO, Newgard CB, Bonner-Weir S, Weir G, Spiegelman BM. Suppression of beta cell energy metabolism and insulin release by PGC-1alpha. Dev Cell. 2003 Jul; 5(1):73-83.
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Lin J, Tarr PT, Yang R, Rhee J, Puigserver P, Newgard CB, Spiegelman BM. PGC-1beta in the regulation of hepatic glucose and energy metabolism. J Biol Chem. 2003 Aug 15; 278(33):30843-8.
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Puigserver P, Rhee J, Donovan J, Walkey CJ, Yoon JC, Oriente F, Kitamura Y, Altomonte J, Dong H, Accili D, Spiegelman BM. Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction. Nature. 2003 May 29; 423(6939):550-5.
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Rhee J, Inoue Y, Yoon JC, Puigserver P, Fan M, Gonzalez FJ, Spiegelman BM. Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis. Proc Natl Acad Sci U S A. 2003 Apr 01; 100(7):4012-7.
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Puigserver P, Spiegelman BM. Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator. Endocr Rev. 2003 Feb; 24(1):78-90.
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Tritos NA, Mastaitis JW, Kokkotou EG, Puigserver P, Spiegelman BM, Maratos-Flier E. Characterization of the peroxisome proliferator activated receptor coactivator 1 alpha (PGC 1alpha) expression in the murine brain. Brain Res. 2003 Jan 31; 961(2):255-60.
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J. Rhee, Y. Inoue, J.C. Yoon, P. Puigserver, M. Fan, F.J. Gonzalez, B.M. Spiegelman. Regulation of hepatic fasting response by PPARgamma coactivator-1 alpha (PGC-1): Requirement for hepatocyte nuclear factor 4 alpha in gluconeogenesis. Proc. Natl. Acad. Sci. USA. 2003; 100:4012-7.
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J. Cliff Yoon, G. Xu, J.T. Deeny, S. Yang, J. Rhee, P. Puigserver, R. Yang, C. Zhang, B.B. Lowell, P.O. Berggren, C.B. Newgard, S. Bonner-Weir, G. Weir and B. M. Spiegelman. Suppression of β-Cell Energy Metabolism and Insulin release by PGC-1α. Dev. Cell. 2003; 5:73-83.
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B.M. Spiegelman and P. Puigserver. PGC-1α: Metabolic Regulator and Transcriptional Coactivator. Endocr. Rev. 2003; 24(1):78-90.
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P. Puigserver, J. Rhee, J. Donovan, C.J. Walkey, J.C. Yoon, F. Oriente, Y. Kitamura, J. Altomonte, H. Dong, D. Accili and B.M. Spiegelman. Insulin-Regulated Hepatic Gluconeogenesis Through FOXO1/PGC-1α Interaction. Nature. 2003; 423:550-5.
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Lin J, Wu H, Tarr PT, Zhang CY, Wu Z, Boss O, Michael LF, Puigserver P, Isotani E, Olson EN, Lowell BB, Bassel-Duby R, Spiegelman BM. Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres. Nature. 2002 Aug 15; 418(6899):797-801.
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J. Lin, P. Puigserver, J. Donovan, P. Tarr and B.M. Spiegelman. PGC-1β: A novel transcription coactivator associated with host cell factor. J. Biol. Chem. 2002; 277:1645-1648.
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J. Lin, H. Wu, P. Tarr, C.Y. Zhang, Z. Wu, O. Boss, L.F. Michael, P. Puigserver, E. Isotani, E. N. Olson, B. Lowell, R. Bassel-Duby and B.M. Spiegelman. Transcriptional Co-activator PGC-1α drives the formation of slow-twitch muscle fibers. Nature. 2002; 418:797-801.
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Lin J, Puigserver P, Donovan J, Tarr P, Spiegelman BM. Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor. J Biol Chem. 2002 Jan 18; 277(3):1645-8.
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Puigserver P, Rhee J, Lin J, Wu Z, Yoon JC, Zhang CY, Krauss S, Mootha VK, Lowell BB, Spiegelman BM. Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1. Mol Cell. 2001 Nov; 8(5):971-82.
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Herzig S, Long F, Jhala US, Hedrick S, Quinn R, Bauer A, Rudolph D, Schutz G, Yoon C, Puigserver P, Spiegelman B, Montminy M. CREB regulates hepatic gluconeogenesis through the coactivator PGC-1. Nature. 2001 Sep 13; 413(6852):179-83.
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Yoon JC, Puigserver P, Chen G, Donovan J, Wu Z, Rhee J, Adelmant G, Stafford J, Kahn CR, Granner DK, Newgard CB, Spiegelman BM. Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature. 2001 Sep 13; 413(6852):131-8.
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Michael LF, Wu Z, Cheatham RB, Puigserver P, Adelmant G, Lehman JJ, Kelly DP, Spiegelman BM. Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1. Proc Natl Acad Sci U S A. 2001 Mar 27; 98(7):3820-5.
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P. Puigserver, ,J. Rhee, J. Lin, Z. Wu, J.C. Yoon, C. Zhang, S. Krauss, V. Mootha. B.B. Lowell and B. M. Spiegelman. Cytokine-Activation of Energy Expenditure through p38 MAP kinase phosphorylation of the PPARγ coactivator (PGC-1). Mol. Cell. 2001; 8:971-982.
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S. Herzig, F. Long, U. Jhala, S. Hedrick, R. Quinn, A. Bauer, D. Rudolph, G. Schutz, J.C. Yoon, P. Puigserver, B.M. Spiegelman, and M. Montminy. CREB Regulates Hepatic Gluconeogenesis via the Co-activator PGC-1. Nature. 2001; 413:179-183.
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L.F. Michael, Z. Wu, R.B. Cheatham, P. Puigserver, G. Adelmant, J.J. Lehman, D.P. Kelly, and B.M. Spiegelman. Restoration of Insulin-Sensitive Glucose Transporter (GLUT-4) Gene Expression in Muscle Cells by the Transcriptional Coactivator PGC-1. Proc. Natl. Acad. Sci. 2001; 98:3820-3825.
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Spiegelman BM, Puigserver P, Wu Z. Regulation of adipogenesis and energy balance by PPARgamma and PGC-1. Int J Obes Relat Metab Disord. 2000 Nov; 24 Suppl 4:S8-10.
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Monsalve M, Wu Z, Adelmant G, Puigserver P, Fan M, Spiegelman BM. Direct coupling of transcription and mRNA processing through the thermogenic coactivator PGC-1. Mol Cell. 2000 Aug; 6(2):307-16.
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Rosen ED, Walkey CJ, Puigserver P, Spiegelman BM. Transcriptional regulation of adipogenesis. Genes Dev. 2000 Jun 01; 14(11):1293-307.
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Tcherepanova I, Puigserver P, Norris JD, Spiegelman BM, McDonnell DP. Modulation of estrogen receptor-alpha transcriptional activity by the coactivator PGC-1. J Biol Chem. 2000 May 26; 275(21):16302-8.
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B. M. Spiegelman, P. Puigserver, Z. Wu. Regulation of adipogenesis and energy balance by PPARγ and PGC-1. Int. J. Obes. Relat. Metab. Disord. 2000; 24(4):S8-10.
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Wu Z, Puigserver P, Spiegelman BM. Transcriptional activation of adipogenesis. Curr Opin Cell Biol. 1999 Dec; 11(6):689-94.
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Puigserver P, Adelmant G, Wu Z, Fan M, Xu J, O'Malley B, Spiegelman BM. Activation of PPARgamma coactivator-1 through transcription factor docking. Science. 1999 Nov 12; 286(5443):1368-71.
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Wu Z, Puigserver P, Andersson U, Zhang C, Adelmant G, Mootha V, Troy A, Cinti S, Lowell B, Scarpulla RC, Spiegelman BM. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell. 1999 Jul 09; 98(1):115-24.
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Serra F, Bonet ML, Puigserver P, Oliver J, Palou A. Stimulation of uncoupling protein 1 expression in brown adipocytes by naturally occurring carotenoids. Int J Obes Relat Metab Disord. 1999 Jun; 23(6):650-5.
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B.M. Spiegelman, G. Castillo, S. Hauser and P. Puigserver. Regulation of energy balance by PPARγ and its coactivators. Progress in Obesity Research. Edited by B. Guy-Grand and G. Ailhaud. 1999; 39-46.
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F. Serra, M.L. Bonet, P. Puigserver, J. Oliver, A. Palou. Stimulation of uncoupling protein 1 expression in brown adipocyte by naturally occurring carotenoids. Int. J. Obes. Relat. Metab. Disord. 1999; 23:650-5.
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P. Puigserver, G. Adelmant, Z. Wu, M. Fan, J. Xu, B. O’Malley, B.M. Spiegelman. Activation of PPARγ Coactivator (PGC-1) Through Transcription Factor Docking. Science. 1999; 286(5443):1368-71.
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Picó C, Puigserver P, Oliver P, Palou A. 2-Methoxyestradiol, an endogenous metabolite of 17beta-estradiol, inhibits adipocyte proliferation. Mol Cell Biochem. 1998 Dec; 189(1-2):1-7.
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Puigserver P, Ribot J, Serra F, Gianotti M, Bonet ML, Nadal-Ginard B, Palou A. Involvement of the retinoblastoma protein in brown and white adipocyte cell differentiation: functional and physical association with the adipogenic transcription factor C/EBPalpha. Eur J Cell Biol. 1998 Oct; 77(2):117-23.
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Bruce M. Spiegelman, Pere Puigserver and Zhidan Wu. PGC-1alpha. Novel Brown Fat PPARgamma coactivator. 1998.
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Puigserver P, Wu Z, Park CW, Graves R, Wright M, Spiegelman BM. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell. 1998 Mar 20; 92(6):829-39.
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C. Pico, P. Puigserver, P. Oliver, A. Palou. 2-Methoxyoestradiol, an endogenous metabolite of 17-β-estradiol, inhibits adipocyte proliferation. Mol. Cell. Biochem. 1998; 189:1-7.
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Garcia-Palmer FJ, Pericas J, Matamala JC, Puigserver P, Bonet ML, Palou A, Gianotti M. Diminished response to food deprivation of the rat brown adipose tissue mitochondrial uncoupling system with age. Biochem Mol Biol Int. 1997 Sep; 42(6):1151-61.
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Bonet ML, Puigserver P, Serra F, Ribot J, Vázquez F, Pico C, Palou A. Retinoic acid modulates retinoid X receptor alpha and retinoic acid receptor alpha levels of cultured brown adipocytes. FEBS Lett. 1997 Apr 07; 406(1-2):196-200.
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M.L. Bonet, P. Puigserver, F. Serra, F. Vazquez, C. Pico, A. Palou. Retinoic acid modulates RARα and RXRα levels in cultured brown adipocytes. FEBS Lett. 1997; 406:196-200.
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F.J. Garcia-Palmer, J. Pericas, J.C. Matamala, P. Puigserver, M.L. Bonet, A Palou, M. Gianotti. Diminished response to food deprivation of the rat brown adipose tissue mitochondrial uncoupling system with age. Biochem. Mol. Biol. Int. 1997; 42:1151-1161.
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Puigserver P, Vázquez F, Bonet ML, Picó C, Palou A. In vitro and in vivo induction of brown adipocyte uncoupling protein (thermogenin) by retinoic acid. Biochem J. 1996 Aug 01; 317 ( Pt 3):827-33.
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Puigserver P, Picó C, Stock MJ, Palou A. Effect of selective beta-adrenoceptor stimulation on UCP synthesis in primary cultures of brown adipocytes. Mol Cell Endocrinol. 1996 Mar 01; 117(1):7-16.
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P. Puigserver, F. Vazquez, M.L. Bonet, C. Pico, A. Palou. In vitro an in vivo induction of the uncoupling protein thermogenin by retinoids. Biochem. J. 1996; 317:827-833.
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P. Puigserver, C. Pico, M.J. Stock, A. Palou. Effect of selective ß-adrenoceptor stimulation on UCP expression in primary cultures of brown adipocytes. Mol. Cell Endocrinol. 1996; 117:7-16.
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Moreno M, Puigserver P, Llull J, Gianotti M, Lanni A, Goglia F, Palou A. Cold exposure induces different uncoupling-protein thermogenin masking/unmasking processes in brown adipose tissue depending on mitochondrial subtypes. Biochem J. 1994 Jun 01; 300 ( Pt 2):463-8.
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Puigserver P, Palou A, Gianotti M. Dietary regulation of fasting-induced mitochondrial protein degradation in adult rat brown adipose tissue. Biochem Int. 1992 Sep; 27(6):1037-46.
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Puigserver P, Herron D, Gianotti M, Palou A, Cannon B, Nedergaard J. Induction and degradation of the uncoupling protein thermogenin in brown adipocytes in vitro and in vivo. Evidence for a rapidly degradable pool. Biochem J. 1992 Jun 01; 284 ( Pt 2):393-8.
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Puigserver P, Gianotti M, Palou A. Impaired starvation-induced loss of mitochondrial protein in the brown adipose tissue of dietary obese rats. Int J Obes Relat Metab Disord. 1992 Apr; 16(4):255-61.
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P. Puigserver, A. Palou, M. Gianotti. Impaired starvation-induced loss of mitochondrial protein in the brown adipose tissue of dietary obese rats. Int. J. Obes. 1992; 16:255-261.
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Pere Puigserver. Adrenergic stimulation and obesity status regulate induction and degradation of the thermogenic uncoupling protein in brown adipose in-vitro and in-vivo. 1992.
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Puigserver P, Lladó I, Palou A, Gianotti M. Evidence for masking of brown adipose tissue mitochondrial GDP-binding sites in response to fasting in rats made obese by dietary manipulation. Effects of reversion to standard diet. Biochem J. 1991 Oct 15; 279 ( Pt 2):575-9.
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J. Nedergaard, M. Néchad, S. Rehnmark, D. Herron, A. Jacobsson, P. Kuusela, P. Puigserver, J. Houstek, G. Bronnikov and B. Cannon. Adrenergic regulation of differentiation and proliferation in brown adipocyte cultures. Obesity in Europe. Edited by G. Ailhaud et al. 1991; 355-361.
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