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Rosalind A. Segal, MD, PhD


Pediatric Hematology/Oncology


Researcher

  • Edward J. Benz Jr., MD, Chair
  • Professor of Neurobiology, Harvard Medical School

Centers/Programs

Clinical Interests

  • Brain tumors
  • Pediatric brain tumors

Contact Information

  • Office Phone Number617-632-4737
  • Fax617-394-2936

Bio

Dr. Segal received her PhD in 1985 from Rockefeller University and her MD in 1986 from Cornell University Medical College, followed by a residency in the Harvard Neurology Program. As a postdoctoral fellow at Massachusetts Institute of Technology, she investigated the role of nerve growth factors in regulating cerebellar development and tumor formation. She joined DFCI in 1998, where she is principally involved in laboratory research on nervous system development.

Recent Awards:

  • National Merit Scholarship 1975
  • National Science Foundation Pre-doctoral Fellowship 1979
  • Phi Beta Kappa, Harvard College 1979
  • Summa Cum Laude, Harvard University 1979
  • Medical Science Training Program Pre-doctoral Fellowship 1980
  • Dana Foundation Postdoctoral Fellowship 1990
  • Robert Ebert Clinical Scholar Klingenstein Award 1996
  • Claudia Adams Barr Investigator, Barr Foundation 1998
  • Pediatric Brain Tumor Foundation Award 2001
  • McDonnell Foundation Award 2001
  • NIH Director's Pioneer Award 2006
  • Ted Williams Senior Investigator, Dana-Farber Cancer Institute 2009
  • American Association of Physicians 2011

Research

Growth Factors in Central Nervous System Development and Oncogenesis

Our lab is interested in mechanisms whereby extracellular stimuli regulate proliferation and survival in the developing nervous system.

Neurotrophin Signaling

In order for target-derived neurotrophins to regulate the survival of a developing presynaptic cell, a signal must be propagated from the nerve terminal along the axon to the nucleus. We found that activated Trk receptors function as rapid retrograde signal carriers to elicit neuclear responses to target derived neurotrophins. Our data indicate that the mechanism of signal propagation is retrograde vesicular transport of activated Trk-ligand complexes. Once they reach the cell body, activated receptors elicit nuclear responses-including phosphorylation of the transcription factor CREB and subsequent induction of the immediate early gene c-fos.

We are currently studying other intermediates required for retrograde signaling and the potential differences in the biological responses to retrograde or local stimulation with growth factors.

Neurotrophins & Cancer

While our studies have highlighted the role of BDNF in normal cerebellar development, we have also demonstrated that neurotrophins, in particular NT3, have a role in cerebellar diseases.

Unregulated growth of cerebellar granule neuronal precursors results in formation of a tumor, known as medulloblastoma. We have found the NT3 receptor TrkC is expressed in these tumors, and that the level of expression is a prognostic indicator for clinical progression. Furthermore, our data show that NT3 induces an apoptotic response in meullobastoma tumor cells, indicating that neurotrophins have potential application in tumor therapy.

Cerebellar Development

While target derived neurotrophins are required for the survival of developing neurons in the peripheral nervous system, the functions of neurotrophins in the central nervous system have been unclear. Mice with a targeted gene deletion of brain-derived neurotrophic factor (BDNF) exhibit a wide based gait, and a defect in cerebellar foliation pattern. At the cellular level cerebellar granule cell survival and migration are both impaired in mutant animals. However, there is an increase in granule cell proliferation in mutants. These data suggest that BDNF acts as an autocrine/paracrine factor to regulate survival, migration, and differentiation of developming CNS neurons, and thereby affects neural patterning.

Pease-Raissi SE, Pazyra-Murphy MF, Li Y, Wachter F, Fukuda Y, Fenstermacher SJ, Barclay LA, Bird GH, Walensky LD, Segal RA. Paclitaxel Reduces Axonal Bclw to Initiate IP3R1-Dependent Axon Degeneration. Neuron. 2017 Oct 11; 96(2):373-386.e6.
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Zhao X, Pak E, Ornell KJ, Pazyra-Murphy MF, MacKenzie EL, Chadwick EJ, Ponomaryov T, Kelleher JF, Segal RA. A Transposon Screen Identifies Loss of Primary Cilia as a Mechanism of Resistance to SMO Inhibitors. Cancer Discov. 2017 12; 7(12):1436-1449.
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Fukuda Y, Li Y, Segal RA. A Mechanistic Understanding of Axon Degeneration in Chemotherapy-Induced Peripheral Neuropathy. Front Neurosci. 2017; 11:481.
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Sun Y, Alberta JA, Pilarz C, Calligaris D, Chadwick EJ, Ramkissoon SH, Ramkissoon LA, Garcia VM, Mazzola E, Goumnerova L, Kane M, Yao Z, Kieran MW, Ligon KL, Hahn WC, Garraway LA, Rosen N, Gray NS, Agar NY, Buhrlage SJ, Segal RA, Stiles CD. A brain-penetrant RAF dimer antagonist for the noncanonical BRAF oncoprotein of pediatric low-grade astrocytomas. Neuro Oncol. 2017 06 01; 19(6):774-785.
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Pak E, Segal RA. Hedgehog Signal Transduction: Key Players, Oncogenic Drivers, and Cancer Therapy. Dev Cell. 2016 08 22; 38(4):333-44.
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Ni J, Xie S, Ramkissoon SH, Luu V, Sun Y, Bandopadhayay P, Beroukhim R, Roberts TM, Stiles CD, Segal RA, Ligon KL, Hahn WC, Zhao JJ. Tyrosine receptor kinase B is a drug target in astrocytomas. Neuro Oncol. 2017 01; 19(1):22-30.
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Arnaout A, Kuchuk I, Bouganim N, Pond G, Verma S, Segal R, Dent S, Gertler S, Song X, Kanji F, Clemons M. Can the referring surgeon enhance accrual of breast cancer patients to medical and radiation oncology trials? The ENHANCE study. Curr Oncol. 2016 Jun; 23(3):e276-9.
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Tasdemir-Yilmaz OE, Segal RA. There and back again: coordinated transcription, translation and transport in axonal survival and regeneration. Curr Opin Neurobiol. 2016 Aug; 39:62-8.
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Cosker KE, Fenstermacher SJ, Pazyra-Murphy MF, Elliott HL, Segal RA. The RNA-binding protein SFPQ orchestrates an RNA regulon to promote axon viability. Nat Neurosci. 2016 05; 19(5):690-696.
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Segal RA. Lessons from a bridge generation. Science. 2016 Mar 25; 351(6280):1494.
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Chadwick EJ, Yang DP, Filbin MG, Mazzola E, Sun Y, Behar O, Pazyra-Murphy MF, Goumnerova L, Ligon KL, Stiles CD, Segal RA. A Brain Tumor/Organotypic Slice Co-culture System for Studying Tumor Microenvironment and Targeted Drug Therapies. J Vis Exp. 2015 Nov 07; (105):e53304.
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Balastik M, Zhou XZ, Alberich-Jorda M, Weissova R, Žiak J, Pazyra-Murphy MF, Cosker KE, Machonova O, Kozmikova I, Chen CH, Pastorino L, Asara JM, Cole A, Sutherland C, Segal RA, Lu KP. Prolyl Isomerase Pin1 Regulates Axon Guidance by Stabilizing CRMP2A Selectively in Distal Axons. Cell Rep. 2015 Oct 27; 13(4):812-828.
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Zhao X, Segal RA. A Polyamine Twist on Hedgehog Signaling. Dev Cell. 2015 Oct 12; 35(1):1-2.
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Zhou P, Erfani S, Liu Z, Jia C, Chen Y, Xu B, Deng X, Alfáro JE, Chen L, Napier D, Lu M, Huang JA, Liu C, Thibault O, Segal R, Zhou BP, Kyprianou N, Horbinski C, Yang XH. CD151-a3ß1 integrin complexes are prognostic markers of glioblastoma and cooperate with EGFR to drive tumor cell motility and invasion. Oncotarget. 2015 Oct 06; 6(30):29675-93.
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Filbin MG, Segal RA. How neuronal activity regulates glioma cell proliferation. Neuro Oncol. 2015 Dec; 17(12):1543-4.
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Zhao X, Ponomaryov T, Ornell KJ, Zhou P, Dabral SK, Pak E, Li W, Atwood SX, Whitson RJ, Chang AL, Li J, Oro AE, Chan JA, Kelleher JF, Segal RA. RAS/MAPK Activation Drives Resistance to Smo Inhibition, Metastasis, and Tumor Evolution in Shh Pathway-Dependent Tumors. Cancer Res. 2015 Sep 01; 75(17):3623-35.
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Bergthold G, Bandopadhayay P, Hoshida Y, Ramkissoon S, Ramkissoon L, Rich B, Maire CL, Paolella BR, Schumacher SE, Tabak B, Ferrer-Luna R, Ozek M, Sav A, Santagata S, Wen PY, Goumnerova LC, Ligon AH, Stiles C, Segal R, Golub T, Grill J, Ligon KL, Chan JA, Kieran MW, Beroukhim R. Expression profiles of 151 pediatric low-grade gliomas reveal molecular differences associated with location and histological subtype. Neuro Oncol. 2015 Nov; 17(11):1486-96.
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Eisner A, Pazyra-Murphy MF, Durresi E, Zhou P, Zhao X, Chadwick EC, Xu PX, Hillman RT, Scott MP, Greenberg ME, Segal RA. The Eya1 phosphatase promotes Shh signaling during hindbrain development and oncogenesis. Dev Cell. 2015 Apr 06; 33(1):22-35.
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Pease SE, Segal RA. Preserve and protect: maintaining axons within functional circuits. Trends Neurosci. 2014 Oct; 37(10):572-82.
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Persson L, Witt RM, Galligan M, Greer PL, Eisner A, Pazyra-Murphy MF, Datta SR, Segal RA. Shh-proteoglycan interactions regulate maturation of olfactory glomerular circuitry. Dev Neurobiol. 2014 Dec; 74(12):1255-67.
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Bergthold G, Bandopadhayay P, Bi WL, Ramkissoon L, Stiles C, Segal RA, Beroukhim R, Ligon KL, Grill J, Kieran MW. Pediatric low-grade gliomas: how modern biology reshapes the clinical field. Biochim Biophys Acta. 2014 Apr; 1845(2):294-307.
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Cosker KE, Segal RA. Neuronal signaling through endocytosis. Cold Spring Harb Perspect Biol. 2014 Feb 01; 6(2).
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Pak E, Segal RA, Stiles CD. New progenitors NESTIN(g) in the EGL. Nat Neurosci. 2013 Dec; 16(12):1710-2.
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Kuchuk I, Bouganim N, Beusterien K, Grinspan J, Vandermeer L, Gertler S, Dent SF, Song X, Segal R, Mazzarello S, Crawley F, Dranitsaris G, Clemons M. Preference weights for chemotherapy side effects from the perspective of women with breast cancer. Breast Cancer Res Treat. 2013 Nov; 142(1):101-7.
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Filbin MG, Dabral SK, Pazyra-Murphy MF, Ramkissoon S, Kung AL, Pak E, Chung J, Theisen MA, Sun Y, Franchetti Y, Sun Y, Shulman DS, Redjal N, Tabak B, Beroukhim R, Wang Q, Zhao J, Dorsch M, Buonamici S, Ligon KL, Kelleher JF, Segal RA. Coordinate activation of Shh and PI3K signaling in PTEN-deficient glioblastoma: new therapeutic opportunities. Nat Med. 2013 Nov; 19(11):1518-23.
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Witt RM, Hecht ML, Pazyra-Murphy MF, Cohen SM, Noti C, van Kuppevelt TH, Fuller M, Chan JA, Hopwood JJ, Seeberger PH, Segal RA. Heparan sulfate proteoglycans containing a glypican 5 core and 2-O-sulfo-iduronic acid function as Sonic Hedgehog co-receptors to promote proliferation. J Biol Chem. 2013 Sep 06; 288(36):26275-88.
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Cosker KE, Pazyra-Murphy MF, Fenstermacher SJ, Segal RA. Target-derived neurotrophins coordinate transcription and transport of bclw to prevent axonal degeneration. J Neurosci. 2013 Mar 20; 33(12):5195-207.
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Segal R, Burnett AL. Avanafil for the treatment of erectile dysfunction. Drugs Today (Barc). 2012 Jan; 48(1):7-15.
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Fainzilber M, Budnik V, Segal RA, Kreutz MR. From synapse to nucleus and back again--communication over distance within neurons. J Neurosci. 2011 Nov 09; 31(45):16045-8.
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Segal R, Pond GR, Vallis M, Dion M, Pritchard KI, Ligibel JA, Levine MN, Goodwin PJ. Randomized trial of a lifestyle intervention for women with early-stage breast cancer (BC) receiving adjuvant hormone therapy: Initial results. J Clin Oncol. 2011 May 20; 29(15_suppl):512.
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Zhou P, Alfaro J, Chang EH, Zhao X, Porcionatto M, Segal RA. Numb links extracellular cues to intracellular polarity machinery to promote chemotaxis. Dev Cell. 2011 May 17; 20(5):610-22.
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Courchesne SL, Pazyra-Murphy MF, Lee DJ, Segal RA. Neuromuscular junction defects in mice with mutation of dynein heavy chain 1. PLoS One. 2011 Feb 04; 6(2):e16753.
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Courchesne SL, Karch C, Pazyra-Murphy MF, Segal RA. Sensory neuropathy attributable to loss of Bcl-w. J Neurosci. 2011 Feb 02; 31(5):1624-34.
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Cosker KE, Segal RA. The longer U(T)R, the further you go. Nat Neurosci. 2010 Mar; 13(3):273-5.
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Gruber-Olipitz M, Segal RA. Live or let die: CCM2 provides the link. Neuron. 2009 Sep 10; 63(5):559-60.
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Pazyra-Murphy MF, Hans A, Courchesne SL, Karch C, Cosker KE, Heerssen HM, Watson FL, Kim T, Greenberg ME, Segal RA. A retrograde neuronal survival response: target-derived neurotrophins regulate MEF2D and bcl-w. J Neurosci. 2009 May 20; 29(20):6700-9.
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Arimura N, Kimura T, Nakamuta S, Taya S, Funahashi Y, Hattori A, Shimada A, Ménager C, Kawabata S, Fujii K, Iwamatsu A, Segal RA, Fukuda M, Kaibuchi K. Anterograde transport of TrkB in axons is mediated by direct interaction with Slp1 and Rab27. Dev Cell. 2009 May; 16(5):675-86.
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Chan JA, Balasubramanian S, Witt RM, Nazemi KJ, Choi Y, Pazyra-Murphy MF, Walsh CO, Thompson M, Segal RA. Proteoglycan interactions with Sonic Hedgehog specify mitogenic responses. Nat Neurosci. 2009 Apr; 12(4):409-17.
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Witt RM, Galligan MM, Despinoy JR, Segal R. Olfactory behavioral testing in the adult mouse. J Vis Exp. 2009 Jan 28; (23).
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Chan JA, S Balasubramanian, RM Witt, KJ Nazemi, YJ Choi, CA Olson, M Thompson, RA Segal. Proteoglycan interactions with Sonic Hedgehog are selectively required for mitogenic responses. Nature Neuroscience. 2009; revised ms submitted.
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Pazyra-Murphy MF, Segal RA. Preparation and maintenance of dorsal root ganglia neurons in compartmented cultures. J Vis Exp. 2008 Oct 17; (20).
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Ha J, Lo KW, Myers KR, Carr TM, Humsi MK, Rasoul BA, Segal RA, Pfister KK. A neuron-specific cytoplasmic dynein isoform preferentially transports TrkB signaling endosomes. J Cell Biol. 2008 Jun 16; 181(6):1027-39.
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Cosker KE, Courchesne SL, Segal RA. Action in the axon: generation and transport of signaling endosomes. Curr Opin Neurobiol. 2008 Jun; 18(3):270-5.
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Zhou P, Porcionatto M, Pilapil M, Chen Y, Choi Y, Tolias KF, Bikoff JB, Hong EJ, Greenberg ME, Segal RA. Polarized signaling endosomes coordinate BDNF-induced chemotaxis of cerebellar precursors. Neuron. 2007 Jul 05; 55(1):53-68.
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Redjal N, Chan JA, Segal RA, Kung AL. CXCR4 inhibition synergizes with cytotoxic chemotherapy in gliomas. Clin Cancer Res. 2006 Nov 15; 12(22):6765-71.
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McKenzie MR, Chi KN, Neville A, Ellard S, Baerg B, Ruether D, Winquist E, Segal R, Lukka H. Phase II study of neoadjuvant docetaxel and androgen suppression (AS) plus radiation therapy (RT) for high-risk localized prostate cancer (HRLCaP). J Clin Oncol. 2006 Jun 20; 24(18_suppl):4631.
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Segal R, Dent SF, Verma S, Canil CM, Azzi J, Vandermeer L, Spaans J. Changing demographics of locally advanced breast cancer: Data from a regional cancer centre. J Clin Oncol. 2006 Jun 20; 24(18_suppl):10780.
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Choi Y, Borghesani PR, Chan JA, Segal RA. Migration from a mitogenic niche promotes cell-cycle exit. J Neurosci. 2005 Nov 09; 25(45):10437-45.
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Kenney AM, Segal RA. Subtracting the Math: prominin-positive cerebellar stem cells in white matter. Nat Neurosci. 2005 Jun; 8(6):699-701.
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Heerssen HM, Pazyra MF, Segal RA. Dynein motors transport activated Trks to promote survival of target-dependent neurons. Nat Neurosci. 2004 Jun; 7(6):596-604.
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Kim JY, Nelson AL, Algon SA, Graves O, Sturla LM, Goumnerova LC, Rowitch DH, Segal RA, Pomeroy SL. Medulloblastoma tumorigenesis diverges from cerebellar granule cell differentiation in patched heterozygous mice. Dev Biol. 2003 Nov 01; 263(1):50-66.
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Rubin JB, Kung AL, Klein RS, Chan JA, Sun Y, Schmidt K, Kieran MW, Luster AD, Segal RA. A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors. Proc Natl Acad Sci U S A. 2003 Nov 11; 100(23):13513-8.
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Segal RA. Selectivity in neurotrophin signaling: theme and variations. Annu Rev Neurosci. 2003; 26:299-330.
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Sthoeger ZM, Dayan M, Tcherniack A, Green L, Toledo S, Segal R, Elkayam O, Mozes E. Modulation of autoreactive responses of peripheral blood lymphocytes of patients with systemic lupus erythematosus by peptides based on human and murine anti-DNA autoantibodies. Clin Exp Immunol. 2003 Feb; 131(2):385-92.
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Carter AR, Berry EM, Segal RA. Regional expression of p75NTR contributes to neurotrophin regulation of cerebellar patterning. Mol Cell Neurosci. 2003 Jan; 22(1):1-13.
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Rubin JB, Segal RA. Growth, survival and migration: the Trk to cancer. Cancer Treat Res. 2003; 115:1-18.
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Wang KC, Kim JA, Sivasankaran R, Segal R, He Z. P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp. Nature. 2002 Nov 07; 420(6911):74-8.
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Kim JY, Koralnik IJ, LeFave M, Segal RA, Pfister LA, Pomeroy SL. Medulloblastomas and primitive neuroectodermal tumors rarely contain polyomavirus DNA sequences. Neuro Oncol. 2002 07; 4(3):165-70.
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Bhattacharyya A, Watson FL, Pomeroy SL, Zhang YZ, Stiles CD, Segal RA. High-resolution imaging demonstrates dynein-based vesicular transport of activated Trk receptors. J Neurobiol. 2002 Jun 15; 51(4):302-12.
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Ginty DD, Segal RA. Retrograde neurotrophin signaling: Trk-ing along the axon. Curr Opin Neurobiol. 2002 Jun; 12(3):268-74.
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Rubin JB, Choi Y, Segal RA. Cerebellar proteoglycans regulate sonic hedgehog responses during development. Development. 2002 May; 129(9):2223-32.
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Heerssen HM, Segal RA. Location, location, location: a spatial view of neurotrophin signal transduction. Trends Neurosci. 2002 Mar; 25(3):160-5.
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Borghesani PR, Peyrin JM, Klein R, Rubin J, Carter AR, Schwartz PM, Luster A, Corfas G, Segal RA. BDNF stimulates migration of cerebellar granule cells. Development. 2002 Mar; 129(6):1435-42.
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Carter AR, Chen C, Schwartz PM, Segal RA. Brain-derived neurotrophic factor modulates cerebellar plasticity and synaptic ultrastructure. J Neurosci. 2002 Feb 15; 22(4):1316-27.
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Watson FL, Heerssen HM, Bhattacharyya A, Klesse L, Lin MZ, Segal RA. Neurotrophins use the Erk5 pathway to mediate a retrograde survival response. Nat Neurosci. 2001 Oct; 4(10):981-8.
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Segal R, Poznansky MC, Connors L, Sands K, Barlam T. Changing patterns of presentations of patients with HIV-related disease at a tertiary referral centre and its implications for physician training. Int J STD AIDS. 2001 Jul; 12(7):453-9.
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Klein RS, Rubin JB, Gibson HD, DeHaan EN, Alvarez-Hernandez X, Segal RA, Luster AD. SDF-1 alpha induces chemotaxis and enhances Sonic hedgehog-induced proliferation of cerebellar granule cells. Development. 2001 Jun; 128(11):1971-81.
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Segal R. Neurotrophins: which way did they go? Sci STKE. 2001 May 29; 2001(84):pe1.
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Alberta JA, Segal RA. Generation and utilization of phosphorylation state-specific antibodies to investigate signaling pathways. Curr Protoc Neurosci. 2001 May; Chapter 3:Unit 3.14.
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Carter AR, Segal RA. Rett syndrome model suggests MECP2 gives neurons the quiet they need to think. Nat Neurosci. 2001 Apr; 4(4):342-3.
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Choi DY, Toledo-Aral JJ, Segal R, Halegoua S. Sustained signaling by phospholipase C-gamma mediates nerve growth factor-triggered gene expression. Mol Cell Biol. 2001 Apr; 21(8):2695-705.
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Segal R, Lukka H, Klotz LH, Eady A, Bestic N, Johnston M. Surveillance programs for early stage non-seminomatous testicular cancer: a practice guideline. Can J Urol. 2001 Feb; 8(1):1184-92.
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Segal R, Evans W, Johnson D, Smith J, Colletta S, Gayton J, Woodard S, Wells G, Reid R. Structured exercise improves physical functioning in women with stages I and II breast cancer: results of a randomized controlled trial. J Clin Oncol. 2001 Feb 01; 19(3):657-65.
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Segal R, Dayan M, Zinger H, Mozes E. Suppression of experimental systemic lupus erythematosus (SLE) in mice via TNF inhibition by an anti-TNFalpha monoclonal antibody and by pentoxiphylline. Lupus. 2001; 10(1):23-31.
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Choi DY, Toledo-Aral JJ, Segal RA, Halegoua S. Sustained signaling by PLCgamma mediates NGF-triggered gene expression. Mol Cell Bio. 2001; 21:2695-2705.
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O'Brien SP, Seipel K, Medley QG, Bronson R, Segal R, Streuli M. Skeletal muscle deformity and neuronal disorder in Trio exchange factor-deficient mouse embryos. Proc Natl Acad Sci U S A. 2000 Oct 24; 97(22):12074-8.
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Zhang Y, Moheban DB, Conway BR, Bhattacharyya A, Segal RA. Cell surface Trk receptors mediate NGF-induced survival while internalized receptors regulate NGF-induced differentiation. J Neurosci. 2000 Aug 01; 20(15):5671-8.
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Dayan M, Segal R, Sthoeger Z, Waisman A, Brosh N, Elkayam O, Eilat E, Fridkin M, Mozes E. Immune response of SLE patients to peptides based on the complementarity determining regions of a pathogenic anti-DNA monoclonal antibody. J Clin Immunol. 2000 May; 20(3):187-94.
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Borghesani PR, Alt FW, Bottaro A, Davidson L, Aksoy S, Rathbun GA, Roberts TM, Swat W, Segal RA, Gu Y. Abnormal development of Purkinje cells and lymphocytes in Atm mutant mice. Proc Natl Acad Sci U S A. 2000 Mar 28; 97(7):3336-41.
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Dayan M, Segal R, Globerson A, Habut B, Shearer GM, Mozes E. Effect of aging on cytokine production in normal and experimental systemic lupus erythematosus-afflicted mice. Exp Gerontol. 2000 Mar; 35(2):225-36.
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Huan SD, Stewart DJ, Aitken SE, Segal R, Yau JC. Combination of epirubicin and cisplatin in hormone-refractory metastatic prostate cancer. Am J Clin Oncol. 1999 Oct; 22(5):471-4.
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Watson FL, Heerssen HM, Moheban DB, Lin MZ, Sauvageot CM, Bhattacharyya A, Pomeroy SL, Segal RA. Rapid nuclear responses to target-derived neurotrophins require retrograde transport of ligand-receptor complex. J Neurosci. 1999 Sep 15; 19(18):7889-900.
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Watson FL, Porcionatto MA, Bhattacharyya A, Stiles CD, Segal RA. TrkA glycosylation regulates receptor localization and activity. J Neurobiol. 1999 May; 39(2):323-36.
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Crook JM, Szumacher E, Malone S, Huan S, Segal R. Intermittent androgen suppression in the management of prostate cancer. Urology. 1999 Mar; 53(3):530-4.
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Kim JY, Sutton ME, Lu DJ, Cho TA, Goumnerova LC, Goritchenko L, Kaufman JR, Lam KK, Billet AL, Tarbell NJ, Wu J, Allen JC, Stiles CD, Segal RA, Pomeroy SL. Activation of neurotrophin-3 receptor TrkC induces apoptosis in medulloblastomas. Cancer Res. 1999 Feb 01; 59(3):711-9.
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Ma Q, Jones D, Borghesani PR, Segal RA, Nagasawa T, Kishimoto T, Bronson RT, Springer TA. Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice. Proc Natl Acad Sci U S A. 1998 Aug 04; 95(16):9448-53.
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Schwartz PM, Levy RL, Borghesani PR, Segal RA. Cerebellar pathology in BDNF -/- mice: the classic view of neurotrophins is changing. Mol Psychiatry. 1998 Mar; 3(2):116-20.
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Pomeroy SL, Sutton ME, Goumnerova LC, Segal RA. Neurotrophins in cerebellar granule cell development and medulloblastoma. J Neurooncol. 1997 Dec; 35(3):347-52.
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Bhattacharyya A, Watson FL, Bradlee TA, Pomeroy SL, Stiles CD, Segal RA. Trk receptors function as rapid retrograde signal carriers in the adult nervous system. J Neurosci. 1997 Sep 15; 17(18):7007-16.
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Schwartz PM, Borghesani PR, Levy RL, Pomeroy SL, Segal RA. Abnormal cerebellar development and foliation in BDNF-/- mice reveals a role for neurotrophins in CNS patterning. Neuron. 1997 Aug; 19(2):269-81.
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Cabelli RJ, Shelton DL, Segal RA, Shatz CJ. Blockade of endogenous ligands of trkB inhibits formation of ocular dominance columns. Neuron. 1997 Jul; 19(1):63-76.
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Segal R, Dayan M, Globerson A, Habut B, Shearer GM, Mozes E. Effect of aging on cytokine production in normal and experimental systemic lupus erythematosus afflicted mice. Mech Ageing Dev. 1997 Jun; 96(1-3):47-58.
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Dayan M, Segal R, Mozes E. Cytokine manipulation by methotrexate treatment in murine experimental systemic lupus erythematosus. J Rheumatol. 1997 Jun; 24(6):1075-82.
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Segal R, Bermas BL, Dayan M, Kalush F, Shearer GM, Mozes E. Kinetics of cytokine production in experimental systemic lupus erythematosus: involvement of T helper cell 1/T helper cell 2-type cytokines in disease. J Immunol. 1997 Mar 15; 158(6):3009-16.
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Dudek H, Datta SR, Franke TF, Birnbaum MJ, Yao R, Cooper GM, Segal RA, Kaplan DR, Greenberg ME. Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science. 1997 Jan 31; 275(5300):661-5.
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Segal RA, Rua L, Schwartz P. Neurotrophins and programmed cell death during cerebellar development. Adv Neurol. 1997; 72:79-86.
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Pomeroy SL, Segal RA. Development of the Nervous System. Neonatal and Fetal Medicine, Poland RA and Fox WW, eds. 1997.
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Nachmanoff DB, Segal RA, Dawson DM, Brown RB, De Girolami U. Hereditary ataxia with sensory neuronopathy: Biemond's ataxia. Neurology. 1997 Jan; 48(1):273-5.
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Segal RA, Bhattacharyya A, Rua LA, Alberta JA, Stephens RM, Kaplan DR, Stiles CD. Differential utilization of Trk autophosphorylation sites. J Biol Chem. 1996 Aug 16; 271(33):20175-81.
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Mozes E, Segal R, Sthoeger Z, Dayan M, Zinger H, Kohn LD, Singer DS. Modulation of experimental systemic lupus erythematosus. Isr J Med Sci. 1996 Jan; 32(1):19-21.
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Segal RA, Greenberg ME. Intracellular signaling pathways activated by neurotrophic factors. Annu Rev Neurosci. 1996; 19:463-89.
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Segal R, Dayan M, Zinger H, Mozes E. Methotrexate treatment in murine experimental systemic lupus erythematosus (SLE); clinical benefits associated with cytokine manipulation. Clin Exp Immunol. 1995 Jul; 101(1):66-72.
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Segal RA, Pomeroy SL, Stiles CD. Axonal growth and fasciculation linked to differential expression of BDNF and NT3 receptors in developing cerebellar granule cells. J Neurosci. 1995 Jul; 15(7 Pt 1):4970-81.
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Segal RA, Goumnerova LC, Kwon YK, Stiles CD, Pomeroy SL. Expression of the neurotrophin receptor TrkC is linked to a favorable outcome in medulloblastoma. Proc Natl Acad Sci U S A. 1994 Dec 20; 91(26):12867-71.
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Segal R, Globerson A, Zinger H, Mozes E. Inhibition of autoantibody production in experimental SLE by pre-immunization with DNA. Autoimmunity. 1994; 17(2):149-56.
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Segal RA, Takahashi H, McKay RD. Changes in neurotrophin responsiveness during the development of cerebellar granule neurons. Neuron. 1992 Dec; 9(6):1041-52.
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Segal R, Globerson A, Zinger H, Mozes E. The influence of aging on the induction and manifestations of experimental systemic lupus erythematosus. J Clin Immunol. 1992 Sep; 12(5):341-6.
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Segal R, Globerson A, Zinger H, Mozes E. Induction of experimental systemic lupus erythematosus (SLE) in mice with severe combined immunodeficiency (SCID). Clin Exp Immunol. 1992 Aug; 89(2):239-43.
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Segal RA, Chapman C, Barlow J. Monozygotic twins with seizures. Shared characteristics. Arch Neurol. 1991 Oct; 48(10):1041-5.
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Elkayam O, Zinger H, Zisman E, Segal R, Yaron M, Brautbar C, Mozes E. Regulatory T cell activity specific to human type II and III collagens in rheumatoid arthritis. J Rheumatol. 1991 Apr; 18(4):516-21.
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Frank G, Huecker E, Segal R, Forwell S, Bagatell N. Assessment and treatment of a pediatric patient in chronic care: ethnographic methods applied to occupational therapy practice. Am J Occup Ther. 1991 Mar; 45(3):252-63.
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Mendlovic S, Segal R, Shoenfeld Y, Mozes E. Anti-DNA idiotype- and anti-idiotype-specific T cell responses in patients with systemic lupus erythematosus and their first-degree relatives. Clin Exp Immunol. 1990 Dec; 82(3):504-8.
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Mendlovic S, Shoenfeld Y, Bakimer R, Segal R, Dayan M, Mozes E. In vitro T-cell functions specific to an anti-DNA idiotype and serological markers in patients with systemic lupus erythematosus (SLE). J Clin Immunol. 1988 May; 8(3):178-87.
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Marion DW, Segal R, Thompson ME. Subarachnoid hemorrhage and the heart. Neurosurgery. 1986 Jan; 18(1):101-6.
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Segal RA, Luck DJ. Phosphorylation in isolated Chlamydomonas axonemes: a phosphoprotein may mediate the Ca2+-dependent photophobic response. J Cell Biol. 1985 Nov; 101(5 Pt 1):1702-12.
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Segal RA, Huang B, Ramanis Z, Luck DJ. Mutant strains of Chlamydomonas reinhardtii that move backwards only. J Cell Biol. 1984 Jun; 98(6):2026-34.
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Hsieh P, Segal R, Chen LB. Studies of fibronectin matrices in living cells with fluoresceinated gelatin. J Cell Biol. 1980 Oct; 87(1):14-22.
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Chen LB, Murray A, Segal RA, Bushnell A, Walsh ML. Studies on intercellular LETS glycoprotein matrices. Cell. 1978 Jun; 14(2):377-91.
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Krueger JG, Segal RA, Moyer RC. Differences in the responsiveness of splenic, lymph node, and peripheral blood lymphoid cells to tumor membrane extracts. Cancer Res. 1977 Jan; 37(1):320-2.
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