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Suzanne Gaudet, PhD



Researcher

  • Assistant Professor of Genetics

Contact Information

  • Office Phone Number617-632-4269

Bio

Suzanne Gaudet obtained her PhD in Biochemistry from Harvard University where she cloned and characterized PDZ-binding kinase, PBK, a mitotic kinase in human cells. She then joined Peter Sorger's laboratory at MIT as a postdoctoral associate for the launch of a project to study how TNF, EGF and insulin affect the cell death decision, using a systems approach. From 2003 to 2008, she worked as a research scientist and scientific coordinator at the Cell Decision Processes Center at MIT and Harvard. She is now assistant professor at the Department Genetics at Harvard Medical School and the Department of Cancer Biology at the Dana-Farber Cancer Insitute. Her research focuses on the quantitative understanding of how TNF-superfamily ligands control cell fate.

Research

TNF

We study TNF-induced fate decisions in mammalian cells. TNF is particularly interesting because it induces both pro-survival and prodeath signals. Combining mathematical modeling and single-cell measurements, we exploit variability in response in a cell population to explore how these signals are integrated in time and space to control cell fate.

Wong VC, Bass VL, Bullock ME, Chavali AK, Lee REC, Mothes W, Gaudet S, Miller-Jensen K. NF-?B-Chromatin Interactions Drive Diverse Phenotypes by Modulating Transcriptional Noise. Cell Rep. 2018 Jan 16; 22(3):585-599.
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Mathew S, Thurber AE, Gaudet S. Finding the Optimal Tradeoffs. Cell Syst. 2017 Feb 22; 4(2):149-151.
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Lee RE, Qasaimeh MA, Xia X, Juncker D, Gaudet S. NF-?B signalling and cell fate decisions in response to a short pulse of tumour necrosis factor. Sci Rep. 2016 12 22; 6:39519.
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Gaudet S, Miller-Jensen K. Redefining Signaling Pathways with an Expanding Single-Cell Toolbox. Trends Biotechnol. 2016 06; 34(6):458-469.
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Tan L, Wang J, Tanizaki J, Huang Z, Aref AR, Rusan M, Zhu SJ, Zhang Y, Ercan D, Liao RG, Capelletti M, Zhou W, Hur W, Kim N, Sim T, Gaudet S, Barbie DA, Yeh JR, Yun CH, Hammerman PS, Mohammadi M, Jänne PA, Gray NS. Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors. Proc Natl Acad Sci U S A. 2014 Nov 11; 111(45):E4869-77.
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Hill SJ, Rolland T, Adelmant G, Xia X, Owen MS, Dricot A, Zack TI, Sahni N, Jacob Y, Hao T, McKinney KM, Clark AP, Reyon D, Tsai SQ, Joung JK, Beroukhim R, Marto JA, Vidal M, Gaudet S, Hill DE, Livingston DM. Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage. Genes Dev. 2014 Sep 01; 28(17):1957-75.
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Xia X, Owen MS, Lee RE, Gaudet S. Cell-to-cell variability in cell death: can systems biology help us make sense of it all? Cell Death Dis. 2014 May 29; 5:e1261.
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Lee RE, Walker SR, Savery K, Frank DA, Gaudet S. Fold change of nuclear NF-?B determines TNF-induced transcription in single cells. Mol Cell. 2014 Mar 20; 53(6):867-79.
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Zhu Z, Aref AR, Cohoon TJ, Barbie TU, Imamura Y, Yang S, Moody SE, Shen RR, Schinzel AC, Thai TC, Reibel JB, Tamayo P, Godfrey JT, Qian ZR, Page AN, Maciag K, Chan EM, Silkworth W, Labowsky MT, Rozhansky L, Mesirov JP, Gillanders WE, Ogino S, Hacohen N, Gaudet S, Eck MJ, Engelman JA, Corcoran RB, Wong KK, Hahn WC, Barbie DA. Inhibition of KRAS-driven tumorigenicity by interruption of an autocrine cytokine circuit. Cancer Discov. 2014 Apr; 4(4):452-65.
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Gaudet S, Spencer SL, Chen WW, Sorger PK. Exploring the contextual sensitivity of factors that determine cell-to-cell variability in receptor-mediated apoptosis. PLoS Comput Biol. 2012; 8(4):e1002482.
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Gaudet S, Langlois MJ, Lue RA, Rivard N, Viel A. The MEK2-binding tumor suppressor hDlg is recruited by E-cadherin to the midbody ring. BMC Cell Biol. 2011 Dec 20; 12:55.
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Aldridge BB, Gaudet S, Lauffenburger DA, Sorger PK. Lyapunov exponents and phase diagrams reveal multi-factorial control over TRAIL-induced apoptosis. Mol Syst Biol. 2011 Nov 22; 7:553.
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Gaudet S. Connecting cell fate decision networks in hematopoeisis from the outside in. Mol Syst Biol. 2010 Oct 05; 6:418.
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Kim KA, Spencer SL, Albeck JG, Burke JM, Sorger PK, Gaudet S, Kim DH. Systematic calibration of a cell signaling network model. BMC Bioinformatics. 2010 Apr 23; 11:202.
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Spencer SL, Gaudet S, Albeck JG, Burke JM, Sorger PK. Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis. Nature. 2009 May 21; 459(7245):428-32.
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Albeck JG, MacBeath G, White FM, Sorger PK, Lauffenburger DA, Gaudet S. Collecting and organizing systematic sets of protein data. Nat Rev Mol Cell Biol. 2006 Nov; 7(11):803-12.
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Janes KA, Gaudet S, Albeck JG, Nielsen UB, Lauffenburger DA, Sorger PK. The response of human epithelial cells to TNF involves an inducible autocrine cascade. Cell. 2006 Mar 24; 124(6):1225-39.
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Janes KA, Albeck JG, Gaudet S, Sorger PK, Lauffenburger DA, Yaffe MB. A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis. Science. 2005 Dec 09; 310(5754):1646-53.
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Gaudet S, Janes KA, Albeck JG, Pace EA, Lauffenburger DA, Sorger PK. A compendium of signals and responses triggered by prodeath and prosurvival cytokines. Mol Cell Proteomics. 2005 Oct; 4(10):1569-90.
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El-Ali J, Gaudet S, Günther A, Sorger PK, Jensen KF. Cell stimulus and lysis in a microfluidic device with segmented gas-liquid flow. Anal Chem. 2005 Jun 01; 77(11):3629-36.
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Lu H, Gaudet S, Schmidt MA, Jensen KF. A microfabricated device for subcellular organelle sorting. Anal Chem. 2004 Oct 01; 76(19):5705-12.
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Janes KA, Kelly JR, Gaudet S, Albeck JG, Sorger PK, Lauffenburger DA. Cue-signal-response analysis of TNF-induced apoptosis by partial least squares regression of dynamic multivariate data. J Comput Biol. 2004; 11(4):544-61.
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Fritz J, Cooper EB, Gaudet S, Sorger PK, Manalis SR. Electronic detection of DNA by its intrinsic molecular charge. Proc Natl Acad Sci U S A. 2002 Oct 29; 99(22):14142-6.
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McLaughlin M, Hale R, Ellston D, Gaudet S, Lue RA, Viel A. The distribution and function of alternatively spliced insertions in hDlg. J Biol Chem. 2002 Feb 22; 277(8):6406-12.
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Gaudet S, Branton D, Lue RA. Characterization of PDZ-binding kinase, a mitotic kinase. Proc Natl Acad Sci U S A. 2000 May 09; 97(10):5167-72.
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Location

Dana-Farber Cancer Institute
450 Brookline Avenue
Smith 836B
Boston MA, 02215
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