News tagged ‘Genomics’ clear
- Cambridge-based Foundation Medicine is bringing high-tech tools to the battle against cancer. Founded in 2009 by leaders in genome technology including Dana-Farber, the company is analyzing patients' tumors for the entire coding sequence of 200-plus genes known to be altered in human cancers.
- Dr. Bruce E. Johnson said researchers at Foundation Medicine in Cambridge, Mass., have been routinely testing for certain "alterations" in cancer cells to help target treatments and new technologies.
Tags: Genomics, TargetedTherapy
- Epigenetics was the subject of a particularly interesting session, held on April 1st, at a meeting of the American Association for Cancer Research in Chicago. James Bradner, MD, described how his group has shown that a substance known as JQ1, which inhibits an epigenetic regulator called BRD4, blocks the activity of a gene by the name of Myc.
- Hospitals are using DNA sequencing to generate better treatments and diagnoses for patients, including Dana-Farber, which offers adult patients a test for almost 500 gene variations. Dr. Barrett Rollins say cancer is among the most promising targets because it is essentially a disease in which damaged genes let cells grow without restraint.
- Dana-Farber researchers, including Dr. Kornelia Polyak, have developed a mathematical model to predict how a patient’s tumor is likely to behave and which of several possible treatments is most likely to be effective.
Tags: BreastCancer, Genomics