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News tagged ‘Genomics’ clear

  • Cambridge-based Foundation Medicine is bringing high-tech tools to the battle against cancer. Founded in 2009 by leaders in genome technology including Dana-Farber, the company is analyzing patients' tumors for the entire coding sequence of 200-plus genes known to be altered in human cancers.

Tags: Genomics

  • Dr. David Williams talks about gene therapy in Bubble Boy Syndrome, a rare, immune deficiency disease.

Tags: BasicResearch, Genomics, ImmuneSystem

  • Dr. Bruce E. Johnson said researchers at Foundation Medicine in Cambridge, Mass., have been routinely testing for certain "alterations" in cancer cells to help target treatments and new technologies.

Tags: Genomics, TargetedTherapy

  • Epigenetics was the subject of a particularly interesting session, held on April 1st, at a meeting of the American Association for Cancer Research in Chicago. James Bradner, MD, described how his group has shown that a substance known as JQ1, which inhibits an epigenetic regulator called BRD4, blocks the activity of a gene by the name of Myc.

Tags: Genomics

  • Dr. David Steensma comments on genomic studies cataloging the mutations that drive endometrial cancer and acute myeloid leukemia.

Tags: Genomics, Leukemia

  • Hospitals are using DNA sequencing to generate better treatments and diagnoses for patients, including Dana-Farber, which offers adult patients a test for almost 500 gene variations. Dr. Barrett Rollins say cancer is among the most promising targets because it is essentially a disease in which damaged genes let cells grow without restraint.

Tags: Genomics

  • Dana-Farber researchers, including Dr. Kornelia Polyak, have developed a mathematical model to predict how a patient’s tumor is likely to behave and which of several possible treatments is most likely to be effective.

Tags: BreastCancer, Genomics

  • A new study co-authored by Dr. Rameen Beroukhim may enable researchers to identify biological pathways that lead to endometrial cancer, as well as possible approaches to treatment.

Tags: BasicResearch, Genomics, GynecologicCancers

  • Judy Garber, MD, MPH, discussed the potential clinical implications of the findings from a study from The Cancer Genome Atlas that identified four genetically distinct types of breast cancer.

Tags: BreastCancer, Genomics

  • Dr. David Steensma says new genomic studies cataloging the mutations that drive two deadly cancers is a landmark that will stand the test of time.

Tags: Genomics, Leukemia

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