News tagged ‘Genomics’ clear
- Cambridge-based Foundation Medicine is bringing high-tech tools to the battle against cancer. Founded in 2009 by leaders in genome technology including Dana-Farber, the company is analyzing patients' tumors for the entire coding sequence of 200-plus genes known to be altered in human cancers.
- Dr. Bruce E. Johnson said researchers at Foundation Medicine in Cambridge, Mass., have been routinely testing for certain "alterations" in cancer cells to help target treatments and new technologies.
Tags: Genomics, TargetedTherapy
- Epigenetics was the subject of a particularly interesting session, held on April 1st, at a meeting of the American Association for Cancer Research in Chicago. James Bradner, MD, described how his group has shown that a substance known as JQ1, which inhibits an epigenetic regulator called BRD4, blocks the activity of a gene by the name of Myc.
- Hospitals are using DNA sequencing to generate better treatments and diagnoses for patients, including Dana-Farber, which offers adult patients a test for almost 500 gene variations. Dr. Barrett Rollins say cancer is among the most promising targets because it is essentially a disease in which damaged genes let cells grow without restraint.
- Judy Garber, MD, MPH, discussed the potential clinical implications of the findings from a study from The Cancer Genome Atlas that identified four genetically distinct types of breast cancer.
Tags: BreastCancer, Genomics
- Dr. David Steensma says new genomic studies cataloging the mutations that drive two deadly cancers is a landmark that will stand the test of time.
Tags: Genomics, Leukemia
- Dr. Pasi Jänne and colleagues found that more than half of lung and colon cancer patients may benefit from high-speed tests that detect DNA flaws doctors can target with existing medicines.
Tags: ColonCancer, Genomics, LungCancer
- Dr. Andrea Richardson and colleagues have identified a genetic marker that may predict which aggressive "triple negative" breast cancers and certain ovarian cancers will likely respond to platinum-based chemotherapies.
Tags: BreastCancer, Genomics, OvarianCancer, GynecologicCancers