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News tagged ‘BasicResearch’ clear

  • A test developed by Dana-Farber scientists is the first to identify which malignant blood cells are highly vulnerable to a promising type of experimental drugs that unleash pent-up cell suicide factors to destroy the cancer.

Tags: BasicResearch, Leukemia

  • In an elegant, multiple-gene knockout experiment, a team of Boston scientists has discovered that a trio of molecules, called FoxOs, are fundamentally critical in preventing some cancers, maintaining blood vessel stability, and in keeping blood-forming stem cells healthy.

Tags: BasicResearch

  • A study led by researchers at Dana-Farber Cancer Institute and Broad Institute of the Massachusetts Institute of Technology and Harvard University provides the first demonstration of a practical method of screening tumors for cancer-related gene abnormalities that might be treated with "targeted" drugs.

Tags: BasicResearch, Genomics, Genetics

  • Using a novel three-part screening process, scientists at Dana-Farber Cancer Institute have identified a gene that is made inappropriately in about a third of all breast cancers. The discovery, reached in collaboration with researchers at Brigham and Womens Hospital (BWH) and the Broad Institute of Harvard and MIT, is reported in the June 15, 2007, issue of the journal Cell.

Tags: BasicResearch, BreastCancer

  • Researchers at Dana-Farber have identified a long-sought "master switch" in mice for the production of brown fat, a type of adipose tissue that generates heat and counters obesity caused by overeating.

Tags: BasicResearch

  • Dana-Farber scientists have identified a protein that prevents the body's immune system from recognizing and attacking Hodgkin lymphoma cells. Based on this finding, the researchers are now investigating targeted therapies to disable this molecular "bodyguard" and boost a patient's ability to fight the blood cancer.

Tags: BasicResearch, ImmuneSystem, Lymphoma

  • Collaborating scientists in Boston and North Carolina have found that a particular gene can block key steps of the lung cancer process in mice. The researchers report in the journal Nature that LKB1 is not only a "tumor-suppressor" gene for non-small cell lung cancer in mice, it also may be more powerful than other, better-known suppressors.

Tags: BasicResearch, LungCancer

  • The National Human Genome Research Institute (NHGRI), part of the National Institutes of Health (NIH), recently announced grants expected to total approximately $30 million to establish a new Center of Excellence in Genomic Science at Dana-Farber Cancer Institute and continue its support of the center at Stanford University.

Tags: BasicResearch, Genomics

  • By coaxing the HIV-1 protein to reveal a hidden portion of its protein coat, scientists at Dana-Farber Cancer Institute and Harvard Medical School have provided a newly detailed picture of how protective, or so-called broadly neutralizing, antibodies block HIV-1 infection.

Tags: Antibody, BasicResearch

  • In an effort to improve the success rate of investigational cancer drugs entering clinical trials, the Center for Applied Cancer Science (CACS) of the Dana-Farber Cancer Institute and Merck and Co., Inc., have established a collaboration to identify promising drug targets, and develop therapeutic candidates to reach those targets.

Tags: BasicResearch

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