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News tagged ‘Genomics’ clear

  • In a paper published online yesterday by the journal Nature, Dana-Farber researchers map out a mechanism by which micronuclei could potentially disrupt the chromosomes within them and produce cancer-causing gene mutations. The findings may point to a vulnerability in cancer cells that could be attacked by new therapies.

Tags: BasicResearch, Genomics

  • In one of the largest breast cancer sequencing efforts to date, scientists from Dana-Farber and their colleagues have discovered surprising alterations in genes that were not previously associated with breast cancer.

Tags: BasicResearch, BreastCancer, Genomics

  • The National Human Genome Research Institute (NHGRI), part of the National Institutes of Health (NIH), recently announced grants expected to total approximately $30 million to establish a new Center of Excellence in Genomic Science at Dana-Farber Cancer Institute and continue its support of the center at Stanford University.

Tags: BasicResearch, Genomics

  • Kornelia Polyak, MD, PhD, and colleagues identified a network of growth-spurring genes that drive stem-like breast cancer cells enriched in triple-negative breast tumors.

Tags: BreastCancer, Genomics

  • Dana-Farber and Brigham and Women's Hospital have launched Profile, one of the most comprehensive cancer research studies to help accelerate the development of personalized treatments for every person with cancer.

Tags: BasicResearch, Genomics, TargetedTherapy, Genetics

  • Genetic specialists at Dana-Farber/Children’s Hospital Cancer Center (DF/CHCC) are recommending that children being treated for sarcoma should be offered genetic counseling for Li-Fraumeni syndrome, a rare condition that greatly raises a person’s risk of developing additional cancers

Tags: BasicResearch, Genomics, Sarcoma

  • Jessie M. English, PhD, has been appointed the head of Research of the Belfer Institute for Applied Cancer Science at Dana-Farber. The Belfer Institute offers the full array of innovative drug discovery capabilities, from the identification of cancer-causing genetic mutations to the validation and selection of new drug targets.

Tags: Genomics, LungCancer, TargetedTherapy, TranslationalResearch

  • Findings by Dana-Farber scientists and others show the disarray in the on-off mechanism – known as methylation – is one of the defining characteristics of cancer and helps tumors adapt to changing circumstances.

Tags: BasicResearch, Genomics

  • Scientists from Brigham and Women's Hospital and Dana-Farber Cancer Institute and their colleagues have found a genetic marker that predicts which aggressive "triple negative" breast cancers and certain ovarian cancers will likely respond to platinum-based chemotherapies.

Tags: BasicResearch, BreastCancer, Genomics, OvarianCancer, GynecologicCancers

  • Dr. Gimelbrant is mapping gene activation to better understand the mechanisms essential for gene silencing. His findings could lead to the design of highly customized cancer treatments.

Tags: BasicResearch, Genomics

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