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News tagged ‘Genomics’ clear

  • Websites that market personalized cancer care services often overemphasize their purported benefits and downplay their limitations, and many sites offer genetic tests whose value for guiding cancer treatment has not been shown to be clinically useful, according to a new study from Dana-Farber Cancer Institute.

Tags: Genomics, Genetics

  • Dana-Farber experts share five things you should know about precision medicine.

Tags: Genomics, TargetedTherapy

  • Scientists publish the first comprehensive catalog of genetic mutations and other abnormal changes found in 279 cancers of the head and neck, identifying several broken molecular pathways that might be targeted by existing and future cancer drugs.

Tags: BasicResearch, Genomics, HeadNeckCancers

  • Immunotherapy, genomic profiling, and investigating game-changing drug therapies topped the list of most important cancer research and clinical developments at Dana-Farber Cancer Institute in 2014.

Tags: EGFR, Genomics, LungCancer, OvarianCancer, ProstateCancer, Lymphoma, Immunotherapy

  • Small cell lung cancer – a disease for which no new drugs have been approved for many years – has shown itself vulnerable to an agent that disables part of tumor cells’ basic survival machinery, researchers at Dana-Farber Cancer Institute and the Massachusetts Institute of Technology reported.

Tags: Genomics, LungCancer

  • Findings by Dana-Farber scientists and others show the disarray in the on-off mechanism – known as methylation – is one of the defining characteristics of cancer and helps tumors adapt to changing circumstances.

Tags: BasicResearch, Genomics

  • Scientists will be better able to trace how genetic changes give rise to diseases ranging from cancer to Huntington’s disease with a new map of protein-protein interactions within human cells produced by researchers at the Center for Cancer Systems Biology (CCSB) at Dana-Farber and associates around the world.

Tags: Genomics, Genetics

  • Scientists have identified a genetic mutation in about 20 percent of colorectal and endometrial cancers that had been overlooked in recent large, comprehensive gene searches. With this discovery, the altered gene, called RNF43, now ranks as one of the most common mutations in the two cancer types.

Tags: ColonCancer, Genomics, GynecologicCancers

  • Scientists have redoubled efforts to disable the mutated cancer gene KRAS, which confers an especially poor prognosis and has proved extraordinarily difficult to target. New research has identified an additional hurdle: inhibiting KRAS can activate a backup pathway in cancer cells that enables them to survive and thrive in the oncogene's absence.

Tags: BasicResearch, Genomics

  • Researchers studying a rare, always fatal brain tumor in children have found several molecular alterations that drive the cancer, according to a new study from scientists at Dana-Farber/Boston Children's Cancer and Blood Disorders Center and McGill University. The findings, published in Nature Genetics, identify potential new targets for drug treatments.

Tags: ChildhoodCancer, Genomics, TargetedTherapy, BrainTumors

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