News tagged ‘Leukemia’ clear
- Dana-Farber and colleagues report that an oral targeted drug has shown encouraging activity and tolerable side effects in patients with treatment-resistant or relapsed acute myelogenous leukemia (AML) in a phase 2 clinical trial.
- A normal enzyme called SYK pairs with FLT3, the most commonly mutated enzyme found in acute myelogenous leukemia, to promote progression of the cancer and its resistance to treatment with FLT3-blocking drugs, which may explain relatively poor results in clinical studies. In a mouse model, treatment with a combination of drugs to inhibit the two enzymes was more effective than treatment with either drug alone.
Tags: chemotherapy, BasicResearch, ChildhoodCancer, Leukemia
- Dana-Farber researchers have developed a method for determining how ready acute myeloid leukemia cells are to die, a finding that may enable oncologists to choose more effective treatments for their patients.
Tags: BasicResearch, StemCellTransplant, Leukemia
- A test developed by Dana-Farber scientists is the first to identify
which malignant blood cells are highly vulnerable to a promising type of
experimental drugs that unleash pent-up cell suicide factors to destroy
Tags: BasicResearch, Leukemia
- In a major advance in the care of patients with leukemia and other blood disorders, physicians at Dana-Farber/Brigham and Women's Cancer Center have begun using Rapid Heme Panel, a high-tech genetic test that provides, within a matter of days, an unprecedented amount of critical information to aid the choice of treatment.
Tags: StemCellTransplant, TranslationalResearch, Leukemia
- Dana-Farber investigators led a phase 1 trial in which a new oral targeted drug, idelalisib, (GS-1101), showed the potential to stave off the need for additional treatments for relapsed or treatment-resistant CLL.
- Researchers at Dana-Farber/Children's Hospital Cancer Center have created a peptide that overcomes drug resistance and reactivates programmed cell death in recurrent blood cancers.
Tags: chemotherapy, DrugResistance, Leukemia, Lymphoma
- Researchers have found several new altered genes that drive chronic lymphocitic leukemia through powerful DNA sequencing, a finding that could potentially help doctors predict whether a patient’s disease will progress rapidly or remain indolent for years.
Tags: BasicResearch, Leukemia
- Children with acute lymphoblastic leukemia (ALL), the most common form of pediatric cancer, can safely receive intravenous infusions of a reformulated mainstay of chemotherapy that has been delivered via painful intramuscular injection for more than 40 years, research suggests.
Tags: chemotherapy, ChildhoodCancer, Leukemia
- Dana-Farber/Boston Children's researchers reported promising outcomes data for the first group of boys with X-linked severe combined immunodeficiency syndrome (SCID-X1), a fatal genetic immunodeficiency also known as "bubble boy" disease, who were treated in an international clinical study of a new form of gene therapy.
Tags: ChildhoodCancer, ImmuneSystem, Genetics, Leukemia
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