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News tagged ‘Leukemia’ clear

  • A normal enzyme called SYK pairs with FLT3, the most commonly mutated enzyme found in acute myelogenous leukemia, to promote progression of the cancer and its resistance to treatment with FLT3-blocking drugs, which may explain relatively poor results in clinical studies. In a mouse model, treatment with a combination of drugs to inhibit the two enzymes was more effective than treatment with either drug alone.

Tags: chemotherapy, BasicResearch, ChildhoodCancer, Leukemia

  • Dana-Farber researchers have developed a method for determining how ready acute myeloid leukemia cells are to die, a finding that may enable oncologists to choose more effective treatments for their patients.

Tags: BasicResearch, StemCellTransplant, Leukemia

  • A test developed by Dana-Farber scientists is the first to identify which malignant blood cells are highly vulnerable to a promising type of experimental drugs that unleash pent-up cell suicide factors to destroy the cancer.

Tags: BasicResearch, Leukemia

  • In a major advance in the care of patients with leukemia and other blood disorders, physicians at Dana-Farber/Brigham and Women's Cancer Center have begun using Rapid Heme Panel, a high-tech genetic test that provides, within a matter of days, an unprecedented amount of critical information to aid the choice of treatment.

Tags: StemCellTransplant, TranslationalResearch, Leukemia

  • Dana-Farber investigators led a phase 1 trial in which a new oral targeted drug, idelalisib, (GS-1101), showed the potential to stave off the need for additional treatments for relapsed or treatment-resistant CLL.

Tags: Leukemia

  • Researchers at Dana-Farber/Children's Hospital Cancer Center have created a peptide that overcomes drug resistance and reactivates programmed cell death in recurrent blood cancers.

Tags: chemotherapy, DrugResistance, Leukemia, Lymphoma

  • Researchers have found several new altered genes that drive chronic lymphocitic leukemia through powerful DNA sequencing, a finding that could potentially help doctors predict whether a patient’s disease will progress rapidly or remain indolent for years.

Tags: BasicResearch, Leukemia

  • Children with acute lymphoblastic leukemia (ALL), the most common form of pediatric cancer, can safely receive intravenous infusions of a reformulated mainstay of chemotherapy that has been delivered via painful intramuscular injection for more than 40 years, research suggests.

Tags: chemotherapy, ChildhoodCancer, Leukemia

  • Dana-Farber/Boston Children's researchers reported promising outcomes data for the first group of boys with X-linked severe combined immunodeficiency syndrome (SCID-X1), a fatal genetic immunodeficiency also known as "bubble boy" disease, who were treated in an international clinical study of a new form of gene therapy.

Tags: ChildhoodCancer, ImmuneSystem, Genetics, Leukemia

  • Pediatric patients with B-precursor acute lymphoblastic leukemia who are likely to relapse after chemotherapy treatment can reduce those odds by receiving additional courses of chemotherapy, according to research by Dana-Farber/Children's Hospital Cancer Center investigators.

Tags: chemotherapy, ChildhoodCancer, Leukemia

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