News tagged ‘TargetedTherapy’ clear
The Cancer Genome Atlas Research Network has identified a large number and variety of DNA alterations in squamous cell lung cancer tumors, which could serve as potential therapeutic targets for treating the second most common type of lung cancer.
Tags: Genomics, LungCancer, TargetedTherapy
Regorafenib was found to reduce the risk of disease progression or death by more than 70 percent in patients whose tumors had become resistant to Gleevec and Sutent.
Tags: DrugResistance, Sarcoma, TargetedTherapy
Newly discovered gene mutations in certain non-small cell and colorectal cancers share similarities with other genetic abnormalities that are known to respond to targeted cancer treatments. This suggests that existing therapies, already approved, could be used to treat patients with these tumors.
Tags: ColonCancer, Genomics, KinaseInhibitor, LungCancer, TargetedTherapy
- In a demonstration that even some of the most hard-to-treat
tumors may one day succumb to therapies aimed at molecular "weak
points," researchers at Dana-Farber report the first instance in which
metastatic melanoma has been driven into remission by a targeted
therapy.
Tags: Melanoma, TargetedTherapy
- A new study by an international team of investigators led by Dana-Farber Cancer Institute scientists is the first to demonstrate that chemotherapy and a new, targeted therapy work better in combination than chemotherapy alone in treating patients with the most common genetic subtype of lung cancer.
Tags: LungCancer, TargetedTherapy, Genetics
Dana-Farber scientists found that pancreatic cancer cells' growth and spread are fueled by an unusual metabolic pathway that someday might be blocked with targeted drugs to control the deadly cancer.
Tags: BasicResearch, PancreaticCancer, TargetedTherapy
A new discovery by Jean Zhao, PhD, and colleagues may help physicians predict which tumors are likely to become resistant to a given drug. In the report, published by Nature Medicine, researchers described how they created a genetically engineered mouse model of human breast cancer in which the most frequently occurring breast cancer oncogene, PIK3CA, could be turned on and off.
Tags: BreastCancer, Genomics, TargetedTherapy, Genetics
A study by scientists at Dana-Farber Cancer Institute, the Broad Institute, and other research centers, may offer clues to why rates of esophageal adenocarcinomas (EACs) have risen so sharply. The findings, in Nature Genetics, point to an array of abnormal genes and proteins that may be lynchpins of EAC cell growth and therefore serve as targets for new therapies.
Tags: BasicResearch, Genomics, TargetedTherapy
Dana-Farber researchers have discovered how some cancer cells can evade the effect of cetuximab. This insight may explain why some cancers that initially respond to cetuximab become resistant to it, or how to overcome such resistance.
Tags: ColonCancer, EGFR, TargetedTherapy
Showing 11-20 of 23 items