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News tagged ‘BasicResearch’ clear

  • Scientists have redoubled efforts to disable the mutated cancer gene KRAS, which confers an especially poor prognosis and has proved extraordinarily difficult to target. New research has identified an additional hurdle: inhibiting KRAS can activate a backup pathway in cancer cells that enables them to survive and thrive in the oncogene's absence.

Tags: BasicResearch, Genomics

  • Dana-Farber scientists report on a natural hormone that is increased by physical exercise and by exposure to cold improves blood sugar control, suppresses inflammation, and burns fat to mold leaner bodies in mice can be made in the laboratory and could have therapeutic potential for several diseases.

Tags: BasicResearch

  • According to new research, a technique for reading the genetic abnormalities in patient tumors with a simple blood test has passed a critical test of accuracy and reliability.

Tags: BasicResearch

  • Scientists at Dana-Farber Cancer Institute have identified natural human antibodies against the virus that causes Middle East Respiratory Syndrome (MERS), a step toward developing treatments for the newly emerging and often-fatal disease.

Tags: Antibody, BasicResearch

  • A team of researchers led by Dana-Farber Cancer Institute investigators has uncovered a connection between people with Down syndrome and having a heightened risk of developing acute lymphoblastic leukemia (ALL) during childhood.

Tags: BasicResearch, Leukemia

  • A normal enzyme called SYK pairs with FLT3, the most commonly mutated enzyme found in acute myelogenous leukemia, to promote progression of the cancer and its resistance to treatment with FLT3-blocking drugs, which may explain relatively poor results in clinical studies. In a mouse model, treatment with a combination of drugs to inhibit the two enzymes was more effective than treatment with either drug alone.

Tags: chemotherapy, BasicResearch, ChildhoodCancer, Leukemia

  • "Beige" fat cells found in healthy subcutaneous fat play a critical role in protecting the body against the disease risks of obesity in mice, report researchers at Dana-Farber Cancer Institute, who say their study findings may have implications for therapy of obesity-related illness in humans.

Tags: BasicResearch

  • The most comprehensive genetic study to date of the blood cancer multiple myeloma has revealed that the genetic landscape of the disease may be more complicated than previously thought.

Tags: BasicResearch, MultipleMyeloma, Genetics

  • Ludwig Cancer Research, on behalf of its founder, Daniel K. Ludwig, has given Harvard Medical School $90 million to spur innovative scientific inquiry and discovery in a newly expanded center. The Ludwig Center at Harvard will be co-directed by Joan Brugge, PhD, of Harvard Medical School and George Demetri, MD, of Dana-Farber.

Tags: BasicResearch, Development

  • Dana-Farber researchers and colleagues completed a comprehensive genomic analysis of cervical cancer, identifying recurrent genetic mutations not previously found and shedding light on the role human papillomavirus (HPV) plays in the development of the disease.

Tags: BasicResearch, CervicalCancer, Genomics

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