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News tagged ‘BasicResearch’ clear

  • Dana-Farber researchers report that multiple myeloma is driven to spread by a subset of the myeloma cells within a patient’s body, and that attacking those specific subsets with targeted drugs may be better targets for therapy.

Tags: BasicResearch, MultipleMyeloma

  • The "molecular mail" sent by multiple myeloma cells provides clues to how well patients with the disease are likely to respond to treatment, according to a study by researchers at Dana-Farber Cancer.

Tags: BasicResearch, MultipleMyeloma

  • A research team led by Dana-Farber Cancer Institute and Brigham and Women’s Hospital has uncovered surprising new findings that underscore the role of an important signaling pathway, already known to be critical in cancer, in the development of type 2 diabetes.

Tags: BasicResearch

  • Dana-Farber scientists and colleagues report on a compound that can stop the blood cancer multiple myeloma from spreading, leading to a new approach in addressing metastasis, one of the deadliest aspects of cancer.

Tags: BasicResearch, MultipleMyeloma

  • Dana-Farber scientists and international colleagues have discovered how a single protein can exert both a push and a pull force to nudge a neuron in the desired direction, helping neurons navigate to their assigned places in the developing brain.

Tags: BasicResearch

  • Researchers find that targeting growth-driving cells within tumors, not the fastest-proliferating cells within tumors, may lead to more effective treatments.

Tags: BasicResearch

  • In a massive effort to catalog the molecular causes of stomach cancer, scientists, including researchers from Dana-Farber Cancer Institute, have identified four subtypes of tumors based on shared mutations and other molecular abnormalities.

Tags: BasicResearch

  • Dana-Farber scientists identify a protein that is a cause of cachexia, a severe wasting of fat and muscle in half of all cancer patients, and show that blocking the protein in mice can prevent or halt the debilitating condition.

Tags: BasicResearch

  • Dana-Farber and colleagues from the Cancer Genome Atlas (TCGA) Research Network identified novel mutations in a well-known cancer-causing pathway in lung adenocarcinoma, potentially identifying a greater number of patients with treatable mutations because many potent cancer drugs that target these mutations already exist. Additionally, these findings may expand the number of possible new therapeutic targets for this disease.

Tags: BasicResearch, LungCancer

  • Research led by Bruce Spiegelman, PhD, and colleagues shows that adipsin, a cell signaling protein made by fat cells, plays a critical, previously unsuspected role in stimulating insulin secretion to control blood sugar, and the discovery could have implications for treatment of type 2 diabetes.

Tags: BasicResearch

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