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News tagged ‘BasicResearch’ clear

  • Dana-Farber scientists have discovered the mechanism behind thalidomide's cancer-killing properties, which could aid development of safer versions and a new class of cancer drugs.

Tags: BasicResearch, MultipleMyeloma, Lymphoma

  • Dana-Farber/Harvard Cancer Center researchers receive six Specialized Program of Research Excellence (SPORE) grants, which support research that moves from the laboratory to the clinic.

Tags: BasicResearch, Grants

  • Scientists at Dana-Farber Cancer Institute and the University of Colorado Cancer Center report on a gene fusion that spurs the cells to divide rapidly. Treating the cells with a compound that blocks the protein caused the cells to die which may offer a targeted therapy in patients.

Tags: BasicResearch, LungCancer

  • A protein that is increased by endurance exercise has been isolated and given to non-exercising mice, in which it turned on genes that promote brain health and encourage the growth of new nerves involved in learning and memory, report scientists from Dana-Farber Cancer Institute and Harvard Medical School.

Tags: BasicResearch, Exercise

  • Research led by Dana-Farber/Boston Children's Cancer and Blood Disorders Center reports the discovery of a new genetic target for potential therapy of sickle cell disease.

Tags: BasicResearch, Genetics

  • A multi-institutional team of researchers, including those at Dana-Farber, have identified a new molecular pathway responsible for causing heart failure and showed that a first-in-class prototype drug, JQ1, blocks this pathway to protect the heart from damage.

Tags: BasicResearch

  • Dana-Farber scientists find when given together, two orally available experimental drugs – sapacitabine and seliciclib – worked together to elicit antitumor effects in patients with incurable BRCA-deficient cancers.

Tags: BasicResearch, BreastCancer, PancreaticCancer, GynecologicCancers

  • Dana-Farber scientists have discovered a molecular switch that enables advanced prostate cancers to spread without stimulation by male hormones, a finding that could serve as a treatment target for castration-resistant prostate cancers.

Tags: BasicResearch, ProstateCancer

  • Researchers at Dana-Farber/Children's Hospital Cancer Center have taken the first preliminary steps toward developing a form of gene therapy for sickle cell disease.

Tags: BasicResearch

  • Kornelia Polyak, MD, PhD, was presented with the 2012 AACR Outstanding Investigator Award for Breast Cancer Research at the 35th annual CTRC-AACR San Antonio Breast Cancer Symposium.

Tags: BasicResearch, BreastCancer, Honors

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