News tagged ‘BasicResearch’ clear
- Research led by Bruce Spiegelman, PhD, and colleagues shows that adipsin, a cell signaling protein made by fat cells, plays a critical, previously unsuspected role in stimulating insulin secretion to control blood sugar, and the discovery could have implications for treatment of type 2 diabetes.
- In prostate cancer patients with a certain genetic variant, a high level
of selenium in the blood was associated with a two-fold greater risk of
poorer outcomes than men with the lowest amounts of selenium.
Tags: BasicResearch, ProstateCancer
- Dana-Farber scientists have identified a trigger point on a
naturally occurring "death protein" that may lead to designer drugs that
force cancer cells to commit suicide.
- Scientists have for the first time partially reversed age-related
degeneration in mice, using a strategy that might one day treat
conditions such as rare genetic premature aging syndromes.
- A protein that is increased by endurance exercise has been isolated and given to non-exercising mice, in which it turned on genes that promote brain health and encourage the growth of new nerves involved in learning and memory, report scientists from Dana-Farber Cancer Institute and Harvard Medical School.
Tags: BasicResearch, Exercise
- Researchers report that these antibodies have the potential for use in combination with other treatments to prevent or treat certain types of avian and seasonal flu.
- Scientists at Dana-Farber Cancer Institute have identified natural human antibodies against the virus that causes Middle East Respiratory Syndrome (MERS), a step toward developing treatments for the newly emerging and often-fatal disease.
Tags: Antibody, BasicResearch
- Scientists have redoubled efforts to disable the mutated cancer gene KRAS, which confers an especially poor prognosis and has proved extraordinarily difficult to target. New research has identified an additional hurdle: inhibiting KRAS can activate a backup pathway in cancer cells that enables them to survive and thrive in the oncogene's absence.
Tags: BasicResearch, Genomics
- Dana-Farber scientists report on a natural hormone that is increased by physical exercise and by exposure to cold improves blood sugar control, suppresses inflammation, and burns fat to mold leaner bodies in mice can be made in the laboratory and could have therapeutic potential for several diseases.
- Researchers at Dana-Farber have identified a long-sought "master switch"
in mice for the production of brown fat, a type of adipose tissue that
generates heat and counters obesity caused by overeating.
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