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News tagged ‘BasicResearch’ clear

  • Dana-Farber scientists find when given together, two orally available experimental drugs – sapacitabine and seliciclib – worked together to elicit antitumor effects in patients with incurable BRCA-deficient cancers.

Tags: BasicResearch, BreastCancer, PancreaticCancer, GynecologicCancers

  • Research led by Bruce Spiegelman, PhD, and colleagues shows that adipsin, a cell signaling protein made by fat cells, plays a critical, previously unsuspected role in stimulating insulin secretion to control blood sugar, and the discovery could have implications for treatment of type 2 diabetes.

Tags: BasicResearch

  • In prostate cancer patients with a certain genetic variant, a high level of selenium in the blood was associated with a two-fold greater risk of poorer outcomes than men with the lowest amounts of selenium.

Tags: BasicResearch, ProstateCancer

  • Dana-Farber scientists and international colleagues have discovered how a single protein can exert both a push and a pull force to nudge a neuron in the desired direction, helping neurons navigate to their assigned places in the developing brain.

Tags: BasicResearch

  • Dana-Farber scientists have identified a trigger point on a naturally occurring "death protein" that may lead to designer drugs that force cancer cells to commit suicide.

Tags: BasicResearch

  • Scientists have for the first time partially reversed age-related degeneration in mice, using a strategy that might one day treat conditions such as rare genetic premature aging syndromes.

Tags: BasicResearch

  • A protein that is increased by endurance exercise has been isolated and given to non-exercising mice, in which it turned on genes that promote brain health and encourage the growth of new nerves involved in learning and memory, report scientists from Dana-Farber Cancer Institute and Harvard Medical School.

Tags: BasicResearch, Exercise

  • Researchers report that these antibodies have the potential for use in combination with other treatments to prevent or treat certain types of avian and seasonal flu.

Tags: BasicResearch

  • Scientists at Dana-Farber Cancer Institute have identified natural human antibodies against the virus that causes Middle East Respiratory Syndrome (MERS), a step toward developing treatments for the newly emerging and often-fatal disease.

Tags: Antibody, BasicResearch

  • Scientists have redoubled efforts to disable the mutated cancer gene KRAS, which confers an especially poor prognosis and has proved extraordinarily difficult to target. New research has identified an additional hurdle: inhibiting KRAS can activate a backup pathway in cancer cells that enables them to survive and thrive in the oncogene's absence.

Tags: BasicResearch, Genomics

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