News tagged ‘TargetedTherapy’ clear
- Newly discovered gene mutations in certain non-small cell and colorectal cancers share similarities with other genetic abnormalities that are known to respond to targeted cancer treatments. This suggests that existing therapies, already approved, could be used to treat patients with these tumors.
Tags: ColonCancer, Genomics, KinaseInhibitor, LungCancer, TargetedTherapy
- A study by researchers at Dana-Farber Cancer Institute shows that not all doctors are ready to embrace tests that look for hundreds of DNA changes in patients' tumor samples, while others plan to offer this type of cancer gene testing to most of their patients.
Tags: Genomics, TargetedTherapy
- In a demonstration that even some of the most hard-to-treat
tumors may one day succumb to therapies aimed at molecular "weak
points," researchers at Dana-Farber report the first instance in which
metastatic melanoma has been driven into remission by a targeted
Tags: Melanoma, TargetedTherapy
- A new study by an international team of investigators led by Dana-Farber Cancer Institute scientists is the first to demonstrate that chemotherapy and a new, targeted therapy work better in combination than chemotherapy alone in treating patients with the most common genetic subtype of lung cancer.
Tags: LungCancer, TargetedTherapy, Genetics
- Researchers studying a rare, always fatal brain tumor in children have found several molecular alterations that drive the cancer, according to a new study from scientists at Dana-Farber/Boston Children's Cancer and Blood Disorders Center and McGill University. The findings, published in Nature Genetics, identify potential new targets for drug treatments.
Tags: ChildhoodCancer, Genomics, TargetedTherapy, BrainTumors
- Dana-Farber scientists found that pancreatic cancer cells' growth and spread are fueled by an unusual metabolic pathway that someday might be blocked with targeted drugs to control the deadly cancer.
Tags: PancreaticCancer, TargetedTherapy
- A new discovery by Jean Zhao, PhD, and colleagues may help physicians predict which tumors are likely to become resistant to a given drug. In the report, published by Nature Medicine, researchers described how they created a genetically engineered mouse model of human breast cancer in which the most frequently occurring breast cancer oncogene, PIK3CA, could be turned on and off.
Tags: BreastCancer, Genomics, TargetedTherapy, Genetics
- A study by scientists at Dana-Farber Cancer Institute, the Broad Institute, and other research centers, may offer clues to why rates of esophageal adenocarcinomas (EACs) have risen so sharply. The findings, in Nature Genetics, point to an array of abnormal genes and proteins that may be lynchpins of EAC cell growth and therefore serve as targets for new therapies.
Tags: Genomics, TargetedTherapy
- Dana-Farber researchers have discovered how some cancer cells can evade the effect of cetuximab. This insight may explain why some cancers that initially respond to cetuximab become resistant to it, or how to overcome such resistance.
Tags: ColonCancer, EGFR, TargetedTherapy
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