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News tagged ‘Genomics’ clear

  • In a paper published online yesterday by the journal Nature, Dana-Farber researchers map out a mechanism by which micronuclei could potentially disrupt the chromosomes within them and produce cancer-causing gene mutations. The findings may point to a vulnerability in cancer cells that could be attacked by new therapies.

Tags: BasicResearch, Genomics

  • Dana-Farber and Brigham and Women's Hospital have launched Profile, one of the most comprehensive cancer research studies to help accelerate the development of personalized treatments for every person with cancer.

Tags: BasicResearch, Genomics, TargetedTherapy, Genetics

  • Dana-Farber and the Broad Institute researchers have found high levels of the bacterium Fusobacterium in colorectal cancers, a sign that it might contribute to the disease and potentially lead to further research.

Tags: BasicResearch, ColonCancer, Genomics

  • A new discovery by Jean Zhao, PhD, and colleagues may help physicians predict which tumors are likely to become resistant to a given drug. In the report, published by Nature Medicine, researchers described how they created a genetically engineered mouse model of human breast cancer in which the most frequently occurring breast cancer oncogene, PIK3CA, could be turned on and off.

Tags: BreastCancer, Genomics, TargetedTherapy, Genetics

  • Kornelia Polyak, MD, PhD, and colleagues identified a network of growth-spurring genes that drive stem-like breast cancer cells enriched in triple-negative breast tumors.

Tags: BreastCancer, Genomics

  • Researchers from the Broad Institute, Dana-Farber Cancer Institute and Weill Cornell Medical College have laid bare the full genetic blueprint of multiple prostate tumors, uncovering alterations that have never before been detected and offering a deep view of the genetic missteps that underlie the disease.

Tags: Genomics, ProstateCancer

  • A team of scientists led by Dana-Farber has created the first molecule able to control gene activity in cancer.

Tags: Genomics, TargetedTherapy

  • Dr. Gimelbrant is mapping gene activation to better understand the mechanisms essential for gene silencing. His findings could lead to the design of highly customized cancer treatments.

Tags: BasicResearch, Genomics

  • Study finds similarities in genetic characteristics of different tumor types, which could lead to common strategies for treating them.

Tags: BasicResearch, Genomics

  • Researchers working in genomics and molecular biology have demonstrated that a surplus of a gene known as GOLPH3 can spur cancer cell growth.

Tags: Genomics, Genetics

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