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News tagged ‘BasicResearch’ clear

  • Researchers at Dana-Farber/Children's Hospital Cancer Center have devised a strategy to directly activate a natural "death" protein, triggering the self-destruction of cells — which could lead to new possibilities for designing cancer drugs.

Tags: BasicResearch

  • The discovery of a connection between seizure resistance and a protein that modifies metabolism in the brain may result in a new treatment for epilepsy that parallels the results of the ketogenic diet, say researchers from Dana-Farber and Harvard Medical School.

Tags: BasicResearch

  • William G. Kaelin, Jr., MD, received the 2012 American Society for Clinical Investigation’s Stanley J. Korsmeyer Award in recognition of his contributions to the molecular understanding of cellular oxygen sensing and cellular adaptation to hypoxia.

Tags: BasicResearch, Honors

  • Dana-Farber researchers report that advanced pancreatic cancers are dependent on the continued expression of a mutant oncogene that "rewires" key metabolic pathways, which suggests that these altered pathways might be potential targets for future drugs.

Tags: BasicResearch, PancreaticCancer

  • The American Association for Cancer Research named Alan D. D'Andrea, MD, the recipient of the 52nd Annual AACR G.H.A. Clowes Memorial Award for his work in understanding cancer survival and progression.

Tags: BasicResearch, ChildhoodCancer, Honors

  • Dana-Farber scientists and colleagues have published results from the Cancer Cell Line Encyclopedia, a resource that marries cancer genome data with predictors of drug responses. This information could refine cancer clinical trials and future treatments.

Tags: BasicResearch, Genomics

  • Scientists from Brigham and Women's Hospital and Dana-Farber Cancer Institute and their colleagues have found a genetic marker that predicts which aggressive "triple negative" breast cancers and certain ovarian cancers will likely respond to platinum-based chemotherapies.

Tags: BasicResearch, BreastCancer, Genomics, OvarianCancer, GynecologicCancers

  • Genetic specialists at Dana-Farber/Children’s Hospital Cancer Center (DF/CHCC) are recommending that children being treated for sarcoma should be offered genetic counseling for Li-Fraumeni syndrome, a rare condition that greatly raises a person’s risk of developing additional cancers

Tags: BasicResearch, Genomics, Sarcoma

  • The Massachusetts Life Sciences Center has awarded Dana-Farber Cancer Institute a $10 million grant to support the expansion of its pioneering cancer imaging research program with a new imaging facility which will support more rapid assessment of therapies and play a key role in the delivery of personalized medicine.

Tags: BasicResearch, Grants, TargetedTherapy, Imaging

  • In a paper published online yesterday by the journal Nature, Dana-Farber researchers map out a mechanism by which micronuclei could potentially disrupt the chromosomes within them and produce cancer-causing gene mutations. The findings may point to a vulnerability in cancer cells that could be attacked by new therapies.

Tags: BasicResearch, Genomics

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