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News tagged ‘BasicResearch’ clear

  • A normal enzyme called SYK pairs with FLT3, the most commonly mutated enzyme found in acute myelogenous leukemia, to promote progression of the cancer and its resistance to treatment with FLT3-blocking drugs, which may explain relatively poor results in clinical studies. In a mouse model, treatment with a combination of drugs to inhibit the two enzymes was more effective than treatment with either drug alone.

Tags: chemotherapy, BasicResearch, ChildhoodCancer, Leukemia

  • "Beige" fat cells found in healthy subcutaneous fat play a critical role in protecting the body against the disease risks of obesity in mice, report researchers at Dana-Farber Cancer Institute, who say their study findings may have implications for therapy of obesity-related illness in humans.

Tags: BasicResearch

  • The most comprehensive genetic study to date of the blood cancer multiple myeloma has revealed that the genetic landscape of the disease may be more complicated than previously thought.

Tags: BasicResearch, MultipleMyeloma, Genetics

  • Ludwig Cancer Research, on behalf of its founder, Daniel K. Ludwig, has given Harvard Medical School $90 million to spur innovative scientific inquiry and discovery in a newly expanded center. The Ludwig Center at Harvard will be co-directed by Joan Brugge, PhD, of Harvard Medical School and George Demetri, MD, of Dana-Farber.

Tags: BasicResearch, Development

  • Dana-Farber researchers and colleagues completed a comprehensive genomic analysis of cervical cancer, identifying recurrent genetic mutations not previously found and shedding light on the role human papillomavirus (HPV) plays in the development of the disease.

Tags: BasicResearch, CervicalCancer, Genomics

  • Dana-Farber scientists have discovered the mechanism behind thalidomide's cancer-killing properties, which could aid development of safer versions and a new class of cancer drugs.

Tags: BasicResearch, MultipleMyeloma, Lymphoma

  • Dana-Farber/Harvard Cancer Center researchers receive six Specialized Program of Research Excellence (SPORE) grants, which support research that moves from the laboratory to the clinic.

Tags: BasicResearch, Grants

  • Scientists at Dana-Farber Cancer Institute and the University of Colorado Cancer Center report on a gene fusion that spurs the cells to divide rapidly. Treating the cells with a compound that blocks the protein caused the cells to die which may offer a targeted therapy in patients.

Tags: BasicResearch, LungCancer

  • A protein that is increased by endurance exercise has been isolated and given to non-exercising mice, in which it turned on genes that promote brain health and encourage the growth of new nerves involved in learning and memory, report scientists from Dana-Farber Cancer Institute and Harvard Medical School.

Tags: BasicResearch, Exercise

  • Research led by Dana-Farber/Boston Children's Cancer and Blood Disorders Center reports the discovery of a new genetic target for potential therapy of sickle cell disease.

Tags: BasicResearch, Genetics

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