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News tagged ‘TargetedTherapy’ clear

  • One of the shortcomings of a therapy that uses millions of identical antibodies to boost the immune system's attack on cancer cells is that many patients whose tumors recede in response to the treatment also experience serious inflammatory problems, such as severe diarrhea and rashes. In a new study, a team led by Dana-Farber Cancer Institute researchers shows that giving periodic infusions of such "monoclonal" antibodies to patients who have received a widely used cancer vaccine unleashes a strong immune response to tumors, with less-harsh side effects.

Tags: Melanoma, OvarianCancer, TargetedTherapy

  • In a demonstration that even some of the most hard-to-treat tumors may one day succumb to therapies aimed at molecular "weak points," researchers at Dana-Farber report the first instance in which metastatic melanoma has been driven into remission by a targeted therapy.

Tags: Melanoma, TargetedTherapy

  • Belfer Institute and sanofi-aventis scientists will work jointly with the goal of discovering new anticancer drugs targeted at specific patient populations.

Tags: TargetedTherapy, TranslationalResearch

  • A team of scientists led by Dana-Farber has created the first molecule able to control gene activity in cancer.

Tags: Genomics, TargetedTherapy

  • A new oral drug caused dramatic shrinkage of a patient's rare, aggressive form of soft-tissue cancer that was driven by an abnormally activated protein, physician-scientists from Dana-Farber Cancer Institute report.

Tags: Sarcoma, TargetedTherapy

  • Dana-Farber researchers have discovered how some cancer cells can evade the effect of cetuximab. This insight may explain why some cancers that initially respond to cetuximab become resistant to it, or how to overcome such resistance.

Tags: ColonCancer, EGFR, TargetedTherapy

  • A new discovery by Jean Zhao, PhD, and colleagues may help physicians predict which tumors are likely to become resistant to a given drug. In the report, published by Nature Medicine, researchers described how they created a genetically engineered mouse model of human breast cancer in which the most frequently occurring breast cancer oncogene, PIK3CA, could be turned on and off.

Tags: BreastCancer, Genomics, TargetedTherapy, Genetics

  • Dana-Farber and Brigham and Women's Hospital have launched Profile, one of the most comprehensive cancer research studies to help accelerate the development of personalized treatments for every person with cancer.

Tags: BasicResearch, Genomics, TargetedTherapy, Genetics

  • The Massachusetts Life Sciences Center has awarded Dana-Farber Cancer Institute a $10 million grant to support the expansion of its pioneering cancer imaging research program with a new imaging facility which will support more rapid assessment of therapies and play a key role in the delivery of personalized medicine.

Tags: BasicResearch, Grants, TargetedTherapy, Imaging

  • Treatment with three "targeted" cancer drugs has been linked to a slightly elevated chance of fatal side effects, according to a new analysis led by scientists at Dana-Farber. These risks remain low, but they should be factored in when developing patients’ treatment plans.

Tags: chemotherapy, PatientEducation, PatientSafety, TargetedTherapy

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