News tagged ‘Genomics’ clear
- Dana-Farber scientists and colleagues have published results from the Cancer Cell Line Encyclopedia, a resource that marries cancer genome data with predictors of drug responses. This information could refine cancer clinical trials and future treatments.
Tags: BasicResearch, Genomics
- Scientists have identified a genetic mutation in about 20 percent of colorectal and endometrial cancers that had been overlooked in recent large, comprehensive gene searches. With this discovery, the altered gene, called RNF43, now ranks as one of the most common mutations in the two cancer types.
Tags: ColonCancer, Genomics, GynecologicCancers
- Dana-Farber researchers are studying melanoma tumors' microenvironments to better understand how some melanoma continue to grow and survive despite the presence of anti-cancer drugs.
Tags: BasicResearch, Genomics, Melanoma
- A study led by researchers at Dana-Farber Cancer Institute and Broad
Institute of the Massachusetts Institute of Technology and Harvard
University provides the first demonstration of a practical method of
screening tumors for cancer-related gene abnormalities that might be
treated with "targeted" drugs.
Tags: BasicResearch, Genomics, Genetics
- Scientists at Dana-Farber Cancer Institute have shown in a laboratory
study that revving up a crucial set of muscle genes counteracts the
damage caused by a form of muscular dystrophy.
Tags: Genomics, Genetics
- Dana-Farber scientists have linked genetic variants to the regulation of genes involved in breast cancer, including four genes not previously implicated in breast cancer, shedding new insights into the biology of breast cancer.
Tags: BreastCancer, Genomics
- Researchers working in genomics and molecular biology have demonstrated that a surplus of a gene known as GOLPH3 can spur cancer cell growth.
Tags: Genomics, Genetics
- A study by scientists at Dana-Farber Cancer Institute, the Broad Institute, and other research centers, may offer clues to why rates of esophageal adenocarcinomas (EACs) have risen so sharply. The findings, in Nature Genetics, point to an array of abnormal genes and proteins that may be lynchpins of EAC cell growth and therefore serve as targets for new therapies.
Tags: Genomics, TargetedTherapy
- A new discovery by Jean Zhao, PhD, and colleagues may help physicians predict which tumors are likely to become resistant to a given drug. In the report, published by Nature Medicine, researchers described how they created a genetically engineered mouse model of human breast cancer in which the most frequently occurring breast cancer oncogene, PIK3CA, could be turned on and off.
Tags: BreastCancer, Genomics, TargetedTherapy, Genetics
- A first of its kind study has revealed marked differences in the genomic terrain of the two most common types of cervical cancer, suggesting that patients might benefit from targeted therapies for each type’s molecular idiosyncrasies.
Tags: CervicalCancer, Genomics, GynecologicCancers