News tagged ‘LungCancer’ clear
- By mapping the interlocking structures of small molecules and mutated
protein "receptors" in non-small cell lung cancer (NSCLC) cells,
scientists at Dana-Farber and their colleagues have energized efforts to
design molecules that mesh with these receptors, potentially
interfering with cancer cell growth and survival.
- Dana-Farber researchers report a novel compound has become the first targeted therapy to benefit patients with non-small cell lung cancer.
Tags: LungCancer, TargetedTherapy
- A new study by an international team of investigators led by Dana-Farber Cancer Institute scientists is the first to demonstrate that chemotherapy and a new, targeted therapy work better in combination than chemotherapy alone in treating patients with the most common genetic subtype of lung cancer.
Tags: LungCancer, TargetedTherapy, Genetics
- Researchers have halted non-small cell lung tumors resistant to Iressa
and Tarceva with a newly constructed compound that may also have fewer
Tags: DrugResistance, LungCancer
- Newly discovered gene mutations in certain non-small cell and colorectal cancers share similarities with other genetic abnormalities that are known to respond to targeted cancer treatments. This suggests that existing therapies, already approved, could be used to treat patients with these tumors.
Tags: ColonCancer, Genomics, KinaseInhibitor, LungCancer, TargetedTherapy
- The Cancer Genome Atlas Research Network has identified a large number and variety of DNA alterations in squamous cell lung cancer tumors, which could serve as potential therapeutic targets for treating the second most common type of lung cancer.
Tags: Genomics, LungCancer, TargetedTherapy
- An international research team, led by investigators from the
Massachusetts General Hospital (MGH) Cancer Center and Dana-Farber
Cancer Institute, has found a new way that some lung tumors become
resistant to treatment with targeted therapy drugs like Iressa and
- Collaborating scientists in Boston and North Carolina have found that a
particular gene can block key steps of the lung cancer process in mice.
The researchers report in the journal Nature that LKB1
is not only a "tumor-suppressor" gene for non-small cell lung cancer in
mice, it also may be more powerful than other, better-known
Tags: BasicResearch, LungCancer
- A collaborative study involving Dana-Farber researchers has
unearthed a variety of genetic alterations in lung tumors, more than
doubling the number already linked to the disease.
Tags: Genomics, LungCancer