News tagged ‘TargetedTherapy’ clear
- One of the shortcomings of a therapy that uses millions of
identical antibodies to boost the immune system's attack on cancer cells
is that many patients whose tumors recede in response to the treatment
also experience serious inflammatory problems, such as severe diarrhea
and rashes. In a new study, a team led by Dana-Farber Cancer Institute
researchers shows that giving periodic infusions of such "monoclonal"
antibodies to patients who have received a widely used cancer vaccine
unleashes a strong immune response to tumors, with less-harsh side
effects.
Tags: Melanoma, OvarianCancer, TargetedTherapy
Treatment with three "targeted" cancer drugs has been linked to a slightly elevated chance of fatal side effects, according to a new analysis led by scientists at Dana-Farber. These risks remain low, but they should be factored in when developing patients’ treatment plans.
Tags: chemotherapy, PatientEducation, PatientSafety, TargetedTherapy
Dana-Farber researchers reported that patients with non-small cell lung cancer (NSCLC) whose tumor cells harbored an abnormal ALK gene responded better to targeted therapy than traditional chemotherapy.
Tags: BasicResearch, LungCancer, TargetedTherapy
Dana-Farber researchers report a novel compound has become the first targeted therapy to benefit patients with non-small cell lung cancer.
Tags: LungCancer, TargetedTherapy
Dana-Farber researchers have discovered how some cancer cells can evade the effect of cetuximab. This insight may explain why some cancers that initially respond to cetuximab become resistant to it, or how to overcome such resistance.
Tags: ColonCancer, EGFR, TargetedTherapy
A study by scientists at Dana-Farber Cancer Institute, the Broad Institute, and other research centers, may offer clues to why rates of esophageal adenocarcinomas (EACs) have risen so sharply. The findings, in Nature Genetics, point to an array of abnormal genes and proteins that may be lynchpins of EAC cell growth and therefore serve as targets for new therapies.
Tags: BasicResearch, Genomics, TargetedTherapy
A new discovery by Jean Zhao, PhD, and colleagues may help physicians predict which tumors are likely to become resistant to a given drug. In the report, published by Nature Medicine, researchers described how they created a genetically engineered mouse model of human breast cancer in which the most frequently occurring breast cancer oncogene, PIK3CA, could be turned on and off.
Tags: BreastCancer, Genomics, TargetedTherapy, Genetics
Dana-Farber scientists found that pancreatic cancer cells' growth and spread are fueled by an unusual metabolic pathway that someday might be blocked with targeted drugs to control the deadly cancer.
Tags: BasicResearch, PancreaticCancer, TargetedTherapy
- A new study by an international team of investigators led by Dana-Farber Cancer Institute scientists is the first to demonstrate that chemotherapy and a new, targeted therapy work better in combination than chemotherapy alone in treating patients with the most common genetic subtype of lung cancer.
Tags: LungCancer, TargetedTherapy, Genetics