Breast and Ovarian Cancer Risk and Prevention
Research Studies
GEMS: Genetic Modifiers of BRCA1 and BRCA2 Study
Why is this study important?
Many questions remain about why some people get cancer and others do not. Although mutations in either BRCA1 or BRCA2 may lead to an increased risk of breast and ovarian cancer, not all women who have mutations in these genes will ultimately get cancer. Furthermore, genetic disposition is not the only cause of breast cancer. There are environmental risk factors that also may be associated with breast cancer. A better understanding of genetic and environmental factors that may affect breast cancer risk in those with and without BRCA1 and BRCA2 mutations may help women make more informed decisions about lifestyle choices and treatment. Discovering why some women with a BRCA1 or BRCA2 mutation develop breast cancer and others do not will also help to improve our understanding of the role genes play in causing cancer and will assist in providing insights into cancer-related health surveillance decisions.
Who is eligible to participate?
- Women with DCIS (ductal carcinoma in situ) or a breast cancer diagnosis
What is involved?
- Consent to protocol 94-138
- Completion of CRIS survey, REACH Supplement, and GEMS survey
- A blood sample (optional)
How can I get more information about the GEMS study?
Kathryn Stoeckert
kathryn_stoeckert@dfci.harvard.edu
(617) 632-6693
