Hypoxia-positron Emission Tomography (PET) and Intensity Modulated Proton Therapy (IMPT) Dose Painting in Patients With Chordomas

Status: Recruiting
Phase: N/A
Diagnosis: Brain/Neuro Cancer: Supportative Care
NCT ID: NCT00713037 (View complete trial on ClinicalTrials.gov)
DFCI Protocol ID: 07-162


Before radiation treatment is given to treat chordomas, CT and MRI scans are used to create a three dimensional picture of the tumor using x-rays. The CT and MRI scans are used to determine the size and location of the area that will receive radiation treatment. The purpose of this research study is to see if combining the images from the FMISO-PET scan and the CT and MRI scans in radiation treatment planning changes the size and location of the area that will receive radiation treatment when compared to planning the radiation treatment with CT and MRI scans alone.


Conducting Institutions:
Massachusetts General Hospital

Overall PI:
Thomas DeLaney, MD, Massachusetts General Hospital

Site-responsible Investigators:

Massachusetts General Hospital: Cancer Trials Call Center, 877-789-6100

Eligibility Criteria

Inclusion Criteria: - Skull base and spinal chordomas diagnosis based on pathology review by Department of Pathology at Massachusetts General Hospital - Patient to be treated with proton or combined photon RT for primary CD or recurrent CD after surgery - 18 years of age or older - Karnofsky Score of 60% or greater - Gross tumor mass larger than 1cm (maximal diameter on MRI) Exclusion Criteria: - Recurrences after RT - Pregnancy - Allergic reaction to FMISO injection
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