Inclusion Criteria: - Incurable advanced solid tumors that are no longer responding to conventional therapy or for which no effective therapy exists - Age 18 years or older - ECOG 0-2 - Life expectancy ≥ 3 months - Evaluable disease - Adequate bone marrow function - Adequate renal function - Adequate liver function - At least 3 weeks from prior systemic treatments including investigational anti-cancer therapy, radiation therapy; and have recovered from prior toxicities - Able to swallow capsules - At least 3 weeks from major surgery - Agree to practice effective contraception - Ability to understand and willingness to sign the informed consent form Exclusion Criteria: - Previously untreated CNS metastases or progressive CNS metastases - Currently receiving radiotherapy, biological therapy, or any other investigational agents - Uncontrolled intercurrent illness including - Pregnant or lactating women - Known to be HIV-positive - A history of active hepatitis B and/or hepatitis C infection