Fluorine F 18 Sodium Fluoride Positron Emission Tomography in Evaluating Response to Dasatinib in Patients With Prostate Cancer and Bone Metastases

Status: Recruiting
Phase: Phase 2
Diagnosis: Prostate Cancer
NCT ID: NCT00936975 (View complete trial on ClinicalTrials.gov)
DFCI Protocol ID:

 

RATIONALE: Diagnostic procedures, such as fluorine F 18 sodium fluoride positron emission tomography (PET), may help doctors predict a patient's response to treatment and help plan the best treatment. PURPOSE: This phase II trial is studying how well fluorine F 18 sodium fluoride PET works in evaluating response to dasatinib in patients with prostate cancer and bone metastases.

 

Conducting Institutions:
Dana-Farber Cancer Institute, Beth-Israel Deaconess Medical Center, Brigham and Women's Hospital

Overall PI:
Glenn Bubley, MD, Beth Israel Deaconess Medical Center

Site-responsible Investigators:
Mary-Ellen Taplin, MD, Dana-Farber Cancer Institute

Contacts:
Beth-Israel Deaconess Medical Center: Cancer Trials Call Center, 617-667-3060
Dana-Farber Cancer Institute: Judith Prisby, 617-632-5068, jprisby@partners.org

Eligibility Criteria

DISEASE CHARACTERISTICS: - Histologically confirmed prostate cancer - Metastatic disease - Has ≥ 1 convincing bone metastasis by bone scintigraphy, CT scan/MRI, or plain x-ray - Castration-resistant disease - Castrate testosterone levels (< 50 ng/dL) - Has undergone prior orchiectomy OR is currently on maintenance luteinizing hormone-releasing hormone (LHRH) agonist or LHRH antagonist - Scheduled to receive treatment with dasatinib on the Febbo clinical trial PATIENT CHARACTERISTICS: - Life expectancy > 12 weeks - Able to lie still for imaging - Weighs ≤ 300 lbs. - No condition that would alter mental status and preclude the basic understanding and/or authorization of informed consent - No serious underlying condition that would otherwise impair the patient's ability to receive treatment and undergo imaging studies - No extremely poor IV access that would preclude the placement of a peripheral IV line for injection of a radiotracer PRIOR CONCURRENT THERAPY: - See Disease Characteristics - At least 4 weeks since prior initiation of bisphosphonate therapy - At least 4 weeks since prior radiotherapy to the bone - At least 4 weeks since prior radiopharmaceutical treatment to the bone - More than 4 weeks since prior GM-CSF or G-CSF
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