Inclusion Criteria: - Patients must have histologically or cytologically invasive breast cancer, with metastatic disease at the time of screening - Measurable CNS disease, as defined as at least one lesion > or equal too 10mm in longest dimension - New or progressive CNS lesions after at least one prior standard CNS-directed therapy for treatment of brain metastases, which could include surgical resection, WBRT, and/or SRS. Patients must have received prior WBRT, SRS or both. - Patient has been evaluated by a radiation oncologist, who feels that the plan to evaluate systemic chemotherapy in place of additional brain radiotherapy is an acceptable option - No increase in corticosteroid use in the week prior to study entry - Up to 3 prior lines of chemotherapy for metastatic breast cancer - 18 years of age of older - Life expectancy of greater than 12 weeks - ECOG Performance Status 0-2 - Patients must have normal organ function as outlined in the protocol Exclusion Criteria: - Patients who have had chemotherapy within 3 weeks prior to entering the study or those who have not recovered from adverse events due to agents administered more than 3 weeks earlier - Patients who have had XRT within 3 weeks prior to entering the study or those who have not recovered from adverse events due to XRT - Patients may not be receiving any other investigational agent - Patients may not be receiving any cancer-directed therapy - Prior treatment with investigational chemotherapy for brain metastases - Prior treatment with epothilone for metastatic breast cancer - Leptomeningeal carcinomatosis as the only site of CNS involvement. - Concurrent treatment with an enzyme inducing antiepileptic drug, including phenytoin, carbamezepine, phenobarbital, or oxacarbazepine - Grade 1, hormone receptive positive tumor - More than 2 seizures over the last four weeks prior to study entry - Known contraindication to MRI or gadolinium contrast, such as cardiac pacemaker, ocular foreign body, or shrapnel - Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements - Pregnant or breastfeeding women.