In-Room PET in Proton Radiation Therapy

Status: Recruiting
Phase: Phase 0
Diagnosis: Brain/Neuro Cancer: Supportative Care, Head and Neck Cancer
NCT ID: NCT01228448 (View complete trial on
DFCI Protocol ID: 10-241


The investigational part of this study is using a mobile PET/CT scanner to take images of the participants tumor immediately after they are treated with proton radiation. This allows the participant to be treated and imaged on the same bed. The information obtained may improve the accuracy of treatment and may help to minimize the dose delivered unnecessarily to healthy tissue.


Conducting Institutions:
Massachusetts General Hospital

Overall PI:
Helen Shih, MD, Massachusetts General Hospital

Site-responsible Investigators:

Massachusetts General Hospital: Cancer Trials Call Center, 877-789-6100

Eligibility Criteria

Inclusion Criteria: - Adult subjects with brain, head and neck, and skull base tumors receiving external beam proton radiotherapy at the Francis H. Burr Proton Therapy Center at MGH - Age 18 or over - ECOG Performance status 0, 1 or 2 - Subjects must have internal CT markers implanted on the skull as part of their radiation treatment planning Exclusion Criteria: - Uncontrolled intercurrent illness that, in the opinion of the investigator, would limit the participant's compliance with study requirements.
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